LOCUS       NM_001143881            1182 bp    mRNA    linear   ROD 26-MAR-2023
DEFINITION  Rattus norvegicus interleukin 20 (Il20), mRNA.
ACCESSION   NM_001143881 XM_001057413 XM_001057481 XM_001060362
VERSION     NM_001143881.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1182)
  AUTHORS   Meng B, Yang B, Qu Y, Liu Y, Wu D, Fu C, He Y, Chen X, Liu C, Kou X
            and Cao Y.
  TITLE     Dual Role of Interleukin-20 in Different Stages of Osteoclast
            Differentiation and Its Osteoimmune Regulation during Alveolar Bone
            Remodeling
  JOURNAL   Int J Mol Sci 24 (4), 3810 (2023)
   PUBMED   36835229
  REMARK    GeneRIF: Dual Role of Interleukin-20 in Different Stages of
            Osteoclast Differentiation and Its Osteoimmune Regulation during
            Alveolar Bone Remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1182)
  AUTHORS   Tsai KL, Hsieh PL, Chou WC, Hung CH, Yang HL, Chang YC, Chu PM,
            Chang MS and Chan SH.
  TITLE     IL-20 promotes hypoxia/reoxygenation-induced mitochondrial
            dysfunction and apoptosis in cardiomyocytes by upregulating
            oxidative stress by activating the PKC/NADPH oxidase pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (5), 165684 (2020)
   PUBMED   31953216
  REMARK    GeneRIF: IL-20 promotes hypoxia/reoxygenation-induced mitochondrial
            dysfunction and apoptosis in cardiomyocytes by upregulating
            oxidative stress by activating the PKC/NADPH oxidase pathway.
REFERENCE   3  (bases 1 to 1182)
  AUTHORS   Pap D, Sziksz E, Kiss Z, Rokonay R, Veres-Szekely A, Lippai R,
            Takacs IM, Kis E, Fekete A, Reusz G, Szabo AJ and Vannay A.
  TITLE     Microarray Analysis Reveals Increased Expression of Matrix
            Metalloproteases and Cytokines of Interleukin-20 Subfamily in the
            Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction:
            A Potential Role of IL-24 in the Regulation of Inflammation and
            Tissue Remodeling
  JOURNAL   Kidney Blood Press Res 42 (1), 16-32 (2017)
   PUBMED   28253513
  REMARK    GeneRIF: Microarray analysis revealed 880 transcripts showing
            2.0-fold change following Unilateral Ureteral Obstruction, enriched
            mainly in immune response related processes. The most up-regulated
            genes were MMPs and members of IL-20 cytokine subfamily.
REFERENCE   4  (bases 1 to 1182)
  AUTHORS   Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ and Chang MS.
  TITLE     Anti-IL-20 monoclonal antibody inhibits the differentiation of
            osteoclasts and protects against osteoporotic bone loss
  JOURNAL   J Exp Med 208 (9), 1849-1861 (2011)
   PUBMED   21844205
REFERENCE   5  (bases 1 to 1182)
  AUTHORS   Chen XY, Jin LW, Chen YW, Tian H, Yuan WT, Niu ZM, Zhang J, Huang W
            and Zheng J.
  TITLE     The association between the IL-20-1723C-->G allele on the 1q
            chromosome and psoriasis triggered or exacerbated by an upper
            respiratory tract infection in the Chinese Han population
  JOURNAL   Dermatology 222 (1), 24-30 (2011)
   PUBMED   21109726
REFERENCE   6  (bases 1 to 1182)
  AUTHORS   Hsu YH and Chang MS.
  TITLE     Interleukin-20 antibody is a potential therapeutic agent for
            experimental arthritis
  JOURNAL   Arthritis Rheum 62 (11), 3311-3321 (2010)
   PUBMED   20722035
REFERENCE   7  (bases 1 to 1182)
  AUTHORS   Chen WY and Chang MS.
  TITLE     IL-20 is regulated by hypoxia-inducible factor and up-regulated
            after experimental ischemic stroke
  JOURNAL   J Immunol 182 (8), 5003-5012 (2009)
   PUBMED   19342680
  REMARK    GeneRIF: IL-20 was responsive to hypoxia in vitro and in the
            ischemic stroke model and that up-regulation of IL-20 in the
            ischemic brain may contribute to brain injury
REFERENCE   8  (bases 1 to 1182)
  AUTHORS   Wei CC, Li HH, Hsu YH, Hsing CH, Sung JM and Chang MS.
  TITLE     Interleukin-20 targets renal cells and is associated with chronic
            kidney disease
  JOURNAL   Biochem Biophys Res Commun 374 (3), 448-453 (2008)
   PUBMED   18639518
REFERENCE   9  (bases 1 to 1182)
  AUTHORS   Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng
            HH and Chang MS.
  TITLE     Function of interleukin-20 as a proinflammatory molecule in
            rheumatoid and experimental arthritis
  JOURNAL   Arthritis Rheum 54 (9), 2722-2733 (2006)
   PUBMED   16947773
REFERENCE   10 (bases 1 to 1182)
  AUTHORS   Rich BE and Kupper TS.
  TITLE     Cytokines: IL-20 - a new effector in skin inflammation
  JOURNAL   Curr Biol 11 (13), R531-R534 (2001)
   PUBMED   11470428
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Jan 22, 2009 this sequence version replaced
            XM_001057481.1, XM_001057413.1, XM_001060362.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ229286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1182
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..1182
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /note="interleukin 20"
                     /db_xref="GeneID:681112"
                     /db_xref="RGD:1583578"
     exon            1..372
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..744
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /note="interferon 2d"
                     /codon_start=1
                     /product="interleukin-20"
                     /protein_id="NP_001137353.1"
                     /db_xref="GeneID:681112"
                     /db_xref="RGD:1583578"
                     /translation="MRGFRLAFGLFSVVGFLLWTPLTGLKTLHLGSCVITANLQAIQK
                     EFSEIRHSVQAEDENIDVRILRTTESLKDTKLSDRCCFLRHLVRFYLDRVFKVYQTPD
                     HHTLRKISSLANSFLIIKKDLSVCHSHMACHCGEEAMEKYNQILSHFTELELQAAVVK
                     ALGELGILLRWMEEML"
     exon            373..438
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /inference="alignment:Splign:2.1.0"
     exon            439..591
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /inference="alignment:Splign:2.1.0"
     exon            592..666
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1182
                     /gene="Il20"
                     /gene_synonym="If2d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtacctaga tcctgaaggg actgggaggc ttctggctga agcagctttt cttaggaagt
       61 tgcgtgaaca catagcactg cctgccgccg cagaagttcc cacccagtgg acagctggtg
      121 ctggcatata cctggtggct agaccggaga agtcaataac cctgaccgat ctctttgaac
      181 ttccacttct ggtctccagg atctaggtgt aagatgagag gctttcgtct tgcctttgga
      241 ctgttctccg ttgtgggttt tcttctctgg actcctttaa ctgggctcaa gacccttcat
      301 ttgggaagct gtgtaatcac tgcaaaccta caggcgatac aaaaggaatt ttctgagatt
      361 cggcatagtg tgcaagctga agatgaaaat atcgacgtca ggattttaag gacgactgag
      421 tccctgaaag acacaaagct ttcggatagg tgctgctttc tccgccatct agtgaggttc
      481 tatctggaca gggtgttcaa agtctaccag acccctgacc atcataccct gcgaaagatc
      541 agcagcctcg ccaattcttt tcttatcatc aagaaggacc tctcagtctg tcattctcac
      601 atggcatgtc attgtggcga agaagcaatg gagaaataca accaaattct cagtcatttc
      661 acagagcttg agctccaggc agccgtggtg aaggctttgg gggaactagg cattcttctg
      721 agatggatgg aggagatgtt atagatgaga gtagagaggc tgctgagaac gctcctgtcc
      781 aagagtccca gacctcagca ccacgaagac aaggccccag gtgctgctga gaacatttct
      841 acccaagagt cccagtcctc agtaccacga agacatggcc tcaaaccacc acccctgtat
      901 gatataattt agtgctgacc acagtgtgta ttttttatat attattggtt cccttatgtg
      961 gaggccttcg tgtgtctctc tattccctta cactgtaatt ttgtaaaatt ttctgtaatg
     1021 tcttttctaa tgctgtctat atttattcat taatatgtat atttattttc tattgaacta
     1081 tatttatttt tgtacttgaa cacaagactt agaagattat atttataacc tgtcaagagc
     1141 aggcgatata ttttcatata ataaacaagc ctgttaaact cc
//
