LOCUS       NM_013163               1580 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interleukin 2 receptor subunit alpha (Il2ra),
            mRNA.
ACCESSION   NM_013163
VERSION     NM_013163.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1580)
  AUTHORS   Liu,Y., Liao,W., Wan,L., Xiang,T. and Zhang,W.
  TITLE     Correlation Between Relative Nasopharyngeal Virus RNA Load and
            Lymphocyte Count Disease Severity in Patients with COVID-19
  JOURNAL   Viral Immunol 34 (5), 330-335 (2021)
   PUBMED   32297828
REFERENCE   2  (bases 1 to 1580)
  AUTHORS   Hou,H., Zhang,B., Huang,H., Luo,Y., Wu,S., Tang,G., Liu,W., Mao,L.,
            Mao,L., Wang,F. and Sun,Z.
  TITLE     Using IL-2R/lymphocytes for predicting the clinical progression of
            patients with COVID-19
  JOURNAL   Clin Exp Immunol 201 (1), 76-84 (2020)
   PUBMED   32365221
REFERENCE   3  (bases 1 to 1580)
  AUTHORS   Chen,L., Liu,H.G., Liu,W., Liu,J., Liu,K., Shang,J., Deng,Y. and
            Wei,S.
  TITLE     [Analysis of clinical features of 29 patients with 2019 novel
            coronavirus pneumonia]
  JOURNAL   Zhonghua Jie He He Hu Xi Za Zhi 43 (3), 203-208 (2020)
   PUBMED   32164089
REFERENCE   4  (bases 1 to 1580)
  AUTHORS   Wang,F.J., Cui,D. and Qian,W.D.
  TITLE     Therapeutic Effect of CD4+CD25+ Regulatory T Cells Amplified In
            Vitro on Experimental Autoimmune Neuritis in Rats
  JOURNAL   Cell Physiol Biochem 47 (1), 390-402 (2018)
   PUBMED   29772575
  REMARK    GeneRIF: Adoptive transfusion of CD4+CD25+ (Interleukin-2 Receptor
            alpha) Regulatory T Cells into Experimental Autoimmune Neuritis
            model rats has significant therapeutic effects.
REFERENCE   5  (bases 1 to 1580)
  AUTHORS   Goudy,K., Aydin,D., Barzaghi,F., Gambineri,E., Vignoli,M., Ciullini
            Mannurita,S., Doglioni,C., Ponzoni,M., Cicalese,M.P., Assanelli,A.,
            Tommasini,A., Brigida,I., Dellepiane,R.M., Martino,S., Olek,S.,
            Aiuti,A., Ciceri,F., Roncarolo,M.G. and Bacchetta,R.
  TITLE     Human IL2RA null mutation mediates immunodeficiency with
            lymphoproliferation and autoimmunity
  JOURNAL   Clin Immunol 146 (3), 248-261 (2013)
   PUBMED   23416241
REFERENCE   6  (bases 1 to 1580)
  AUTHORS   Turner,M., Mee,P.J., Costello,P.S., Williams,O., Price,A.A.,
            Duddy,L.P., Furlong,M.T., Geahlen,R.L. and Tybulewicz,V.L.
  TITLE     Perinatal lethality and blocked B-cell development in mice lacking
            the tyrosine kinase Syk
  JOURNAL   Nature 378 (6554), 298-302 (1995)
   PUBMED   7477352
REFERENCE   7  (bases 1 to 1580)
  AUTHORS   Willerford,D.M., Chen,J., Ferry,J.A., Davidson,L., Ma,A. and
            Alt,F.W.
  TITLE     Interleukin-2 receptor alpha chain regulates the size and content
            of the peripheral lymphoid compartment
  JOURNAL   Immunity 3 (4), 521-530 (1995)
   PUBMED   7584142
REFERENCE   8  (bases 1 to 1580)
  AUTHORS   Page,T.H. and Dallman,M.J.
  TITLE     Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha
            and beta chain genes: differentially regulated gene activity in
            response to mitogenic stimulation
  JOURNAL   Eur J Immunol 21 (9), 2133-2138 (1991)
   PUBMED   1889461
REFERENCE   9  (bases 1 to 1580)
  AUTHORS   Fernandez-Ruiz,E., Rebollo,A., Nieto,M.A., Sanz,E., Somoza,C.,
            Ramirez,F., Lopez-Rivas,A. and Silva,A.
  TITLE     IL-2 protects T cell hybrids from the cytolytic effect of
            glucocorticoids. Synergistic effect of IL-2 and dexamethasone in
            the induction of high-affinity IL-2 receptors
  JOURNAL   J Immunol 143 (12), 4146-4151 (1989)
   PUBMED   2592769
REFERENCE   10 (bases 1 to 1580)
  AUTHORS   Tsudo,M., Kitamura,F. and Miyasaka,M.
  TITLE     Characterization of the interleukin 2 receptor beta chain using
            three distinct monoclonal antibodies
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1982-1986 (1989)
   PUBMED   2467293
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013163.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M55049.1, FQ228242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676809 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               JAXUCZ010000017.1  71808295-71808475   c
            182-358             JAXUCZ010000017.1  71776431-71776607   c
            359-469             JAXUCZ010000017.1  71773922-71774032   c
            470-685             JAXUCZ010000017.1  71770779-71770994   c
            686-757             JAXUCZ010000017.1  71769019-71769090   c
            758-829             JAXUCZ010000017.1  71768253-71768324   c
            830-896             JAXUCZ010000017.1  71766482-71766548   c
            897-1580            JAXUCZ010000017.1  71761322-71762005   c
FEATURES             Location/Qualifiers
     source          1..1580
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..1580
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /note="interleukin 2 receptor subunit alpha"
                     /db_xref="GeneID:25704"
                     /db_xref="RGD:2895"
     exon            1..181
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..921
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /note="interleukin 2 receptor, alpha chain; IL2-RA;
                     IL-2-RA; IL-2 receptor alpha subunit; IL-2R subunit alpha;
                     IL-2 receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-2 receptor subunit alpha precursor"
                     /protein_id="NP_037295.1"
                     /db_xref="GeneID:25704"
                     /db_xref="RGD:2895"
                     /translation="MEPHLLMLGFLSFTIVPGCWAELCLYDPPEVPNATFKALSYKNG
                     TILNCECKRGFRRLNELVYMACLGNSWSNNCQCTSNSHDNSREQVTPQPEGQKEQQTT
                     DTQKSTQSVYQENLAGHCREPPPWRHEDTKRIYHFVEGQIVLYTCIQGYKALQRGPAI
                     SICKTVCGEIRWTHPQLTCVDEKEHHQFLASEESQGSRNSFPESEASCPTPNTDFSQL
                     TEATTTMETFVFTKEYQVAVASCIFLLLSILLLSGFTWQHRWRKSRRTI"
     exon            182..358
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            359..469
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            470..685
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            686..757
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            758..829
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            830..896
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1580
                     /gene="Il2ra"
                     /gene_synonym="IL2RAC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccgagcc cttgttctgg cattctccca ggaggatgca gaaaaggggc tgacccaaca
       61 ttctgcagag aatttcatcc agttccttcc tgcatcctga tcccacgtgc cagggagatg
      121 gagccacact tgctgatgtt ggggtttctc tcattcacca tagtacccgg ctgttgggca
      181 gagctgtgtc tgtatgaccc accggaggtc cccaatgcca cgttcaaagc cctctcctac
      241 aagaacggca ccatcctaaa ctgtgaatgc aagagaggtt tccgaagact gaatgagctg
      301 gtctatatgg cttgtctagg aaactcctgg agcaacaact gtcagtgcac aagcaactcc
      361 catgacaact caagagagca agttacacct caacctgaag gacagaaaga gcaacagacc
      421 acggacacgc agaaatcaac acagtctgtg taccaggaga accttgcagg tcactgcagg
      481 gagccccctc cttggagaca tgaagacacc aagagaatct accacttcgt ggaaggacag
      541 atagttctct acacgtgtat tcaaggatac aaggctctac agagaggtcc tgctatcagc
      601 atctgcaaga cagtgtgtgg ggagataagg tggacgcatc cccagctcac gtgtgtagat
      661 gaaaaagaac accatcaatt tctggctagt gaagaatctc aaggaagcag aaattctttc
      721 ccagagagtg aggcttcctg tcccaccccc aacacagact tctcacaact cacagaagca
      781 actacaacta tggagacatt cgtgttcaca aaggagtatc aggtagcagt ggccagctgc
      841 atcttcctgc tcctcagcat cctcctcctg agtgggttca cctggcaaca tagatggagg
      901 aagagcagaa gaaccatcta gcaagctaga acagttggag cccaagggaa gatgatggga
      961 ctcatgaagc tcaagaaaca cctgaggggt caaacgtgca ctcgacgggt gcctgtctcc
     1021 ttttgatccc tcgggtcctg gaaagttatg aagtcccgag acacaatggc acatcgggaa
     1081 atagcaactt catcactaaa ccgaactttc cattgaagaa taggatctga ccatttcagt
     1141 gcagcagttc taaagcttta acgggaggga gggcccaacg gtgccctgtg tgttttgttt
     1201 tgtgtacatg tgttgatggg agctgcgatg gtgtggtcac ttttcgtgga acacacaata
     1261 tagaaaagtt gctttatgtt gacttctttt ggagagccca gcactaatgt aaatactccc
     1321 tcctcgtctt cctcctcttc ctctttctct tcctccttcc tcctcccctg ggtccaccca
     1381 cctccaccca tccacttttc ttcttccttt ctgctctcac aaggtcatcc taggcacatg
     1441 tatggctggc tcctttctca acctctgttt gcctaactgg ttcttgtgat ttcatcactt
     1501 actgatcagt tttttaaaac tctgggctga caatgaggac tccatgtttt tagaaggaaa
     1561 ccccctttcc actgaagctt
//
