LOCUS       NM_177935               2165 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus interleukin 1 receptor accessory protein-like 1
            (Il1rapl1), mRNA.
ACCESSION   NM_177935 XM_579708
VERSION     NM_177935.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Yamagata,A., Yoshida,T., Sato,Y., Goto-Ito,S., Uemura,T., Maeda,A.,
            Shiroshima,T., Iwasawa-Okamoto,S., Mori,H., Mishina,M. and Fukai,S.
  TITLE     Mechanisms of splicing-dependent trans-synaptic adhesion by
            PTPdelta-IL1RAPL1/IL-1RAcP for synaptic differentiation
  JOURNAL   Nat Commun 6, 6926 (2015)
   PUBMED   25908590
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Valnegri,P., Montrasio,C., Brambilla,D., Ko,J., Passafaro,M. and
            Sala,C.
  TITLE     The X-linked intellectual disability protein IL1RAPL1 regulates
            excitatory synapse formation by binding PTPdelta and RhoGAP2
  JOURNAL   Hum Mol Genet 20 (24), 4797-4809 (2011)
   PUBMED   21926414
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Yoshida,T., Yasumura,M., Uemura,T., Lee,S.J., Ra,M., Taguchi,R.,
            Iwakura,Y. and Mishina,M.
  TITLE     IL-1 receptor accessory protein-like 1 associated with mental
            retardation and autism mediates synapse formation by trans-synaptic
            interaction with protein tyrosine phosphatase delta
  JOURNAL   J Neurosci 31 (38), 13485-13499 (2011)
   PUBMED   21940441
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Pavlowsky,A., Gianfelice,A., Pallotto,M., Zanchi,A., Vara,H.,
            Khelfaoui,M., Valnegri,P., Rezai,X., Bassani,S., Brambilla,D.,
            Kumpost,J., Blahos,J., Roux,M.J., Humeau,Y., Chelly,J.,
            Passafaro,M., Giustetto,M., Billuart,P. and Sala,C.
  TITLE     A postsynaptic signaling pathway that may account for the cognitive
            defect due to IL1RAPL1 mutation
  JOURNAL   Curr Biol 20 (2), 103-115 (2010)
   PUBMED   20096586
  REMARK    GeneRIF: interaction of IL1RAPL1 with PSD-95 discloses a novel
            pathophysiological mechanism of cognitive impairment associated
            with alterations of the JNK pathway leading to a mislocalization of
            PSD-95 and abnormal synaptic organization and function
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Gambino,F., Pavlowsky,A., Begle,A., Dupont,J.L., Bahi,N.,
            Courjaret,R., Gardette,R., Hadjkacem,H., Skala,H., Poulain,B.,
            Chelly,J., Vitale,N. and Humeau,Y.
  TITLE     IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein
            involved in cognitive functions, regulates N-type Ca2+-channel and
            neurite elongation
  JOURNAL   Proc Natl Acad Sci U S A 104 (21), 9063-9068 (2007)
   PUBMED   17502602
  REMARK    GeneRIF: IL1RAPL1-related mental retardation could result from a
            disruption of N-type voltage-gated calcium channels and/or neuronal
            calcium sensor-1-dependent synaptic and neuronal activities
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   Tabolacci,E., Pomponi,M.G., Pietrobono,R., Terracciano,A.,
            Chiurazzi,P. and Neri,G.
  TITLE     A truncating mutation in the IL1RAPL1 gene is responsible for
            X-linked mental retardation in the MRX21 family
  JOURNAL   Am J Med Genet A 140 (5), 482-487 (2006)
   PUBMED   16470793
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Bahi,N., Friocourt,G., Carrie,A., Graham,M.E., Weiss,J.L.,
            Chafey,P., Fauchereau,F., Burgoyne,R.D. and Chelly,J.
  TITLE     IL1 receptor accessory protein like, a protein involved in X-linked
            mental retardation, interacts with Neuronal Calcium Sensor-1 and
            regulates exocytosis
  JOURNAL   Hum Mol Genet 12 (12), 1415-1425 (2003)
   PUBMED   12783849
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Carrie,A., Jun,L., Bienvenu,T., Vinet,M.C., McDonell,N.,
            Couvert,P., Zemni,R., Cardona,A., Van Buggenhout,G., Frints,S.,
            Hamel,B., Moraine,C., Ropers,H.H., Strom,T., Howell,G.R.,
            Whittaker,A., Ross,M.T., Kahn,A., Fryns,J.P., Beldjord,C.,
            Marynen,P. and Chelly,J.
  TITLE     A new member of the IL-1 receptor family highly expressed in
            hippocampus and involved in X-linked mental retardation
  JOURNAL   Nat Genet 23 (1), 25-31 (1999)
   PUBMED   10471494
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY216593.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_177935.3.
            
            On or before Apr 19, 2005 this sequence version replaced
            XM_579708.1, NM_177935.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY216593.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760396 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..2165
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /note="interleukin 1 receptor accessory protein-like 1"
                     /db_xref="GeneID:317553"
                     /db_xref="RGD:727891"
     exon            1..89
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2098
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /EC_number="3.2.2.6"
                     /note="X-linked interleukin-1 receptor accessory
                     protein-like 1; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1"
                     /codon_start=1
                     /product="interleukin-1 receptor accessory protein-like 1
                     precursor"
                     /protein_id="NP_808796.1"
                     /db_xref="GeneID:317553"
                     /db_xref="RGD:727891"
                     /translation="MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSVDIKKYQVL
                     VGEPVRIKCALFYGYIRTNYTLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDS
                     IWFRPTLLQDSGLYACVIRNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSK
                     EISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIKEVKEDDIGNYTCEL
                     KYGGFVVRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGGSANLTCRAFFGYSGD
                     VSPLIYWMKGEKFIEDLDENRVWESDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSC
                     YVENGNGRRHASVLLHKRELMYTVELAGGLGAILLLLVCSVTIYKCYKIEIMLFYRNH
                     FGAEELDGDNKDYDAYLSYTKVDPDQWNQETGEEERFALEILPDMLEKHYGYKLFIPD
                     RDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIKVI
                     LIECSELRGIMNYQEVEALKHTIKLLTVIKWHGPKCNKLNSKFWKRLQYEMPFKRIEP
                     ITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQKHY
                     YRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQRPQTKSSREPNPDEAHTNSAIL
                     PLLARETSISSVIW"
     exon            90..369
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            370..556
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            557..710
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            711..785
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            786..918
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1064
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1208
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1379
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..2165
                     /gene="Il1rapl1"
                     /gene_synonym="Il1rapl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaagatg aaagctccga ttccacattt gattctctta tatgctactt tcactcagag
       61 tctgaaggtt gtgaccaaaa gaggttctgc tgatggatgc actgattggt ctgttgatat
      121 caagaagtac caagtattgg tgggagagcc tgttagaatc aagtgtgcgc tcttttatgg
      181 ttatatcaga acaaactaca ctctcgccca aagtgctgga ctcagcctaa tgtggtataa
      241 aagctctggt ccaggagatt ttgaagaacc cattgcgttt gatggaagta gaatgagcaa
      301 agaggaagac tccatttggt tcagaccaac attactacag gacagtgggc tttatgcctg
      361 tgtcatcagg aactccacat actgtatgaa agtatccatc tcactgacag taggagaaaa
      421 tgacactgga ctttgctaca attccaagat gaaatacttt gaaaaagctg aacttagcaa
      481 aagcaaggaa atttcatgcc gtgacataga agacttttta ttaccaacca gggaacctga
      541 aatcctttgg tacaaggaat gtagaacaaa aacatggcga ccgagtattg tattcaaaag
      601 agataccttg cttataaaag aagtcaaaga agatgacatt ggaaactata cctgtgaatt
      661 aaaatatgga ggctttgttg tgagaagaac cactgagtta acggttacag ctcctctgac
      721 tgataagcca cctaaacttt tgtatcccat ggaaagtaaa ctgacaattc aggagactca
      781 actaggtggt tcagctaacc ttacctgcag agccttcttt gggtacagtg gagacgtcag
      841 tcctttaatt tactggatga aaggagagaa atttattgaa gatctggatg aaaatagagt
      901 ttgggaaagt gacattagaa tccttaagga acatcttgga gaacaggaag tttctatctc
      961 attaattgtt gactctgtgg aagaaggtga cctggggaat tattcttgtt atgttgaaaa
     1021 tgggaatgga cgtcggcatg ccagtgttct ccttcataaa cgagagttga tgtacactgt
     1081 tgaacttgct ggagggcttg gcgctattct cttgctgctc gtctgctcgg tgaccatata
     1141 taaatgttac aagatagaaa tcatgctctt ctacaggaat cattttggag ctgaggaact
     1201 ggacggagat aacaaagatt atgatgccta tctgtcatat accaaagtgg atcctgacca
     1261 gtggaatcaa gagactgggg aagaagaacg ttttgccctt gaaatcctcc ctgatatgct
     1321 tgaaaagcat tatggatata agttgtttat accagataga gatttgatcc caactggaac
     1381 atacattgaa gatgtggcta gatgcgtaga tcaaagtaag cggctgatta ttgtcatgac
     1441 cccaaattat gtagtccgaa ggggctggag catctttgag ctggaaacga gacttcgaaa
     1501 catgcttgtg actggagaaa tcaaagtgat actgatcgaa tgcagcgaac tccgaggaat
     1561 tatgaactac caggaggtgg aggccctcaa gcataccatc aagcttctga ccgttattaa
     1621 atggcatgga ccaaaatgca acaagttgaa ctcgaagttc tggaagcgtt tacagtacga
     1681 aatgcctttt aagaggatag aacccattac acatgagcag gcgttagatg ttagtgagca
     1741 ggggcctttt ggggagctgc agactgtctc ggccatttca atggctgcgg ccacctccac
     1801 agctctagcc actgcccatc cagatctccg ttctaccttt cacaacacct accattcaca
     1861 aatgcgtcag aaacactact atcgaagcta tgagtacgac gtacctccta cgggcaccct
     1921 gccacttacc tccataggaa atcagcatac ctactgtaac atccctatga cactcatcaa
     1981 tgggcagcgg ccacagacaa agtcaagcag ggagccgaat ccagatgaag cccacacaaa
     2041 cagtgccatc ctgccgttgt tggcaaggga aaccagtata tccagtgtga tttggtaaca
     2101 gaaaagcaaa ggacatcccg ttcctgggag tttgaaagga atctgcagtc cagtgcctgg
     2161 aactc
//
