LOCUS       NM_031512               1339 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus interleukin 1 beta (Il1b), mRNA.
ACCESSION   NM_031512
VERSION     NM_031512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Feng,H.N., Zhong,L.Q., Xu,C.X., Wang,T.T., Wu,H., Wang,L.,
            Traub,R.J., Chen,X. and Cao,D.Y.
  TITLE     Up-regulation of IL-1beta and sPLA2-III in the medial prefrontal
            cortex contributes to orofacial and somatic hyperalgesia induced by
            malocclusion via glial-neuron crosstalk
  JOURNAL   Eur J Pharmacol 982, 176933 (2024)
   PUBMED   39182540
  REMARK    GeneRIF: Up-regulation of IL-1beta and sPLA2-III in the medial
            prefrontal cortex contributes to orofacial and somatic hyperalgesia
            induced by malocclusion via glial-neuron crosstalk.
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Green-Fulgham,S.M., Ball,J.B., Kwilasz,A.J., Harland,M.E.,
            Frank,M.G., Dragavon,J.M., Grace,P.M. and Watkins,L.R.
  TITLE     Interleukin-1beta and inflammasome expression in spinal cord
            following chronic constriction injury in male and female rats
  JOURNAL   Brain Behav Immun 115, 157-168 (2024)
   PUBMED   37838078
  REMARK    GeneRIF: Interleukin-1beta and inflammasome expression in spinal
            cord following chronic constriction injury in male and female rats.
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Kosyreva,A.M., Dzhalilova,D.S., Tsvetkov,I.S., Makarova,M.A. and
            Makarova,O.V.
  TITLE     Ex Vivo Production of IL-1beta and IL-10 by Activated Blood Cells
            of Wistar Rats with Different Resistance to Hypoxia after Systemic
            Inflammatory Response Syndrome
  JOURNAL   Bull Exp Biol Med 176 (2), 290-296 (2023)
   PUBMED   38194074
  REMARK    GeneRIF: Ex Vivo Production of IL-1beta and IL-10 by Activated
            Blood Cells of Wistar Rats with Different Resistance to Hypoxia
            after Systemic Inflammatory Response Syndrome.
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Fei,J., Wang,H., Han,J., Zhang,X., Ma,H., Qin,X., Yu,C. and
            Jiang,J.
  TITLE     TXNIP activates NLRP3/IL-1beta and participate in inflammatory
            response and oxidative stress to promote deep venous thrombosis
  JOURNAL   Exp Biol Med (Maywood) 248 (18), 1588-1597 (2023)
   PUBMED   37749991
  REMARK    GeneRIF: TXNIP activates NLRP3/IL-1beta and participate in
            inflammatory response and oxidative stress to promote deep venous
            thrombosis.
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Tanaka,S., Tabuchi,S., Watanabe,K., Takigawa,H., Akatsuka,K.,
            Numata,H., Hokama,Y. and Hori,T.
  TITLE     Preventive effects of interleukin 1 beta for ACNU-induced
            myelosuppression in malignant brain tumors: the experimental and
            preliminary clinical studies
  JOURNAL   J Neurooncol 14 (2), 159-168 (1992)
   PUBMED   1331350
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Warren,J.S.
  TITLE     Relationship between interleukin-1 beta and platelet-activating
            factor in the pathogenesis of acute immune complex alveolitis in
            the rat
  JOURNAL   Am J Pathol 141 (3), 551-560 (1992)
   PUBMED   1519663
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Schilling,V., Negri,B., Bujia,J., Schulz,P. and Kastenbauer,E.
  TITLE     Possible role of interleukin 1 alpha and interleukin 1 beta in the
            pathogenesis of cholesteatoma of the middle ear
  JOURNAL   Am J Otol 13 (4), 350-355 (1992)
   PUBMED   1384343
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Fleisher,L.N., Ferrell,J.B. and McGahan,M.C.
  TITLE     Synergistic uveitic effects of tumor necrosis factor-alpha and
            interleukin-1 beta
  JOURNAL   Invest Ophthalmol Vis Sci 33 (7), 2120-2127 (1992)
   PUBMED   1318867
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Jobe,L.W., Vertrees,S., Wilson,C.A., Jacobs,C., Wilson,D.L.,
            Picha,K.S., Baker,P. and Lernmark,A.
  TITLE     In vivo effects of interleukin-1 beta on blood leukocytes in BB
            rats prone or resistant to diabetes
  JOURNAL   Autoimmunity 11 (4), 233-237 (1992)
   PUBMED   1581467
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091141.1.
            
            On Oct 12, 2007 this sequence version replaced NM_031512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091141.1, M98820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760396 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1339
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /note="interleukin 1 beta"
                     /db_xref="GeneID:24494"
                     /db_xref="RGD:2891"
     exon            1..41
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            42..103
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..863
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /note="IL-1 beta"
                     /codon_start=1
                     /product="interleukin-1 beta"
                     /protein_id="NP_113700.2"
                     /db_xref="GeneID:24494"
                     /db_xref="RGD:2891"
                     /translation="MATVPELNCEIAAFDSEENDLFFEADRPQKIKDCFQALDLGCPD
                     ESIQLQISQQHLDKSFRKAVSLIVAVEKLWQLPMSCPWSFQDEDPSTFFSFIFEEEPV
                     LCDSWDDDDLLVCDVPIRQLHCRLRDEQQKCLVLSDPCELKALHLNGQNISQQVVFSM
                     SFVQGETSNDKIPVALGLKGKNLYLSCVMKDGTPTLQLESVDPKQYPKKKMEKRFVFN
                     KIEVKTKVEFESAQFPNWYISTSQAEHRPVFLGNSNGRDIVDFTMEPVSS"
     exon            104..152
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            153..354
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            355..522
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..653
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..1314
                     /gene="Il1b"
                     /gene_synonym="IL-1F2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcatctg ggatcctctc cagtcaggct tccttgtgca agtgtctgaa gcagctatgg
       61 caactgtccc tgaactcaac tgtgaaatag cagctttcga cagtgaggag aatgacctgt
      121 tctttgaggc tgacagaccc caaaagatta aggattgctt ccaagccctt gacttgggct
      181 gtccagatga gagcatccag cttcaaatct cacagcagca tctcgacaag agcttcagga
      241 aggcagtgtc actcattgtg gctgtggaga agctgtggca gctacctatg tcttgcccgt
      301 ggagcttcca ggatgaggac ccaagcacct tcttttcctt catctttgaa gaagagcccg
      361 tcctctgtga ctcgtgggat gatgacgacc tgctagtgtg tgatgttccc attagacagc
      421 tgcactgcag gcttcgagat gaacaacaaa aatgcctcgt gctgtctgac ccatgtgagc
      481 tgaaagctct ccacctcaat ggacagaaca taagccaaca agtggtattc tccatgagct
      541 ttgtacaagg agagacaagc aacgacaaaa tccctgtggc cttgggcctc aaggggaaga
      601 atctatacct gtcctgtgtg atgaaagacg gcacacccac cctgcagctg gagagtgtgg
      661 atcccaaaca atacccaaag aagaagatgg aaaagcggtt tgtcttcaac aagatagaag
      721 tcaagaccaa agtggagttt gagtctgcac agttccccaa ctggtacatc agcacctctc
      781 aagcagagca cagacctgtc ttcctaggaa acagcaatgg tcgggacata gttgacttca
      841 ccatggaacc cgtgtcttcc taaagatggc tgcactattc ctaatgcctt ccccaggaca
      901 tgctagggag cccccttgtc gagaatgggc agtctccagg ggaagccttt gtcctctgcc
      961 aagtcaggtc tctcagagcc ataagaaaac cgtggcacat tctggtcaaa gaaaacgtgt
     1021 gtttccctcc ctgcctctga caggcaacca cttacctatt tatttatgta tttattgatt
     1081 ggttgatcta tttaagttga ttcagggggg tcacgaggca gcattgtcga cagaagaatc
     1141 tagttgtccg tgtgtatggg atgaattgaa tttggaccag tgcacagcca gcactgagtt
     1201 ctttcattga tgctgaaaat gaagagtttc atattgtgtg gatgagagtg tttatgaatg
     1261 aagcacaagc acatcatttt gatgagtatg aaataaatgt cactaaaaca aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaa
//
