LOCUS       NM_080889               1611 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus interleukin 2 receptor subunit gamma (Il2rg),
            mRNA.
ACCESSION   NM_080889 XM_343800
VERSION     NM_080889.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Liu Y, Liao W, Wan L, Xiang T and Zhang W.
  TITLE     Correlation Between Relative Nasopharyngeal Virus RNA Load and
            Lymphocyte Count Disease Severity in Patients with COVID-19
  JOURNAL   Viral Immunol 34 (5), 330-335 (2021)
   PUBMED   32297828
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Menoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal
            C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau
            E, Nerriere-Daguin V, Duteille F, Bellier-Waast F, Fraichard A,
            Nguyen TH and Anegon I.
  TITLE     Generation of Immunodeficient Rats With Rag1 and Il2rg Gene
            Deletions and Human Tissue Grafting Models
  JOURNAL   Transplantation 102 (8), 1271-1278 (2018)
   PUBMED   29688994
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov
            IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G,
            Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W,
            Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L,
            Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA,
            Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ and
            Yancopoulos GD.
  TITLE     Conditionals by inversion provide a universal method for the
            generation of conditional alleles
  JOURNAL   Proc Natl Acad Sci U S A 110 (34), E3179-E3188 (2013)
   PUBMED   23918385
REFERENCE   4  (bases 1 to 1611)
  AUTHORS   Mashimo T, Takizawa A, Voigt B, Yoshimi K, Hiai H, Kuramoto T and
            Serikawa T.
  TITLE     Generation of knockout rats with X-linked severe combined
            immunodeficiency (X-SCID) using zinc-finger nucleases
  JOURNAL   PLoS One 5 (1), e8870 (2010)
   PUBMED   20111598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1611)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1611)
  AUTHORS   Olosz F and Malek TR.
  TITLE     Structural basis for binding multiple ligands by the common
            cytokine receptor gamma-chain
  JOURNAL   J Biol Chem 277 (14), 12047-12052 (2002)
   PUBMED   11815609
  REMARK    GeneRIF: Structural basis for binding multiple ligands by the
            common cytokine receptor gamma-chain
REFERENCE   7  (bases 1 to 1611)
  AUTHORS   Nakajima H and Leonard WJ.
  TITLE     Role of Bcl-2 in alpha beta T cell development in mice deficient in
            the common cytokine receptor gamma-chain: the requirement for Bcl-2
            differs depending on the TCR/MHC affinity
  JOURNAL   J Immunol 162 (2), 782-790 (1999)
   PUBMED   9916699
REFERENCE   8  (bases 1 to 1611)
  AUTHORS   Kondo M, Akashi K, Domen J, Sugamura K and Weissman IL.
  TITLE     Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in
            common gamma chain-deficient mice
  JOURNAL   Immunity 7 (1), 155-162 (1997)
   PUBMED   9252128
REFERENCE   9  (bases 1 to 1611)
  AUTHORS   Clark PA, Lester T, Genet S, Jones AM, Hendriks R, Levinsky RJ and
            Kinnon C.
  TITLE     Screening for mutations causing X-linked severe combined
            immunodeficiency in the IL-2R gamma chain gene by single-strand
            conformation polymorphism analysis
  JOURNAL   Hum Genet 96 (4), 427-432 (1995)
   PUBMED   7557965
REFERENCE   10 (bases 1 to 1611)
  AUTHORS   Zurawski SM, Vega F Jr, Doyle EL, Huyghe B, Flaherty K, McKay DB
            and Zurawski G.
  TITLE     Definition and spatial location of mouse interleukin-2 residues
            that interact with its heterotrimeric receptor
  JOURNAL   EMBO J 12 (13), 5113-5119 (1993)
   PUBMED   8262055
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079343.1.
            
            On Apr 19, 2005 this sequence version replaced XM_343800.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079343.1, SRR8487227.303125.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132297,
                                           SAMD00155303 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1611
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /note="interleukin 2 receptor subunit gamma"
                     /db_xref="GeneID:140924"
                     /db_xref="RGD:621466"
     exon            1..129
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1121
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /note="interleukin 2 receptor, gamma (severe combined
                     immunodeficiency); cytokine receptor common subunit gamma"
                     /codon_start=1
                     /product="cytokine receptor common subunit gamma
                     precursor"
                     /protein_id="NP_543165.1"
                     /db_xref="GeneID:140924"
                     /db_xref="RGD:621466"
                     /translation="MLKPLLPSRSFLLLQLLLLRVGWSSKVLMSSGNEDTKSDLLLTS
                     MDLKHLSVPTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTMHYRYKGSDNNTFQEC
                     SHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDPQKPQRRAEQKLNLQNLVIPWAPENL
                     TLYNLSESQVELRWKSRYIERCLQYLVQYRSNRDRSWTEQIVDHEPRFSLPSVDEQKL
                     YTFRVRSRFNPICGSTQQWSKWSQPIHWGSHTAEENPSLFALEAVLIPVGTMGLIITL
                     IFVYCWLERMPRIPAIKNLEDLVTEYHGNFSAWSGVSKGLTESLQPDYSERFCHVSEI
                     PPKGGALGEGPGGSPCSLHSPYWPPPCYSLKPEA"
     exon            130..283
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            284..468
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            469..608
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            772..868
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            869..935
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1586
                     /gene="Il2rg"
                     /gene_synonym="Ab2-183; Cd132"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagagcaag cgccatgttg aaaccattat tgccatctag atccttctta ctccttcagc
       61 tgcttctgct gagggtaggg tggagctcca aggtcctcat gtccagtggg aatgaagaca
      121 ccaaatctga tctcttgctg acttctatgg accttaaaca tctcagtgtt cctactctgc
      181 ccctcccaga ggttcaatgc tttgtgttca atgtcgagta tatgaattgc acttggaata
      241 gcagttctga gcctcagccg accaacctca ctatgcacta taggtacaag ggatctgata
      301 ataatacatt ccaggagtgc agccactatc tgttctcaaa agagattact tctggctgtc
      361 agatacaaaa agaagatatc cagctctacc agacatttgt tgtccagctt caggaccccc
      421 agaaacccca gaggcgagcc gaacagaagc taaacctaca gaatcttgtg atcccatggg
      481 ctccagagaa tctaacactt tataacctga gtgaatctca ggtagaactg aggtggaaaa
      541 gcagatacat agaacgctgt ttacaatact tggtgcagta ccggagcaac cgagatcgaa
      601 gctggacgga acaaatagtg gatcatgagc ctagattctc cctgcctagt gtggatgaac
      661 agaagctgta cacatttcgg gttcggagcc gctttaaccc gatctgtgga agtactcaac
      721 agtggagtaa atggagccaa ccaatccact gggggagcca tactgcagag gagaatcctt
      781 ccttgtttgc actggaagct gtgcttatcc ctgttggcac catggggttg attattaccc
      841 tgatctttgt gtactgttgg ttggaacgaa tgcctcgaat tcccgccatc aagaatctag
      901 aggatctggt tactgaatac catgggaact tttcggcctg gagtggtgtg tctaaagggc
      961 tgactgagag tctgcagcca gactacagtg aacggttctg ccacgtcagt gagattcccc
     1021 cgaaaggagg agccctagga gaggggcctg gaggctctcc ttgcagcctt catagccctt
     1081 actggcctcc cccatgttat tctctgaagc ctgaagcctg agcctccaat cccttgatgg
     1141 aacctcaaag tcctatagcc ctaagtgatg ctaacctccc cctacacatt ttgccaacct
     1201 ggatccaatg cttattgcct cccgctatgg ctaattttca atttcatgtc ccatgtaact
     1261 gcttttccat tccatacgcc ctacttgaga atgccccttg ccccctttcc ctgcacaagc
     1321 cctcccgtgc ctagtctagt actttttcac tttttttttg agagagtctt accctgtagt
     1381 ccggggtggc tgggaactta ctacgtaggc cagattggcc tataactcag aggcgatcat
     1441 cccacttctt cttctcaagt gtcggcgttc ttggcaagca ccaccacatc cagcacggcc
     1501 ctcttctttt acaggattct ccctcccttt ttctacctac cattcaactg ttgccaaatc
     1561 aataagaaat aaagttttta accaataaaa aaaaaaaaaa aaaaaaaaaa a
//
