LOCUS       NM_001127689            2065 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus interleukin 1 receptor-like 1 (Il1rl1),
            transcript variant 2, mRNA.
ACCESSION   NM_001127689
VERSION     NM_001127689.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Wu,L., Zhu,X., Luo,C., Zhao,Y., Pan,S., Shi,K., Chen,Y., Qiu,J.,
            Shen,Z., Guo,J. and Jie,W.
  TITLE     Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence
  JOURNAL   Life Sci 348, 122701 (2024)
   PUBMED   38724005
  REMARK    GeneRIF: Mechanistic role of RND3-regulated IL33/ST2 signaling on
            cardiomyocyte senescence.
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Jin,Y., Zhou,J., Fang,Y., Song,H., Lin,S., Pan,B., Liu,L. and
            Xiong,B.
  TITLE     Electroacupuncture prevents the development or establishment of
            chronic pain via IL-33/ST2 signaling in hyperalgesic priming model
            rats
  JOURNAL   Neurosci Lett 820, 137611 (2024)
   PUBMED   38142925
  REMARK    GeneRIF: Electroacupuncture prevents the development or
            establishment of chronic pain via IL-33/ST2 signaling in
            hyperalgesic priming model rats.
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Sitzia,C., Vianello,E., Dozio,E., Kalousova,M., Zima,T.,
            Brizzola,S., Roccabianca,P., Tedeschi,G., Lamont,J., Tacchini,L.
            and Corsi-Romanelli,M.M.
  TITLE     Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to
            Obesity in Zucker Fatty Rats
  JOURNAL   Int J Mol Sci 24 (3), 1991 (2023)
   PUBMED   36768322
  REMARK    GeneRIF: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac
            Remodeling Due to Obesity in Zucker Fatty Rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Zhao,Y.N., Li,H., Zhao,C. and Liu,G.H.
  TITLE     ST2 silencing aggravates ventricular remodeling and chronic heart
            failure in rats by mediating the IL-33/ST2 axis
  JOURNAL   J Tissue Eng Regen Med 14 (9), 1201-1212 (2020)
   PUBMED   32592632
  REMARK    GeneRIF: ST2 silencing aggravates ventricular remodeling and
            chronic heart failure in rats by mediating the IL-33/ST2 axis.
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Zhou,J., Zhuang,T., Ma,P., Shan,L., Sun,X.D., Gong,S., Tao,J.,
            Yu,X.M. and Jiang,X.
  TITLE     MicroRNA-547-5p-mediated interleukin-33/suppressor of
            tumorigenicity 2 signaling underlies the genesis and maintenance of
            neuropathic pain and is targeted by the therapy with bone marrow
            stromal cells
  JOURNAL   Mol Pain 16, 1744806920931737 (2020)
   PUBMED   32513089
  REMARK    GeneRIF: MicroRNA-547-5p-mediated interleukin-33/suppressor of
            tumorigenicity 2 signaling underlies the genesis and maintenance of
            neuropathic pain and is targeted by the therapy with bone marrow
            stromal cells.
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Shelburne,C.P., McCoy,M.E., Piekorz,R., Sexl,V., Roh,K.H.,
            Jacobs-Helber,S.M., Gillespie,S.R., Bailey,D.P., Mirmonsef,P.,
            Mann,M.N., Kashyap,M., Wright,H.V., Chong,H.J., Bouton,L.A.,
            Barnstein,B., Ramirez,C.D., Bunting,K.D., Sawyer,S., Lantz,C.S. and
            Ryan,J.J.
  TITLE     Stat5 expression is critical for mast cell development and survival
  JOURNAL   Blood 102 (4), 1290-1297 (2003)
   PUBMED   12714518
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Oshikawa,K., Kuroiwa,K., Tago,K., Iwahana,H., Yanagisawa,K.,
            Ohno,S., Tominaga,S.I. and Sugiyama,Y.
  TITLE     Elevated soluble ST2 protein levels in sera of patients with asthma
            with an acute exacerbation
  JOURNAL   Am J Respir Crit Care Med 164 (2), 277-281 (2001)
   PUBMED   11463601
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Walzl,G., Matthews,S., Kendall,S., Gutierrez-Ramos,J.C.,
            Coyle,A.J., Openshaw,P.J. and Hussell,T.
  TITLE     Inhibition of T1/ST2 during respiratory syncytial virus infection
            prevents T helper cell type 2 (Th2)- but not Th1-driven
            immunopathology
  JOURNAL   J Exp Med 193 (7), 785-792 (2001)
   PUBMED   11283151
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Rossler,U., Thomassen,E., Hultner,L., Baier,S., Danescu,J. and
            Werenskiold,A.K.
  TITLE     Secreted and membrane-bound isoforms of T1, an orphan receptor
            related to IL-1-binding proteins, are differently expressed in vivo
  JOURNAL   Dev Biol 168 (1), 86-97 (1995)
   PUBMED   7883081
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Bergers,G., Reikerstorfer,A., Braselmann,S., Graninger,P. and
            Busslinger,M.
  TITLE     Alternative promoter usage of the Fos-responsive gene Fit-1
            generates mRNA isoforms coding for either secreted or
            membrane-bound proteins related to the IL-1 receptor
  JOURNAL   EMBO J 13 (5), 1176-1188 (1994)
   PUBMED   8131748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U04317.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..2065
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /note="interleukin 1 receptor-like 1"
                     /db_xref="GeneID:25556"
                     /db_xref="RGD:2894"
     exon            1..154
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..353
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1975
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /EC_number="3.2.2.6"
                     /note="isoform Fit-1M precursor is encoded by transcript
                     variant 2; fos-responsive gene 1 protein"
                     /codon_start=1
                     /product="interleukin-1 receptor-like 1 isoform Fit-1M
                     precursor"
                     /protein_id="NP_001121161.1"
                     /db_xref="GeneID:25556"
                     /db_xref="RGD:2894"
                     /translation="MIGKWRMGLWALAILTVPMYFIVTEGRKTSWGLENEALIVRCPQ
                     RGGAINPVEWYYSNTNERIPTQKRNRIFVSRDRLKFLPAKVEDSGIYTCVIRSPESIK
                     TGSLNVTIYKRPPNCKIPDYMMYSTVDGSDKNSKITCPTIALYNWTAPVQWFKNCKAL
                     QGPRFRAHMSYLFIDKVSHVDEGDYTCRFTHTENGTNYIVTATRSFTVEEKGFSTFPV
                     ITNPPHNYTVEVEIGKTANIACSACFGTASQFVAVLWQINKTRIGSFGKARIQEEKGP
                     NKSSSNGMICLTSLLRITGVTDKDFSLKYDCVAMNHHGVIRHPVRLRRKQPIDHQSTY
                     YIVAGCSLLLMFINVLVIVLKVFWIEVALFWRDIMAPYKTQNDGKLYDAYIIYPRVFR
                     GSAAGTGSVEYFVHYTLPDVLENKCGYKLCIYGRDLLPGQDAATVVESSIQNSRRQVF
                     VLAPHMMHSKEFAYEQEIALHSALIQNNSKVILIEMEPMGEASRLQLGDLQDSLQHLV
                     KMQGTIKWREDHVADKQSLSSKFWKHVRYQMPVPKRPPKMASVAAPLSGKVCLDLKHF
                     "
     exon            354..564
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..739
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..902
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..971
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1110
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1256
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1403
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1571
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2065
                     /gene="Il1rl1"
                     /gene_synonym="Fit-1; FIT1; St2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagaaaag actgggatat gctagcttgc tagctccagc aagcggcggt atgcgcggtc
       61 tttaaaatag acagacatag aggctttggg ggagaggaag aagtgcctgg gatgaagaag
      121 agatgcacct acccggcagg ggtgaaatcc caagctacac tgatttctct tttggaccct
      181 acatcagaca gcacacatca accgcctagt ggactcaccg ttaccttcct gtgccattgc
      241 catcggagag atctcggcca tcaatcacta gcacatgatt ggcaaatgga gaatggggct
      301 ttgggctttg gcaattctga cagttcccat gtatttcata gtgacagagg gcagaaaaac
      361 atcctggggt ctagaaaacg aggctttaat tgtcagatgc ccccaaagag gaggtgcgat
      421 taaccctgtg gaatggtatt attcaaatac aaatgaaaga attcctactc aaaagagaaa
      481 tcggatcttc gtctcaagag atcgtctgaa gtttctacca gccaaagtgg aagactctgg
      541 gatttatacg tgtgttatca gaagccctga atcgattaag accggatctt tgaatgtcac
      601 catatataaa agaccaccaa actgcaaaat ccctgattac atgatgtact cgacagtaga
      661 tggatcagat aaaaattcca agataacatg tccaacaatt gccttgtata attggacagc
      721 gcctgttcag tggtttaaga actgcaaagc tctccaaggg ccaaggttca gggcacacat
      781 gtcctatttg ttcattgaca aagtgagtca tgttgatgaa ggtgactaca catgtcgatt
      841 cactcacacg gagaacggaa ccaattacat tgtgactgcc accagatcat tcacagttga
      901 agaaaaaggc ttctctacat ttccagtaat tacaaaccct ccacacaact acacagtgga
      961 agtggaaata ggaaaaacag caaacattgc ctgctcagct tgctttggca cagcctctca
     1021 gttcgttgct gtcctgtggc agattaacaa aacgagaatt ggatcttttg gcaaagcaag
     1081 aattcaagaa gagaaaggcc caaataaaag ttccagcaat ggcatgattt gcttaacctc
     1141 actgttaagg ataactggtg tgaccgacaa ggacttctcc ctgaaatatg actgtgtggc
     1201 catgaaccat cacggagtga taaggcaccc cgtaagactg agaaggaaac aaccaattga
     1261 ccaccaaagc acctactaca tagttgccgg atgtagttta ttgctaatgt ttatcaatgt
     1321 cttggtgata gtcttaaaag tgttctggat tgaggttgct ctgttctgga gagatataat
     1381 ggcaccttac aaaacccaga atgatggaaa gctctatgat gcttacatca tttaccctcg
     1441 ggtcttccgg ggcagcgcag cagggaccgg ctctgtggag tactttgttc actacactct
     1501 gcccgacgtt ctcgaaaata aatgtggcta caagttgtgc atttacggga gagacctgct
     1561 gcctgggcaa gatgcggcca ctgtggtgga aagcagtatc cagaatagta gacggcaagt
     1621 gtttgtcctg gcccctcaca tgatgcacag caaagagttt gcctatgagc aggagatcgc
     1681 cctgcacagc gccctcatcc agaacaactc caaggtgatt ctgattgaaa tggagcctat
     1741 gggtgaggca agccgactgc agcttgggga tctgcaagat tctctccagc atcttgtgaa
     1801 aatgcagggg accatcaagt ggagggaaga ccacgtggcc gacaaacagt ctctaagctc
     1861 caaattctgg aagcatgtga gataccaaat gccagtcccg aaaagacccc ccaagatggc
     1921 atctgttgcc gctccgttga gtggcaaggt gtgcttggac ctgaaacact tttgagtcgt
     1981 ggacttgcct actcagagct ggggaatccc agcagtaggc cccagaagtg aaggtgtgaa
     2041 gacttgaaat gccaagggtg gggcc
//
