LOCUS       NM_001014166            2459 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Rattus norvegicus interleukin 33 (Il33), transcript variant 2,
            mRNA.
ACCESSION   NM_001014166 XM_342042
VERSION     NM_001014166.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Wu,L., Zhu,X., Luo,C., Zhao,Y., Pan,S., Shi,K., Chen,Y., Qiu,J.,
            Shen,Z., Guo,J. and Jie,W.
  TITLE     Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence
  JOURNAL   Life Sci 348, 122701 (2024)
   PUBMED   38724005
  REMARK    GeneRIF: Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence.
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Jin,Y., Zhou,J., Fang,Y., Song,H., Lin,S., Pan,B., Liu,L. and
            Xiong,B.
  TITLE     Electroacupuncture prevents the development or establishment of
            chronic pain via IL-33/ST2 signaling in hyperalgesic priming model
            rats
  JOURNAL   Neurosci Lett 820, 137611 (2024)
   PUBMED   38142925
  REMARK    GeneRIF: Electroacupuncture prevents the development or
            establishment of chronic pain via IL-33/ST2 signaling in
            hyperalgesic priming model rats.
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Sitzia,C., Vianello,E., Dozio,E., Kalousova,M., Zima,T.,
            Brizzola,S., Roccabianca,P., Tedeschi,G., Lamont,J., Tacchini,L.
            and Corsi-Romanelli,M.M.
  TITLE     Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to
            Obesity in Zucker Fatty Rats
  JOURNAL   Int J Mol Sci 24 (3), 1991 (2023)
   PUBMED   36768322
  REMARK    GeneRIF: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac
            Remodeling Due to Obesity in Zucker Fatty Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2459)
  AUTHORS   Liu,J., Liu,L., Su,Y., Wang,Y., Zhu,Y., Sun,X., Guo,Y. and Shan,J.
  TITLE     IL-33 Participates in the Development of Esophageal Adenocarcinoma
  JOURNAL   Pathol Oncol Res 28, 1610474 (2022)
   PUBMED   36110250
  REMARK    GeneRIF: IL-33 Participates in the Development of Esophageal
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2459)
  AUTHORS   Li,Z., Jiang,W., Chu,H., Ge,J., Wang,X., Jiang,J., Xiao,Q.,
            Meng,Q., Hao,W. and Wei,X.
  TITLE     Exploration of potential mechanism of interleukin-33 up-regulation
            caused by 1,4-naphthoquinone black carbon in RAW264.7 cells
  JOURNAL   Sci Total Environ 835, 155357 (2022)
   PUBMED   35452731
  REMARK    GeneRIF: Exploration of potential mechanism of interleukin-33
            up-regulation caused by 1,4-naphthoquinone black carbon in RAW264.7
            cells.
REFERENCE   6  (bases 1 to 2459)
  AUTHORS   Hudson,C.A., Christophi,G.P., Gruber,R.C., Wilmore,J.R.,
            Lawrence,D.A. and Massa,P.T.
  TITLE     Induction of IL-33 expression and activity in central nervous
            system glia
  JOURNAL   J Leukoc Biol 84 (3), 631-643 (2008)
   PUBMED   18552204
  REMARK    Erratum:[J Leukoc Biol. 2011 Feb;89(2):319]
REFERENCE   7  (bases 1 to 2459)
  AUTHORS   Miller,A.M., Xu,D., Asquith,D.L., Denby,L., Li,Y., Sattar,N.,
            Baker,A.H., McInnes,I.B. and Liew,F.Y.
  TITLE     IL-33 reduces the development of atherosclerosis
  JOURNAL   J Exp Med 205 (2), 339-346 (2008)
   PUBMED   18268038
  REMARK    Erratum:[J Exp Med. 2012 Dec 17;209(13):2515]
REFERENCE   8  (bases 1 to 2459)
  AUTHORS   Hayakawa,H., Hayakawa,M., Kume,A. and Tominaga,S.
  TITLE     Soluble ST2 blocks interleukin-33 signaling in allergic airway
            inflammation
  JOURNAL   J Biol Chem 282 (36), 26369-26380 (2007)
   PUBMED   17623648
REFERENCE   9  (bases 1 to 2459)
  AUTHORS   Sanada,S., Hakuno,D., Higgins,L.J., Schreiter,E.R., McKenzie,A.N.
            and Lee,R.T.
  TITLE     IL-33 and ST2 comprise a critical biomechanically induced and
            cardioprotective signaling system
  JOURNAL   J Clin Invest 117 (6), 1538-1549 (2007)
   PUBMED   17492053
REFERENCE   10 (bases 1 to 2459)
  AUTHORS   Carriere,V., Roussel,L., Ortega,N., Lacorre,D.A., Americh,L.,
            Aguilar,L., Bouche,G. and Girard,J.P.
  TITLE     IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a
            chromatin-associated nuclear factor in vivo
  JOURNAL   Proc Natl Acad Sci U S A 104 (1), 282-287 (2007)
   PUBMED   17185418
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Apr 4, 2023 this sequence version replaced NM_001014166.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081993.1, SRR21887623.1215998.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000001.1  237134946-237135009
            65-172              JAXUCZ010000001.1  237138757-237138864
            173-298             JAXUCZ010000001.1  237141423-237141548
            299-409             JAXUCZ010000001.1  237142175-237142285
            410-532             JAXUCZ010000001.1  237143977-237144099
            533-580             JAXUCZ010000001.1  237144616-237144663
            581-678             JAXUCZ010000001.1  237146068-237146165
            679-2459            JAXUCZ010000001.1  237148117-237149897
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2459
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /note="interleukin 33"
                     /db_xref="GeneID:361749"
                     /db_xref="RGD:1311155"
     exon            1..64
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            65..172
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..870
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /note="IL-33"
                     /codon_start=1
                     /product="interleukin-33"
                     /protein_id="NP_001014188.1"
                     /db_xref="GeneID:361749"
                     /db_xref="RGD:1311155"
                     /translation="MRPRMKYSNSKISPAKCDSTSGRALVPPCKITRSQQKTKDICHV
                     YCMRLRSGLTIRKETCYFGKEPAKRYSLKSGSKHEGRLSTCLPDSRKRSLLGSIQAFA
                     ASVDTLSIQGTSLLTESCALSTYNDQSVSFVLENGCYVINVEDCGKNQEKDKVLLRYY
                     ESSFPAQSGDGVDGKKLMVNMSPIKDTDIWLNANDKDYSVELQKGDVSPPDQAFFVLH
                     KKSSDFVSFECKNLPGTYIGVKDNQLALVEENDESCNNIMFKLSKM"
     exon            173..298
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            299..409
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            410..532
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            533..580
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            581..678
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
     exon            679..2459
                     /gene="Il33"
                     /gene_synonym="RGD1311155"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacaaggg ctcactgcag gaaagtacat cctttaagac cagctatctc ccatcactat
       61 taagaaacct gaaaaatgag acctagaatg aagtattcga actccaagat ttccccggca
      121 aagtgcgaca gcacatcagg cagagccctg gtcccgcctt gcaaaatcac aagatcccaa
      181 cagaagacca aagatatctg ccatgtctac tgcatgaggc tccgttctgg cctcaccata
      241 agaaaggaga cctgttattt tggaaaagaa cccgccaaaa gatattcact aaaatcaggt
      301 agcaagcatg aagggaggct ctctacctgt ttaccagatt ctaggaagag atccctgctt
      361 ggcagtatcc aagcgtttgc tgcatcagtt gacacactga gtatccaagg aacttcactg
      421 ctaacagaat cttgtgccct gagcacatac aacgaccaat ctgttagttt tgttttggag
      481 aatggatgtt acgtgatcaa tgttgaagat tgtgggaaaa accaagaaaa agataaggtg
      541 ctactccgtt actacgagtc ttcctttcct gcacaatcag gagacggtgt ggatgggaag
      601 aagctgatgg tgaacatgag tcctatcaaa gacacagaca tctggctgaa tgccaatgac
      661 aaggactact ctgtggagct ccaaaagggt gatgtctctc cgccagatca ggccttcttt
      721 gttcttcaca aaaagtcctc tgacttcgtt tcattcgaat gcaagaatct tcctggcact
      781 tacataggag taaaagacaa ccaactggct ctggtagaag agaatgatga gagctgtaac
      841 aatatcatgt ttaagctctc taagatgtaa cgtaataaaa ggtctgtgcc ttctgggtta
      901 aatggttcaa tgcttccaac tgaagaaagg ccaacagaga gaaagaaagc cgttcttggt
      961 ttaagatgat gtgaaatgtt atatagaaga ttttctctta tttccttttg tagagctgca
     1021 tgttcaacaa agacgtgatt ctatgactta gggcaattgg taaagaaaca gattcagtcc
     1081 tgccctttcc ttttctctgc tttgagtcct gcatgaaatc acactcacag acctgttcag
     1141 aagagcacgc accacagctc acgttttgct ttcaaaaatc ttcatcaaaa gaaaacaaca
     1201 aaacaaaact aaaaaaataa aaaccctaca caattttccc tggttctaag ccaaagattg
     1261 taatactaga gcagttgggg gggaggacca gctagaggga ggaccagcta gggggaggac
     1321 cagctaaggg gaggaccaac tgccccagag actgttcaga ataaaatgcc aaatgcatcg
     1381 ctatatgccc caggcacccc tcagatcagc cctttctgtc aagaacccta gcactccaga
     1441 tgtctacatg tctagacaga caagtctgtg tttgtgaagt ggagtgatat tacctgcgct
     1501 tgtttccttc ttaaaattcc attttttttt caacacagca acttaacttt aagcaagcca
     1561 gcttacatta ggaaacgaaa cacattttag ttcgcacctg tgactgaaat cattgacgat
     1621 atttaacaaa cttcaagtct tctgtaagaa ctaaccaggg acatacacta gggtatctca
     1681 atagcatggg atcccatggt gcagtcagaa gtcctcttac tagaaagaca ctaaattgac
     1741 ctcaactttt caatagctgg ttattgccta tgtttgtggc atgctgtgtc cttctcgctg
     1801 acttccgaag agctgaggct ttcgatgcac ccatctactt ggatgaaatg tctctgctgc
     1861 ctgtctgctt gctttccttc cacacaagtt ctgttctgcc ccttctttgg ttcttttgac
     1921 caacatatcc gtaacaggtc tccttctcac taagcattgt ttctgttttc tctgatgtct
     1981 atacgccatc cgctgtattt agtctgcaat gcagaatttt acatagactt actggttaca
     2041 agcttgttcc ttaaactttg tgtatgttta agtgttacta aagtagtact aaagaaaggt
     2101 ttgtattcaa ccacgtagta atatttcaag ctactaaagg aatagtttta cctatttaga
     2161 caacagcaat ttctactaca ttttttataa gcttaaaact cactatgtat acaatagccg
     2221 gtggggtgta gaacaaaaga ggccaggaac caccgtatac aattagagcg ggtataattg
     2281 tttcattaat ttgtcacagt tttactgtaa aggaaagtag aggcagaatc tttatactcc
     2341 ccccgaaaac cacaatgctg actctatgaa tctgcacgcc atccttaaaa tagtaattaa
     2401 gtagccaaat gtgttcttga cgttgttcac aactttgaat aaactaagtt tcaaagcca
//
