LOCUS       NM_019165               1197 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus interleukin 18 (Il18), mRNA.
ACCESSION   NM_019165 XM_001070641
VERSION     NM_019165.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1197)
  AUTHORS   Borgonetti,V., Cruz,B., Vozella,V., Khom,S., Steinman,M.Q.,
            Bullard,R., D'Ambrosio,S., Oleata,C.S., Vlkolinsky,R., Bajo,M.,
            Zorrilla,E.P., Kirson,D. and Roberto,M.
  TITLE     IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a
            Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
  JOURNAL   Cells 12 (15), 1943 (2023)
   PUBMED   37566022
  REMARK    GeneRIF: IL-18 Signaling in the Rat Central Amygdala Is Disrupted
            in a Comorbid Model of Post-Traumatic Stress and Alcohol Use
            Disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1197)
  AUTHORS   Tavarna,T., Wolfe,B., Wu,X.J. and Reyes,L.
  TITLE     Porphyromonas gingivalis-mediated disruption in spiral artery
            remodeling is associated with altered uterine NK cell populations
            and dysregulated IL-18 and Htra1
  JOURNAL   Sci Rep 12 (1), 14799 (2022)
   PUBMED   36042379
  REMARK    GeneRIF: Porphyromonas gingivalis-mediated disruption in spiral
            artery remodeling is associated with altered uterine NK cell
            populations and dysregulated IL-18 and Htra1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1197)
  AUTHORS   Abu-Risha,S.E., Mousa,M.A. and Elsisi,A.E.
  TITLE     Protective role of irbesartan against cyclophosphamide-induced
            testicular damage in rats via up-regulating PPAR-gamma signaling
            and ameliorating NF-kappaB/NLRP3/IL-18 inflammatory axis
  JOURNAL   Life Sci 289, 120218 (2022)
   PUBMED   34890588
  REMARK    GeneRIF: Protective role of irbesartan against
            cyclophosphamide-induced testicular damage in rats via
            up-regulating PPAR-gamma signaling and ameliorating
            NF-kappaB/NLRP3/IL-18 inflammatory axis.
REFERENCE   4  (bases 1 to 1197)
  AUTHORS   Simanullang,R.H., Situmorang,P.C., Ginting,L., Tarigan,E.R.,
            Syahputra,R.A., Chairunisa,C. and Maliki,M.F.
  TITLE     PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa
  JOURNAL   Pak J Biol Sci 25 (11), 986-992 (2022)
   PUBMED   36591929
  REMARK    GeneRIF: PDGF-beta and IL-18 Expressions on Carcinoma Cervical by
            Rhodomyrtus tomentosa.
REFERENCE   5  (bases 1 to 1197)
  AUTHORS   Wang,Y.F., Wang,Y., Zhang,Y., Guo,X., He,X., Zhang,J.L. and
            Rong,P.J.
  TITLE     [Effect of transcutaneous auricular vagus nerve stimulation on the
            expression of TLR4MyD88IL-18 protein in the prefrontal cortex of
            depression rats]
  JOURNAL   Zhen Ci Yan Jiu 46 (7), 580-585 (2021)
   PUBMED   34369678
  REMARK    GeneRIF: [Effect of transcutaneous auricular vagus nerve
            stimulation on the expression of TLR4MyD88IL-18 protein in the
            prefrontal cortex of depression rats].
REFERENCE   6  (bases 1 to 1197)
  AUTHORS   Wildbaum,G., Youssef,S., Grabie,N. and Karin,N.
  TITLE     Neutralizing antibodies to IFN-gamma-inducing factor prevent
            experimental autoimmune encephalomyelitis
  JOURNAL   J Immunol 161 (11), 6368-6374 (1998)
   PUBMED   9834127
REFERENCE   7  (bases 1 to 1197)
  AUTHORS   Xu,B., Aoyama,K., Yu,S., Kitani,A., Okamura,H., Kurimoto,M.,
            Matsuyama,T. and Matsushita,T.
  TITLE     Expression of interleukin-18 in murine contact hypersensitivity
  JOURNAL   J Interferon Cytokine Res 18 (9), 653-659 (1998)
   PUBMED   9781803
REFERENCE   8  (bases 1 to 1197)
  AUTHORS   Culhane,A.C., Hall,M.D., Rothwell,N.J. and Luheshi,G.N.
  TITLE     Cloning of rat brain interleukin-18 cDNA
  JOURNAL   Mol Psychiatry 3 (4), 362-366 (1998)
   PUBMED   9702748
REFERENCE   9  (bases 1 to 1197)
  AUTHORS   Conti,B., Jahng,J.W., Tinti,C., Son,J.H. and Joh,T.H.
  TITLE     Induction of interferon-gamma inducing factor in the adrenal cortex
  JOURNAL   J Biol Chem 272 (4), 2035-2037 (1997)
   PUBMED   8999896
REFERENCE   10 (bases 1 to 1197)
  AUTHORS   Micallef,M.J., Ohtsuki,T., Kohno,K., Tanabe,F., Ushio,S., Namba,M.,
            Tanimoto,T., Torigoe,K., Fujii,M., Ikeda,M., Fukuda,S. and
            Kurimoto,M.
  TITLE     Interferon-gamma-inducing factor enhances T helper 1 cytokine
            production by stimulated human T cells: synergism with
            interleukin-12 for interferon-gamma production
  JOURNAL   Eur J Immunol 26 (7), 1647-1651 (1996)
   PUBMED   8766574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 20, 2020 this sequence version replaced NM_019165.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY077842.1, CF109780.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760494, SAMN17050747 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000008.1  59802072-59802185
            115-156             JAXUCZ010000008.1  59802403-59802444
            157-321             JAXUCZ010000008.1  59803327-59803491
            322-482             JAXUCZ010000008.1  59813421-59813581
            483-566             JAXUCZ010000008.1  59822654-59822737
            567-578             JAXUCZ010000008.1  59823916-59823927
            579-713             JAXUCZ010000008.1  59825273-59825407
            714-847             JAXUCZ010000008.1  59826634-59826767
            848-1197            JAXUCZ010000008.1  59828926-59829275
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q23"
     gene            1..1197
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="interleukin 18"
                     /db_xref="GeneID:29197"
                     /db_xref="RGD:2889"
     exon            1..114
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            115..156
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            157..321
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            322..482
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            483..566
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..1072
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /note="interleukin-1 gamma; IFN-gamma-inducing factor;
                     interferon gamma-inducing factor"
                     /codon_start=1
                     /product="interleukin-18"
                     /protein_id="NP_062038.2"
                     /db_xref="GeneID:29197"
                     /db_xref="RGD:2889"
                     /translation="MAAIPEEGSCVNFKEMMFIDNTLYLIPEDNGDLESDHFGRLHCT
                     TAVMRSINDQVLFVDKRNPPVFEDMPDIDRTANESQTRLIIYMYKDSEVRGLAVTLSV
                     KDGRMSTLSCKNKIISFEEMNPPENIDDIKSDLIFFQKRVPGHNKMEFESSLYEGHFL
                     ACQKEDDAFKLVLKRKDENGDKSVMFTLTNLHQS"
     exon            567..578
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            579..713
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            714..847
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1197
                     /gene="Il18"
                     /gene_synonym="IL-1 gamma; IL-18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttctgaat cagctcttct accagcaaac atctcacttc agtgtctctg tgagcactga
       61 attcatcttg tgcactctcc ttacaacaca gctcttctga ccaccagggc acagcctctc
      121 agttggaagt gaaattggaa agagaaactc agtgagctga ctgaacactg gctgtcccca
      181 caacgatgag tacaccaatc ctgttgttcg taaaccaggc tttcacttct cccctgggga
      241 gtgctgcctg catcacacag agaccttcag aagcctgcta taatcttcag gacccacgta
      301 cagcagtcca acggcagact ggcgcagctg taccccaggg tgcagtttct ctgtagctcc
      361 atgctttccg taatcctagc tgcctgctcc agctgctgac aggactgcca tcttctgcaa
      421 cctccaggat caggaaaaag aaagaggcct cgaagcttcc aaatcacttc ctcttggccc
      481 aggaacaatg gctgccatac cagaagaagg ctcttgtgtc aacttcaaag aaatgatgtt
      541 tattgacaac acactttacc ttatacctga agataatgga gacttggaat cagaccactt
      601 tggcagactt cactgtacaa ccgcagtaat gcggagcata aatgaccaag ttctcttcgt
      661 tgacaaaaga aacccgcctg tgttcgagga catgcctgat atcgaccgaa cagccaacga
      721 atcccagacc agactgataa tatatatgta caaagatagt gaagtaagag gactggctgt
      781 gaccctatct gtgaaggatg gaaggatgtc taccctctcc tgtaaaaaca aaatcatttc
      841 ctttgaggaa atgaatccac ctgaaaatat tgatgatata aaaagtgatc tcatattctt
      901 tcagaaacgt gtgccaggac acaacaaaat ggaatttgaa tcttccctgt atgaaggaca
      961 ctttctagct tgccaaaagg aagatgatgc tttcaaactc gttttgaaaa ggaaggatga
     1021 aaatggggat aaatctgtaa tgttcactct tactaactta catcaaagtt aggtattaag
     1081 gtttctgtat tccagaaaga cgattagtat acacgagcct tatgataacc tactctgtat
     1141 ttctatgaca aaatacctga ggccgcatga tttatagagt aaacaagttt aattgtc
//
