LOCUS       NP_445826                195 aa            linear   ROD 31-MAR-2024
DEFINITION  interleukin-18-binding protein precursor [Rattus norvegicus].
ACCESSION   NP_445826
VERSION     NP_445826.2
DBSOURCE    REFSEQ: accession NM_053374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 195)
  AUTHORS   Liu,X., Pan,Z., Su,D., Yang,Z., Zheng,B., Wang,X. and Tian,J.
  TITLE     Remifentanil Ameliorates Liver Ischemia-Reperfusion Injury Through
            Inhibition of Interleukin-18 Signaling
  JOURNAL   Transplantation 99 (10), 2109-2117 (2015)
   PUBMED   25919765
  REMARK    GeneRIF: Remifentanil protects the liver against I/R injury by
            modulating hepatic IL-18/IL-18BP balance and inhibiting IL-18
            signaling
REFERENCE   2  (residues 1 to 195)
  AUTHORS   Ono,S., Obara,H., Takayanagi,A., Tanabe,M., Kawachi,S., Itano,O.,
            Shinoda,M., Kitago,M., Hibi,T., Chiba,T., Du,W., Matsumoto,K.,
            Tilles,A.W., Yarmush,M.L., Aiso,S., Shimizu,N., Sakamoto,M. and
            Kitagawa,Y.
  TITLE     Suppressive effects of interleukin-18 on liver function in rat
            liver allografts
  JOURNAL   J Surg Res 176 (1), 293-300 (2012)
   PUBMED   21962809
REFERENCE   3  (residues 1 to 195)
  AUTHORS   Reeves,E.P., Williamson,M., Byrne,B., Bergin,D.A., Smith,S.G.,
            Greally,P., O'Kennedy,R., O'Neill,S.J. and McElvaney,N.G.
  TITLE     IL-8 dictates glycosaminoglycan binding and stability of IL-18 in
            cystic fibrosis
  JOURNAL   J Immunol 184 (3), 1642-1652 (2010)
   PUBMED   20026745
REFERENCE   4  (residues 1 to 195)
  AUTHORS   Wang,M., Tan,J., Wang,Y., Meldrum,K.K., Dinarello,C.A. and
            Meldrum,D.R.
  TITLE     IL-18 binding protein-expressing mesenchymal stem cells improve
            myocardial protection after ischemia or infarction
  JOURNAL   Proc Natl Acad Sci U S A 106 (41), 17499-17504 (2009)
   PUBMED   19805173
REFERENCE   5  (residues 1 to 195)
  AUTHORS   Venkatachalam,K., Prabhu,S.D., Reddy,V.S., Boylston,W.H.,
            Valente,A.J. and Chandrasekar,B.
  TITLE     Neutralization of interleukin-18 ameliorates
            ischemia/reperfusion-induced myocardial injury
  JOURNAL   J Biol Chem 284 (12), 7853-7865 (2009)
   PUBMED   19164288
REFERENCE   6  (residues 1 to 195)
  AUTHORS   Chandrasekar,B., Colston,J.T., de la Rosa,S.D., Rao,P.P. and
            Freeman,G.L.
  TITLE     TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in
            cardiomyocytes via NF-kappa B activation
  JOURNAL   Biochem Biophys Res Commun 303 (4), 1152-1158 (2003)
   PUBMED   12684057
REFERENCE   7  (residues 1 to 195)
  AUTHORS   Ludwiczek,O., Kaser,A., Novick,D., Dinarello,C.A., Rubinstein,M.,
            Vogel,W. and Tilg,H.
  TITLE     Plasma levels of interleukin-18 and interleukin-18 binding protein
            are elevated in patients with chronic liver disease
  JOURNAL   J Clin Immunol 22 (6), 331-337 (2002)
   PUBMED   12462332
REFERENCE   8  (residues 1 to 195)
  AUTHORS   Im,S.H., Kim,S.H., Azam,T., Venkatesh,N., Dinarello,C.A., Fuchs,S.
            and Souroujon,M.C.
  TITLE     Rat interleukin-18 binding protein: cloning, expression, and
            characterization
  JOURNAL   J Interferon Cytokine Res 22 (3), 321-328 (2002)
   PUBMED   12034039
  REMARK    GeneRIF: This protein was isolated, cloned and characterized in
            cultured COS cells.
REFERENCE   9  (residues 1 to 195)
  AUTHORS   Mallat,Z., Corbaz,A., Scoazec,A., Graber,P., Alouani,S.,
            Esposito,B., Humbert,Y., Chvatchko,Y. and Tedgui,A.
  TITLE     Interleukin-18/interleukin-18 binding protein signaling modulates
            atherosclerotic lesion development and stability
  JOURNAL   Circ Res 89 (7), E41-E45 (2001)
   PUBMED   11577031
REFERENCE   10 (residues 1 to 195)
  AUTHORS   Novick,D., Kim,S.H., Fantuzzi,G., Reznikov,L.L., Dinarello,C.A. and
            Rubinstein,M.
  TITLE     Interleukin-18 binding protein: a novel modulator of the Th1
            cytokine response
  JOURNAL   Immunity 10 (1), 127-136 (1999)
   PUBMED   10023777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB809932.1, AF154569.1, JAXUCZ010000001.1 and AA925116.1.
            
            On Aug 7, 2012 this sequence version replaced NP_445826.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1175939.1,
                                           SRR26360186.190615.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840127,
                                           SAMN16676786 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..195
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     Protein         1..195
                     /product="interleukin-18-binding protein precursor"
                     /note="interferon gamma inducing factor binding protein"
                     /calculated_mol_wt=17737
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3598
     Region          49..171
                     /region_name="Pox_vIL-18BP"
                     /note="Orthopoxvirus interleukin 18 binding protein;
                     cl23951"
                     /db_xref="CDD:305108"
     CDS             1..195
                     /gene="Il18bp"
                     /gene_synonym="Igifbp"
                     /coded_by="NM_053374.2:194..781"
                     /db_xref="GeneID:84388"
                     /db_xref="RGD:620042"
ORIGIN      
        1 mtmrhcgcaa dpspwwvlll yvhvvilara tsaplttatv ltrsskdpcs swspavptkq
       61 yptldviwpe kevplngtlt lsctacsrfp nfsilywlgn gsfiehlpgr lreghtsreq
      121 rnastwlhra lvleelspsl lstnfsclfv dpgqvaqyhv ilaqlwdglk tapspsqetl
      181 sshspgprsa gpgap
//
