LOCUS       NM_001191988             540 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interleukin 22 (Il22), mRNA.
ACCESSION   NM_001191988 XM_576228
VERSION     NM_001191988.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Li,F., Li,X., Liu,G., Gao,C. and Li,X.
  TITLE     Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL
            in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22
  JOURNAL   J Immunol Res 2019, 8459281 (2019)
   PUBMED   31828174
  REMARK    GeneRIF: The results suggest that the transplantation of
            mesenchymal stem cells can reduce the expression of RANKL in vivo
            by downregulating the levels of IL-22, thereby ameliorating the
            degree of rheumatoid arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Wang,B., Zhao,P., Zhou,Y., Meng,L., Zhu,W., Jiang,C., Wang,L.,
            Cai,Y., Lu,S. and Hou,W.
  TITLE     Increased expression of Th17 cytokines and interleukin-22
            correlates with disease activity in pristane-induced arthritis in
            rats
  JOURNAL   PLoS One 12 (11), e0188199 (2017)
   PUBMED   29182672
  REMARK    GeneRIF: conclude that IL-22 expression level was increased and
            correlated with disease severity, which indicated that IL-22 may
            play an important role in development of PIA, and was helpful to
            explorer the pathogenesis of rheumatoid arthritis
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 540)
  AUTHORS   Hou,W., Wang,B., Zhou,Y., Xu,K., Meng,L., Zhu,W., Jiang,C., Xu,P.
            and Lu,S.
  TITLE     IL-22 expression is increased variedly in the initial phase, onset
            and chronic phase of a pristane-induced arthritis rat model
  JOURNAL   Mol Med Rep 16 (2), 1109-1116 (2017)
   PUBMED   28627588
  REMARK    GeneRIF: IL22 may serve an important role in the pathological
            process of pristaneinduced arthritis, particularly in the chronic
            fluctuation phase.
REFERENCE   4  (bases 1 to 540)
  AUTHORS   Hu,M., Lin,H., Yang,L., Cheng,Y. and Zhang,H.
  TITLE     Interleukin-22 restored mitochondrial damage and impaired
            glucose-stimulated insulin secretion through down-regulation of
            uncoupling protein-2 in INS-1 cells
  JOURNAL   J Biochem 161 (5), 433-439 (2017)
   PUBMED   28069865
  REMARK    GeneRIF: The that IL-22 plays a protective role in this process via
            the down-regulation of uncoupling protein-2 (UCP-2).
REFERENCE   5  (bases 1 to 540)
  AUTHORS   Cho,C.G., Gong,S.H., Kim,H.B., Song,J.J., Park,J.H., Lim,Y.S. and
            Park,S.W.
  TITLE     Role of group 3 innate lymphoid cells during experimental otitis
            media in a rat model
  JOURNAL   Int J Pediatr Otorhinolaryngol 88, 146-152 (2016)
   PUBMED   27497403
REFERENCE   6  (bases 1 to 540)
  AUTHORS   Ziesche,E., Scheiermann,P., Bachmann,M., Sadik,C.D., Hofstetter,C.,
            Zwissler,B., Pfeilschifter,J. and Muhl,H.
  TITLE     Dexamethasone suppresses interleukin-22 associated with bacterial
            infection in vitro and in vivo
  JOURNAL   Clin Exp Immunol 157 (3), 370-376 (2009)
   PUBMED   19664145
REFERENCE   7  (bases 1 to 540)
  AUTHORS   Thessen Hedreul,M., Gillett,A., Olsson,T., Jagodic,M. and
            Harris,R.A.
  TITLE     Characterization of Multiple Sclerosis candidate gene expression
            kinetics in rat experimental autoimmune encephalomyelitis
  JOURNAL   J Neuroimmunol 210 (1-2), 30-39 (2009)
   PUBMED   19269041
REFERENCE   8  (bases 1 to 540)
  AUTHORS   Liang,S.C., Tan,X.Y., Luxenberg,D.P., Karim,R.,
            Dunussi-Joannopoulos,K., Collins,M. and Fouser,L.A.
  TITLE     Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and
            cooperatively enhance expression of antimicrobial peptides
  JOURNAL   J Exp Med 203 (10), 2271-2279 (2006)
   PUBMED   16982811
REFERENCE   9  (bases 1 to 540)
  AUTHORS   Chang,H., Hanawa,H., Liu,H., Yoshida,T., Hayashi,M., Watanabe,R.,
            Abe,S., Toba,K., Yoshida,K., Elnaggar,R., Minagawa,S., Okura,Y.,
            Kato,K., Kodama,M., Maruyama,H., Miyazaki,J. and Aizawa,Y.
  TITLE     Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene
            ameliorates experimental autoimmune myocarditis in rats
  JOURNAL   J Immunol 177 (6), 3635-3643 (2006)
   PUBMED   16951323
REFERENCE   10 (bases 1 to 540)
  AUTHORS   Wei,C.C., Ho,T.W., Liang,W.G., Chen,G.Y. and Chang,M.S.
  TITLE     Cloning and characterization of mouse IL-22 binding protein
  JOURNAL   Genes Immun 4 (3), 204-211 (2003)
   PUBMED   12700595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 17, 2010 this sequence version replaced XM_576228.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ630444.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000007.1  55687061-55687246
            187-252             JAXUCZ010000007.1  55687651-55687716
            253-396             JAXUCZ010000007.1  55687833-55687976
            397-462             JAXUCZ010000007.1  55688998-55689063
            463-540             JAXUCZ010000007.1  55691449-55691526
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..540
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /note="interleukin 22"
                     /db_xref="GeneID:500836"
                     /db_xref="RGD:1561292"
     CDS             1..540
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /note="interferon 2b1"
                     /codon_start=1
                     /product="interleukin-22 precursor"
                     /protein_id="NP_001178917.1"
                     /db_xref="GeneID:500836"
                     /db_xref="RGD:1561292"
                     /translation="MSVLRKSMSFSLMGTLAASCLLLVALWAQKADALPINSQCKLEA
                     ANFQQPYIVNRTFMLAKEASLADNNTDVRLIGEELFRGVKAKDQCYLMKQVLNFTLED
                     VLLPQSDRFQPYMQEVVPFLTKLSSHLSPCHISGDDQNIQKNVRQLKETVQKLGESGE
                     IKAIGELDLLFMSLRNACV"
     exon            1..186
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /inference="alignment:Splign:2.1.0"
     exon            187..252
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /inference="alignment:Splign:2.1.0"
     exon            253..396
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /inference="alignment:Splign:2.1.0"
     exon            397..462
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /inference="alignment:Splign:2.1.0"
     exon            463..540
                     /gene="Il22"
                     /gene_synonym="If2b1; RGD1561292"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtctgtcc tgaggaaatc tatgagcttt tcccttatgg ggactttggc cgccagctgc
       61 ctgcttctcg ttgctctgtg ggctcagaag gcagatgctc tgcccatcaa ctcccaatgc
      121 aaacttgagg cagccaactt ccagcagcca tacatcgtca accgcacctt tatgctggcc
      181 aaggaggcca gccttgcaga taacaacaca gatgtcaggc tcatcgggga ggaactgttc
      241 cgaggagtca aagccaagga tcaatgctac ttgatgaagc aggtgctcaa cttcaccctt
      301 gaagatgttc tgctccccca gtcagacaga ttccagcctt acatgcagga ggtggtgcct
      361 ttcctgacca agctcagcag tcacctcagc ccctgtcaca tcagcggtga tgaccagaac
      421 atccagaaga acgtaagaca gctgaaggaa acagtgcaaa agcttggaga gagtggagag
      481 attaaagcga tcggggaact ggatctgctg tttatgtccc tgagaaacgc ttgcgtctga
//
