LOCUS       NM_053374                951 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interleukin 18 binding protein (Il18bp), mRNA.
ACCESSION   NM_053374
VERSION     NM_053374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 951)
  AUTHORS   Liu,X., Pan,Z., Su,D., Yang,Z., Zheng,B., Wang,X. and Tian,J.
  TITLE     Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through
            Inhibition of Interleukin-18 Signaling
  JOURNAL   Transplantation 99 (10), 2109-2117 (2015)
   PUBMED   25919765
  REMARK    GeneRIF: Remifentanil protects the liver against I/R injury by
            modulating hepatic IL-18/IL-18BP balance and inhibiting IL-18
            signaling
REFERENCE   2  (bases 1 to 951)
  AUTHORS   Ono,S., Obara,H., Takayanagi,A., Tanabe,M., Kawachi,S., Itano,O.,
            Shinoda,M., Kitago,M., Hibi,T., Chiba,T., Du,W., Matsumoto,K.,
            Tilles,A.W., Yarmush,M.L., Aiso,S., Shimizu,N., Sakamoto,M. and
            Kitagawa,Y.
  TITLE     Suppressive effects of interleukin-18 on liver function in rat
            liver allografts
  JOURNAL   J Surg Res 176 (1), 293-300 (2012)
   PUBMED   21962809
REFERENCE   3  (bases 1 to 951)
  AUTHORS   Reeves,E.P., Williamson,M., Byrne,B., Bergin,D.A., Smith,S.G.,
            Greally,P., O'Kennedy,R., O'Neill,S.J. and McElvaney,N.G.
  TITLE     IL-8 dictates glycosaminoglycan binding and stability of IL-18 in
            cystic fibrosis
  JOURNAL   J Immunol 184 (3), 1642-1652 (2010)
   PUBMED   20026745
REFERENCE   4  (bases 1 to 951)
  AUTHORS   Wang,M., Tan,J., Wang,Y., Meldrum,K.K., Dinarello,C.A. and
            Meldrum,D.R.
  TITLE     IL-18 binding protein-expressing mesenchymal stem cells improve
            myocardial protection after ischemia or infarction
  JOURNAL   Proc Natl Acad Sci U S A 106 (41), 17499-17504 (2009)
   PUBMED   19805173
REFERENCE   5  (bases 1 to 951)
  AUTHORS   Venkatachalam,K., Prabhu,S.D., Reddy,V.S., Boylston,W.H.,
            Valente,A.J. and Chandrasekar,B.
  TITLE     Neutralization of interleukin-18 ameliorates
            ischemia/reperfusion-induced myocardial injury
  JOURNAL   J Biol Chem 284 (12), 7853-7865 (2009)
   PUBMED   19164288
REFERENCE   6  (bases 1 to 951)
  AUTHORS   Chandrasekar,B., Colston,J.T., de la Rosa,S.D., Rao,P.P. and
            Freeman,G.L.
  TITLE     TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in
            cardiomyocytes via NF-kappa B activation
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1152-1158 (2003)
   PUBMED   12684057
REFERENCE   7  (bases 1 to 951)
  AUTHORS   Ludwiczek,O., Kaser,A., Novick,D., Dinarello,C.A., Rubinstein,M.,
            Vogel,W. and Tilg,H.
  TITLE     Plasma levels of interleukin-18 and interleukin-18 binding protein
            are elevated in patients with chronic liver disease
  JOURNAL   J Clin Immunol 22 (6), 331-337 (2002)
   PUBMED   12462332
REFERENCE   8  (bases 1 to 951)
  AUTHORS   Im,S.H., Kim,S.H., Azam,T., Venkatesh,N., Dinarello,C.A., Fuchs,S.
            and Souroujon,M.C.
  TITLE     Rat interleukin-18 binding protein: cloning, expression, and
            characterization
  JOURNAL   J Interferon Cytokine Res 22 (3), 321-328 (2002)
   PUBMED   12034039
  REMARK    GeneRIF: This protein was isolated, cloned and characterized in
            cultured COS cells.
REFERENCE   9  (bases 1 to 951)
  AUTHORS   Mallat,Z., Corbaz,A., Scoazec,A., Graber,P., Alouani,S.,
            Esposito,B., Humbert,Y., Chvatchko,Y. and Tedgui,A.
  TITLE     Interleukin-18/interleukin-18 binding protein signaling modulates
            atherosclerotic lesion development and stability
  JOURNAL   Circ Res 89 (7), E41-E45 (2001)
   PUBMED   11577031
REFERENCE   10 (bases 1 to 951)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB809932.1, AF154569.1, JAXUCZ010000001.1 and AA925116.1.
            
            On Aug 7, 2012 this sequence version replaced NM_053374.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1175939.1,
                                           SRR26360186.190615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840127,
                                           SAMN16676786 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               CB809932.1         12-200
            190-303             AF154569.1         1-114
            304-419             JAXUCZ010000001.1  165786040-165786155 c
            420-806             AF154569.1         231-617
            807-951             AA925116.1         1-145               c
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..951
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /note="interleukin 18 binding protein"
                     /db_xref="GeneID:84388"
                     /db_xref="RGD:620042"
     exon            1..147
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
     exon            148..224
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..781
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /note="interferon gamma inducing factor binding protein"
                     /codon_start=1
                     /product="interleukin-18-binding protein precursor"
                     /protein_id="NP_445826.2"
                     /db_xref="GeneID:84388"
                     /db_xref="RGD:620042"
                     /translation="MTMRHCGCAADPSPWWVLLLYVHVVILARATSAPLTTATVLTRS
                     SKDPCSSWSPAVPTKQYPTLDVIWPEKEVPLNGTLTLSCTACSRFPNFSILYWLGNGS
                     FIEHLPGRLREGHTSREQRNASTWLHRALVLEELSPSLLSTNFSCLFVDPGQVAQYHV
                     ILAQLWDGLKTAPSPSQETLSSHSPGPRSAGPGAP"
     exon            225..419
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
     exon            420..543
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
     exon            544..691
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
     exon            692..935
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attggttcac agtagggacc gggattccta gttcagagag aaagtgaaag tgaaaatagt
       61 cgggagcttt cctagaagct gtctgctgcc tgccttccca gaacaagggc cggctggcga
      121 actggcgaac ggagtgttac ttcccagagg aagtcacagt taggcaccag gcttgcctgc
      181 ttccacattc atcatgacca tgagacactg tggctgtgca gcagacccca gtccttggtg
      241 ggtcctgctt ctatatgtcc atgttgtcat tctggccaga gccacatctg cacctctgac
      301 aacagccact gtcttaacca gaagctcaaa ggacccgtgc tcttcctggt ctccagcagt
      361 cccaactaag cagtacccaa cattggatgt gatctggcca gagaaagaag tgccactgaa
      421 tggaacgctg accttgtcct gcactgcctg cagccgcttc cccaacttca gcatcctcta
      481 ctggctgggc aatggctcct tcattgagca cctcccaggc cggctgaggg agggccacac
      541 aagccgggag cagaggaacg caagcacctg gctacacagg gccttggtgc tggaggaact
      601 gagcccctcc ctactaagta ccaacttctc ctgtctgttt gtggatcccg gacaggtggc
      661 ccagtatcat gtcattctgg cccagctctg ggatggattg aagacagccc catccccttc
      721 tcaagaaacc ctctccagcc acagcccagg acccagatca gcaggcccag gggccccatg
      781 aagccaacca cagcatgacc ttgaccggag cctggctctc atctacctgg agggtgaagt
      841 ctacaccaca ggctgtgatt gcctctttcc agcggctgaa cctcaaactc aagcttcatt
      901 tctacctaga ttacaatagt tattaagtcc ttggaaaaaa aaaaaaaaaa a
//
