LOCUS       NM_001108943            3005 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus interleukin 21 (Il21), mRNA.
ACCESSION   NM_001108943 XM_001068859 XM_345201
VERSION     NM_001108943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Hao,K., Lin,P., Li,J., Hu,J., Wang,J. and Li,F.
  TITLE     IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate
            the progression of shoulder arthritis
  JOURNAL   Aging (Albany NY) 16 (9), 7915-7927 (2024)
   PUBMED   38728237
  REMARK    GeneRIF: IL21 inhibits miR-361-5p to promote MAP3K9 and further
            aggravate the progression of shoulder arthritis.
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Zhang,X., Hu,Q., Jiang,B., Xie,F., Zhang,Z., Hafezi-Moghadam,A. and
            Sun,D.
  TITLE     Role of Interleukin-21 in retinal ischemia-reperfusion injury:
            Unveiling the impact on retinal ganglion cell apoptosis
  JOURNAL   Int Immunopharmacol 128, 111480 (2024)
   PUBMED   38194747
  REMARK    GeneRIF: Role of Interleukin-21 in retinal ischemia-reperfusion
            injury: Unveiling the impact on retinal ganglion cell apoptosis.
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Shen,Z., Wu,J., Gao,Z., Wang,J., Zhu,H., Mao,R., Wang,X., Zhang,J.,
            Xie,Y. and Liu,J.
  TITLE     Characterization of IL-21-expressing recombinant hepatitis B virus
            (HBV) as a therapeutic agent targeting persisting HBV infection
  JOURNAL   Theranostics 10 (12), 5600-5612 (2020)
   PUBMED   32373234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Sun,Z., Hu,Y., Wang,Y., Feng,J. and Dou,Y.
  TITLE     Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal
            dysbiosis in rats through T helper 17/T regulatory cell signaling
            pathway
  JOURNAL   J Tradit Chin Med 40 (1), 38-48 (2020)
   PUBMED   32227764
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Abu El-Hamd,M., Assaf,H.A.R., Sedky,A. and Mohammad,S.H.
  TITLE     Possible role of interleukin 21 and interleukin 33 in patients with
            genital warts
  JOURNAL   Dermatol Ther 32 (5), e13063 (2019)
   PUBMED   31414711
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Brady,J., Hayakawa,Y., Smyth,M.J. and Nutt,S.L.
  TITLE     IL-21 induces the functional maturation of murine NK cells
  JOURNAL   J Immunol 172 (4), 2048-2058 (2004)
   PUBMED   14764669
  REMARK    Erratum:[J Immunol. 2006 Mar 15;176(6):3840]
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Sivori,S., Cantoni,C., Parolini,S., Marcenaro,E., Conte,R.,
            Moretta,L. and Moretta,A.
  TITLE     IL-21 induces both rapid maturation of human CD34+ cell precursors
            towards NK cells and acquisition of surface killer Ig-like
            receptors
  JOURNAL   Eur J Immunol 33 (12), 3439-3447 (2003)
   PUBMED   14635054
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Zhang,J.L., Foster,D. and Sebald,W.
  TITLE     Human IL-21 and IL-4 bind to partially overlapping epitopes of
            common gamma-chain
  JOURNAL   Biochem Biophys Res Commun 300 (2), 291-296 (2003)
   PUBMED   12504082
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Strengell,M., Sareneva,T., Foster,D., Julkunen,I. and Matikainen,S.
  TITLE     IL-21 up-regulates the expression of genes associated with innate
            immunity and Th1 response
  JOURNAL   J Immunol 169 (7), 3600-3605 (2002)
   PUBMED   12244150
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 6, 2022 this sequence version replaced NM_001108943.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ387062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000002.1  122054925-122055142 c
            219-254             JAXUCZ010000002.1  122054774-122054809 c
            255-410             JAXUCZ010000002.1  122050350-122050505 c
            411-488             JAXUCZ010000002.1  122047845-122047922 c
            489-3005            JAXUCZ010000002.1  122045240-122047756 c
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..3005
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /note="interleukin 21"
                     /db_xref="GeneID:365769"
                     /db_xref="RGD:1307384"
     exon            1..218
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..512
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /codon_start=1
                     /product="interleukin-21 precursor"
                     /protein_id="NP_001102413.1"
                     /db_xref="GeneID:365769"
                     /db_xref="RGD:1307384"
                     /translation="MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKI
                     YENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPA
                     KRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS"
     exon            219..254
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /inference="alignment:Splign:2.1.0"
     exon            255..410
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /inference="alignment:Splign:2.1.0"
     exon            411..488
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3005
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagtcagg ttgaagtgag aaccagacca aggccttgtt catcagctgc tggagaccca
       61 ggtctggtgg catggagagg acccttgtct gtctgatact catcttcttg gggaccgtgg
      121 cccataaatc aagcccccaa aggccagatc accttctgat tagacttcgt caccttatgg
      181 acattgttga acagctgaaa atctatgaga atgacttgga tcctgaactt ctaacagctc
      241 cacaagatgt aaaggggcaa tgtgagcacg aagcttttgc ctgttttcag aaagccaaac
      301 tcaagccatc aaacactgga aacaataaga cattcatcaa cgacttgttg gcacagctga
      361 ggaggaggct gcctgctaag aggacaggaa ataaacagag gcacatggct aaatgccctt
      421 cctgtgattt gtatgagaaa aaaacaccca aagaattcct tgaaagacta aaatggctcc
      481 ttcaaaagat gattcatcag catctttcct agaacacata ggacctgaag attcccgagg
      541 acagcggaca gtatagacgc tcacaaacac aggagtacat ctttcctcct gggattctga
      601 gtggagaagt acgatatatt atgataggaa caactaagaa aagctgcaga ttaagatcct
      661 tttgcccact tactgtgcag atattgcggt tccctgcaca gactccatgc tgtcaacatg
      721 gaaaatctct tctcagcaag agccagctta ttgtggtgac aggatttctg ggacttctca
      781 cgttgtggct tcatcttatt gcccgactgt gacattcttt gatcagaaag ggaaaactaa
      841 aaattttaac taaaaataag gctagagaac ttgttggtct gcaagaataa gacctattat
      901 gaccctaact gaaggatgta agctgaaaat acataagcat aagattatat tgaagactga
      961 agtctttatt ctttacgaaa atctttgtac ttgaaagcat gtctgaaggg tttactcgtt
     1021 acattaacat ctggcccagt gataactgat ctacttattc tctaccggac agcttctcct
     1081 gatgggcaca aacaattttt cttcttgatt aggtctatta aaatatttaa gtatggtaga
     1141 atttaaccta tttatgaggt tcacccctgg ccttcactgt ttttctaaag cgggaaggac
     1201 gtgttaagaa gcaggcttga cttgccttcc tctcaatgtc aagatccttt ataagctaat
     1261 agtgtaatct tgtgaagaag gtaaccaaat atcaccagtc ttctggagcc aaatatagtc
     1321 tccagttttg tagcgctcac ctccagtggt tatgggtgtg ctgtgaggaa tctgctaact
     1381 ccagcctcag tctcctctcc cacatccttt ccttcctttc tgatgcgtaa aatgaaactt
     1441 ctaagaacag gcatttccaa caagttcagc atttaagaca catcacgtgc acacttttga
     1501 taagttaagt tcaatcatgt atttaaagtc gaaatcagga gataagtcaa gagaccagag
     1561 gttctgtccc ggttttaaac ggacctttac ctaccattct gatcttttaa ccacagagcc
     1621 tacactgagc aaatggttcc accatttgat atcaattcca acagtatgtt tcaacagcaa
     1681 gttaaaaagt ctagaaagtc atttcccctg gaatagtata atctctttgt aaatttctta
     1741 ctgttaaaat ggatctgaga tcccaggcat gacctggggg aagtctttgc tccaagaaaa
     1801 aagtatctgt atttaaaagt acctttaaaa caagcgcaga cacagcacac tgctctaaga
     1861 cagagctgac tattattaat tgattcccag aaaagtgtca caatcagaaa caatgtattt
     1921 tcttaaattg ttaaactatg tattgcaaag aaacggtgta actgtgaatg tgcgactctt
     1981 gatgacattc tagcccactt aagtgtctga cggtgctagc atgggttgtt gaatttgctg
     2041 ctgggaagct gaagtagaga tgcaatgatg gagagggaca gcttctctgt gtcttattct
     2101 gtgactattt ctggctgtat aactgttgac ttcttgacac tgtgattttt atatttaaga
     2161 cgacatattt attttggtgt gtttattgtt aaaaatctgt tctaggcttt taaaccattg
     2221 actatttcta ctctagaagt acaactaatt cagtgcagac aggctaagag cttgcagagt
     2281 tcggaagccc taaaggcctc tccactagcc aaggccaagc gatgctttac taactagaca
     2341 gagcaagtct tgcacagcag tcttgaacct ctctgtgctc gagactcagc cagtccttga
     2401 catttttgtt ctctgtgggt ggcaatacct tgggcctgat acactgttga catggaggtt
     2461 gcccctggtg taagcttttt ttggttttca ttttcctatc tatagaacaa ggatgtgtga
     2521 ctttcctaag tctattctgt attttttttt gagctttata tgtctgagtt ttaatgtttc
     2581 cagtacactt acaagagcac ctgaccacac tcatgagtta aatttcatcc caagtgtgat
     2641 atttagttgc tcaaaaagga aagaaagaag gaagaaaggc gagagagaga gagagagaga
     2701 gagagagaga gagagagaga gagagagaga gagacattgc tgtaggtcat gagagttcag
     2761 agaaaatcag ttatggctgt taatagtgta gctgaaagtg ttttctttgt atatgtgaat
     2821 aaatttatag cattattgac ctatgttact gctctgtttt atttacagtc acatctgaga
     2881 atttagtttt aatatgaatg atgtacttta taacttaatg attatttatt atgtatttgg
     2941 ttttgaatgt ttgtattcat ggcttcttat ttaagacatg atcgtattaa atactactca
     3001 gtcag
//
