LOCUS       NM_001395124            2616 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus interleukin 27 receptor subunit alpha (Il27ra),
            mRNA.
ACCESSION   NM_001395124 XM_006255227
VERSION     NM_001395124.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2616)
  AUTHORS   Koltsova,E.K., Kim,G., Lloyd,K.M., Saris,C.J., von Vietinghoff,S.,
            Kronenberg,M. and Ley,K.
  TITLE     Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice
  JOURNAL   Circ Res 111 (10), 1274-1285 (2012)
   PUBMED   22927332
REFERENCE   2  (bases 1 to 2616)
  AUTHORS   Yoshizaki,A., Yanaba,K., Iwata,Y., Komura,K., Ogawa,A., Muroi,E.,
            Ogawa,F., Takenaka,M., Shimizu,K., Hasegawa,M., Fujimoto,M. and
            Sato,S.
  TITLE     Elevated serum interleukin-27 levels in patients with systemic
            sclerosis: association with T cell, B cell and fibroblast
            activation
  JOURNAL   Ann Rheum Dis 70 (1), 194-200 (2011)
   PUBMED   20705635
REFERENCE   3  (bases 1 to 2616)
  AUTHORS   Shimanoe,Y., Miyazaki,Y., Hara,H., Inokuchi,A. and Yoshida,H.
  TITLE     Amelioration of experimental allergic rhinitis with suppression of
            topical immune responses by lack of IL-27/WSX-1 signaling
  JOURNAL   Ann Allergy Asthma Immunol 102 (3), 223-232 (2009)
   PUBMED   19354069
REFERENCE   4  (bases 1 to 2616)
  AUTHORS   Miyazaki,Y., Inoue,H., Matsumura,M., Matsumoto,K., Nakano,T.,
            Tsuda,M., Hamano,S., Yoshimura,A. and Yoshida,H.
  TITLE     Exacerbation of experimental allergic asthma by augmented Th2
            responses in WSX-1-deficient mice
  JOURNAL   J Immunol 175 (4), 2401-2407 (2005)
   PUBMED   16081811
REFERENCE   5  (bases 1 to 2616)
  AUTHORS   Holscher,C., Holscher,A., Ruckerl,D., Yoshimoto,T., Yoshida,H.,
            Mak,T., Saris,C. and Ehlers,S.
  TITLE     The IL-27 receptor chain WSX-1 differentially regulates
            antibacterial immunity and survival during experimental
            tuberculosis
  JOURNAL   J Immunol 174 (6), 3534-3544 (2005)
   PUBMED   15749890
REFERENCE   6  (bases 1 to 2616)
  AUTHORS   Pflanz,S., Timans,J.C., Cheung,J., Rosales,R., Kanzler,H.,
            Gilbert,J., Hibbert,L., Churakova,T., Travis,M., Vaisberg,E.,
            Blumenschein,W.M., Mattson,J.D., Wagner,J.L., To,W., Zurawski,S.,
            McClanahan,T.K., Gorman,D.M., Bazan,J.F., de Waal Malefyt,R.,
            Rennick,D. and Kastelein,R.A.
  TITLE     IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein,
            induces proliferation of naive CD4+ T cells
  JOURNAL   Immunity 16 (6), 779-790 (2002)
   PUBMED   12121660
REFERENCE   7  (bases 1 to 2616)
  AUTHORS   Chen,Q., Ghilardi,N., Wang,H., Baker,T., Xie,M.H., Gurney,A.,
            Grewal,I.S. and de Sauvage,F.J.
  TITLE     Development of Th1-type immune responses requires the type I
            cytokine receptor TCCR
  JOURNAL   Nature 407 (6806), 916-920 (2000)
   PUBMED   11057672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jun 4, 2021 this sequence version replaced XM_006255227.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.60924.1,
                                           SRR26643429.55523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680417, SAMN06680422
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000019.1  41014730-41014864
            136-253             JAXUCZ010000019.1  41015097-41015214
            254-411             JAXUCZ010000019.1  41016085-41016242
            412-569             JAXUCZ010000019.1  41016333-41016490
            570-726             JAXUCZ010000019.1  41017657-41017813
            727-800             JAXUCZ010000019.1  41017903-41017976
            801-984             JAXUCZ010000019.1  41020196-41020379
            985-1173            JAXUCZ010000019.1  41020469-41020657
            1174-1275           JAXUCZ010000019.1  41022549-41022650
            1276-1434           JAXUCZ010000019.1  41022731-41022889
            1435-1560           JAXUCZ010000019.1  41024932-41025057
            1561-1651           JAXUCZ010000019.1  41025476-41025566
            1652-1745           JAXUCZ010000019.1  41025674-41025767
            1746-2616           JAXUCZ010000019.1  41025870-41026740
FEATURES             Location/Qualifiers
     source          1..2616
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..2616
                     /gene="Il27ra"
                     /note="interleukin 27 receptor subunit alpha"
                     /db_xref="GeneID:288905"
                     /db_xref="RGD:1305029"
     exon            1..135
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1946
                     /gene="Il27ra"
                     /note="interleukin 27 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-27 receptor subunit alpha precursor"
                     /protein_id="NP_001382053.1"
                     /db_xref="GeneID:288905"
                     /db_xref="RGD:1305029"
                     /translation="MSWLRVARLKPLELLLPLLPLLLGTRPHGSPGPLQCYSVGPLGI
                     LNCSWEPLGDLETPPVLYHQSQKYHPNRTKEVKVPSRQSWVTIPRKQFTTADELLIWG
                     TQEGQLLWPPVSVNLETQMKPDTPQIFSDVDFFKEETLEAIVQWEPPKWPLHKVLICQ
                     FRYKKCQTKEWTQLEPQLKTDLMTPIEMQNLEPGTGYQVSGRCQVENGYPWGEWSPDL
                     SFPTPFLAPEDVWVSGTICETSGKPAALLFWKDPGPCVQVTYTVWLGVGDVTTTQEEV
                     PCCKSPIPAQIEWAVVSTGNQTSWMPLTNLSLVCLAPESAPCDVRVSSTDGSPGIKVT
                     WKQETGKPWAYVVDWAQDGDSLDKLNWTRLPPENLSTLLSGDFQAGVPYRITVTSVYS
                     GGLAAAPSVWGFIKELAPLAGPAVWRLPDDPTGTPVVAWGEVPRHQLRGQATHYTFCR
                     QSRGIPTICMNVSSQTKTVTLPNLYSGPFKLWVMVSTAAGQGPPGPSLSLHIPDNRIR
                     WKFLPWVLSLWGLLLVGCGLSLAPPRCLYQRHKLLPQWIWERVPDPANSNSGQPYIKE
                     VSLPQPPKDGPILEVEEMELQPVTESPKASVPLYSGYEKHFLPTPEELGLLRPPAPRV
                     LDCSASG"
     exon            136..253
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            254..411
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            412..569
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            570..726
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            727..800
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            801..984
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1173
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1275
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1434
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1560
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1651
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1745
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..2616
                     /gene="Il27ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcaggttg taagacccag gcctggcggt gtcacttgtc cctgagagtc atgagctggc
       61 tccgggttgc acgcctcaag ccgttggagc ttctactgcc gctgctacca ctgctgctcg
      121 ggacgcggcc ccatggcagt ccaggcccac tgcagtgcta cagcgttggc cccttgggaa
      181 tcctgaactg ctcttgggaa cctctgggcg acctggagac tccccctgtg ctgtatcacc
      241 agagtcagaa ataccatccc aatagaacta aggaggtgaa ggtgccttcc agacagagct
      301 gggtgaccat tccccggaaa cagttcacca cggctgacga actcctcatc tgggggacac
      361 aagaaggaca acttctctgg ccccctgtct ctgtgaacct ggagacccaa atgaagccag
      421 acacccccca gatcttctct gatgtggact tttttaagga agaaaccctg gaggccattg
      481 tgcagtggga accaccgaag tggccactgc ataaagtcct catctgtcag ttccggtaca
      541 aaaaatgcca gactaaagag tggacccagc tggagccaca gctgaagaca gacctgatga
      601 ctcctattga gatgcagaac ctggaacctg gcacgggcta ccaggtatct ggccgctgcc
      661 aagtggagaa tggatatcca tggggcgagt ggagcccgga cctgtcgttc ccgacgccat
      721 tcttggctcc tgaagatgtg tgggtatcgg ggaccatctg tgaaacatct ggcaaaccgg
      781 cagccctgct cttctggaag gacccaggac cctgtgtgca agtgacttac acagtctggc
      841 ttggggtcgg agatgttact acaacccaag aagaggtccc gtgctgcaag tcccctatcc
      901 ctgcacagat agagtgggca gtggtctcta ctggcaacca gaccagctgg atgcctctca
      961 ccaacctgtc tttggtgtgc ttggctccag aatctgcccc ctgtgatgtg agagtcagca
     1021 gtactgacgg gagcccaggg ataaaggtga cctggaaaca agaaactggg aaaccatggg
     1081 catacgtggt agactgggct caagatggtg acagcctgga caagctcaac tggacccgtc
     1141 tccccccgga aaacctcagc actttgttat caggggattt ccaagcaggg gtcccctatc
     1201 gaattacagt gacttcagta tactctggag gattggctgc tgcaccctca gtttggggat
     1261 tcataaagga attagcaccg cttgctggac cagcagtttg gcgactccca gatgacccca
     1321 cagggacacc tgttgtagca tggggagagg taccaaggca ccagctccga ggccaggcta
     1381 ctcactacac cttctgcagg cagagccgag gcatccccac tatctgcatg aatgtgagca
     1441 gtcaaaccaa gactgtcact ctgcccaacc tttactcggg tcccttcaag ctgtgggtga
     1501 tggtgtccac cgctgcagga cagggcccac ctggtcccag cctttcactt cacataccag
     1561 ataataggat caggtggaaa tttctgccct gggttctgtc cctgtggggc ttgcttctgg
     1621 tgggctgtgg cctgagcctg gcccctccca ggtgcttata ccagagacac aagttgcttc
     1681 cccaatggat ctgggagaga gttcctgacc ctgccaacag caattctggg caaccttaca
     1741 taaaggaggt gagcctgccc caaccaccca aagacggacc catcctggag gtagaggaaa
     1801 tggagctaca gcctgttaca gagtccccta aagcctctgt cccactttac tctgggtatg
     1861 agaaacactt cctgcccaca ccagaggagc tgggccttct gaggcctcca gcccccagag
     1921 ttctagactg ttctgcttca ggctaggggc tgtatcccta tcttgggtta gacattttta
     1981 gttttagttt tttgagactg gatctcacta tggctggcct gaaactcaca gagactcacc
     2041 tggttctgcc tcccaaggac tgaaaagaaa ggagtgtgcc accatgcccc aaccaacttt
     2101 gtttttcttg cctctgtgtc tttgacatct gtttgctact gcagaagaat taatgttctc
     2161 acagccacaa ctcttttgtt gttctttgcc tcagttcgtc agaggcttga taggtagcca
     2221 aggctggtct ccaacttgtg atcctcctgt tgcagcatcc ccaatgctag gattccaggt
     2281 gtcttatctc atccagtcat aacctttgat tataataaga acaacttcca agcaggctat
     2341 gaggaggtga ttcggaagac acgttcaagg gcctgaaccg gttaagagcc cttgttttct
     2401 tgcagtagac caaagtttgg ttccctgccc ttgcagaaga cccaggttca gttagcaccc
     2461 acagggcagc tcagaatcac ctgtgactcc agatctaggg aatcaaatgc cctcttctgg
     2521 cttctgtgag ccctgaatgc acacggttac ttacgcgcag acaaaacact cacacgcata
     2581 aaataaaaat aaataaaaga taaataataa aataaa
//
