LOCUS       NM_001108570             720 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus interleukin 36, beta (Il36b), mRNA.
ACCESSION   NM_001108570 XM_001077066 XM_342377
VERSION     NM_001108570.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 720)
  AUTHORS   Vigne,S., Palmer,G., Martin,P., Lamacchia,C., Strebel,D.,
            Rodriguez,E., Olleros,M.L., Vesin,D., Garcia,I., Ronchi,F.,
            Sallusto,F., Sims,J.E. and Gabay,C.
  TITLE     IL-36 signaling amplifies Th1 responses by enhancing proliferation
            and Th1 polarization of naive CD4+ T cells
  JOURNAL   Blood 120 (17), 3478-3487 (2012)
   PUBMED   22968459
REFERENCE   2  (bases 1 to 720)
  AUTHORS   Vigne,S., Palmer,G., Lamacchia,C., Martin,P., Talabot-Ayer,D.,
            Rodriguez,E., Ronchi,F., Sallusto,F., Dinh,H., Sims,J.E. and
            Gabay,C.
  TITLE     IL-36R ligands are potent regulators of dendritic and T cells
  JOURNAL   Blood 118 (22), 5813-5823 (2011)
   PUBMED   21860022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 3, 2022 this sequence version replaced NM_001108570.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.12095.1,
                                           SRR26643294.12100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000003.1  27428593-27428678   c
            87-194              JAXUCZ010000003.1  27427957-27428064   c
            195-334             JAXUCZ010000003.1  27424407-27424546   c
            335-720             JAXUCZ010000003.1  27423171-27423556   c
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..720
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /note="interleukin 36, beta"
                     /db_xref="GeneID:362076"
                     /db_xref="RGD:1307847"
     exon            1..86
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..547
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /note="interleukin 1 family, member 8"
                     /codon_start=1
                     /product="interleukin-36 beta"
                     /protein_id="NP_001102040.2"
                     /db_xref="GeneID:362076"
                     /db_xref="RGD:1307847"
                     /translation="MMAFPPQSHVCFTPPKSSDFDNINKGVQAFPSTYRVHDSQHKAW
                     VLAGNSLTAVPASNSVKSVILSLIACRDMEFQDEKKGNLVFLGIKGRSLCLFCAEIEG
                     KPTLQLKDVDIMDLYNEKKAQKAFLFYHGIEGSTSVFQSVLYPGWFIATSSTARQTII
                     LTQERGEANNTNFYLESEN"
     exon            87..194
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /inference="alignment:Splign:2.1.0"
     exon            195..334
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /inference="alignment:Splign:2.1.0"
     exon            335..720
                     /gene="Il36b"
                     /gene_synonym="Il1f8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accggcaatg atggctttcc ctccacaatc tcatgtatgt tttactcctc caaaaagctc
       61 tgactttgac aatatcaaca aaggggttca agcatttccc agtacctaca gagttcatga
      121 ctcccaacac aaggcgtggg tcctggctgg aaattctttg acagcggttc ctgctagcaa
      181 cagcgtcaaa tctgtcattc ttagcttgat agcatgtaga gacatggaat tccaagatga
      241 aaagaagggt aatctagttt tcctgggaat caaaggcaga agtctctgcc tcttctgtgc
      301 tgagatcgag ggcaaaccga ctttgcagct taaggatgta gacatcatgg atttgtacaa
      361 tgagaaaaaa gcacagaaag cctttctctt ctaccatggc atagagggat ctacttctgt
      421 ctttcagtca gtcttgtatc ctggctggtt tatagccacc tcttccacag caagacaaac
      481 aatcattctt acacaggaga ggggtgaagc taataacact aacttctact tagagtctga
      541 gaattagatc taccatgggc catatgtggc cagttgcagg ccaaagaatc aaactgttgg
      601 agaatctttt acttgaaaac atagcaagac atcttagaag accaccatgt ttcctcttct
      661 cctgacatcc atgtctgaaa tgccattcat tggtataaga gaataaaaaa tagggctgga
//
