LOCUS       NM_001003404            2505 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus interleukin 22 receptor subunit alpha 2
            (Il22ra2), mRNA.
ACCESSION   NM_001003404 XM_579098
VERSION     NM_001003404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Lindahl,H., Guerreiro-Cacais,A.O., Bedri,S.K., Linnerbauer,M.,
            Linden,M., Abdelmagid,N., Tandre,K., Hollins,C., Irving,L.,
            Glover,C., Jones,C., Alfredsson,L., Ronnblom,L., Kockum,I.,
            Khademi,M., Jagodic,M. and Olsson,T.
  TITLE     IL-22 Binding Protein Promotes the Disease Process in Multiple
            Sclerosis
  JOURNAL   J Immunol 203 (4), 888-898 (2019)
   PUBMED   31292217
  REMARK    GeneRIF: Our results demonstrate a pathogenic role of IL-22BP in
            three species with a potential mechanism of action involving T cell
            polarization
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Martin,J.C., Wolk,K., Beriou,G., Abidi,A., Witte-Handel,E.,
            Louvet,C., Kokolakis,G., Drujont,L., Dumoutier,L., Renauld,J.C.,
            Sabat,R. and Josien,R.
  TITLE     Limited Presence of IL-22 Binding Protein, a Natural IL-22
            Inhibitor, Strengthens Psoriatic Skin Inflammation
  JOURNAL   J Immunol 198 (9), 3671-3678 (2017)
   PUBMED   28356382
  REMARK    GeneRIF: this study shows that rats with genetic IL-22BP deficiency
            (Il22ra2-/-) display exacerbated psoriasis that is associated with
            enhanced expression of IL-22-inducible antimicrobial peptides
REFERENCE   3  (bases 1 to 2505)
  AUTHORS   Martin,J.C., Beriou,G., Heslan,M., Bossard,C., Jarry,A., Abidi,A.,
            Hulin,P., Menoret,S., Thinard,R., Anegon,I., Jacqueline,C.,
            Lardeux,B., Halary,F., Renauld,J.C., Bourreille,A. and Josien,R.
  TITLE     IL-22BP is produced by eosinophils in human gut and blocks IL-22
            protective actions during colitis
  JOURNAL   Mucosal Immunol 9 (2), 539-549 (2016)
   PUBMED   26329427
  REMARK    GeneRIF: IL-22BP is produced by eosinophils in the gut and blocks
            IL-22 protective actions in colitis.
REFERENCE   4  (bases 1 to 2505)
  AUTHORS   Huber,S., Gagliani,N., Zenewicz,L.A., Huber,F.J., Bosurgi,L.,
            Hu,B., Hedl,M., Zhang,W., O'Connor,W. Jr., Murphy,A.J.,
            Valenzuela,D.M., Yancopoulos,G.D., Booth,C.J., Cho,J.H., Ouyang,W.,
            Abraham,C. and Flavell,R.A.
  TITLE     IL-22BP is regulated by the inflammasome and modulates
            tumorigenesis in the intestine
  JOURNAL   Nature 491 (7423), 259-263 (2012)
   PUBMED   23075849
REFERENCE   5  (bases 1 to 2505)
  AUTHORS   Beyeen,A.D., Adzemovic,M.Z., Ockinger,J., Stridh,P., Becanovic,K.,
            Laaksonen,H., Lassmann,H., Harris,R.A., Hillert,J., Alfredsson,L.,
            Celius,E.G., Harbo,H.F., Kockum,I., Jagodic,M. and Olsson,T.
  TITLE     IL-22RA2 associates with multiple sclerosis and macrophage effector
            mechanisms in experimental neuroinflammation
  JOURNAL   J Immunol 185 (11), 6883-6890 (2010)
   PUBMED   21041731
  REMARK    GeneRIF: Through a combined approach including genetic and
            immunological investigation in an animal model and large-scale
            association studies of patients with multiple sclerosis (MS),
            IL-22RA2 is established as an MS risk gene.
REFERENCE   6  (bases 1 to 2505)
  AUTHORS   Weiss,B., Wolk,K., Grunberg,B.H., Volk,H.D., Sterry,W.,
            Asadullah,K. and Sabat,R.
  TITLE     Cloning of murine IL-22 receptor alpha 2 and comparison with its
            human counterpart
  JOURNAL   Genes Immun 5 (5), 330-336 (2004)
   PUBMED   15201862
REFERENCE   7  (bases 1 to 2505)
  AUTHORS   Wei,C.C., Ho,T.W., Liang,W.G., Chen,G.Y. and Chang,M.S.
  TITLE     Cloning and characterization of mouse IL-22 binding protein
  JOURNAL   Genes Immun 4 (3), 204-211 (2003)
   PUBMED   12700595
REFERENCE   8  (bases 1 to 2505)
  AUTHORS   Kotenko,S.V., Izotova,L.S., Mirochnitchenko,O.V., Esterova,E.,
            Dickensheets,H., Donnelly,R.P. and Pestka,S.
  TITLE     Identification, cloning, and characterization of a novel soluble
            receptor that binds IL-22 and neutralizes its activity
  JOURNAL   J Immunol 166 (12), 7096-7103 (2001)
   PUBMED   11390454
REFERENCE   9  (bases 1 to 2505)
  AUTHORS   Dumoutier,L., Lejeune,D., Colau,D. and Renauld,J.C.
  TITLE     Cloning and characterization of IL-22 binding protein, a natural
            antagonist of IL-10-related T cell-derived inducible factor/IL-22
  JOURNAL   J Immunol 166 (12), 7090-7095 (2001)
   PUBMED   11390453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001003404.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            22 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ555485.1, SRR26643292.134.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN09345330
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000001.1  16184129-16184214
            87-222              JAXUCZ010000001.1  16186458-16186593
            223-401             JAXUCZ010000001.1  16188973-16189151
            402-571             JAXUCZ010000001.1  16194492-16194661
            572-2505            JAXUCZ010000001.1  16195551-16197484
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..2505
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /note="interleukin 22 receptor subunit alpha 2"
                     /db_xref="GeneID:444986"
                     /db_xref="RGD:1303169"
     exon            1..86
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..721
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /note="IL22BP; IL-22R-alpha-2; interleukin-22-binding
                     protein; cytokine receptor family type 2, soluble 1;
                     IL-22BP; IL-22RA2; IL-22 receptor subunit alpha-2;
                     cytokine receptor family II soluble 1; interleukin 22
                     receptor, alpha 2"
                     /codon_start=1
                     /product="interleukin-22 receptor subunit alpha-2
                     precursor"
                     /protein_id="NP_001003404.1"
                     /db_xref="GeneID:444986"
                     /db_xref="RGD:1303169"
                     /translation="MPKHCFLGLLIMLLTTATETQPAHVSLKPQKVQFQSRNFHNILH
                     WQPGNSLTSNGSVYFVQYKTYGQGQWKDKNDCWGTTALFCDLTKETLDPYEPYYGRVM
                     MAWAGSYSEWTRTPRFTPWWETKLDPPVVTITRVNASLRVRLRPPELPHRNQTGKNTS
                     MENYYNLVYRVSIINNSLEKEQKAYEGTQRAVEIQGLTPHCSYCVVAEMYQPMFDRRS
                     PRSKERCVQIP"
     exon            87..222
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..401
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..571
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..2505
                     /gene="Il22ra2"
                     /gene_synonym="Crf2-s1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggtttccag acaggcacac ttgcaaccac gatgcctaag cactgctttc taggcctcct
       61 catcatgctc ttgaccactg ccacagaaac gcagccagcc catgtgtctc tgaagcctca
      121 gaaggtccaa tttcagtcca gaaatttcca caacattttg cactggcaac cagggaactc
      181 cctcaccagc aacggcagcg tctactttgt gcagtacaag acgtatggac agggacaatg
      241 gaaagataaa aatgactgct gggggaccac agcgctcttt tgtgacctga ccaaagaaac
      301 cttagaccca tacgagccat actatgggag ggtgatgatg gcctgggctg gaagctactc
      361 tgaatggacc aggacacccc gcttcactcc atggtgggaa acaaaattag atcctccggt
      421 cgtgactata acccgagtta atgcatcttt gagggttcgt ctccgccccc cagagttgcc
      481 acatagaaac caaactggaa aaaatacgtc catggaaaat tactacaact tagtataccg
      541 agtttccata atcaacaatt cactggagaa ggaacaaaaa gcctacgaag gaactcagag
      601 agctgttgaa attcaaggtc tgacacctca ttgcagttac tgcgtagtgg ctgaaatgta
      661 ccagcccatg ttcgacagaa gaagcccaag aagcaaggag agatgtgtgc agattccata
      721 aactggtctg aaaccgggag catatccaaa agaggatggc ttgtgccttg aacggctcac
      781 ttctgtttga ttttcttaga gcattgtcta cccacacctt tcaagggttt tttttattca
      841 ttctttctgt ttatttcagt tataaagtaa attcgaacag attcaaaaat agaatttcaa
      901 gaggagataa agaataaaga gcttgtggta acagacatct ttaatcccag cactaagagg
      961 cagaatcagg cagatttctg tctttagggc cagcctggtc tacatagaga gttccaggct
     1021 agccagggtc acagagtgag accgtgcctc aataaagtaa gatgttaaga taaaaatctt
     1081 ctataaaata cagaagttta tctgaatata gcaaccctaa caatactctt ttttttctgt
     1141 taaaatcccc aaataagaac caaaaaatta caggcattta ataaaatgtc gcaatgagtt
     1201 ttaaagcatt atatacagaa aatcctgaac caatgatttt ttatactcta tcaagccttt
     1261 tgctttgcca gggatatacc aatttaatac tttgtgtgaa cgagtatatt tctgtacatt
     1321 tctattttag atgaatatgt ttttattttt ttatttctca tgaggtattt ctacttagtg
     1381 aactaacact ttaaaaataa tctctcgtgg ctgtctctaa attaatctcc agaataagat
     1441 tttcaataac agcatgtaaa tagaaggaag tcttcataat acaatttccc ctcacttaac
     1501 acccaacctt agtatgacta ccctttctgg ctttgctttt aatattgcct tagaaggtaa
     1561 cctatgccgt agaagtggag tgtatatttt tcaacagcaa ggatagaaag aagaaacagc
     1621 taagccacag tgataactcg gcaaagttat cattcaggca aagggatctc tctgttctgg
     1681 gaacaactgg agaccatata ggaaacttgg cttgaagcca aaggcacact gtgggtgctt
     1741 aagttgtttc tgggattata aggaaaacca caaccctgcg aactacactg cctctcctaa
     1801 gcaaagatta ggtggccgaa ggctcagaaa gtggccagcg ttgctaagtc tcttgttagc
     1861 tcttgaactt agactagctg ctcctgaaaa gacatgtggg agagaacatc tgtggtcttc
     1921 atgaaaggtg ctccaacgta ttacttcaga aagtacagtc aatgtgtctg tctgcttaca
     1981 tctaccatga taaatggtag tagaccatta aaaaatgtgg gagacgtgaa aaccaagagt
     2041 gagggcatcg tcctggctgt tctgtgtgtt caaaaaacac tggctttcac tcctattttt
     2101 gaattattca atttttattt ctttagtggc ttaatacctg cttggagttt ctttgggttt
     2161 tttgtttctt tgaatgtttg tcttctattt tgtacgttgg gaagggcgag acttgagaag
     2221 gataacctgt ctttgggaat caggaccacg tgtggtggca gcattcatgt tgtaagatgc
     2281 ggtagtctaa agcctcatga tacaaaaggc aatgaatgta tatggatgtt gtcaggtaac
     2341 agagctttgc tttgattctg tttccttggg gtctgccttc ttgcatgaac acagccatgc
     2401 tcagataagt ataaaaccct ctgaaaacca ttaccatgtt cacattcttg atcatgttaa
     2461 caacatactg tctctgtact tcaataaatc ttactttgta cttta
//
