LOCUS       NM_021834                399 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus interleukin 5 (Il5), mRNA.
ACCESSION   NM_021834 XM_340797
VERSION     NM_021834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 399)
  AUTHORS   Hall,B.M., Plain,K.M., Tran,G.T., Verma,N.D., Robinson,C.M.,
            Nomura,M., Boyd,R. and Hodgkinson,S.J.
  TITLE     Cytokines affecting CD4+T regulatory cells in transplant tolerance.
            III. Interleukin-5 (IL-5) promotes survival of alloantigen-specific
            CD4+ T regulatory cells
  JOURNAL   Transpl Immunol 43-44, 33-41 (2017)
   PUBMED   28652007
  REMARK    GeneRIF: IL-5 promoted the survival of alloantigen-specific
            CD4(+)CD25(+)T cells that mediate transplant tolerance.
REFERENCE   2  (bases 1 to 399)
  AUTHORS   Zhou,Y., Li,C., Li,D., Zheng,Y. and Wang,J.
  TITLE     IL-5 blocks apoptosis and tau hyperphosphorylation induced by
            Abeta25-35 peptide in PC12 cells
  JOURNAL   J Physiol Biochem 73 (2), 259-266 (2017)
   PUBMED   28132394
  REMARK    GeneRIF: Data suggest that IL5/IL5Ra signaling activates JAK2 in
            neurons down-regulating cell apoptosis and down-regulating
            hyperphosphorylation of Tau [up-regulated in Alzheimer disease via
            amyloid-beta(25-35) peptide]. [IL5 = interleukin-5 ; IL5Ra =
            interleukin-5 receptor, alpha subunit; JAK2 = Janus kinase 2]
REFERENCE   3  (bases 1 to 399)
  AUTHORS   Andemariam,B., Adami,A.J., Singh,A., McNamara,J.T., Secor,E.R.,
            Guernsey,L.A. and Thrall,R.S.
  TITLE     The sickle cell mouse lung: proinflammatory and primed for allergic
            inflammation
  JOURNAL   Transl Res 166 (3), 254-268 (2015)
   PUBMED   25843670
REFERENCE   4  (bases 1 to 399)
  AUTHORS   Su,Y.C., Townsend,D., Herrero,L.J., Zaid,A., Rolph,M.S.,
            Gahan,M.E., Nelson,M.A., Rudd,P.A., Matthaei,K.I., Foster,P.S.,
            Dent,L., Tripp,R.A., Lee,J., Simson,L. and Mahalingam,S.
  TITLE     Dual proinflammatory and antiviral properties of pulmonary
            eosinophils in respiratory syncytial virus vaccine-enhanced disease
  JOURNAL   J Virol 89 (3), 1564-1578 (2015)
   PUBMED   25410867
REFERENCE   5  (bases 1 to 399)
  AUTHORS   Liu,D., Li,Y., Zhong,L.L. and Tan,Y.P.
  TITLE     [Effects of suplatast tosilate on airway inflammation and
            interleukin-5 in asthmatic rats]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 16 (7), 759-763 (2014)
   PUBMED   25008888
REFERENCE   6  (bases 1 to 399)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   7  (bases 1 to 399)
  AUTHORS   Sasaki,O., Sugaya,H., Ishida,K. and Yoshimura,K.
  TITLE     Ablation of eosinophils with anti-IL-5 antibody enhances the
            survival of intracranial worms of Angiostrongylus cantonensis in
            the mouse
  JOURNAL   Parasite Immunol 15 (6), 349-354 (1993)
   PUBMED   8361777
REFERENCE   8  (bases 1 to 399)
  AUTHORS   Tominaga,A., Takaki,S., Koyama,N., Katoh,S., Matsumoto,R.,
            Migita,M., Hitoshi,Y., Hosoya,Y., Yamauchi,S., Kanai,Y. et al.
  TITLE     Transgenic mice expressing a B cell growth and differentiation
            factor gene (interleukin 5) develop eosinophilia and autoantibody
            production
  JOURNAL   J Exp Med 173 (2), 429-437 (1991)
   PUBMED   1988543
REFERENCE   9  (bases 1 to 399)
  AUTHORS   Uberla,K., Li,W.Q., Qin,Z.H., Richter,G., Raabe,T., Diamantstein,T.
            and Blankenstein,T.
  TITLE     The rat interleukin-5 gene: characterization and expression by
            retroviral gene transfer and polymerase chain reaction
  JOURNAL   Cytokine 3 (1), 72-81 (1991)
   PUBMED   1653053
REFERENCE   10 (bases 1 to 399)
  AUTHORS   Yamaguchi,Y., Matsui,T., Kasahara,T., Etoh,S., Tominaga,A.,
            Takatsu,K., Miura,Y. and Suda,T.
  TITLE     In vivo changes of hemopoietic progenitors and the expression of
            the interleukin 5 gene in eosinophilic mice infected with Toxocara
            canis
  JOURNAL   Exp Hematol 18 (11), 1152-1157 (1990)
   PUBMED   1699772
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ011299.1.
            
            On Oct 10, 2004 this sequence version replaced XM_340797.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="LOU/M"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..399
                     /gene="Il5"
                     /note="interleukin 5"
                     /db_xref="GeneID:24497"
                     /db_xref="RGD:2900"
     CDS             1..399
                     /gene="Il5"
                     /note="TRF; IL-5; BCGF-II; B-cell growth factor II; T-cell
                     replacing factor; cytotoxic T-lymphocyte inducer;
                     eosinophil differentiation factor; Interleukin 5
                     (colony-stimulating factor, eosinophil)"
                     /codon_start=1
                     /product="interleukin-5 precursor"
                     /protein_id="NP_068606.1"
                     /db_xref="GeneID:24497"
                     /db_xref="RGD:2900"
                     /translation="MRMLLCLNVLTLSCVWAIAMEIPMSTVVKETLIQLSTHRALLTS
                     NETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEIPFQNLSLIKKYIDGQKEK
                     CGEERRKTRHFLDYLQEFLGVMSTEWAMEV"
     exon            1..138
                     /gene="Il5"
                     /inference="alignment:Splign:2.1.0"
     exon            139..171
                     /gene="Il5"
                     /inference="alignment:Splign:2.1.0"
     exon            172..300
                     /gene="Il5"
                     /inference="alignment:Splign:2.1.0"
     exon            301..399
                     /gene="Il5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaggatgc ttctgtgctt gaacgttcta actctcagct gtgtctgggc cattgctatg
       61 gagatcccca tgagcacagt ggtgaaagag accttgatac agctgtccac tcaccgagct
      121 ctgttgacga gcaatgagac gatgaggctt cctgttccta ctcataaaaa tcaccagcta
      181 tgcattggag aaatctttca ggggctagac atactgaaga atcaaactgt ccgagggggc
      241 actgtggaaa taccattcca aaacttgtca ttaataaaga aatacattga cggacaaaaa
      301 gagaagtgtg gcgaagagag gcggaagacc aggcatttcc tggattacct gcaagagttc
      361 cttggcgtga tgagtacaga gtgggcaatg gaagtctga
//
