LOCUS       NM_001192007            1067 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interleukin 25 (Il25), mRNA.
ACCESSION   NM_001192007 XM_577423
VERSION     NM_001192007.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1067)
  AUTHORS   Noor,Z., Watanabe,K., Abhyankar,M.M., Burgess,S.L., Buonomo,E.L.,
            Cowardin,C.A. and Petri,W.A. Jr.
  TITLE     Role of Eosinophils and Tumor Necrosis Factor Alpha in
            Interleukin-25-Mediated Protection from Amebic Colitis
  JOURNAL   mBio 8 (1), e02329-16 (2017)
   PUBMED   28246365
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1067)
  AUTHORS   Huang,Y.H., Li,Q., Yang,P., Yan,Y.N. and Ma,H.F.
  TITLE     [Effects of acupuncture stimulation of different acupoint groups on
            sleeping latency, serum and hippocampal TNF-alpha and IL-25
            contents in rats with gastric mucosal injury]
  JOURNAL   Zhen Ci Yan Jiu 40 (2), 131-135 (2015)
   PUBMED   26054198
REFERENCE   3  (bases 1 to 1067)
  AUTHORS   Beale,J., Jayaraman,A., Jackson,D.J., Macintyre,J.D.R.,
            Edwards,M.R., Walton,R.P., Zhu,J., Man Ching,Y., Shamji,B.,
            Edwards,M., Westwick,J., Cousins,D.J., Yi Hwang,Y., McKenzie,A.,
            Johnston,S.L. and Bartlett,N.W.
  TITLE     Rhinovirus-induced IL-25 in asthma exacerbation drives type 2
            immunity and allergic pulmonary inflammation
  JOURNAL   Sci Transl Med 6 (256), 256ra134 (2014)
   PUBMED   25273095
REFERENCE   4  (bases 1 to 1067)
  AUTHORS   Kim,B.E., Bin,L., Ye,Y.M., Ramamoorthy,P. and Leung,D.Y.M.
  TITLE     IL-25 enhances HSV-1 replication by inhibiting filaggrin
            expression, and acts synergistically with Th2 cytokines to enhance
            HSV-1 replication
  JOURNAL   J Invest Dermatol 133 (12), 2678-2685 (2013)
   PUBMED   23657503
REFERENCE   5  (bases 1 to 1067)
  AUTHORS   Motomura,Y., Kitamura,H., Hijikata,A., Matsunaga,Y., Matsumoto,K.,
            Inoue,H., Atarashi,K., Hori,S., Watarai,H., Zhu,J., Taniguchi,M.
            and Kubo,M.
  TITLE     The transcription factor E4BP4 regulates the production of IL-10
            and IL-13 in CD4+ T cells
  JOURNAL   Nat Immunol 12 (5), 450-459 (2011)
   PUBMED   21460847
REFERENCE   6  (bases 1 to 1067)
  AUTHORS   Mishra,N.C., Rir-Sima-Ah,J., Langley,R.J., Singh,S.P.,
            Pena-Philippides,J.C., Koga,T., Razani-Boroujerdi,S., Hutt,J.,
            Campen,M., Kim,K.C., Tesfaigzi,Y. and Sopori,M.L.
  TITLE     Nicotine primarily suppresses lung Th2 but not goblet cell and
            muscle cell responses to allergens
  JOURNAL   J Immunol 180 (11), 7655-7663 (2008)
   PUBMED   18490768
REFERENCE   7  (bases 1 to 1067)
  AUTHORS   Ballantyne,S.J., Barlow,J.L., Jolin,H.E., Nath,P., Williams,A.S.,
            Chung,K.F., Sturton,G., Wong,S.H. and McKenzie,A.N.
  TITLE     Blocking IL-25 prevents airway hyperresponsiveness in allergic
            asthma
  JOURNAL   J Allergy Clin Immunol 120 (6), 1324-1331 (2007)
   PUBMED   17889290
REFERENCE   8  (bases 1 to 1067)
  AUTHORS   Kang,C.M., Jang,A.S., Ahn,M.H., Shin,J.A., Kim,J.H., Choi,Y.S.,
            Rhim,T.Y. and Park,C.S.
  TITLE     Interleukin-25 and interleukin-13 production by alveolar
            macrophages in response to particles
  JOURNAL   Am J Respir Cell Mol Biol 33 (3), 290-296 (2005)
   PUBMED   15961726
  REMARK    GeneRIF: study demonstrated at the protein and mRNA levels, both in
            vivo and in vitro, that alveolar macrophages produce IL-25 and
            IL-13 in response to fine particles of TiO2
REFERENCE   9  (bases 1 to 1067)
  AUTHORS   Hurst,S.D., Muchamuel,T., Gorman,D.M., Gilbert,J.M., Clifford,T.,
            Kwan,S., Menon,S., Seymour,B., Jackson,C., Kung,T.T.,
            Brieland,J.K., Zurawski,S.M., Chapman,R.W., Zurawski,G. and
            Coffman,R.L.
  TITLE     New IL-17 family members promote Th1 or Th2 responses in the lung:
            in vivo function of the novel cytokine IL-25
  JOURNAL   J Immunol 169 (1), 443-453 (2002)
   PUBMED   12077275
REFERENCE   10 (bases 1 to 1067)
  AUTHORS   Pan,G., French,D., Mao,W., Maruoka,M., Risser,P., Lee,J.,
            Foster,J., Aggarwal,S., Nicholes,K., Guillet,S., Schow,P. and
            Gurney,A.L.
  TITLE     Forced expression of murine IL-17E induces growth retardation,
            jaundice, a Th2-biased response, and multiorgan inflammation in
            mice
  JOURNAL   J Immunol 167 (11), 6559-6567 (2001)
   PUBMED   11714825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 14, 2022 this sequence version replaced NM_001192007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840107,
                              SAMN12840121 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000015.1  32378750-32378834
            86-330              JAXUCZ010000015.1  32378991-32379235
            331-1067            JAXUCZ010000015.1  32381405-32382141
FEATURES             Location/Qualifiers
     source          1..1067
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1067
                     /gene="Il25"
                     /gene_synonym="RGD1561632"
                     /note="interleukin 25"
                     /db_xref="GeneID:501996"
                     /db_xref="RGD:1561632"
     exon            1..85
                     /gene="Il25"
                     /gene_synonym="RGD1561632"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..586
                     /gene="Il25"
                     /gene_synonym="RGD1561632"
                     /codon_start=1
                     /product="interleukin-25"
                     /protein_id="NP_001178936.1"
                     /db_xref="GeneID:501996"
                     /db_xref="RGD:1561632"
                     /translation="MYQAVAFLAMVVGTHTVSLRIQEDCSHLPRCCPSKQQEFPEEWL
                     KWNPAPVSPPEPLRHTHHPESCRASKDGPLNSRAISPWSYELDRDLNRVPQDLYHARC
                     LCPHCVSLQTGSHMDPMGNSVPLYHNQTVFYRRPCHGEQGAHGRYCLERRLYRVSLAC
                     VCVRPRMMA"
     exon            86..330
                     /gene="Il25"
                     /gene_synonym="RGD1561632"
                     /inference="alignment:Splign:2.1.0"
     exon            331..1067
                     /gene="Il25"
                     /gene_synonym="RGD1561632"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccgctcc agtcagcctg cttctagaag gcctgtcagg cagggcagta cctgtggctg
       61 gtgagcagtg tccggcatgt accaggctgt tgcgttcttg gcaatggttg tgggaaccca
      121 caccgtcagt ttgcggatcc aggaggactg cagccactta cccagatgct gtcccagcaa
      181 acaacaagaa ttccccgagg agtggctgaa gtggaaccct gcacctgtgt ctcccccaga
      241 gcctctgagg cacacccacc acccagaatc ctgcagggcc agcaaggacg gccctctcaa
      301 cagcagggcc atctctcctt ggagctatga gttggacagg gacttgaatc gggtccccca
      361 ggatctgtac catgctcgat gcctgtgccc acactgcgtc agcctacaga caggatctca
      421 catggaccca atgggcaact cagtaccact ctaccacaac cagacagtct tctaccggcg
      481 gccatgccac ggcgagcaag gtgcccacgg ccgttactgc ttggagcgca ggctctaccg
      541 agtctccttg gcttgtgtgt gtgtgcggcc ccgtatgatg gcttagtcct gcttgccacc
      601 tgcctgaggc tgatcccttg ttgggagaat gggccagggg tcccttgcca aagtggggca
      661 gggtacctgg atgtgaagcc cttccaaagc cctacctgaa gcagcaggat cctaggacaa
      721 gatggaggac ttggggagaa actctgactt ttgcactttt taaaagcact tttgggaagg
      781 aatgggttca gcttgtgctg ccggaagacg ctgttgtggc agttcctctc aggaacaaac
      841 tccaaaggcc tgctgacccc tggaagccat attcccggtt cttcctttcc tctgaacccc
      901 ccagcccagc actggcactt tcttcaccct gccccttttg cctgccattg catttgtgaa
      961 cgccgactct gctcacggcc aggtgctttg aagcagacgg ctctgaggcg aaagttgtta
     1021 ttgaacgtga agagatttgt ccaaataaat gtctgtgttt taaaatg
//
