LOCUS       NM_001012469            2426 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interleukin 21 receptor (Il21r), mRNA.
ACCESSION   NM_001012469 XM_219332
VERSION     NM_001012469.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2426)
  AUTHORS   Ruffin,N., Lantto,R., Pensieroso,S., Sammicheli,S., Hejdeman,B.,
            Rethi,B. and Chiodi,F.
  TITLE     Immune activation and increased IL-21R expression are associated
            with the loss of memory B cells during HIV-1 infection
  JOURNAL   J Intern Med 272 (5), 492-503 (2012)
   PUBMED   22530560
REFERENCE   2  (bases 1 to 2426)
  AUTHORS   Terrier,B., Geri,G., Chaara,W., Allenbach,Y., Rosenzwajg,M.,
            Costedoat-Chalumeau,N., Fouret,P., Musset,L., Benveniste,O.,
            Six,A., Klatzmann,D., Saadoun,D. and Cacoub,P.
  TITLE     Interleukin-21 modulates Th1 and Th17 responses in giant cell
            arteritis
  JOURNAL   Arthritis Rheum 64 (6), 2001-2011 (2012)
   PUBMED   22147555
REFERENCE   3  (bases 1 to 2426)
  AUTHORS   Nimmo,E.R., Prendergast,J.G., Aldhous,M.C., Kennedy,N.A.,
            Henderson,P., Drummond,H.E., Ramsahoye,B.H., Wilson,D.C.,
            Semple,C.A. and Satsangi,J.
  TITLE     Genome-wide methylation profiling in Crohn's disease identifies
            altered epigenetic regulation of key host defense mechanisms
            including the Th17 pathway
  JOURNAL   Inflamm Bowel Dis 18 (5), 889-899 (2012)
   PUBMED   22021194
REFERENCE   4  (bases 1 to 2426)
  AUTHORS   Spolski,R., Wang,L., Wan,C.K., Bonville,C.A., Domachowske,J.B.,
            Kim,H.P., Yu,Z. and Leonard,W.J.
  TITLE     IL-21 promotes the pathologic immune response to pneumovirus
            infection
  JOURNAL   J Immunol 188 (4), 1924-1932 (2012)
   PUBMED   22238461
REFERENCE   5  (bases 1 to 2426)
  AUTHORS   Geri,G., Terrier,B., Rosenzwajg,M., Wechsler,B., Touzot,M.,
            Seilhean,D., Tran,T.A., Bodaghi,B., Musset,L., Soumelis,V.,
            Klatzmann,D., Cacoub,P. and Saadoun,D.
  TITLE     Critical role of IL-21 in modulating TH17 and regulatory T cells in
            Behcet disease
  JOURNAL   J Allergy Clin Immunol 128 (3), 655-664 (2011)
   PUBMED   21724243
REFERENCE   6  (bases 1 to 2426)
  AUTHORS   Salzer,U., Neumann,C., Thiel,J., Woellner,C., Pan-Hammarstrom,Q.,
            Lougaris,V., Hagena,T., Jung,J., Birmelin,J., Du,L., Metin,A.,
            Webster,D.A., Plebani,A., Moschese,V., Hammarstrom,L.,
            Schaffer,A.A. and Grimbacher,B.
  TITLE     Screening of functional and positional candidate genes in families
            with common variable immunodeficiency
  JOURNAL   BMC Immunol 9, 3 (2008)
   PUBMED   18254984
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2426)
  AUTHORS   Fujita,S., Yamashita,N., Ishii,Y., Sato,Y., Sato,K., Eizumi,K.,
            Fukaya,T., Nozawa,R., Takamoto,Y., Yamashita,N., Taniguchi,M. and
            Sato,K.
  TITLE     Regulatory dendritic cells protect against allergic airway
            inflammation in a murine asthmatic model
  JOURNAL   J Allergy Clin Immunol 121 (1), 95-104 (2008)
   PUBMED   17920666
REFERENCE   8  (bases 1 to 2426)
  AUTHORS   Ueda,C., Akasaka,T., Kurata,M., Maesako,Y., Nishikori,M.,
            Ichinohasama,R., Imada,K., Uchiyama,T. and Ohno,H.
  TITLE     The gene for interleukin-21 receptor is the partner of BCL6 in
            t(3;16)(q27;p11), which is recurrently observed in diffuse large
            B-cell lymphoma
  JOURNAL   Oncogene 21 (3), 368-376 (2002)
   PUBMED   11821949
REFERENCE   9  (bases 1 to 2426)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
REFERENCE   10 (bases 1 to 2426)
  AUTHORS   Ozaki,K., Kikly,K., Michalovich,D., Young,P.R. and Leonard,W.J.
  TITLE     Cloning of a type I cytokine receptor most related to the IL-2
            receptor beta chain
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11439-11444 (2000)
   PUBMED   11016959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089857.1.
            
            On Apr 20, 2005 this sequence version replaced XM_219332.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680416, SAMN06680429
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2426
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2426
                     /gene="Il21r"
                     /note="interleukin 21 receptor"
                     /db_xref="GeneID:308977"
                     /db_xref="RGD:1304950"
     exon            1..359
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            360..492
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            493..555
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..2072
                     /gene="Il21r"
                     /codon_start=1
                     /product="interleukin-21 receptor precursor"
                     /protein_id="NP_001012487.1"
                     /db_xref="GeneID:308977"
                     /db_xref="RGD:1304950"
                     /translation="MPRGLAAPLLLLILHGGWSCLDLTCYTDYLWTITCVLETWSPNP
                     SILSLTWQDEYEELQDKETSCSLHASGHNTTHMWYTCHMRLSQFMSDDVFTVNMMDQS
                     SNSSQECGSFVLAESIKPAPPLNVTVTFSGRYDISWDSIYEEPSNYVLRGKLQYELQY
                     RNLRDPYAVRPVTKLISVDSRNISLLPQEFQKDSSYQLQVRAAPQPGTSFRGTWSEWS
                     DPIIFQTQAEEPEAGWDPHVLLLLAVLILVLVFMGLKNHLPWRLCKKIWAPVPTPESF
                     FQPLYREHSGNFKKWVNTPFTASSVELGPQSPTTSVLHLSLYPAKGKKFLGPLGLEEQ
                     LECDGMSGPGHKCQGVSAYSEERDRPYGLVSIDTVTVGDAEGLGAWPFSCEDDGYPAL
                     NLDAVRESGPNGEDLLLVTDPAFLSCGCVSGSGLRLGGSPGSLLDRLRLSFAKEGDWT
                     AGPPWRTGSLEGGSESEAGSPPGLDMDTFDSGFAGSDCGSPVETDEGPPRSYLRQWVV
                     RTPPPVDSGAQNS"
     exon            556..658
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            659..858
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1013
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1191
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1288
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1373
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2403
                     /gene="Il21r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctgtggt gtgcctcaca gtcacttgcc tgtctgaccg caagtctgtc catccctggg
       61 gcagctaatt ggcctcagtc cctgctccag cagggccctg tctctgtctg gctgccccag
      121 ccctgctgtc tccctctgtg taggctctgt ccagatgacc ggctggtcct cagcttcaag
      181 acaatctcag tggtgactca ccgagattct ggacttccac cagactgaaa tcctgcctac
      241 cttctcaaac ccacacctcc caccaccact ctgaattctg ctgtgactcc catcctggga
      301 ggccatccaa ttgccccaac ctgaagaatg gctttctgaa gaagaccctg aagaagtagg
      361 gaacactggg acaagccagg cctcatctgt ggaccatgca gaggggctgc ggttcaggga
      421 gcacgctgtg aggattgcca actcaggcca ggagagcagc tgatgtctgc ctgtgacctg
      481 tgcagagctg aggtttggga cacagcatgc cacggggcct ggctgctccc ttactcctac
      541 tgattctcca tggaggttgg agctgcctgg acctcacctg ctacactgac tacctctgga
      601 ccatcacctg tgtcctggag acatggagcc ccaaccctag catactcagt ctcacctggc
      661 aagatgaata cgaggaactt caggacaaag aaacatcctg cagcctgcac gcgtctggcc
      721 acaacaccac acatatgtgg tacacgtgcc atatgcgctt gtctcaattc atgtctgatg
      781 acgttttcac tgtcaacatg atggaccagt ctagcaacag ctcccaagag tgtggcagct
      841 ttgtcctggc tgagagcatc aagccagctc cccccttgaa tgtgactgtg accttctcag
      901 gacgatatga tatctcctgg gactcaattt atgaagaacc ctccaactac gtgctgaggg
      961 gcaagctaca atatgagctg cagtatcgga acctcagaga cccctatgct gtgaggccgg
     1021 tgaccaagct gatctcagtg gactcgagaa acatctctct tctccctcaa gagttccaga
     1081 aagattctag ctaccagctg caggtgcggg cagcacctca gccaggcact tcattcaggg
     1141 ggacctggag tgagtggagt gaccccatca tctttcagac ccaggctgag gagcccgagg
     1201 caggctggga ccctcacgta ctgctgctcc tggctgtctt gatccttgtt ctggttttca
     1261 tgggtctgaa gaaccatctg ccttggaggc tatgcaagaa gatatgggca ccggtgccca
     1321 cccccgagag tttcttccag cccctgtaca gggagcacag cgggaacttc aagaaatggg
     1381 ttaatacccc tttcacggcc tccagcgtgg agctggggcc acagagtccc acaacatcag
     1441 ttttacatct gtcattgtat ccagccaagg ggaagaagtt cctggggccg ctgggtctgg
     1501 aagaacagct ggagtgtgat ggaatgtctg gacctggtca caagtgccaa ggggtctcag
     1561 cctacagtga ggagagagac cggccatatg gtctggtgtc cattgacaca gtgaccgtgg
     1621 gggatgcaga gggcctgggt gcttggccct ttagctgtga agatgatggc tacccagccc
     1681 tgaacctgga tgctgtccga gagtctggcc ctaacggaga ggacctgctc ttggtcacag
     1741 accctgcttt tctgtcttgt ggctgtgtct cagggagtgg actcaggcta ggaggctccc
     1801 caggcagcct actggacagg ttgaggctgt catttgccaa ggaaggggac tggacagcag
     1861 gcccaccctg gagaactggg tccctagaag gaggctctga gagtgaagca ggttcacccc
     1921 ctggtctgga catggacaca tttgacagcg gctttgcagg ttcagactgc ggcagccctg
     1981 tggagactga tgaaggaccc cctcgaagct atctccgcca gtgggtggtc aggactcctc
     2041 cacctgtgga cagtggagcc cagaacagct agcatttaat agccagctta atgagaagag
     2101 accagaagcc tgtgacctct tggtaggctt ctgagctgac atttacagtg tgaatgtgta
     2161 ggagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2221 tgtgtggctt gagtgttatt agcacatccg tgttgaggtt tggtcggttg ctatgtattg
     2281 taatgctaaa ttctgtaccc aaagttctag gcttacgagt gaattctcat gtttacaaac
     2341 tggttgtgta aaccttgttc cttaatttaa tactattggt taaataaaat tgactacaac
     2401 caaaaaaaaa aaaaaaaaaa aaaaaa
//
