LOCUS       NP_001012487             521 aa            linear   ROD 24-JUN-2024
DEFINITION  interleukin-21 receptor precursor [Rattus norvegicus].
ACCESSION   NP_001012487 XP_219332
VERSION     NP_001012487.1
DBSOURCE    REFSEQ: accession NM_001012469.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Ruffin,N., Lantto,R., Pensieroso,S., Sammicheli,S., Hejdeman,B.,
            Rethi,B. and Chiodi,F.
  TITLE     Immune activation and increased IL-21R expression are associated
            with the loss of memory B cells during HIV-1 infection
  JOURNAL   J Intern Med 272 (5), 492-503 (2012)
   PUBMED   22530560
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Terrier,B., Geri,G., Chaara,W., Allenbach,Y., Rosenzwajg,M.,
            Costedoat-Chalumeau,N., Fouret,P., Musset,L., Benveniste,O.,
            Six,A., Klatzmann,D., Saadoun,D. and Cacoub,P.
  TITLE     Interleukin-21 modulates Th1 and Th17 responses in giant cell
            arteritis
  JOURNAL   Arthritis Rheum 64 (6), 2001-2011 (2012)
   PUBMED   22147555
REFERENCE   3  (residues 1 to 521)
  AUTHORS   Nimmo,E.R., Prendergast,J.G., Aldhous,M.C., Kennedy,N.A.,
            Henderson,P., Drummond,H.E., Ramsahoye,B.H., Wilson,D.C.,
            Semple,C.A. and Satsangi,J.
  TITLE     Genome-wide methylation profiling in Crohn's disease identifies
            altered epigenetic regulation of key host defense mechanisms
            including the Th17 pathway
  JOURNAL   Inflamm Bowel Dis 18 (5), 889-899 (2012)
   PUBMED   22021194
REFERENCE   4  (residues 1 to 521)
  AUTHORS   Spolski,R., Wang,L., Wan,C.K., Bonville,C.A., Domachowske,J.B.,
            Kim,H.P., Yu,Z. and Leonard,W.J.
  TITLE     IL-21 promotes the pathologic immune response to pneumovirus
            infection
  JOURNAL   J Immunol 188 (4), 1924-1932 (2012)
   PUBMED   22238461
REFERENCE   5  (residues 1 to 521)
  AUTHORS   Geri,G., Terrier,B., Rosenzwajg,M., Wechsler,B., Touzot,M.,
            Seilhean,D., Tran,T.A., Bodaghi,B., Musset,L., Soumelis,V.,
            Klatzmann,D., Cacoub,P. and Saadoun,D.
  TITLE     Critical role of IL-21 in modulating TH17 and regulatory T cells in
            Behcet disease
  JOURNAL   J Allergy Clin Immunol 128 (3), 655-664 (2011)
   PUBMED   21724243
REFERENCE   6  (residues 1 to 521)
  AUTHORS   Salzer,U., Neumann,C., Thiel,J., Woellner,C., Pan-Hammarstrom,Q.,
            Lougaris,V., Hagena,T., Jung,J., Birmelin,J., Du,L., Metin,A.,
            Webster,D.A., Plebani,A., Moschese,V., Hammarstrom,L.,
            Schaffer,A.A. and Grimbacher,B.
  TITLE     Screening of functional and positional candidate genes in families
            with common variable immunodeficiency
  JOURNAL   BMC Immunol 9, 3 (2008)
   PUBMED   18254984
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 521)
  AUTHORS   Fujita,S., Yamashita,N., Ishii,Y., Sato,Y., Sato,K., Eizumi,K.,
            Fukaya,T., Nozawa,R., Takamoto,Y., Yamashita,N., Taniguchi,M. and
            Sato,K.
  TITLE     Regulatory dendritic cells protect against allergic airway
            inflammation in a murine asthmatic model
  JOURNAL   J Allergy Clin Immunol 121 (1), 95-104 (2008)
   PUBMED   17920666
REFERENCE   8  (residues 1 to 521)
  AUTHORS   Ueda,C., Akasaka,T., Kurata,M., Maesako,Y., Nishikori,M.,
            Ichinohasama,R., Imada,K., Uchiyama,T. and Ohno,H.
  TITLE     The gene for interleukin-21 receptor is the partner of BCL6 in
            t(3;16)(q27;p11), which is recurrently observed in diffuse large
            B-cell lymphoma
  JOURNAL   Oncogene 21 (3), 368-376 (2002)
   PUBMED   11821949
REFERENCE   9  (residues 1 to 521)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
REFERENCE   10 (residues 1 to 521)
  AUTHORS   Ozaki,K., Kikly,K., Michalovich,D., Young,P.R. and Leonard,W.J.
  TITLE     Cloning of a type I cytokine receptor most related to the IL-2
            receptor beta chain
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11439-11444 (2000)
   PUBMED   11016959
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089857.1.
            
            On Apr 20, 2005 this sequence version replaced XP_219332.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680416, SAMN06680429
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     Protein         1..521
                     /product="interleukin-21 receptor precursor"
                     /calculated_mol_wt=55441
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2016
     Region          120..225
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(120,192,207)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            order(214..215,217..218)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..521
                     /gene="Il21r"
                     /coded_by="NM_001012469.1:507..2072"
                     /db_xref="GeneID:308977"
                     /db_xref="RGD:1304950"
ORIGIN      
        1 mprglaapll llilhggwsc ldltcytdyl wtitcvletw spnpsilslt wqdeyeelqd
       61 ketscslhas ghntthmwyt chmrlsqfms ddvftvnmmd qssnssqecg sfvlaesikp
      121 applnvtvtf sgrydiswds iyeepsnyvl rgklqyelqy rnlrdpyavr pvtklisvds
      181 rnisllpqef qkdssyqlqv raapqpgtsf rgtwsewsdp iifqtqaeep eagwdphvll
      241 llavlilvlv fmglknhlpw rlckkiwapv ptpesffqpl yrehsgnfkk wvntpftass
      301 velgpqsptt svlhlslypa kgkkflgplg leeqlecdgm sgpghkcqgv sayseerdrp
      361 yglvsidtvt vgdaeglgaw pfsceddgyp alnldavres gpngedlllv tdpaflscgc
      421 vsgsglrlgg spgslldrlr lsfakegdwt agppwrtgsl eggseseags ppgldmdtfd
      481 sgfagsdcgs pvetdegppr sylrqwvvrt pppvdsgaqn s
//
