LOCUS       NP_001020937             234 aa            linear   ROD 05-MAY-2025
DEFINITION  interleukin-34 isoform 1 precursor [Rattus norvegicus].
ACCESSION   NP_001020937 XP_038953860 XP_574240
VERSION     NP_001020937.1
DBSOURCE    REFSEQ: accession NM_001025766.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 234)
  AUTHORS   Freuchet,A., Salama,A., Bezie,S., Tesson,L., Remy,S., Humeau,R.,
            Regue,H., Serazin,C., Flippe,L., Peterson,P., Vimond,N., Usal,C.,
            Menoret,S., Heslan,J.M., Duteille,F., Blanchard,F., Giral,M.,
            Colonna,M., Anegon,I. and Guillonneau,C.
  TITLE     IL-34 deficiency impairs FOXP3+ Treg function in a model of
            autoimmune colitis and decreases immune tolerance homeostasis
  JOURNAL   Clin Transl Med 12 (8), e988 (2022)
   PUBMED   36030499
  REMARK    GeneRIF: IL-34 deficiency impairs FOXP3(+) Treg function in a model
            of autoimmune colitis and decreases immune tolerance homeostasis.
REFERENCE   2  (residues 1 to 234)
  AUTHORS   Wlodarczyk,A., Benmamar-Badel,A., Cedile,O., Jensen,K.N.,
            Kramer,I., Elsborg,N.B. and Owens,T.
  TITLE     CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+
            Microglia in EAE
  JOURNAL   Front Cell Neurosci 12, 523 (2019)
   PUBMED   30687013
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 234)
  AUTHORS   Kuboyama,K., Fujikawa,A., Suzuki,R., Tanga,N. and Noda,M.
  TITLE     Role of Chondroitin Sulfate (CS) Modification in the Regulation of
            Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity:
            PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE
            DIFFERENTIATION
  JOURNAL   J Biol Chem 291 (35), 18117-18128 (2016)
   PUBMED   27445335
REFERENCE   4  (residues 1 to 234)
  AUTHORS   Zhou,S.L., Hu,Z.Q., Zhou,Z.J., Dai,Z., Wang,Z., Cao,Y., Fan,J.,
            Huang,X.W. and Zhou,J.
  TITLE     miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular
            carcinoma metastasis
  JOURNAL   Hepatology 63 (5), 1560-1575 (2016)
   PUBMED   26754294
REFERENCE   5  (residues 1 to 234)
  AUTHORS   Bezie,S., Picarda,E., Ossart,J., Tesson,L., Usal,C., Renaudin,K.,
            Anegon,I. and Guillonneau,C.
  TITLE     IL-34 is a Treg-specific cytokine and mediates transplant tolerance
  JOURNAL   J Clin Invest 125 (10), 3952-3964 (2015)
   PUBMED   26389674
  REMARK    GeneRIF: In a rat cardiac allograft model, IL-34 induced transplant
            tolerance associated with a total inhibition of alloantibody
            production. Treatment of rats with IL-34 promoted allograft
            tolerance mediated by induction of CD8+ and CD4+ Tregs.
REFERENCE   6  (residues 1 to 234)
  AUTHORS   Gomez-Nicola,D., Fransen,N.L., Suzzi,S. and Perry,V.H.
  TITLE     Regulation of microglial proliferation during chronic
            neurodegeneration
  JOURNAL   J Neurosci 33 (6), 2481-2493 (2013)
   PUBMED   23392676
REFERENCE   7  (residues 1 to 234)
  AUTHORS   Foucher,E.D., Blanchard,S., Preisser,L., Garo,E., Ifrah,N.,
            Guardiola,P., Delneste,Y. and Jeannin,P.
  TITLE     IL-34 induces the differentiation of human monocytes into
            immunosuppressive macrophages. antagonistic effects of GM-CSF and
            IFNgamma
  JOURNAL   PLoS One 8 (2), e56045 (2013)
   PUBMED   23409120
  REMARK    Erratum:[PLoS One. 2014;9(1).
            doi:10.1371/annotation/a732b069-ac19-4ca4-8474-97cbe0a7d7ee]
REFERENCE   8  (residues 1 to 234)
  AUTHORS   Ma,X., Lin,W.Y., Chen,Y., Stawicki,S., Mukhyala,K., Wu,Y.,
            Martin,F., Bazan,J.F. and Starovasnik,M.A.
  TITLE     Structural basis for the dual recognition of helical cytokines
            IL-34 and CSF-1 by CSF-1R
  JOURNAL   Structure 20 (4), 676-687 (2012)
   PUBMED   22483114
REFERENCE   9  (residues 1 to 234)
  AUTHORS   Lin,H., Lee,E., Hestir,K., Leo,C., Huang,M., Bosch,E.,
            Halenbeck,R., Wu,G., Zhou,A., Behrens,D., Hollenbaugh,D.,
            Linnemann,T., Qin,M., Wong,J., Chu,K., Doberstein,S.K. and
            Williams,L.T.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Nov 14, 2024 this sequence version replaced
            XP_038953860.1, XP_574240.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.161281.1,
                                           SRR26643286.45656.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..234
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..234
                     /product="interleukin-34 isoform 1 precursor"
                     /note="IL-34"
                     /calculated_mol_wt=24586
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2205
     mat_peptide     21..234
                     /product="Interleukin-34. /id=PRO_0000294350"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM46.1)"
                     /calculated_mol_wt=24586
     Region          28..183
                     /region_name="IL34"
                     /note="Interleukin 34; pfam15036"
                     /db_xref="CDD:434409"
     Site            99
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q4KM46.1)"
     Region          215..234
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM46.1)"
     CDS             1..234
                     /gene="Il34"
                     /coded_by="NM_001025766.2:593..1297"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:498951"
                     /db_xref="RGD:1586038"
ORIGIN      
        1 mpwglawlyc lgilldvalg nenleiwtla qdkecdltgy lrgklqyknr lqymkhyfpi
       61 nyriavpyeg vlrvanitrl kahvserelr ylwvlvslna tesvldvlle ghpswkylqe
      121 vqtllenvqr slmdveigph veavlsllst pglslklvrp kalldncfrv mellycscck
      181 qspilkwqdc elprlhphsp eslmqcaatn vyplprqppt slprspssnh gplp
//
