LOCUS       NM_053836                740 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus interleukin 2 (Il2), mRNA.
ACCESSION   NM_053836
VERSION     NM_053836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 740)
  AUTHORS   Burovenko,I.Y., Sonin,D.L., Borshcheva,O.V., Istomina,M.S.,
            Zaitseva,E.A., Protsak,E.S., Borshchev,V.Y., Borshchev,Y.Y. and
            Galagudza,M.M.
  TITLE     Influence of Interleukin-2 and Brain-Derived Neurotrophic Factor
            (BDNF) on the Size of Myocardial Infarction in Rats with Systemic
            Inflammatory Response
  JOURNAL   Bull Exp Biol Med 175 (2), 219-224 (2023)
   PUBMED   37464198
  REMARK    GeneRIF: Influence of Interleukin-2 and Brain-Derived Neurotrophic
            Factor (BDNF) on the Size of Myocardial Infarction in Rats with
            Systemic Inflammatory Response.
REFERENCE   2  (bases 1 to 740)
  AUTHORS   Fraser,D.D., Cepinskas,G., Slessarev,M., Martin,C., Daley,M.,
            Miller,M.R., O'Gorman,D.B., Gill,S.E., Patterson,E.K. and Dos
            Santos,C.C.
  TITLE     Inflammation Profiling of Critically Ill Coronavirus Disease 2019
            Patients
  JOURNAL   Crit Care Explor 2 (6), e0144 (2020)
   PUBMED   32696007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 740)
  AUTHORS   Huang,C., Wang,Y., Li,X., Ren,L., Zhao,J., Hu,Y., Zhang,L., Fan,G.,
            Xu,J., Gu,X., Cheng,Z., Yu,T., Xia,J., Wei,Y., Wu,W., Xie,X.,
            Yin,W., Li,H., Liu,M., Xiao,Y., Gao,H., Guo,L., Xie,J., Wang,G.,
            Jiang,R., Gao,Z., Jin,Q., Wang,J. and Cao,B.
  TITLE     Clinical features of patients infected with 2019 novel coronavirus
            in Wuhan, China
  JOURNAL   Lancet 395 (10223), 497-506 (2020)
   PUBMED   31986264
  REMARK    Erratum:[Lancet. 2020 Feb 15;395(10223):496. doi:
            10.1016/S0140-6736(20)30252-X.. PMID: 32007144]
REFERENCE   4  (bases 1 to 740)
  AUTHORS   Taylor,A.E., Carey,A.N., Kudira,R., Lages,C.S., Shi,T., Lam,S.,
            Karns,R., Simmons,J., Shanmukhappa,K., Almanan,M., Chougnet,C.A.
            and Miethke,A.G.
  TITLE     Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and
            Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis
  JOURNAL   Hepatology 68 (5), 1905-1921 (2018)
   PUBMED   29698570
REFERENCE   5  (bases 1 to 740)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 740)
  AUTHORS   Casey,L.S., Lichtman,A.H. and Boothby,M.
  TITLE     IL-4 induces IL-2 receptor p75 beta-chain gene expression and
            IL-2-dependent proliferation in mouse T lymphocytes
  JOURNAL   J Immunol 148 (11), 3418-3426 (1992)
   PUBMED   1588041
REFERENCE   7  (bases 1 to 740)
  AUTHORS   Choyke,P.L., Miller,D.L., Lotze,M.T., Whiteis,J.M., Ebbitt,B. and
            Rosenberg,S.A.
  TITLE     Delayed reactions to contrast media after interleukin-2
            immunotherapy
  JOURNAL   Radiology 183 (1), 111-114 (1992)
   PUBMED   1549655
REFERENCE   8  (bases 1 to 740)
  AUTHORS   Schorle,H., Holtschke,T., Hunig,T., Schimpl,A. and Horak,I.
  TITLE     Development and function of T cells in mice rendered interleukin-2
            deficient by gene targeting
  JOURNAL   Nature 352 (6336), 621-624 (1991)
   PUBMED   1830926
REFERENCE   9  (bases 1 to 740)
  AUTHORS   Su,M., Qian,D.H. and Chen,Y.H.
  TITLE     [Effect of diethyldithiocarbamate on interleukin 2 production of
            patients with oral lichen planus and its clinical therapeutic
            efficacy]
  JOURNAL   Zhongguo Yao Li Xue Bao 12 (4), 378-380 (1991)
   PUBMED   1666936
REFERENCE   10 (bases 1 to 740)
  AUTHORS   Hsieh,K.H., Chou,C.C. and Huang,S.F.
  TITLE     Interleukin 2 therapy in severe atopic dermatitis
  JOURNAL   J Clin Immunol 11 (1), 22-28 (1991)
   PUBMED   1673687
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M22899.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..740
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..740
                     /gene="Il2"
                     /note="interleukin 2"
                     /db_xref="GeneID:116562"
                     /db_xref="RGD:620047"
     exon            1..161
                     /gene="Il2"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..482
                     /gene="Il2"
                     /note="IL-2; TCGF; T-cell growth factor"
                     /codon_start=1
                     /product="interleukin-2 precursor"
                     /protein_id="NP_446288.1"
                     /db_xref="GeneID:116562"
                     /db_xref="RGD:620047"
                     /translation="MYSMQLASCVALTLVLLVNSAPTSSPAKETQQHLEQLLLDLQVL
                     LRGIDNYKNLKLPMMLTFKFYLPKQATELKHLQCLENELGALQRVLDLTQSKSFHLED
                     AGNFISNIRVTVVKLKGSENKFECQFDDEPATVVEFLRRWIAICQSIISTMTQ"
     exon            162..221
                     /gene="Il2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..368
                     /gene="Il2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..740
                     /gene="Il2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagtcctgc aagcatgtac agcatgcagc tcgcatcctg tgttgcactg acgcttgtcc
       61 tccttgtcaa cagcgcaccc acttcaagcc ctgcaaagga aacacagcag cacctggagc
      121 agctgttgct ggacttacag gtgctcctga gagggatcga taattacaag aatctgaaac
      181 tccccatgat gctcacgttt aaattttact tgcccaagca ggccacagaa ttgaaacatc
      241 ttcagtgcct ggaaaatgaa ctcggagctc tgcagcgtgt gttggatttg actcaaagca
      301 aaagctttca cttggaagac gctggaaatt tcatcagcaa tatcagagta actgttgtaa
      361 aactaaaggg ctctgaaaac aaatttgagt gccaattcga tgatgagcca gcaactgtgg
      421 tggaatttct gaggagatgg atagccatct gtcaaagcat catctcaaca atgactcagt
      481 aattatgtgc ctcctactta taacacacaa ggctttttat ttatttaaat atttaacttt
      541 atatttattt tggatgtatt gtttactatc ttttgtaact actagtcttc agatgataaa
      601 tatggatctt taaagattct ttttgtaagc cccaagggct caaaaatgtt ttaaactatt
      661 tatctgaaat tatttattat attgaattgt taaatgtgta tgtagattca ttaataaaag
      721 tatttagaag agtcgatgaa
//
