LOCUS       NM_133380               3514 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus interleukin 4 receptor (Il4r), mRNA.
ACCESSION   NM_133380
VERSION     NM_133380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3514)
  AUTHORS   Nakamaru,Y., Takagi,D., Homma,A., Hatakeyama,S. and Fukuda,S.
  TITLE     Oxidative stress regulates IL-4 gene expression in mast cells
            through the reduction of histone deacetylase
  JOURNAL   Otolaryngol Head Neck Surg 152 (1), 48-52 (2015)
   PUBMED   25411311
  REMARK    GeneRIF: Our results suggest that oxidative stress may up-regulate
            IL-4 gene expression in mast cells via a decrease in HDAC activity.
REFERENCE   2  (bases 1 to 3514)
  AUTHORS   Qiu,Y., Nguyen,K.D., Odegaard,J.I., Cui,X., Tian,X., Locksley,R.M.,
            Palmiter,R.D. and Chawla,A.
  TITLE     Eosinophils and type 2 cytokine signaling in macrophages
            orchestrate development of functional beige fat
  JOURNAL   Cell 157 (6), 1292-1308 (2014)
   PUBMED   24906148
REFERENCE   3  (bases 1 to 3514)
  AUTHORS   Leipe,J., Schramm,M.A., Prots,I., Schulze-Koops,H. and Skapenko,A.
  TITLE     Increased Th17 cell frequency and poor clinical outcome in
            rheumatoid arthritis are associated with a genetic variant in the
            IL4R gene, rs1805010
  JOURNAL   Arthritis Rheumatol 66 (5), 1165-1175 (2014)
   PUBMED   24782180
REFERENCE   4  (bases 1 to 3514)
  AUTHORS   Garcia-Berrocoso,T., Giralt,D., Bustamante,A., Llombart,V.,
            Rubiera,M., Penalba,A., Boada,C., Espadaler,M., Molina,C. and
            Montaner,J.
  TITLE     Role of beta-defensin 2 and interleukin-4 receptor as stroke
            outcome biomarkers
  JOURNAL   J Neurochem 129 (3), 463-472 (2014)
   PUBMED   24386991
REFERENCE   5  (bases 1 to 3514)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   6  (bases 1 to 3514)
  AUTHORS   Chen,G., Nagasawa,R., Imasawa,T., Eto,Y., Kikuchi,K. and
            Maruyama,N.
  TITLE     Identification of soluble interleukin-4 receptor in rat glomerular
            epithelial cells(1)
  JOURNAL   Biochim Biophys Acta 1452 (1), 79-88 (1999)
   PUBMED   10525162
REFERENCE   7  (bases 1 to 3514)
  AUTHORS   Grimbacher,B., Holland,S.M. and Puck,J.M.
  TITLE     The interleukin-4 receptor variant Q576R in hyper-IgE syndrome
  JOURNAL   N Engl J Med 338 (15), 1073-1074 (1998)
   PUBMED   9537881
REFERENCE   8  (bases 1 to 3514)
  AUTHORS   Hershey,G.K., Friedrich,M.F., Esswein,L.A., Thomas,M.L. and
            Chatila,T.A.
  TITLE     The association of atopy with a gain-of-function mutation in the
            alpha subunit of the interleukin-4 receptor
  JOURNAL   N Engl J Med 337 (24), 1720-1725 (1997)
   PUBMED   9392697
REFERENCE   9  (bases 1 to 3514)
  AUTHORS   Richter,G., Hein,G., Blankenstein,T. and Diamantstein,T.
  TITLE     The rat interleukin 4 receptor: coevolution of ligand and receptor
  JOURNAL   Cytokine 7 (3), 237-241 (1995)
   PUBMED   7640343
REFERENCE   10 (bases 1 to 3514)
  AUTHORS   Gessner,A., Schroppel,K., Will,A., Enssle,K.H., Lauffer,L. and
            Rollinghoff,M.
  TITLE     Recombinant soluble interleukin-4 (IL-4) receptor acts as an
            antagonist of IL-4 in murine cutaneous Leishmaniasis
  JOURNAL   Infect Immun 62 (10), 4112-4117 (1994)
   PUBMED   7927664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB015747.1, BQ204155.1 and AW527353.1.
            
            On Oct 23, 2007 this sequence version replaced NM_133380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB015747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2944              AB015747.1         8-2951
            2945-3495           BQ204155.1         19-569              c
            3496-3514           AW527353.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3514
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /note="interleukin 4 receptor"
                     /db_xref="GeneID:25084"
                     /db_xref="RGD:2899"
     exon            1..73
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            74..154
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            155..241
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2577
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /note="interleukin-4 receptor alpha chain; interleukin-4
                     receptor subunit alpha; IL-4R-alpha; IL-4RA; IL-4R subunit
                     alpha; IL-4 receptor subunit alpha; interleukin 4
                     receptor, alpha"
                     /codon_start=1
                     /product="interleukin-4 receptor subunit alpha precursor"
                     /protein_id="NP_596871.2"
                     /db_xref="GeneID:25084"
                     /db_xref="RGD:2899"
                     /translation="MGWLCTKFLSSVSCLILLWVTGSGGIKVLGDPTCFSDYIRTSTC
                     EWQLDSTVDCSSQLLLDYRLLFEFSENLTCTPKNSADTVCVCQMAIEEPIQADTYWLE
                     LWSERGQLWQGSFKPSDNVKPPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKGLICM
                     VNISREDNPAEFKVYNVTYTEPKLSFPVNTLTSGVRYRARVRVLSQSFPGIWSEWSPS
                     ITWYNHFQLPLLQRLPLGVSISCICILLFCLTCYFSIIKIKKIWWDQIPTPARSPLAA
                     IIIQDTKVSLWEKQTRSQESTKSRHWKTCLTKLLPCLLEHRVKKERESPKAAKTKPLQ
                     SPEKAGWYPAEVSRTVLWPENVHVSVVRCMELFEAPVQNVEEEEDEMVKGDLSMSPEN
                     SGGGFQESQADIMARLTENLFSDLLGAENGGVGQSSMAESSSLLPSESGQASTSWACF
                     PTGPSETTCQVTGQQPPHPDPERATGTACTQVPLVISDNPAYRSFSDFSSPAPNPGEL
                     ASEQKQAGHLEEGDLLSPVDPHSSGPPMQQAESWEQILHMSVLQHGTAGSTPAPTSGY
                     QEFVQAVKQGASQDAGVPGVGPSGDTGYKAFSSLLSSSGVCTDTAAAGTDSGCGGYKP
                     FQNPVPNQSPNSMPLFTFGLDMELPPSPLNSAPPNSTPECLGLELGLKGGTWLKAPPP
                     SEQVPKPFGDDLGLGIVYSSLTCHLCGHLKQHHSQEEDGQIHVVASPGCGCCYDEKSP
                     SLGNLSGTLESCPGEMSQEANLTLAPRTPSNLSGVGKGPGHSPVPSQTTEVPVGTLGV
                     TVS"
     exon            242..380
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            381..532
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            533..684
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            685..841
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            842..941
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1020
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1070
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..3498
                     /gene="Il4r"
                     /gene_synonym="Il4ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcgtag gaaaccgggc gaggtccttc gcgcaggaaa gccccgcacg gcgcgtggag
       61 cctgaacaca caggtgctgg agagggagcc caggatctgg gggccaggta cgctgccact
      121 gagctgcatt ccagtctctc cctgtatagc ccaggcacct ttgtgtccgc aatggggtgg
      181 ctttgcacca agttcctgtc ctccgtgagc tgtctgattt tgctatgggt gactggctct
      241 gggggcatca aggtcctggg tgaccccacc tgcttctctg actacatccg cacttctacg
      301 tgtgagtggc agctggatag cactgtggac tgcagttctc agctcctcct ggactacagg
      361 ctgctctttg agttctctga aaacctcaca tgcaccccca agaacagtgc cgacaccgtg
      421 tgtgtgtgcc aaatggccat agaggagccg atccaggcag acacatactg gctggaactg
      481 tggtctgagc ggggacagct gtggcaaggc tccttcaagc ctagtgacaa tgtgaagccc
      541 ccagctccag acaacctcac actccacacc aatgtctcca atgcgctgct gctgatgtgg
      601 agcaacccat acccatcgaa caacttcctg cacaaaggcc tcatctgcat ggtcaacatc
      661 tccagagagg acaacccggc ggaattcaaa gtctataatg tgacctacac ggaacccaag
      721 ctgagcttcc cagtcaacac cctaacatca ggggtgcgct atagggcacg tgtgagggtc
      781 ttgtcccaga gcttccctgg catctggagt gagtggagtc ccagcatcac gtggtacaac
      841 cacttccagc tgcccctgct gcagcgcctc ccgctgggtg tcagcatctc ctgcatctgc
      901 atcctattgt tttgcctgac ctgttacttc agcattatca agattaagaa gatatggtgg
      961 gaccagattc ccactccagc acgcagtccc ttagcagcca tcatcattca ggacacgaag
     1021 gtgtccctct gggagaagca gacccgaagc caggagtcaa ccaagagccg gcactggaag
     1081 acttgtctaa ccaagctgct gccctgcttg ctggagcata gagtgaagaa agagagagaa
     1141 tccccgaagg ctgccaaaac caagcctctc cagagtcctg aaaaagcagg ctggtatcct
     1201 gcggaggtca gcaggaccgt cctctggcca gagaacgttc atgtcagtgt ggtgcgctgt
     1261 atggagctgt ttgaggcccc agtacagaat gtggaggagg aagaggatga gatggtcaaa
     1321 ggggacctga gcatgtcacc tgagaacagc ggagggggct tccaggagag tcaggcagac
     1381 atcatggccc ggctcactga gaacctgttt tcagacttgc tgggggctga gaatggaggc
     1441 gttggccagt cgagcatggc agagtcatcc tcccttctgc cttcagaaag tgggcaagct
     1501 tctacgtcct gggcctgctt ccccacgggg cccagtgaga ccacatgcca ggtcacaggg
     1561 cagcagcctc cacacccaga ccctgagaga gcaactggca cagcctgcac acaggtcccc
     1621 cttgtcattt cagacaatcc tgcctaccgg agttttagtg acttctccag ccccgcccca
     1681 aatcctggag agctggcttc agaacagaag caggctggac atctggaaga aggggatctt
     1741 ctgagcccgg ttgaccccca ttcttcaggg ccaccaatgc agcaagcgga gagctgggag
     1801 cagatccttc acatgagtgt cctgcagcac gggacagctg gctccacccc agcccctacc
     1861 agtggctacc aagagtttgt gcaggcagtg aagcagggtg cgtcccagga cgctggggtg
     1921 cctggtgtcg ggccttctgg agacactggt tacaaggctt tctcgagcct gctcagcagc
     1981 agtggcgtct gcacggacac agcagcagca gggactgaca gtggatgtgg agggtacaag
     2041 cccttccaga accctgttcc taaccagtcc cccaactcca tgcccttatt caccttcgga
     2101 ctggacatgg agctgccacc cagtcccctg aactcagccc cacccaatag caccccagaa
     2161 tgccttggtc tagagctggg gctcaaagga ggcacctggc tgaaggcccc tcctccttca
     2221 gagcaggtgc ccaagccctt tggggatgac ctgggccttg gcattgtgta ctcgtccctc
     2281 acctgccatc tgtgtggcca cctgaagcaa caccacagcc aggaggaaga tggtcagatc
     2341 catgtcgttg ctagccctgg ctgcggctgt tgctatgatg aaaaatcacc atccttgggg
     2401 aatctctcgg ggaccttgga gagctgtcct ggggaaatgt cacaggaagc caacctcacc
     2461 ttagcaccca ggacaccctc caatttgtca ggggtgggca agggccctgg ccactctcct
     2521 gttcccagcc agactactga ggtacctgtg ggcactctgg gcgtcactgt gtcttaggtg
     2581 agtgtgctgt tgttgctgag gtctgtgcta aggccggggt tcctccaagc cagggaagtg
     2641 cttcctgaga gacagcccag ctggcaggtt tcccagaaat cgaaagaatg gtgaagtgaa
     2701 gatgtgaact tggcctgacc ctagaagttc agagcctggc tgtctcccct accgttggcc
     2761 tgggctctcc tccctcacaa gggattcagg gactcatttt gctttctccc acagcagtgc
     2821 tgatattctt aagccctggg ctctcctagc tcttgttgcc ctacctgctc aggcccattc
     2881 tgtccaccca atagaccgtt tgcccaaggc tcacagcagt cctggcatag ctgtcgggtt
     2941 ctcccagctg gaagctggtc ctagaaactc gcagctggcc tggcagtggc ttgggaggcc
     3001 ctaactagtg gaaattttga gttaagggag ggtagatact gccccaagga ggctattcat
     3061 tgaacagctc ggactgagac tagaagcaga gcctgctgtc ccagcttggc ccagttgtgg
     3121 aaagcaacaa gaacgcaaac ttgattgccc aaagtcactg ccagttaccc acatgtggcc
     3181 agaagccagg gctcccagga tgtggaagtg ggatcccagt aaacaaacac agcagcctag
     3241 tggcaggtcc cagtggacac caccactggc agccaaggcg agaccacaag ggaactgtgg
     3301 ggctggttct ggttggtggc cagatgatag ggatggcaga tggcagactg cagtctgact
     3361 gcattctgga ggacgggacc aggctcagga ctgtctgctc gtgtccctac ctttgggaca
     3421 cctagtatgt ttgcaaggag ggcaggacag aagaggtcac gtggagctct atgtcaataa
     3481 agactcttta tcttgtcaaa aaaaaaaaaa aaaa
//
