LOCUS       NM_001025766            1549 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interleukin 34 (Il34), mRNA.
ACCESSION   NM_001025766 XM_574240
VERSION     NM_001025766.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1549)
  AUTHORS   Freuchet,A., Salama,A., Bezie,S., Tesson,L., Remy,S., Humeau,R.,
            Regue,H., Serazin,C., Flippe,L., Peterson,P., Vimond,N., Usal,C.,
            Menoret,S., Heslan,J.M., Duteille,F., Blanchard,F., Giral,M.,
            Colonna,M., Anegon,I. and Guillonneau,C.
  TITLE     IL-34 deficiency impairs FOXP3+ Treg function in a model of
            autoimmune colitis and decreases immune tolerance homeostasis
  JOURNAL   Clin Transl Med 12 (8), e988 (2022)
   PUBMED   36030499
  REMARK    GeneRIF: IL-34 deficiency impairs FOXP3(+) Treg function in a model
            of autoimmune colitis and decreases immune tolerance homeostasis.
REFERENCE   2  (bases 1 to 1549)
  AUTHORS   Wlodarczyk,A., Benmamar-Badel,A., Cedile,O., Jensen,K.N.,
            Kramer,I., Elsborg,N.B. and Owens,T.
  TITLE     CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+
            Microglia in EAE
  JOURNAL   Front Cell Neurosci 12, 523 (2019)
   PUBMED   30687013
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1549)
  AUTHORS   Kuboyama,K., Fujikawa,A., Suzuki,R., Tanga,N. and Noda,M.
  TITLE     Role of Chondroitin Sulfate (CS) Modification in the Regulation of
            Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity:
            PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE
            DIFFERENTIATION
  JOURNAL   J Biol Chem 291 (35), 18117-18128 (2016)
   PUBMED   27445335
REFERENCE   4  (bases 1 to 1549)
  AUTHORS   Zhou,S.L., Hu,Z.Q., Zhou,Z.J., Dai,Z., Wang,Z., Cao,Y., Fan,J.,
            Huang,X.W. and Zhou,J.
  TITLE     miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular
            carcinoma metastasis
  JOURNAL   Hepatology 63 (5), 1560-1575 (2016)
   PUBMED   26754294
REFERENCE   5  (bases 1 to 1549)
  AUTHORS   Bezie,S., Picarda,E., Ossart,J., Tesson,L., Usal,C., Renaudin,K.,
            Anegon,I. and Guillonneau,C.
  TITLE     IL-34 is a Treg-specific cytokine and mediates transplant tolerance
  JOURNAL   J Clin Invest 125 (10), 3952-3964 (2015)
   PUBMED   26389674
  REMARK    GeneRIF: In a rat cardiac allograft model, IL-34 induced transplant
            tolerance associated with a total inhibition of alloantibody
            production. Treatment of rats with IL-34 promoted allograft
            tolerance mediated by induction of CD8+ and CD4+ Tregs.
REFERENCE   6  (bases 1 to 1549)
  AUTHORS   Gomez-Nicola,D., Fransen,N.L., Suzzi,S. and Perry,V.H.
  TITLE     Regulation of microglial proliferation during chronic
            neurodegeneration
  JOURNAL   J Neurosci 33 (6), 2481-2493 (2013)
   PUBMED   23392676
REFERENCE   7  (bases 1 to 1549)
  AUTHORS   Foucher,E.D., Blanchard,S., Preisser,L., Garo,E., Ifrah,N.,
            Guardiola,P., Delneste,Y. and Jeannin,P.
  TITLE     IL-34 induces the differentiation of human monocytes into
            immunosuppressive macrophages. antagonistic effects of GM-CSF and
            IFNgamma
  JOURNAL   PLoS One 8 (2), e56045 (2013)
   PUBMED   23409120
  REMARK    Erratum:[PLoS One. 2014;9(1).
            doi:10.1371/annotation/a732b069-ac19-4ca4-8474-97cbe0a7d7ee]
REFERENCE   8  (bases 1 to 1549)
  AUTHORS   Ma,X., Lin,W.Y., Chen,Y., Stawicki,S., Mukhyala,K., Wu,Y.,
            Martin,F., Bazan,J.F. and Starovasnik,M.A.
  TITLE     Structural basis for the dual recognition of helical cytokines
            IL-34 and CSF-1 by CSF-1R
  JOURNAL   Structure 20 (4), 676-687 (2012)
   PUBMED   22483114
REFERENCE   9  (bases 1 to 1549)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098808.1.
            
            [WARNING] On Nov 14, 2024 this sequence was replaced by
            NM_001025766.2.
            
            On Jul 22, 2005 this sequence version replaced XM_574240.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423, SAMN12840107
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1549
                     /gene="Il34"
                     /note="interleukin 34"
                     /db_xref="GeneID:498951"
                     /db_xref="RGD:1586038"
     exon            1..407
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..1084
                     /gene="Il34"
                     /note="IL-34"
                     /codon_start=1
                     /product="interleukin-34 precursor"
                     /protein_id="NP_001020937.1"
                     /db_xref="GeneID:498951"
                     /db_xref="RGD:1586038"
                     /translation="MPWGLAWLYCLGILLDVALGNENLEIWTLAQDKECDLTGYLRGK
                     LQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLKAHVSERELRYLWVLVSLNATE
                     SVLDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRP
                     KALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPESLMQCAATNVYPLPRQP
                     PTSLPRSPSSNHGPLP"
     exon            408..541
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
     exon            542..619
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
     exon            620..778
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
     exon            779..914
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1525
                     /gene="Il34"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagtcgg gagaaaccag agaaagcgcc acccagcccc agattccaag aggcctgctg
       61 gggactccct tctcttcctc ctccttctcc tctccctctt cctcctcctc ctgagacccc
      121 aaagccactg tctcacacca cttcctgagc cgcaatggag ctcccagcca ccgccccctg
      181 gctgtcctct accctgacaa gcagataggg cggccggtag ctaccccagg agtacctgcc
      241 ccctctcagc ctggggcagc ccttcctgga cttggtggcc acctttgctg acctgaggcc
      301 atgtaggccc tggctcaggc ttccggatac actgctgggg acagtgcctc tgctctcagg
      361 gggcacccag tgcaccatca tgccctgggg actcgcctgg ttatactgtc ttgggatcct
      421 acttgacgtg gctttgggaa acgagaattt ggagatatgg actctggccc aagataaaga
      481 atgtgatctt acaggctacc ttcggggcaa gctgcagtac aagaaccggc ttcagtacat
      541 gaaacattac ttccccatca actacaggat tgctgtgcct tatgaggggg tactcagagt
      601 ggccaacatc acgaggctga aggcccatgt gagtgagcga gagctgcggt acctgtgggt
      661 cttggtgagc ctcaacgcca ctgagtctgt gctggatgtg ctgctggagg gacacccatc
      721 ctggaagtat ctacaggagg ttcagacatt gctggagaat gttcagcgga gcctcatgga
      781 tgtggagatt ggccctcacg tggaagctgt gttatctctt ctgagtaccc ctggcctaag
      841 cctgaagctg gtgcggccca aagccttgtt ggataactgc ttccgggtca tggagctgct
      901 gtactgctct tgctgcaaac aaagtcccat cttaaaatgg caggactgtg agctgcccag
      961 gctccatccc cacagtccag agtccttgat gcaatgtgca gctaccaacg tgtacccttt
     1021 gcctcggcag ccccccacct ccctgcccag gtccccaagt tcaaaccatg gcccgttgcc
     1081 ctgagcaatc tgtgtgttga ccctgtgtcg ggccactgga tgtgtttcag aaaccagcct
     1141 gggtctgaga ctttcctgga tattgggtag gtagcccttt aggaaaggcc tcctgccttc
     1201 tcttccacac ccaggcttcc tgccttctgt acctgtgata tcacctggag cctcggggag
     1261 ggttgtggag gggatggctg gttgttatcc cctacagcca cctctacctg tagccggttc
     1321 taaaatctgc gaacactgtt gccccacagg tgggtggcca ataactactg ggtgccacat
     1381 aggattccgg gacttcctgg ggcttttcag ttgtgttgat tgtggggtgc tggaccaagg
     1441 acggaccaat tgccatatct tgccacgaca atgttcttct ggctcctttt tctattaaat
     1501 ggccatttgt ttggtttggc ttgcaaaaaa aaaaaaaaaa aaaaaaaaa
//
