LOCUS       NM_001106905            2436 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interleukin 18 receptor 1 (Il18r1), mRNA.
ACCESSION   NM_001106905 XM_001059279 XM_237088
VERSION     NM_001106905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2436)
  AUTHORS   Gong,Q., Lin,Y., Lu,Z. and Xiao,Z.
  TITLE     Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling
            Modulates Migraine-like Behavior in Experimental Models of Migraine
  JOURNAL   Neuroscience 451, 207-215 (2020)
   PUBMED   33137409
  REMARK    GeneRIF: Microglia-Astrocyte Cross Talk through IL-18/IL-18R
            Signaling Modulates Migraine-like Behavior in Experimental Models
            of Migraine.
REFERENCE   2  (bases 1 to 2436)
  AUTHORS   Markowitz,G.J., Yang,P., Fu,J., Michelotti,G.A., Chen,R., Sui,J.,
            Yang,B., Qin,W.H., Zhang,Z., Wang,F.S., Diehl,A.M., Li,Q.J.,
            Wang,H. and Wang,X.F.
  TITLE     Inflammation-Dependent IL18 Signaling Restricts Hepatocellular
            Carcinoma Growth by Enhancing the Accumulation and Activity of
            Tumor-Infiltrating Lymphocytes
  JOURNAL   Cancer Res 76 (8), 2394-2405 (2016)
   PUBMED   26893476
REFERENCE   3  (bases 1 to 2436)
  AUTHORS   Pazos,P., Lima,L., Tovar,S., Gonzalez-Touceda,D., Dieguez,C. and
            Garcia,M.C.
  TITLE     Divergent responses to thermogenic stimuli in BAT and subcutaneous
            adipose tissue from interleukin 18 and interleukin 18 receptor
            1-deficient mice
  JOURNAL   Sci Rep 5, 17977 (2015)
   PUBMED   26656097
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2436)
  AUTHORS   Tsutsumi,N., Kimura,T., Arita,K., Ariyoshi,M., Ohnishi,H.,
            Yamamoto,T., Zuo,X., Maenaka,K., Park,E.Y., Kondo,N., Shirakawa,M.,
            Tochio,H. and Kato,Z.
  TITLE     The structural basis for receptor recognition of human
            interleukin-18
  JOURNAL   Nat Commun 5, 5340 (2014)
   PUBMED   25500532
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2436)
  AUTHORS   Wei,H., Wang,D., Qian,Y., Liu,X., Fan,S., Yin,H.S. and Wang,X.
  TITLE     Structural basis for the specific recognition of IL-18 by its alpha
            receptor
  JOURNAL   FEBS Lett 588 (21), 3838-3843 (2014)
   PUBMED   25261253
REFERENCE   6  (bases 1 to 2436)
  AUTHORS   Katchar,K., Eklund,A. and Grunewald,J.
  TITLE     Expression of Th1 markers by lung accumulated T cells in pulmonary
            sarcoidosis
  JOURNAL   J Intern Med 254 (6), 564-571 (2003)
   PUBMED   14641797
REFERENCE   7  (bases 1 to 2436)
  AUTHORS   Kato,Z., Jee,J., Shikano,H., Mishima,M., Ohki,I., Ohnishi,H.,
            Li,A., Hashimoto,K., Matsukuma,E., Omoya,K., Yamamoto,Y.,
            Yoneda,T., Hara,T., Kondo,N. and Shirakawa,M.
  TITLE     The structure and binding mode of interleukin-18
  JOURNAL   Nat Struct Biol 10 (11), 966-971 (2003)
   PUBMED   14528293
REFERENCE   8  (bases 1 to 2436)
  AUTHORS   Kuribayashi,K., Kodama,T., Okamura,H., Sugita,M. and Matsuyama,T.
  TITLE     Effects of post-inhalation treatment with interleukin-12 on airway
            hyper-reactivity, eosinophilia and interleukin-18 receptor
            expression in a mouse model of asthma
  JOURNAL   Clin Exp Allergy 32 (4), 641-649 (2002)
   PUBMED   11972614
REFERENCE   9  (bases 1 to 2436)
  AUTHORS   Tominaga,K., Yoshimoto,T., Torigoe,K., Kurimoto,M., Matsui,K.,
            Hada,T., Okamura,H. and Nakanishi,K.
  TITLE     IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production
            from human T cells
  JOURNAL   Int Immunol 12 (2), 151-160 (2000)
   PUBMED   10653850
REFERENCE   10 (bases 1 to 2436)
  AUTHORS   Hoshino,K., Tsutsui,H., Kawai,T., Takeda,K., Nakanishi,K.,
            Takeda,Y. and Akira,S.
  TITLE     Cutting edge: generation of IL-18 receptor-deficient mice: evidence
            for IL-1 receptor-related protein as an essential IL-18 binding
            receptor
  JOURNAL   J Immunol 162 (9), 5041-5044 (1999)
   PUBMED   10227969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jun 19, 2009 this sequence version replaced NM_001106905.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               JAXUCZ010000009.1  50223491-50223840
            351-434             JAXUCZ010000009.1  50229449-50229532
            435-681             JAXUCZ010000009.1  50232261-50232507
            682-847             JAXUCZ010000009.1  50236342-50236507
            848-992             JAXUCZ010000009.1  50238915-50239059
            993-1055            JAXUCZ010000009.1  50241947-50242009
            1056-1176           JAXUCZ010000009.1  50244521-50244641
            1177-1316           JAXUCZ010000009.1  50246185-50246324
            1317-1475           JAXUCZ010000009.1  50248069-50248227
            1476-1634           JAXUCZ010000009.1  50252825-50252983
            1635-2436           JAXUCZ010000009.1  50254795-50255596
FEATURES             Location/Qualifiers
     source          1..2436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..2436
                     /gene="Il18r1"
                     /note="interleukin 18 receptor 1"
                     /db_xref="GeneID:301365"
                     /db_xref="RGD:1308589"
     exon            1..350
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..434
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1990
                     /gene="Il18r1"
                     /EC_number="3.2.2.6"
                     /note="IL18Ralpha2"
                     /codon_start=1
                     /product="interleukin-18 receptor 1 precursor"
                     /protein_id="NP_001100375.1"
                     /db_xref="GeneID:301365"
                     /db_xref="RGD:1308589"
                     /translation="MHHEELILILCVLVVKSAPKSCIRRSQIHVVEGEPFYLKPCDMS
                     APMHNNETATMRWFKGNASHGYRELNMRSSPRIAFHGHALEFWPVELEDKGTYFSQVG
                     NDRQNWTLNVTKRNKHSCFSEKLVTNRDVEVKKSLWITCENPSYGELINHTLLYKNCK
                     EISKTPMILKDAEFGDEGYYSCVFSVHHNGQQYNITKTVNITVIEGNSKITPAIFGSK
                     SAKVGVELGEDVELNCSAVLNRNDLFYWSIRKEDSLDPNVHEDRNETTWTFEGKLHAS
                     KILRIQKVTEKYLNVLYNCTVANEEATDTKSFILVRKETPDIQGHVFMRGITMVVLTS
                     VAAVCVVILCIIYKVDLVLFYRRVAERDETLTDGKTYDAFVSYLRECHPENGEEYTFA
                     VETLPRVLEKQFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMTNGSRL
                     ELESGLHQALVERKIKIILIEFTPASNITFLPPSLKLLKSYRVLRWKADKPLSSKSRF
                     WKNLLYLMPAKAVKPWREESEARPVLSAP"
     exon            435..681
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..847
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..992
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1055
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1176
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1316
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1475
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1634
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2436
                     /gene="Il18r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccccatccc ccacccccgg aatcgctagc ttttcttttt tctttcattt tcttcaataa
       61 ttccttgggt tgcctgatcc ctctaacaag ctcctggccc tgtctgacca tactctcctt
      121 ccctgtctgg tgtcacagtt gtggacccgg aggtgttcag tctcacctgc ttggtgaatt
      181 ccgcagatgt aagtgaagga gaagccactg tcctgccctg attgtgagtc acctctctga
      241 aggtaagggc aggctctgat gtccagtcct cactgtcttc tgctgtctgg agcaagggga
      301 agggaccacc cactcccagg ggtgcaagga tcctgaaaac aaaatcaatt agaccagtgc
      361 aagcagaagc ctaaacatgc atcatgaaga attaatcttg atactttgtg ttctcgttgt
      421 taaaagtgcc ccgaaaagtt gcattcgccg gtcgcaaatt cacgtagtag agggagagcc
      481 tttttatctg aagccctgtg atatgtctgc acccatgcat aacaatgaga cagccaccat
      541 gagatggttc aaaggcaatg cttcacatgg ctacagagag ctgaacatga gaagctcgcc
      601 cagaatcgct tttcatggtc acgctttgga attctggcca gttgagctgg aggacaaggg
      661 aacgtacttt tctcaagtgg gaaatgatcg tcaaaattgg accttaaatg tcaccaaaag
      721 aaacaaacac agctgcttct ctgagaagct tgtgacgaac agagatgtgg aggttaagaa
      781 atctctgtgg attacctgtg aaaatcctag ctatggagag ctgatcaacc acacgttgct
      841 gtataagaac tgtaaggaaa tatccaaaac cccaatgatc ctgaaggatg ccgagtttgg
      901 agatgaaggt tattactcct gcgtgttttc tgtccaccat aacgggcaac agtacaacat
      961 caccaagact gtcaatataa cggttattga agggaacagt aaaataactc cggctatttt
     1021 tggatcaaag tctgcgaagg ttggtgtaga actaggagaa gatgtggagc tgaactgcag
     1081 tgctgtgctg aatagaaatg atctgtttta ttggagcatc aggaaagagg acagcttaga
     1141 ccctaacgtg catgaagaca ggaacgagac aacatggact tttgaaggca aattgcatgc
     1201 ttcaaaaatc ctgagaattc agaaagttac agaaaaatat ctcaatgttt tatataattg
     1261 taccgtggcc aacgaagaag ccacagacac caaaagcttc atcttggtga gaaaagaaac
     1321 acctgacatc caaggccatg tctttatgag aggaataacc atggttgttc tcacctctgt
     1381 ggcagcagtg tgcgtggtga ttttgtgcat catttataaa gttgatttgg ttttattcta
     1441 tagacgtgta gcagaaagag acgagacact aacagatggt aaaacatatg atgcctttgt
     1501 gtcttacctg agagagtgtc atcctgagaa tggagaagag tacacttttg ctgtggagac
     1561 gttacccagg gtcctggaga aacagtttgg ctataagttg tgcatatttg aaagagatgt
     1621 ggtgcctggt ggagctgtcg ttgatgagat ccattcactg atagagaaaa gccggaggct
     1681 aatcatcgtc ctcagcaaga gttacatgac taatggatcc aggctcgagc tggagagcgg
     1741 actccaccaa gcactggtgg agaggaagat taaaataatc ttaatcgagt ttactccagc
     1801 cagcaacatc acctttctcc cgccgtcgct gaaactcctc aagtcctaca gagttctgag
     1861 gtggaaggct gacaagccac tctcttcgaa atcacgattc tggaagaatc ttctttacct
     1921 gatgcctgcc aaagccgtca agccatggag agaagaatca gaggcccggc ctgttctctc
     1981 agcaccttga gcttcagact agctcagtgt taaagggaag tgaagccctg ctagaggtca
     2041 tgtgtgtgtg ccttttcaca gcggtggctg tggttcaaag gactgaattt tgtgaatatc
     2101 cctcccactc ccagttacga gatttgtcat tgggtcatca cagatgaaac agaaccttga
     2161 ctgtgatcct gaactcccag aagacctggg gattcacgag aaatcagttt gttatgcttc
     2221 cttcccctag agcagtgggt ctcaacctgt gggttgtggc cccttttgca aacctctatc
     2281 ttcaaagaga tttatgctat gattcatatc agtagctaaa ttacagttat gaagtaacaa
     2341 tggcaataat tttatgcttg ggggtcacca ccacgtgatg aactgtatta caggatcaaa
     2401 gcattaggaa ggttgagaac cactgcctcg gagctg
//
