LOCUS       NM_001412594            4999 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Rattus norvegicus interleukin 1 receptor type 1 (Il1r1), transcript
            variant 2, mRNA.
ACCESSION   NM_001412594 NM_013123
VERSION     NM_001412594.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4999)
  AUTHORS   Wang,C., Ma,H., Zhang,B., Hua,T., Wang,H., Wang,L., Han,L., Li,Q.,
            Wu,W., Sun,Y., Yang,H. and Lu,X.
  TITLE     Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through
            ameliorating NLRP3 inflammasome-induced pyroptosis
  JOURNAL   Front Immunol 13, 963582 (2022)
   PUBMED   35990672
  REMARK    GeneRIF: Inhibition of IL1R1 or CASP4 attenuates spinal cord injury
            through ameliorating NLRP3 inflammasome-induced pyroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4999)
  AUTHORS   Zhan,L., Lu,X., Xu,W., Sun,W. and Xu,E.
  TITLE     Inhibition of MLKL-dependent necroptosis via downregulating
            interleukin-1R1 contributes to neuroprotection of hypoxic
            preconditioning in transient global cerebral ischemic rats
  JOURNAL   J Neuroinflammation 18 (1), 97 (2021)
   PUBMED   33879157
  REMARK    GeneRIF: Inhibition of MLKL-dependent necroptosis via
            downregulating interleukin-1R1 contributes to neuroprotection of
            hypoxic preconditioning in transient global cerebral ischemic rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4999)
  AUTHORS   Kanno,K., Shimizu,K., Shinoda,M., Hayashi,M., Takeichi,O. and
            Iwata,K.
  TITLE     Role of macrophage-mediated Toll-like receptor 4-interleukin-1R
            signaling in ectopic tongue pain associated with tooth pulp
            inflammation
  JOURNAL   J Neuroinflammation 17 (1), 312 (2020)
   PUBMED   33081813
  REMARK    GeneRIF: Role of macrophage-mediated Toll-like receptor
            4-interleukin-1R signaling in ectopic tongue pain associated with
            tooth pulp inflammation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4999)
  AUTHORS   Yang,Y., Shen,C., Li,J., Yuan,J., Wei,J., Huang,F., Wang,F., Li,G.,
            Li,Y., Xing,L., Peng,L., Yang,M., Cao,M., Zheng,H., Wu,W., Zou,R.,
            Li,D., Xu,Z., Wang,H., Zhang,M., Zhang,Z., Gao,G.F., Jiang,C.,
            Liu,L. and Liu,Y.
  TITLE     Plasma IP-10 and MCP-3 levels are highly associated with disease
            severity and predict the progression of COVID-19
  JOURNAL   J Allergy Clin Immunol 146 (1), 119-127 (2020)
   PUBMED   32360286
REFERENCE   5  (bases 1 to 4999)
  AUTHORS   Blanco-Melo,D., Nilsson-Payant,B.E., Liu,W.C., Uhl,S., Hoagland,D.,
            Moller,R., Jordan,T.X., Oishi,K., Panis,M., Sachs,D., Wang,T.T.,
            Schwartz,R.E., Lim,J.K., Albrecht,R.A. and tenOever,B.R.
  TITLE     Imbalanced Host Response to SARS-CoV-2 Drives Development of
            COVID-19
  JOURNAL   Cell 181 (5), 1036-1045 (2020)
   PUBMED   32416070
REFERENCE   6  (bases 1 to 4999)
  AUTHORS   Metcalfe,K.A., Hitman,G.A., Pociot,F., Bergholdt,R.,
            Tuomilehto-Wolf,E., Tuomilehto,J., Viswanathan,M., Ramachandran,A.
            and Nerup,J.
  TITLE     An association between type 1 diabetes and the interleukin-1
            receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in
            Finland
  JOURNAL   Hum Immunol 51 (1), 41-48 (1996)
   PUBMED   8911996
REFERENCE   7  (bases 1 to 4999)
  AUTHORS   Bujia,J., Kim,C., Ostos,P., Sudhoff,H., Kastenbauer,E. and
            Hultner,L.
  TITLE     Interleukin 1 (IL-1) and IL-1-receptor antagonist (IL-1-RA) in
            middle ear cholesteatoma: an analysis of protein production and
            biological activity
  JOURNAL   Eur Arch Otorhinolaryngol 253 (4-5), 252-255 (1996)
   PUBMED   8737779
REFERENCE   8  (bases 1 to 4999)
  AUTHORS   Jafarian-Tehrani,M., Amrani,A., Homo-Delarche,F., Marquette,C.,
            Dardenne,M. and Haour,F.
  TITLE     Localization and characterization of interleukin-1 receptors in the
            islets of Langerhans from control and nonobese diabetic mice
  JOURNAL   Endocrinology 136 (2), 609-613 (1995)
   PUBMED   7835294
REFERENCE   9  (bases 1 to 4999)
  AUTHORS   Hart,R.P., Liu,C., Shadiack,A.M., McCormack,R.J. and Jonakait,G.M.
  TITLE     An mRNA homologous to interleukin-1 receptor type I is expressed in
            cultured rat sympathetic ganglia
  JOURNAL   J Neuroimmunol 44 (1), 49-56 (1993)
   PUBMED   7684399
REFERENCE   10 (bases 1 to 4999)
  AUTHORS   Kawaguchi,Y., Harigai,M., Hara,M., Suzuki,K., Kawakami,M.,
            Ishizuka,T., Hidaka,T., Kitani,A., Kawagoe,M. and Nakamura,H.
  TITLE     Increased interleukin 1 receptor, type I, at messenger RNA and
            protein level in skin fibroblasts from patients with systemic
            sclerosis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1504-1510 (1992)
   PUBMED   1375465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 11, 2022 this sequence version replaced NM_013123.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.35059.1,
                                           SRR26360186.1770322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000009.1  50034383-50034693
            312-407             JAXUCZ010000009.1  50035941-50036036
            408-471             JAXUCZ010000009.1  50050653-50050716
            472-709             JAXUCZ010000009.1  50061153-50061390
            710-899             JAXUCZ010000009.1  50061493-50061682
            900-1068            JAXUCZ010000009.1  50062445-50062613
            1069-1134           JAXUCZ010000009.1  50064827-50064892
            1135-1252           JAXUCZ010000009.1  50067748-50067865
            1253-1404           JAXUCZ010000009.1  50069013-50069164
            1405-1548           JAXUCZ010000009.1  50070532-50070675
            1549-1716           JAXUCZ010000009.1  50072657-50072824
            1717-4999           JAXUCZ010000009.1  50073297-50076579
FEATURES             Location/Qualifiers
     source          1..4999
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..4999
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /note="interleukin 1 receptor type 1"
                     /db_xref="GeneID:25663"
                     /db_xref="RGD:2892"
     exon            1..311
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..407
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..471
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..2135
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /EC_number="3.2.2.6"
                     /note="interleukin-1 receptor type I; interleukin 1 beta
                     receptor type 1 soluble form; interleukin 1 bete receptor
                     type 1 long transmembrane form; interleukin 1 beta
                     receptor type 1 short transmembrane form; CD121
                     antigen-like family member A; interleukin-1 receptor
                     alpha"
                     /codon_start=1
                     /product="interleukin-1 receptor type 1 precursor"
                     /protein_id="NP_001399523.1"
                     /db_xref="GeneID:25663"
                     /db_xref="RGD:2892"
                     /translation="MKVLLGFICLIVPLLSLETDKCTEYPNEVISFSSVNEIDIRSCP
                     LTPNEMHGGTIIWYKNDSKTPISADKDSRIHQQNEHLWFVPAKMEDSGYYYCIMRNST
                     YCLKTKITMSVLENDPGLCYNTQASFIQRLHVAGDGSLVCPYLDFFKDENNELPKVQW
                     YKNCKPLPLDDGNFFGFKNKLMVMNVAEEHRGNYTCRTSYTYQGKQYPVTRVITFITI
                     DDSKRDRPVIMSPRNETMEADPGSTIQLICNVTGQFTDLVYWKWNGSEIEWDDPILAE
                     DYQFLEHPSAKRKYTLITTLNVSEVKSQFYRYPFICFVKNTHILETAHVRLVYPVPDF
                     KNYLIGGFAIFTATAVFCACIYKVFKVDIVLWYRDSCSDFLPPKASDGKTYDAYVLYP
                     KTYGEGSFAYLDTFVFKLLPEVLEGQFGYKLFICGRDDYVGEDTIEVTNENVKRSRRL
                     IIILVRDMGSFSCLGQSSEEQIAIYDALIREGIKIILLELEKIQDYEKMPESIQFIKQ
                     KHGAICWSGDFKERPQSAKTRFWKNLRYQMPAQRRSPLSKHHLLTLDPVLDTKEKLQA
                     ETHLPLG"
     exon            472..709
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..899
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1068
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1134
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1252
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1404
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1548
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1716
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..4999
                     /gene="Il1r1"
                     /gene_synonym="IL-1R-1; IL-1R-alpha; IL-1RT-1; IL-1RT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctccgcc tgctgcacgc ccccgcgggc cggctaggag agggaacagc gtgccgccca
       61 ggcggacaga gctggtgcgg gcgccgggag ccgcctagga ccgcggcgcc ggatagagaa
      121 gggcgggagc cccgctggtg cccgcctgtc ccacgaacgg caggaatgtg acccctcgag
      181 cgcgcgccgg agcacccctc gcgtggctcc cagggctccg gttgctcagg cctggacggg
      241 tttagctccg ggtttagctg ggagctgctg gattgctgtg catccccact ggggcacccg
      301 ggcacgccca gccttggctc tgccgaagcc ctgtgccgta atgtggctgg agagtactct
      361 tcatgctgcc gaggcttgtg acatcttcgg ctaaatcctc catcctggag aatatgaaag
      421 tgctacttgg gttcatttgt ctcattgtgc ctctgctgtc gctggagacc gacaaatgca
      481 cggagtatcc aaatgaggtc atttcatttt catccgtaaa tgaaattgac attcgcagct
      541 gtcctcttac tccaaacgaa atgcatggcg gcaccataat ctggtataaa aatgacagca
      601 agacccccat atcagcggac aaggactcca ggattcatca gcagaatgaa catctttggt
      661 ttgttcccgc caagatggag gattcaggct attactattg tataatgaga aactcaacat
      721 actgcctcaa aactaaaata accatgagtg tcttagagaa tgaccctggc ttgtgctata
      781 acacacaagc cagcttcata cagcggctcc atgttgcagg ggatggaagt cttgtgtgcc
      841 cttatctgga ttttttcaaa gatgaaaata acgagttacc caaagttcag tggtataaga
      901 actgtaaacc tctgcctctt gacgatggaa acttctttgg attcaagaat aaactgatgg
      961 tgatgaatgt ggctgaagag cacagaggga actatacttg ccgcacgtcc tacacatacc
     1021 aggggaagca atatcccgtc acacgagtaa taacatttat cacaatagat gacagcaaga
     1081 gggacagacc tgtgattatg agcccacgga atgagacgat ggaagctgac ccaggatcca
     1141 cgatacaact gatctgcaac gtcacgggcc agttcaccga ccttgtctac tggaagtgga
     1201 atgggtcgga aattgaatgg gacgatccaa tcctagccga agactatcag tttttggaac
     1261 acccttcagc caaaagaaag tacactctca ttacaacact taacgtttca gaggtcaaaa
     1321 gccagtttta tcgctatccg ttcatctgct tcgttaagaa cactcatatt ctggagactg
     1381 cacacgtacg gttagtatac ccagttcctg acttcaagaa ttacctcatc gggggctttg
     1441 ccatcttcac agctacagcc gtgttctgtg cttgcatcta caaagtcttc aaggttgata
     1501 tagtgctttg gtacagggac tcctgctctg attttcttcc cccaaaagct tcagatggaa
     1561 agacctatga tgcctatgtt ctttatccca agacctacgg agagggatcc tttgcatact
     1621 tggatacttt tgtgtttaag ctgttgccgg aggtcttgga gggacagttt ggatacaaac
     1681 tgttcatttg tggaagggat gactatgttg gggaagatac catcgaggtt actaatgaaa
     1741 acgtaaagag aagcagaagg ctgatcatca ttttagtgag agatatggga agcttcagct
     1801 gtctgggcca gtcatctgaa gagcagatag caatatacga tgccctcatc cgggaaggaa
     1861 ttaaaatcat cctgctcgag ttggagaaaa tccaagacta tgagaaaatg ccagaatcta
     1921 ttcaattcat taagcagaag catggggcca tttgctggtc aggagacttt aaagaaagac
     1981 cgcagtctgc caagaccagg ttctggaaaa acttaagata ccagatgcca gcccaacggc
     2041 gatcaccact gtctaaacat cacttactaa ccctggatcc tgtgctggac actaaggaga
     2101 aactgcaggc ggagacacac ttaccacttg gctagtgtgg gaaaggcggg cgggccaaga
     2161 ctgttggagt gcctcctgtc gtcagatgct gcagctgggc tctgcctccc agtaaaacag
     2221 tcatgaaaca aaccagtgca gtcccttgtc ccaggtcacc tggaattggc tttgaagaga
     2281 acaagacttg gtgaccaggc catcctgagc agagagcttg ggaagcccca gagtaacagt
     2341 tgctctggga cgttactcag gatgtttggg gaacaatcga ggcagtgaac tgggaggagg
     2401 aagcttcagg aaatggccac atgtgtgggt ggttaaatta gattctgtgg agtctcacag
     2461 agggattatg gttgtctgag gacactttgg gggtcattgt caaaaaagtg cctcccctaa
     2521 gcctcagtgc aggtgaagtt tactggtacc catcagtgga aggcatttct tccctgaatt
     2581 ttccagacaa ctcggctgtc aaacatagtt ttcaaagact aaattctatt gtgtagagct
     2641 tgaaaaccgc ctttttcagt gagaaggatt ctctgggatt cccttccctg cagtcagcta
     2701 agctttctgg attttaaatc aactgtagga ggaagccacc cacctccagg ttcttctatt
     2761 caagtctcca cccttaaatg gctctcacac catattcctt ctgcagggct cattgcttct
     2821 ctggaaataa atgcggtgcc tcctccctcc gtcctgtcac aggcacagtc tgaagattta
     2881 ccttcaagag actctgctct taccccaccc accactgcca ggctagggct gtaatacttc
     2941 tttcgcagaa gcagaaatct aagctcctcc ccttcttgtc tggtcccagg gctccagtca
     3001 gccccctctt caccgtcctg ctgtgtgatt gcagaaggac ctctggatcc tctctgtacc
     3061 tgttctccac acagtgccgc cgctctgtct ttgtccactt cctgtgccca caattcgctc
     3121 ttggcgtttt ctccacctga caaggagttt gctacagttt aaagttcatt ttaatgctaa
     3181 accccatccg cccaatctct gcttactcta agacttttcc actcaagctg ccagccccct
     3241 tgtctgtcag tccatctctg ctgcttctct gtaaaaggtt gtttctttac tcgcataaat
     3301 cagtcctctg agggagaagt agtgagtgtc tctttgctca ttgctttccg aaatggaaac
     3361 agatggtata gatttcctaa ggcctttatt ataaagtcat cttggataat catatttaaa
     3421 tttgaaattg ttctaatttt atatagaaag ggactgaccc atttaacaaa aggacacttt
     3481 taaccctact ggaccttgaa ctttctggtt tctgtccctg tgctctgact tttttttttt
     3541 tttttcagta tgctctgact ttttgatttc aggtctagcc ctgtgtactt accttagtat
     3601 tcagtattta ctcagtactt actcagtact tactcagtac ttagtactca gtatttactc
     3661 agtactcagt acttactcaa tactcatggg aagagacctg ggtgttcttt gggaagtaat
     3721 tgagtggagg catgttttga caggaaccca cagtcccttt cagtgttggg attataaaca
     3781 cctaccttag atattttaga ttttccaata cttgttccct aaaggtcaac atttcttctc
     3841 ccaactacaa gtgaaagaag aggaaaaaaa ttttttgtgg tacagaagtt ttttgtttgt
     3901 ttatttttaa cttgatgact gtcttcagag tagtcctcac agttctggaa ggttgaaaaa
     3961 acccgagttc acatgccaag aacaaaccca gttttaaggg ttgtatatac ggggatatcc
     4021 atctgtctat cagactttga acgtctgctg tgggcgggga caaacgttat ttaaaggcat
     4081 ttctcaccta cataaaagtt gacaaaaaca cacaatttgg gattgtgact cttgagtttt
     4141 gacctcattt ctcacagacc caaccttaca gcagattgat caatggactg ctggggtaga
     4201 gaaagaaagg ttgccccaca ctgcagccag aagtctgatg gaccgaggtg atatcctgac
     4261 tcatgatgtt ttaaaggttt aagcttgctg ataatgtttt tgtctgtcac ccagaaaatg
     4321 tattggcgtg catgtctatt atgtgtgaat gagtgttaat ggaaacttgg ccagaaagta
     4381 taagggggag aggaagaaca gagagccaca gatcttgtga cactgagggg gaaatagaat
     4441 ctgtcccgag aaagcccctc aacaagaaag tagggtcatt gctggttccc aggggccatc
     4501 taagaggatg agacatcacg taagggcaga ggaaactttc tgagacttct ccccgtccac
     4561 cccagaagtg tctggtgtca gctgaggatc acgctttgcc caatacttag atttcaccgt
     4621 actttctggt ggtgtttttt ttaaaaaggc caagtgttgc agaagtttgc acatgcaacc
     4681 gtgtattaat tgccagtgtt taaaactggt ttagcagaat ttatattttt ctctctcctg
     4741 ccttttgaat tttactttat gatagagaaa gtattgagcc atttttagtg actttttaaa
     4801 aataatatat atttatactg gtcaataatg aagggtgttt tttttattat tgaagaactt
     4861 gattttatag ttctgcaaca gatgccaaat attatgtaat cacaaaccac ataatttatg
     4921 tacagtgcct atgacggatc aataaaccga acctgttttc taataaattg ttaaagcctc
     4981 cttggagtat cactgaaaa
//
