LOCUS       NM_022194               1942 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus interleukin 1 receptor antagonist (Il1rn), mRNA.
ACCESSION   NM_022194 XM_001071294 XM_001071330
VERSION     NM_022194.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Bai,N., Zhang,Q., Zhang,W., Liu,B., Yang,F., Brann,D. and Wang,R.
  TITLE     G-protein-coupled estrogen receptor activation upregulates
            interleukin-1 receptor antagonist in the hippocampus after global
            cerebral ischemia: implications for neuronal self-defense
  JOURNAL   J Neuroinflammation 17 (1), 45 (2020)
   PUBMED   32007102
  REMARK    GeneRIF: G-protein-coupled estrogen receptor activation upregulates
            interleukin-1 receptor antagonist in the hippocampus after global
            cerebral ischemia: implications for neuronal self-defense.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Yamato,M., Tamura,Y., Eguchi,A., Kume,S., Miyashige,Y., Nakano,M.,
            Watanabe,Y. and Kataoka,Y.
  TITLE     Brain interleukin-1beta and the intrinsic receptor antagonist
            control peripheral Toll-like receptor 3-mediated suppression of
            spontaneous activity in rats
  JOURNAL   PLoS One 9 (3), e90950 (2014)
   PUBMED   24621600
  REMARK    GeneRIF: IL-1beta is the key trigger of neuroinflammation and that
            IL-1ra prevents the neuroinflammation entering the chronic state
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Teng,Y. and Gao,Y.
  TITLE     Tobacco smoking associated with the increases of the
            bronchoalveolar levels of interleukin-5 and interleukin-1 receptor
            antagonist in acute eosinophilic pneumonia
  JOURNAL   Eur Rev Med Pharmacol Sci 18 (6), 887-893 (2014)
   PUBMED   24706315
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Prins,M., Eriksson,C., Wierinckx,A., Bol,J.G., Binnekade,R.,
            Tilders,F.J. and Van Dam,A.M.
  TITLE     Interleukin-1beta and interleukin-1 receptor antagonist appear in
            grey matter additionally to white matter lesions during
            experimental multiple sclerosis
  JOURNAL   PLoS One 8 (12), e83835 (2013)
   PUBMED   24376764
  REMARK    GeneRIF: Interleukin-1beta and interleukin-1 receptor antagonist
            appear in grey matter additionally to white matter during
            experimental multiple sclerosis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Vijmasi,T., Chen,F.Y., Chen,Y.T., Gallup,M. and McNamara,N.
  TITLE     Topical administration of interleukin-1 receptor antagonist as a
            therapy for aqueous-deficient dry eye in autoimmune disease
  JOURNAL   Mol Vis 19, 1957-1965 (2013)
   PUBMED   24068863
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1942)
  AUTHORS   Ulich,T.R., Guo,K., Yin,S., del Castillo,J., Yi,E.S., Thompson,R.C.
            and Eisenberg,S.P.
  TITLE     Endotoxin-induced cytokine gene expression in vivo. IV. Expression
            of interleukin-1 alpha/beta and interleukin-1 receptor antagonist
            mRNA during endotoxemia and during endotoxin-initiated local acute
            inflammation
  JOURNAL   Am J Pathol 141 (1), 61-68 (1992)
   PUBMED   1385928
REFERENCE   7  (bases 1 to 1942)
  AUTHORS   Dripps,D.J., Verderber,E., Ng,R.K., Thompson,R.C. and
            Eisenberg,S.P.
  TITLE     Interleukin-1 receptor antagonist binds to the type II
            interleukin-1 receptor on B cells and neutrophils
  JOURNAL   J Biol Chem 266 (30), 20311-20315 (1991)
   PUBMED   1834644
REFERENCE   8  (bases 1 to 1942)
  AUTHORS   Granowitz,E.V., Clark,B.D., Mancilla,J. and Dinarello,C.A.
  TITLE     Interleukin-1 receptor antagonist competitively inhibits the
            binding of interleukin-1 to the type II interleukin-1 receptor
  JOURNAL   J Biol Chem 266 (22), 14147-14150 (1991)
   PUBMED   1830582
REFERENCE   9  (bases 1 to 1942)
  AUTHORS   Eisenberg,S.P., Brewer,M.T., Verderber,E., Heimdal,P.,
            Brandhuber,B.J. and Thompson,R.C.
  TITLE     Interleukin 1 receptor antagonist is a member of the interleukin 1
            gene family: evolution of a cytokine control mechanism
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5232-5236 (1991)
   PUBMED   1828896
REFERENCE   10 (bases 1 to 1942)
  AUTHORS   Dripps,D.J., Brandhuber,B.J., Thompson,R.C. and Eisenberg,S.P.
  TITLE     Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1
            receptor but does not initiate IL-1 signal transduction
  JOURNAL   J Biol Chem 266 (16), 10331-10336 (1991)
   PUBMED   1828071
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CK364274.1 and
            BC070930.1.
            
            On or before Jun 25, 2006 this sequence version replaced
            XM_001071294.1, XM_001071330.1, NM_022194.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070930.1, CK364274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-710               CK364274.1         25-734
            711-1942            BC070930.1         705-1936
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1942
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /note="interleukin 1 receptor antagonist"
                     /db_xref="GeneID:60582"
                     /db_xref="RGD:621159"
     exon            1..123
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..541
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /note="interleukin-1 receptor antagonist protein; IRAP;
                     IL-1RN; IL1 inhibitor"
                     /codon_start=1
                     /product="interleukin-1 receptor antagonist protein
                     precursor"
                     /protein_id="NP_071530.1"
                     /db_xref="GeneID:60582"
                     /db_xref="RGD:621159"
                     /translation="MEICRGPYSHLISLLLILLFRSESAGHPAGKRPCKMQAFRIWDT
                     NQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDT
                     KLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLT
                     NTPKEPCTVTKFYFQEDQ"
     exon            124..212
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /inference="alignment:Splign:2.1.0"
     exon            213..325
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /inference="alignment:Splign:2.1.0"
     exon            326..1915
                     /gene="Il1rn"
                     /gene_synonym="IL-1ra; Il1ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggatggaa atctgcaggg gaccttacag tcacctaatc tctctccttc tcatccttct
       61 gtttcgttca gagtcagctg gccaccctgc tgggaaaaga ccctgcaaga tgcaagcctt
      121 cagaatctgg gatactaacc agaagacctt ctacctgagg aacaaccagc tcattgctgg
      181 gtacttacaa ggaccaaata ccaaactaga agaaaagata gacatggtgc ctattgactt
      241 tcggaatgtg ttcttgggca tccacggggg caagctgtgc ctgtcttgtg tcaagtctgg
      301 agatgacacc aagctccagc tggaggaggt taacatcact gatctgaaca agaacaaaga
      361 agaagacaag cgctttacct tcatccgctc cgagacaggc cctaccacca gcttcgaatc
      421 acttgcctgt ccaggatggt tcctctgcac aacactagag gctgatcatc ccgtgagcct
      481 caccaacaca ccaaaagagc cctgtacagt cacaaagttc tacttccagg aagaccaata
      541 gcactgcctc ggcctgtcct tccccactcc caggccagca atgaccacca actgcctgat
      601 cactctggcc atcattgggg tctgaggaac aatttttgca gggtgtacag tagaaggaga
      661 cagaagagtc ctgatgatag atctctgcct tcagtctgtt ggctaaccca atccccatga
      721 tgatttcaga ataatctttc aaactgcatc atggcaggcc ttttcttatt gcctctgccc
      781 tctgggtgaa gtctagacca cttgcttggc ctaggtgtct tctgttctct ctctctctct
      841 ctctctctct ctctctctct ctctctctct ctcacgcacg cacgcgcaca cgcacgcata
      901 cacacacaca cacacactct gacacttttt gttttatcca ttgtcctgca tgtccacagt
      961 ccagaccaat caagtcactt gacaatcccc caagtggctc cttccccttg ttttatagac
     1021 ctgtgccagt ctatggggat ggtttttatt ctccttgtta ttcattttgg ggttttttgg
     1081 agtttctttg tttttcgttt ttttgggttt tggggctttt tggatgcttg ggatgaaacc
     1141 caccagggca tcacatctac taagtttgag ttctaccgcc atggtctgct tcccctcagc
     1201 tttaaggatg tagaaaagag aaattaagga tctcaaagtt atttcattag gccagcctta
     1261 ttccatgtgg gagagaggct tcttgtggaa attatgtgct ttatgagggg agctggggat
     1321 tcgatgctcc tgcatttgcg aagtggttgt aagcttagga aaataggcgg taggctttcc
     1381 tcctttcctt ttctgtgtga tgcccctaaa ctgaaaaagt aaaatttggt ggactgtagt
     1441 attcccataa tctccccacc actttttttt ctcttttgga aatctccaat atcctgtatt
     1501 cctctgtcaa gcccaaacac catcttcact ccaaacctac cagagctgcc taaagaggtt
     1561 ctccactatc tctgtgcaaa catggctctc aagcccttcc tgatgtggtg aatgaatgaa
     1621 tctattgatc atttcttgac cattcatttt atcacctctt taaacttgtg tcgaagtagc
     1681 tatgttcctg tctgtttcct ctgccagact atgagctctg gagagcaggg agcattgtgt
     1741 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tgggtcccta caaggatgag
     1801 caccctcttt ggctcttaga aggcactccc agagtatgtg ttatttgtgc tcatggaaat
     1861 tttcttactc ctccttgtga ctttagcttt attttacaat aaaacattga aaataaaaaa
     1921 aaaaaaaaaa aaaaaaaaaa aa
//
