LOCUS       NP_001102413             146 aa            linear   ROD 13-JUN-2024
DEFINITION  interleukin-21 precursor [Rattus norvegicus].
ACCESSION   NP_001102413 XP_001068859 XP_345202
VERSION     NP_001102413.1
DBSOURCE    REFSEQ: accession NM_001108943.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Hao,K., Lin,P., Li,J., Hu,J., Wang,J. and Li,F.
  TITLE     IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate
            the progression of shoulder arthritis
  JOURNAL   Aging (Albany NY) 16 (9), 7915-7927 (2024)
   PUBMED   38728237
  REMARK    GeneRIF: IL21 inhibits miR-361-5p to promote MAP3K9 and further
            aggravate the progression of shoulder arthritis.
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Zhang,X., Hu,Q., Jiang,B., Xie,F., Zhang,Z., Hafezi-Moghadam,A. and
            Sun,D.
  TITLE     Role of Interleukin-21 in retinal ischemia-reperfusion injury:
            Unveiling the impact on retinal ganglion cell apoptosis
  JOURNAL   Int Immunopharmacol 128, 111480 (2024)
   PUBMED   38194747
  REMARK    GeneRIF: Role of Interleukin-21 in retinal ischemia-reperfusion
            injury: Unveiling the impact on retinal ganglion cell apoptosis.
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Shen,Z., Wu,J., Gao,Z., Wang,J., Zhu,H., Mao,R., Wang,X., Zhang,J.,
            Xie,Y. and Liu,J.
  TITLE     Characterization of IL-21-expressing recombinant hepatitis B virus
            (HBV) as a therapeutic agent targeting persisting HBV infection
  JOURNAL   Theranostics 10 (12), 5600-5612 (2020)
   PUBMED   32373234
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Sun,Z., Hu,Y., Wang,Y., Feng,J. and Dou,Y.
  TITLE     Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal
            dysbiosis in rats through T helper 17/T regulatory cell signaling
            pathway
  JOURNAL   J Tradit Chin Med 40 (1), 38-48 (2020)
   PUBMED   32227764
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Abu El-Hamd,M., Assaf,H.A.R., Sedky,A. and Mohammad,S.H.
  TITLE     Possible role of interleukin 21 and interleukin 33 in patients with
            genital warts
  JOURNAL   Dermatol Ther 32 (5), e13063 (2019)
   PUBMED   31414711
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Brady,J., Hayakawa,Y., Smyth,M.J. and Nutt,S.L.
  TITLE     IL-21 induces the functional maturation of murine NK cells
  JOURNAL   J Immunol 172 (4), 2048-2058 (2004)
   PUBMED   14764669
  REMARK    Erratum:[J Immunol. 2006 Mar 15;176(6):3840]
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Sivori,S., Cantoni,C., Parolini,S., Marcenaro,E., Conte,R.,
            Moretta,L. and Moretta,A.
  TITLE     IL-21 induces both rapid maturation of human CD34+ cell precursors
            towards NK cells and acquisition of surface killer Ig-like
            receptors
  JOURNAL   Eur J Immunol 33 (12), 3439-3447 (2003)
   PUBMED   14635054
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Zhang,J.L., Foster,D. and Sebald,W.
  TITLE     Human IL-21 and IL-4 bind to partially overlapping epitopes of
            common gamma-chain
  JOURNAL   Biochem Biophys Res Commun 300 (2), 291-296 (2003)
   PUBMED   12504082
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Strengell,M., Sareneva,T., Foster,D., Julkunen,I. and Matikainen,S.
  TITLE     IL-21 up-regulates the expression of genes associated with innate
            immunity and Th1 response
  JOURNAL   J Immunol 169 (7), 3600-3605 (2002)
   PUBMED   12244150
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Parrish-Novak,J., Dillon,S.R., Nelson,A., Hammond,A., Sprecher,C.,
            Gross,J.A., Johnston,J., Madden,K., Xu,W., West,J., Schrader,S.,
            Burkhead,S., Heipel,M., Brandt,C., Kuijper,J.L., Kramer,J.,
            Conklin,D., Presnell,S.R., Berry,J., Shiota,F., Bort,S., Hambly,K.,
            Mudri,S., Clegg,C., Moore,M., Grant,F.J., Lofton-Day,C.,
            Gilbert,T., Rayond,F., Ching,A., Yao,L., Smith,D., Webster,P.,
            Whitmore,T., Maurer,M., Kaushansky,K., Holly,R.D. and Foster,D.
  TITLE     Interleukin 21 and its receptor are involved in NK cell expansion
            and regulation of lymphocyte function
  JOURNAL   Nature 408 (6808), 57-63 (2000)
   PUBMED   11081504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001068859.1, XP_345202.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ387062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     Protein         1..146
                     /product="interleukin-21 precursor"
                     /calculated_mol_wt=15191
     sig_peptide     1..17
                     /note="/evidence=ECO:0000250|UniProtKB:Q76LU5; propagated
                     from UniProtKB/Swiss-Prot (A3QPB9.1)"
                     /calculated_mol_wt=1892
     mat_peptide     18..146
                     /product="Interleukin-21. /id=PRO_0000313746"
                     /note="propagated from UniProtKB/Swiss-Prot (A3QPB9.1)"
                     /calculated_mol_wt=15191
     Site            85
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A3QPB9.1)"
     CDS             1..146
                     /gene="Il21"
                     /gene_synonym="IL-21"
                     /coded_by="NM_001108943.3:72..512"
                     /db_xref="GeneID:365769"
                     /db_xref="RGD:1307384"
ORIGIN      
        1 mertlvclil iflgtvahks spqrpdhlli rlrhlmdive qlkiyendld pelltapqdv
       61 kgqceheafa cfqkaklkps ntgnnktfin dllaqlrrrl pakrtgnkqr hmakcpscdl
      121 yekktpkefl erlkwllqkm ihqhls
//
