LOCUS       NM_031513                553 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interleukin 3 (Il3), mRNA.
ACCESSION   NM_031513
VERSION     NM_031513.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 553)
  AUTHORS   Piprode,V., Singh,K., Kumar,A., Josh,S.R. and Wani,M.R.
  TITLE     IL-3 inhibits rat osteoclast differentiation induced by TNF-alpha
            and other pro-osteoclastogenic cytokines
  JOURNAL   J Biosci 46 (2021)
   PUBMED   34183475
  REMARK    GeneRIF: IL-3 inhibits rat osteoclast differentiation induced by
            TNF-alpha and other pro-osteoclastogenic cytokines.
REFERENCE   2  (bases 1 to 553)
  AUTHORS   Lee,J., Lim,S., Song,B.W., Cha,M.J., Ham,O., Lee,S.Y., Lee,C.,
            Park,J.H., Bae,Y., Seo,H.H., Seung,M., Choi,E. and Hwang,K.C.
  TITLE     MicroRNA-29b inhibits migration and proliferation of vascular
            smooth muscle cells in neointimal formation
  JOURNAL   J Cell Biochem 116 (4), 598-608 (2015)
   PUBMED   25389122
  REMARK    GeneRIF: Findings demonstrated that miR-29b successfully suppressed
            the proliferation and migration of smooth muscle cells induced by
            IL-3 stimulation, probably through targeting of Mcl-1 and MMP2.
REFERENCE   3  (bases 1 to 553)
  AUTHORS   Miyake,Y., Tanaka,K. and Arakawa,M.
  TITLE     IL3 rs40401 polymorphism and interaction with smoking in risk of
            asthma in Japanese women: the Kyushu Okinawa Maternal and Child
            Health study
  JOURNAL   Scand J Immunol 79 (6), 410-414 (2014)
   PUBMED   24684517
REFERENCE   4  (bases 1 to 553)
  AUTHORS   Miyake,Y., Tanaka,K. and Arakawa,M.
  TITLE     IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in
            Japanese women: the Kyushu Okinawa maternal and child health study
  JOURNAL   Cytokine 64 (1), 86-89 (2013)
   PUBMED   23953855
REFERENCE   5  (bases 1 to 553)
  AUTHORS   Dougan,M., Li,D., Neuberg,D., Mihm,M., Googe,P., Wong,K.K. and
            Dranoff,G.
  TITLE     A dual role for the immune response in a mouse model of
            inflammation-associated lung cancer
  JOURNAL   J Clin Invest 121 (6), 2436-2446 (2011)
   PUBMED   21537082
REFERENCE   6  (bases 1 to 553)
  AUTHORS   Ito,T., Jagus,R. and May,W.S.
  TITLE     Interleukin 3 stimulates protein synthesis by regulating
            double-stranded RNA-dependent protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7455-7459 (1994)
   PUBMED   7519779
REFERENCE   7  (bases 1 to 553)
  AUTHORS   Tsuji,K., Lyman,S.D., Sudo,T., Clark,S.C. and Ogawa,M.
  TITLE     Enhancement of murine hematopoiesis by synergistic interactions
            between steel factor (ligand for c-kit), interleukin-11, and other
            early acting factors in culture
  JOURNAL   Blood 79 (11), 2855-2860 (1992)
   PUBMED   1375116
REFERENCE   8  (bases 1 to 553)
  AUTHORS   Okada,S., Nakauchi,H., Nagayoshi,K., Nakamura,M., Miura,Y. and
            Suda,T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   9  (bases 1 to 553)
  AUTHORS   Haig,D.M., McMenamin,C., Redmond,J., Brown,D., Young,I.G.,
            Cohen,S.D. and Hapel,A.J.
  TITLE     Rat IL-3 stimulates the growth of rat mucosal mast cells in culture
  JOURNAL   Immunology 65 (2), 205-211 (1988)
   PUBMED   3263940
REFERENCE   10 (bases 1 to 553)
  AUTHORS   Cohen,D.R., Hapel,A.J. and Young,I.G.
  TITLE     Cloning and expression of the rat interleukin-3 gene
  JOURNAL   Nucleic Acids Res 14 (9), 3641-3658 (1986)
   PUBMED   3086845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by NM_031513.3.
            
            On Dec 3, 2020 this sequence version replaced NM_031513.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U81492.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN09345331
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000010.1  38908632-38908810   c
            180-230             JAXUCZ010000010.1  38908497-38908547   c
            231-326             JAXUCZ010000010.1  38906927-38907022   c
            327-368             JAXUCZ010000010.1  38906764-38906805   c
            369-553             JAXUCZ010000010.1  38906460-38906644   c
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..553
                     /gene="Il3"
                     /note="interleukin 3"
                     /db_xref="GeneID:24495"
                     /db_xref="RGD:2897"
     exon            1..179
                     /gene="Il3"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..524
                     /gene="Il3"
                     /note="IL-3; MCGF; mast cell growth factor;
                     P-cell-stimulating factor; hematopoietic growth factor;
                     multipotential colony-stimulating factor"
                     /codon_start=1
                     /product="interleukin-3 precursor"
                     /protein_id="NP_113701.2"
                     /db_xref="GeneID:24495"
                     /db_xref="RGD:2897"
                     /translation="MVLASSTTSILCMLLPLLMLFHQGLQFSGSAHRLLRTLDCRTIA
                     LEILVKLPYPQVSGLNNSDDKANLRNSTLRRVNLDEFLKSQEEFDSQDTMDIKSKLQK
                     LKCCIPAAASDSVLPGVYNKDLDDFKKKLRFYVIHLKDLQPVSVSRPPQPTSSSDNFR
                     PMTVEC"
     exon            180..230
                     /gene="Il3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..326
                     /gene="Il3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..368
                     /gene="Il3"
                     /inference="alignment:Splign:2.1.0"
     exon            369..553
                     /gene="Il3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttggagga ccagaacgag acaatggttc ttgccagctc taccaccagc atcctctgca
       61 tgctgcttcc gctcctgatg ctcttccacc agggactcca gttttcaggc agtgcccacc
      121 gtttactcag gacgttggat tgcaggacta ttgccttgga gattttggtg aagctcccat
      181 atcctcaggt atctggactc aataatagtg atgacaaagc caatctgagg aatagtacct
      241 tgcggagagt aaacctggac gaattcctaa aaagccaaga ggagtttgat tctcaggaca
      301 caatggacat caagtccaaa cttcagaaac ttaagtgttg tattcctgca gctgcgagcg
      361 actctgtgct gccaggtgtc tacaataaag atctggatga ctttaagaag aaactgagat
      421 tctacgtgat ccatcttaag gacctgcagc cagtgtcagt ctctagacca cctcagccca
      481 catctagctc tgacaacttc cgccctatga ccgtggaatg ttaaaacagc aggcagagca
      541 actggagcct gaa
//
