LOCUS       NM_017019               1994 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interleukin 1 alpha (Il1a), mRNA.
ACCESSION   NM_017019
VERSION     NM_017019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Cao,X.Y., Qian,X., Liu,G.D. and Wang,Y.H.
  TITLE     Bioinformatics-based Identification of Key Pathways and Hub Genes
            of Traumatic Brain Injury in a Rat Model
  JOURNAL   Curr Med Sci 41 (3), 610-617 (2021)
   PUBMED   34047944
  REMARK    GeneRIF: Bioinformatics-based Identification of Key Pathways and
            Hub Genes of Traumatic Brain Injury in a Rat Model.
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Mishra,J., Vishwakarma,J., Malik,R., Gupta,K., Pandey,R.,
            Maurya,S.K., Garg,A., Shukla,M., Chattopadhyay,N. and
            Bandyopadhyay,S.
  TITLE     Hypothyroidism Induces Interleukin-1-Dependent Autophagy Mechanism
            as a Key Mediator of Hippocampal Neuronal Apoptosis and Cognitive
            Decline in Postnatal Rats
  JOURNAL   Mol Neurobiol 58 (3), 1196-1211 (2021)
   PUBMED   33106949
  REMARK    GeneRIF: Hypothyroidism Induces Interleukin-1-Dependent Autophagy
            Mechanism as a Key Mediator of Hippocampal Neuronal Apoptosis and
            Cognitive Decline in Postnatal Rats.
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Meng,M., Chen,Y., Chen,X., Zhang,Q., Guo,W., Zhou,X. and Zou,J.
  TITLE     IL-1alpha Regulates Osteogenesis and Osteoclastic Activity of
            Dental Follicle Cells Through JNK and p38 MAPK Pathways
  JOURNAL   Stem Cells Dev 29 (24), 1552-1566 (2020)
   PUBMED   33107399
  REMARK    GeneRIF: IL-1alpha Regulates Osteogenesis and Osteoclastic Activity
            of Dental Follicle Cells Through JNK and p38 MAPK Pathways.
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Murata,Y., Sugimoto,K., Yang,C., Harada,K., Gono,R., Harada,T.,
            Miyashita,Y., Higashisaka,K., Katada,R., Tanaka,J. and Matsumoto,H.
  TITLE     Activated microglia-derived macrophage-like cells exacerbate brain
            edema after ischemic stroke correlate with astrocytic expression of
            aquaporin-4 and interleukin-1 alpha release
  JOURNAL   Neurochem Int 140, 104848 (2020)
   PUBMED   32920036
  REMARK    GeneRIF: Activated microglia-derived macrophage-like cells
            exacerbate brain edema after ischemic stroke correlate with
            astrocytic expression of aquaporin-4 and interleukin-1 alpha
            release.
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Ji,L.J., Li,F., Zhao,P., Weng,L.P., Wei,J., Yan,J. and Liu,L.N.
  TITLE     Silencing interleukin 1alpha underlies a novel inhibitory role of
            miR-181c-5p in alleviating low-grade inflammation of rats with
            irritable bowel syndrome
  JOURNAL   J Cell Biochem 120 (9), 15268-15279 (2019)
   PUBMED   31172560
  REMARK    GeneRIF: Silencing interleukin 1alpha underlies a novel inhibitory
            role of miR-181c-5p in alleviating low-grade inflammation of rats
            with irritable bowel syndrome.
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Nakagawa,M., Terracio,L., Carver,W., Birkedal-Hansen,H. and
            Borg,T.K.
  TITLE     Expression of collagenase and IL-1 alpha in developing rat hearts
  JOURNAL   Dev Dyn 195 (2), 87-99 (1992)
   PUBMED   1297459
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Schilling,V., Negri,B., Bujia,J., Schulz,P. and Kastenbauer,E.
  TITLE     Possible role of interleukin 1 alpha and interleukin 1 beta in the
            pathogenesis of cholesteatoma of the middle ear
  JOURNAL   Am J Otol 13 (4), 350-355 (1992)
   PUBMED   1384343
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Clinton,S.K., Underwood,R., Hayes,L., Sherman,M.L., Kufe,D.W. and
            Libby,P.
  TITLE     Macrophage colony-stimulating factor gene expression in vascular
            cells and in experimental and human atherosclerosis
  JOURNAL   Am J Pathol 140 (2), 301-316 (1992)
   PUBMED   1739124
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Warren,J.S.
  TITLE     Intrapulmonary interleukin 1 mediates acute immune complex
            alveolitis in the rat
  JOURNAL   Biochem Biophys Res Commun 175 (2), 604-610 (1991)
   PUBMED   1826836
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Hawley,T.S., Lach,B., Burns,B.F., May,L.T., Sehgal,P.B. and
            Hawley,R.G.
  TITLE     Expression of retrovirally transduced IL-1 alpha in IL-6-dependent
            B cells: a murine model of aggressive multiple myeloma
  JOURNAL   Growth Factors 5 (4), 327-338 (1991)
   PUBMED   1777241
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017019.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00403.1, SRR26643295.15368.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676785,
                                           SAMN16676787 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000003.1  136989965-136990017 c
            54-108              JAXUCZ010000003.1  136989209-136989263 c
            109-157             JAXUCZ010000003.1  136988069-136988117 c
            158-386             JAXUCZ010000003.1  136986630-136986858 c
            387-560             JAXUCZ010000003.1  136984577-136984750 c
            561-685             JAXUCZ010000003.1  136983114-136983238 c
            686-1994            JAXUCZ010000003.1  136979805-136981113 c
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1994
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /note="interleukin 1 alpha"
                     /db_xref="GeneID:24493"
                     /db_xref="RGD:2890"
     exon            1..53
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     exon            54..108
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..874
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /codon_start=1
                     /product="interleukin-1 alpha"
                     /protein_id="NP_058715.1"
                     /db_xref="GeneID:24493"
                     /db_xref="RGD:2890"
                     /translation="MAKVPDLFEDLKNCYSENEEYSSAIDHLSLNQKSFYDASYGSLH
                     ENCTDKFVSLRTSETSKMSTFTFKESRVVVSATSNKGKILKKRRLSFNQPFTEDDLEA
                     IAHDLEETIQPRSAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASL
                     NDLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETPKLIT
                     GSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSMIDFQIS"
     exon            109..157
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..386
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..560
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..685
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1994
                     /gene="Il1a"
                     /gene_synonym="IL-1 alpha; IL-1F1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagtctcca gggcacagag ggagtcaact cattggcgct tgagtcggca aagaaatcaa
       61 gatggccaaa gttcctgact tgtttgaaga cctaaagaac tgctatagtg aaaatgaaga
      121 atacagttct gccattgacc atctgtctct gaatcagaaa tccttctatg atgcaagcta
      181 tggctcactt catgagaact gcacagataa atttgtatct ctgagaacct ctgaaacatc
      241 aaagatgtcc accttcacct tcaaggagag ccgggtggtg gtgtcagcaa catcaaacaa
      301 agggaagatt ctgaagaaga gacggctaag tttcaatcag ccctttactg aagatgacct
      361 ggaggccata gcccatgatt tagaagagac catccaaccc agatcagcac ctcacagctt
      421 ccagaataat ttgagataca aattgataag gatcgtcaag caggagttca tcatgaatga
      481 ttccctcaac caaaatatat atgtggatat ggacagaata catctcaaag ctgcttcgtt
      541 aaatgacctg cagcttgaag taaaatttga catgtatgcc tactcatcgg gaggagacga
      601 ctctaaatat cctgtgactc tcaaagtctc aaatactcag ctctttgtga gtgctcaggg
      661 agaagacaag cctgtgttgc tgaaggagat tccggaaaca ccaaaactca tcacaggtag
      721 tgagaccgac ctcattttct tctgggaaaa aatcaactct aagaactact tcacatccgc
      781 agctttccca gagctgttaa ttgccacaaa agaacaaagt caggtgcacc tggcacgggg
      841 actgccctcc atgatagatt tccagatatc ataaaaacag ccttatttca ggagtctact
      901 ttcttgagaa gtgctgacaa tctgtatgta ccatgtacag gaaatgttcc tcgtcctaag
      961 tcactcgcat ggcatgtgct gagtctttgt aattctaaat gaatgtttac cctctttgta
     1021 agagaagagc aaagcctagt ggaaccagcc cgacatatga tactgtttgt tatttaaaga
     1081 gtaccctata gtttgctcac tactaatcat tttaattatt attcttcatg gtattcttag
     1141 gagggtcaaa aagactctgc tcatattaca gatgggctaa ctaagggata agacaactga
     1201 aaagtacact caattgcatc tggaatggga attcacagac ccatgaaact tatctcactg
     1261 tgcaccttct gcttctaaag tgccggatgg gtaggataaa gttgtaagaa cgtaatgcta
     1321 tcattttcaa aaggaagggg acaatagcta catctttcct acctcagtgg gttttattcc
     1381 agtaagagca tttggataaa atccttctgt aacagacctc aagaaggaga cagactgttg
     1441 aatgttattt ttaagttatt ttatatatgt atttataaat atatttatga taattatatt
     1501 atttatggca catccttaaa tcctctgagc ttgccaggca tcctcagcag cagaattttc
     1561 taggtggtca gttagatgca gtgtcctctg aaacaccatg ctatagacag acgtacactg
     1621 tttcccacat ccgtggagct ctctttacat tcttgtcctt aggagccctg cagtcatgat
     1681 caccaatctg tactgttcac ttcgttcatt taaaatgata actgggtcag tcttttgccc
     1741 tcctgtcctt aaagctgtct gggtcttctt acatcattca actcacctgt aattaaagct
     1801 aaccatctaa agacgggaag aacctaactg tgacaaccac atccctgtta cctgaagttt
     1861 cttttctagg atgtaatcag tgtttcctct gggttccaaa tttgttctca aaccagggtg
     1921 tcacaaaaat atcaacaata ataatcaact catcattact attgatcata attaaataaa
     1981 gcaagtttga gctg
//
