LOCUS       NM_013195               2629 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interleukin 2 receptor subunit beta (Il2rb),
            mRNA.
ACCESSION   NM_013195
VERSION     NM_013195.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Liu,Y., Liao,W., Wan,L., Xiang,T. and Zhang,W.
  TITLE     Correlation Between Relative Nasopharyngeal Virus RNA Load and
            Lymphocyte Count Disease Severity in Patients with COVID-19
  JOURNAL   Viral Immunol 34 (5), 330-335 (2021)
   PUBMED   32297828
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Zhang,Z., Gothe,F., Pennamen,P., James,J.R., McDonald,D.,
            Mata,C.P., Modis,Y., Alazami,A.M., Acres,M., Haller,W., Bowen,C.,
            Doffinger,R., Sinclair,J., Brothers,S., Zhang,Y., Matthews,H.F.,
            Naudion,S., Pelluard,F., Alajlan,H., Yamazaki,Y., Notarangelo,L.D.,
            Thaventhiran,J.E., Engelhardt,K.R., Al-Mousa,H., Hambleton,S.,
            Rooryck,C., Smith,K.G.C. and Lenardo,M.J.
  TITLE     Human interleukin-2 receptor beta mutations associated with defects
            in immunity and peripheral tolerance
  JOURNAL   J Exp Med 216 (6), 1311-1327 (2019)
   PUBMED   31040185
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Fernandez,I.Z., Baxter,R.M., Garcia-Perez,J.E., Vendrame,E.,
            Ranganath,T., Kong,D.S., Lundquist,K., Nguyen,T., Ogolla,S.,
            Black,J., Galambos,C., Gumbart,J.C., Dawany,N., Kelsen,J.R., de
            Zoeten,E.F., Quinones,R., Eissa,H., Verneris,M.R., Sullivan,K.E.,
            Rochford,R., Blish,C.A., Kedl,R.M., Dutmer,C.M. and Hsieh,E.W.Y.
  TITLE     A novel human IL2RB mutation results in T and NK cell-driven immune
            dysregulation
  JOURNAL   J Exp Med 216 (6), 1255-1267 (2019)
   PUBMED   31040184
  REMARK    Erratum:[J Exp Med. 2019 Jun 3;216(6):1465. doi:
            10.1084/jem.2018201505102019c.. PMID: 31088899]
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Han,W., Ni,Q., Liu,K., Yao,Y., Zhao,D., Liu,X. and Chen,Y.
  TITLE     Decreased CD122 on CD56dim NK associated with its impairment in
            asymptomatic chronic HBV carriers with high levels of HBV DNA,
            HBsAg and HBeAg
  JOURNAL   Life Sci 195, 53-60 (2018)
   PUBMED   29307521
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Yuan,X., Dong,Y., Tsurushita,N., Tso,J.Y. and Fu,W.
  TITLE     CD122 blockade restores immunological tolerance in autoimmune type
            1 diabetes via multiple mechanisms
  JOURNAL   JCI Insight 3 (2), 96600 (2018)
   PUBMED   29367461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Miyazaki,T., Liu,Z.J., Kawahara,A., Minami,Y., Yamada,K.,
            Tsujimoto,Y., Barsoumian,E.L., Permutter,R.M. and Taniguchi,T.
  TITLE     Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc,
            and lck cooperate in hematopoietic cell proliferation
  JOURNAL   Cell 81 (2), 223-231 (1995)
   PUBMED   7736574
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Singh,H., Abdullah,A. and Herndon,D.N.
  TITLE     Effects of rat interleukin-2 and rat interferon on the natural
            killer cell activity of rat spleen cells after thermal injury
  JOURNAL   J Burn Care Rehabil 13 (6), 617-622 (1992)
   PUBMED   1469024
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Masumoto,T., Onji,M. and Ohta,Y.
  TITLE     Decreased interleukin-2 receptor beta chain expression by
            peripheral blood lymphocytes in chronic liver disease
  JOURNAL   J Gastroenterol Hepatol 7 (4), 399-404 (1992)
   PUBMED   1325198
REFERENCE   9  (bases 1 to 2629)
  AUTHORS   Page,T.H. and Dallman,M.J.
  TITLE     Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha
            and beta chain genes: differentially regulated gene activity in
            response to mitogenic stimulation
  JOURNAL   Eur J Immunol 21 (9), 2133-2138 (1991)
   PUBMED   1889461
REFERENCE   10 (bases 1 to 2629)
  AUTHORS   Tsudo,M., Kitamura,F. and Miyasaka,M.
  TITLE     Characterization of the interleukin 2 receptor beta chain using
            three distinct monoclonal antibodies
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1982-1986 (1989)
   PUBMED   2467293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 20, 2020 this sequence version replaced NM_013195.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55050.1, SRR26360172.1884749.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000007.1  111928460-111928537 c
            79-199              JAXUCZ010000007.1  111925260-111925380 c
            200-314             JAXUCZ010000007.1  111924448-111924562 c
            315-396             JAXUCZ010000007.1  111923866-111923947 c
            397-502             JAXUCZ010000007.1  111921860-111921965 c
            503-651             JAXUCZ010000007.1  111919774-111919922 c
            652-817             JAXUCZ010000007.1  111919073-111919238 c
            818-935             JAXUCZ010000007.1  111918255-111918372 c
            936-1020            JAXUCZ010000007.1  111917282-111917366 c
            1021-2629           JAXUCZ010000007.1  111913828-111915436 c
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2629
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /note="interleukin 2 receptor subunit beta"
                     /db_xref="GeneID:25746"
                     /db_xref="RGD:2896"
     exon            1..78
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            79..199
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1728
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /note="interleukin 2 receptor, beta chain; P70-75; high
                     affinity IL-2 receptor subunit beta; IL-2RB; IL-2R subunit
                     beta"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit beta precursor"
                     /protein_id="NP_037327.2"
                     /db_xref="GeneID:25746"
                     /db_xref="RGD:2896"
                     /translation="MATVDLSWRLPLYILLLLLATTWVSAAVNDCSHLKCFYNSRANV
                     SCMWSPEEALNVTSCHIHAKSDMRHWNKTCELTPVRQASWACNLILGPLPDSQSLTSV
                     DLLSLSVVCWEEKGWRRVKTCNFHPFDNLRLIAPHSLQVLHIETRRCNISWEVSQVSH
                     YVNPYLEFEARRRLLDRSWEDASVFSLKQRQQWIFLETLTPDTSYELQVRVIAQRGKT
                     RTWSPWSQPVAFRTRPADPKEIFPLPWLRCLLLVLGCFFGFLSCVCVLVKCRYLGPWL
                     KTLLKCHIPDPSEFFSQLSSQHGGDLQKWLSSPVPQSFFSPTGSAPEISPLEVLDRDS
                     KTMQMLLFQKEKASSPSPSGHSQASCFTNQGYFFFHLSNALEIESCQVYFTYDPCMEE
                     DVEEDGPRLPEESPLPPLLPFTGEQDDYCAFPPRDDLLLFSPSLSTPNTAYGNSITPE
                     ERPPLSLQEGLPSLTSPDLMGLQHPLELVLGDDGEGMSTNSSGQQASVPEGSSHGHDQ
                     DRGQGPVLTLNTDAYLSLQELQAQDSAHLI"
     exon            200..314
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            315..396
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            397..502
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            503..651
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            652..817
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            818..935
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1020
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..2629
                     /gene="Il2rb"
                     /gene_synonym="IL2RBC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaacaggag atggccgtgg acccagtctc cagtaggact gcagggaaca tatcgtcaca
       61 actccatgtt gcagccaggg cttgtgtcct cagctctgcc tctcggatgt gatggccacc
      121 gtagaccttt cgtggcgtct gcccctctac atcctcctct tgctcctggc tacaacttgg
      181 gtgtctgcag cagtgaacga ctgttcccat cttaagtgct tctacaactc aagagccaat
      241 gtctcctgca tgtggagccc tgaagaggcc ctgaacgtca catcctgtca catccatgcc
      301 aagtcggaca tgcgacactg gaataaaacc tgtgagctaa cccctgtgag gcaggcatcc
      361 tgggcctgca acctgattct cgggcccctc ccagattccc agtcactgac ctccgtagac
      421 ctcctcagcc taagtgtggt gtgctgggaa gagaaggggt ggcgtagggt gaagacctgc
      481 aacttccatc cctttgacaa ccttcgcctg attgcccctc attccctaca agtcctgcac
      541 attgaaaccc ggagatgtaa cataagctgg gaggtgtccc aggtctctca ctacgttaat
      601 ccatacttgg aatttgaggc ccgtagacgt cttctggacc gtagctggga ggatgcatcc
      661 gtattcagcc tcaagcagag gcagcagtgg atcttcttgg agacgctgac ccctgacacc
      721 tcatatgagc tccaggtgag ggtcatagct caacgaggca aaaccaggac ctggagcccc
      781 tggagccagc ccgtggcctt tcggacaagg ccagcagatc ctaaggagat cttccccctg
      841 ccatggctca gatgccttct actggtcctc ggctgcttct ttggcttctt gtcctgcgtc
      901 tgcgttttgg tcaagtgccg ctaccttggg ccatggctga agacacttct caagtgccac
      961 atcccagatc cgtctgagtt cttctcccaa ctgagctccc agcatggggg agaccttcag
     1021 aaatggctct cctcgcctgt cccccaatcc ttcttcagcc ccactggctc tgcacctgag
     1081 atctccccac tggaagtgct tgacagagat tccaagacca tgcagatgct cctgtttcag
     1141 aaggagaagg cctcttcacc ctcgcccagt ggccactcac aggccagctg cttcaccaac
     1201 caaggttact tcttcttcca tttgtccaat gccttggaga tcgagtcctg ccaggtgtac
     1261 ttcacctatg acccctgcat ggaggaggat gtggaggaag atgggccaag gctgcccgag
     1321 gaatctcccc tcccacctct gctgcctttc actggagaac aggatgacta ctgtgccttc
     1381 ccgcccaggg atgacctgct gctcttctcc ccaagcctga gcacccccaa cactgcctat
     1441 gggaacagca taaccccgga agaaaggcct cccctctccc tgcaggaggg gctgccctcc
     1501 ctaacatccc ctgacctgat gggcttacag caccctctgg agctggtgct gggagatgac
     1561 ggagaaggga tgtctaccaa tagctctggg caacaggcca gtgtcccgga aggcagctct
     1621 catgggcacg accaggacag aggccagggc cctgtcctga ctctaaacac tgatgcctat
     1681 ctgtctcttc aagaactaca ggcccaagat tcagcccacc taatatagga cgggtgacca
     1741 ggactgggat ctagctacct gaggtcaggt caggcttgag ggagattgct taaggagtct
     1801 cttgaggaca gtccactatt aagggatgtc tctggttatc cccacccgca aacttagtca
     1861 tccacttctg acctccactt gatgcttcct ggtctaacca gggtttgggg tggggagcag
     1921 tggtcagttc caccgctcta tttagtcatg aggtctatag cttcctgtac ctgcctcact
     1981 ctctcgtgct gaccttcaca gggcagccag aacttgcttc ccaaatacaa atgcaacctt
     2041 gctctcttct attcctgagc ttgctgtggc tccctaccac tctctgcccc atttctggtc
     2101 ccaactcttg ccccgtcagc actgctgtgg gtcagctgtc ctcaggatgt gatctggctg
     2161 tacactgtct taatcagggc ggctttgaca agccaaacga agagatcctg ataagactgg
     2221 gtgcaacctg ttgacggttg agggtccctc atagaaggag gggatgggaa ggatcataaa
     2281 tccaccacct gagatcttag ccactttcct gcacccaccc ccaactatgt gtaactctgc
     2341 ccctggtgca tgcattattt tatgtgttct tggaagatgc tggtatatgt agaggggatg
     2401 aattgaagtg agggttccat ctatgttgct ttggggacct tgtcgtctac tctggggcgg
     2461 ggttttctgt gaagcagctt ctttgggatt tattcgcctg tcagtaagcc tgacagactc
     2521 agaggttcac caagctggac ttgagtgtac ttgtgccttt gatgtcgtat ctgggagaag
     2581 tacttacttg ttaatgtatc ctcaaagcca agaaaagctt acaggacaa
//
