LOCUS       NM_130410               1568 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus interleukin 23 subunit alpha (Il23a), mRNA.
ACCESSION   NM_130410
VERSION     NM_130410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1568)
  AUTHORS   Sun,K., Wu,J.H., Bai,H., Xu,S.L., Xia,X.F., Liu,Y.C., Lu,S.F.,
            Gu,Y.H. and Zhang,H.R.
  TITLE     [Effect of electroacupuncture on expression of IL-23/IL-17 axis and
            TLR4 in infarcted tissue in rats with myocardial infarction]
  JOURNAL   Zhongguo Zhen Jiu 41 (9), 1023-1028 (2021)
   PUBMED   34491653
  REMARK    GeneRIF: [Effect of electroacupuncture on expression of IL-23/IL-17
            axis and TLR4 in infarcted tissue in rats with myocardial
            infarction].
REFERENCE   2  (bases 1 to 1568)
  AUTHORS   Dietze-Schwonberg,K., Lorenz,B., Kostka,S.L., Schumak,B.,
            Gessner,A. and von Stebut,E.
  TITLE     Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c
            mice protects against progressive cutaneous leishmaniasis
  JOURNAL   Exp Dermatol 27 (1), 101-103 (2018)
   PUBMED   29078003
REFERENCE   3  (bases 1 to 1568)
  AUTHORS   Liao,Y., Hu,X., Guo,X., Zhang,B., Xu,W. and Jiang,H.
  TITLE     Promoting effects of IL-23 on myocardial ischemia and reperfusion
            are associated with increased expression of IL-17A and upregulation
            of the JAK2-STAT3 signaling pathway
  JOURNAL   Mol Med Rep 16 (6), 9309-9316 (2017)
   PUBMED   29039526
  REMARK    GeneRIF: IL23 aggravated myocardial I/R injury by promoting
            inflammatory responses and myocardial apoptosis.
REFERENCE   4  (bases 1 to 1568)
  AUTHORS   Kitada,S., Kayama,H., Okuzaki,D., Koga,R., Kobayashi,M., Arima,Y.,
            Kumanogoh,A., Murakami,M., Ikawa,M. and Takeda,K.
  TITLE     BATF2 inhibits immunopathological Th17 responses by suppressing
            Il23a expression during Trypanosoma cruzi infection
  JOURNAL   J Exp Med 214 (5), 1313-1331 (2017)
   PUBMED   28356392
REFERENCE   5  (bases 1 to 1568)
  AUTHORS   Qiu,Y., Yu,H., Zhu,Y., Ye,Z., Deng,J., Su,W., Cao,Q., Yuan,G.,
            Kijlstra,A. and Yang,P.
  TITLE     Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers
            Risk to Vogt-Koyanagi-Harada Disease
  JOURNAL   Sci Rep 7 (1), 1007 (2017)
   PUBMED   28432342
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1568)
  AUTHORS   Aggarwal,S., Ghilardi,N., Xie,M.H., de Sauvage,F.J. and Gurney,A.L.
  TITLE     Interleukin-23 promotes a distinct CD4 T cell activation state
            characterized by the production of interleukin-17
  JOURNAL   J Biol Chem 278 (3), 1910-1914 (2003)
   PUBMED   12417590
REFERENCE   7  (bases 1 to 1568)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   8  (bases 1 to 1568)
  AUTHORS   Broberg,E.K., Setala,N., Eralinna,J.P., Salmi,A.A., Roytta,M. and
            Hukkanen,V.
  TITLE     Herpes simplex virus type 1 infection induces upregulation of
            interleukin-23 (p19) mRNA expression in trigeminal ganglia of
            BALB/c mice
  JOURNAL   J Interferon Cytokine Res 22 (6), 641-651 (2002)
   PUBMED   12162874
REFERENCE   9  (bases 1 to 1568)
  AUTHORS   Cooper,A.M., Kipnis,A., Turner,J., Magram,J., Ferrante,J. and
            Orme,I.M.
  TITLE     Mice lacking bioactive IL-12 can generate protective,
            antigen-specific cellular responses to mycobacterial infection only
            if the IL-12 p40 subunit is present
  JOURNAL   J Immunol 168 (3), 1322-1327 (2002)
   PUBMED   11801672
REFERENCE   10 (bases 1 to 1568)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098907.1.
            
            On Jul 13, 2005 this sequence version replaced NM_130410.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098907.1, AY055379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1568
                     /gene="Il23a"
                     /note="interleukin 23 subunit alpha"
                     /db_xref="GeneID:155140"
                     /db_xref="RGD:620873"
     exon            1..469
                     /gene="Il23a"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..898
                     /gene="Il23a"
                     /note="IL-23p19; IL-23 subunit alpha; interleukin-23
                     subunit p19; IL-23-A; Interleukin 23, alpha subunit p19"
                     /codon_start=1
                     /product="interleukin-23 subunit alpha precursor"
                     /protein_id="NP_569094.1"
                     /db_xref="GeneID:155140"
                     /db_xref="RGD:620873"
                     /translation="MLDCRAIILLWLLPWATQGLAVPRSSSPDWAQCQQLSRNLCTLA
                     WSAHTPVGQMDLLREEGEEETKSDVPRIQCGDGCDPQGLKDNSQFCLQRIRQGLVFYK
                     HLLDSDIFTGEPSLLPDSPVDQLHTSLLGLSQLLQPEDHHWETQQMPRLSPSQQWQRS
                     LLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA"
     exon            470..571
                     /gene="Il23a"
                     /inference="alignment:Splign:2.1.0"
     exon            572..718
                     /gene="Il23a"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1541
                     /gene="Il23a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacctaggc ctctagccac agcagcctca ccactcattt cccctggaac tgaggtggca
       61 tacctgggct ctccaaagag ggaggtgatg cagggagggg aaatcccacc tgctctgagt
      121 cacctgctag tgcaaagggc gggccttaca gtgcagggac cttaaaaaga gactgcgaga
      181 caaaaaggaa gaaagcagga agccacttag aagtcagact tcagagttag actcagagca
      241 aaaggaggtt gatagagggt ctagtgcaga gcacagagcc agccagatct gagaagcagg
      301 caacaagatg ctggattgca gagcaataat actcctgtgg ctgttgccct gggccactca
      361 ggggctggct gtgcctagga gtagcagtcc tgactgggct cagtgccagc agctctcccg
      421 gaatctctgc acactagcct ggagtgcaca cacaccagtg ggacaaatgg atctactaag
      481 agaagaaggg gaagaagaga ctaaaagtga cgtgccccgt atccagtgtg gtgatggttg
      541 tgatccccaa ggtctcaagg acaacagcca gttctgtttg caaaggatcc gccaaggtct
      601 ggtgttttat aagcacctgc tggactcgga catcttcaca ggggagcctt ctctactccc
      661 ggatagccct gtggaccagc ttcatacctc cctactgggc ctcagccagc tcctccagcc
      721 agaggatcac cactgggaga ctcaacagat gcctcgcctg agtcccagcc agcagtggca
      781 gcgttctctt ctccgttcca agatccttcg cagcctccaa gcctttctgg ccatagctgc
      841 ccgggtcttt gcccacggag cagcaactct gactgagccc ttagtgccaa cggcttaagg
      901 atagtgccca ggttcccatg gctacagtga taaaactaat ccatcaatgc agacatctgc
      961 aagctaatta acccatcagg acttttgctg ttcttgtttt gtatgttttg tgtgaagggc
     1021 aaggacacca ttattaaaga gaaaagcaac aaaccccaga cggcagctca ctagagggag
     1081 gagatggaga agaggaatca agtcaagccc ttggccttgg aagctggcag acagctgcat
     1141 ggcagaaggg gaagggggtg gagacatcgg agaaactgtg agaagcctgg agcatcagga
     1201 aaagtgagcc taggctttgg ccagaatctg taagtaaaac aagaaaaagg gaatgttata
     1261 cttttctgag tgattcgggg aaatgtgaag actcacagtg ctccagacgg aagctctgta
     1321 actgcctgct tagtccttca gttctaacag aacccagcac taagaactaa cagaactacc
     1381 aacatggact gactcgcgat accgacctgt gacaaagctg cgtatttatt aagtgggaag
     1441 ggaaattttg gtattattta tccttgtaac agtttagagg attgttattt attatattta
     1501 tgaggaatta tgtatttttt taataaagat ttatttatgt gaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaa
//
