LOCUS       NM_001170565            2304 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus interleukin 17 receptor C (Il17rc), mRNA.
ACCESSION   NM_001170565
VERSION     NM_001170565.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2304)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2304)
  AUTHORS   Ho,A.W., Shen,F., Conti,H.R., Patel,N., Childs,E.E., Peterson,A.C.,
            Hernandez-Santos,N., Kolls,J.K., Kane,L.P., Ouyang,W. and
            Gaffen,S.L.
  TITLE     IL-17RC is required for immune signaling via an extended SEF/IL-17R
            signaling domain in the cytoplasmic tail
  JOURNAL   J Immunol 185 (2), 1063-1070 (2010)
   PUBMED   20554964
REFERENCE   3  (bases 1 to 2304)
  AUTHORS   Kuestner,R.E., Taft,D.W., Haran,A., Brandt,C.S., Brender,T.,
            Lum,K., Harder,B., Okada,S., Ostrander,C.D., Kreindler,J.L.,
            Aujla,S.J., Reardon,B., Moore,M., Shea,P., Schreckhise,R.,
            Bukowski,T.R., Presnell,S., Guerra-Lewis,P., Parrish-Novak,J.,
            Ellsworth,J.L., Jaspers,S., Lewis,K.E., Appleby,M., Kolls,J.K.,
            Rixon,M., West,J.W., Gao,Z. and Levin,S.D.
  TITLE     Identification of the IL-17 receptor related molecule IL-17RC as
            the receptor for IL-17F
  JOURNAL   J Immunol 179 (8), 5462-5473 (2007)
   PUBMED   17911633
REFERENCE   4  (bases 1 to 2304)
  AUTHORS   Toy,D., Kugler,D., Wolfson,M., Vanden Bos,T., Gurgel,J., Derry,J.,
            Tocker,J. and Peschon,J.
  TITLE     Cutting edge: interleukin 17 signals through a heteromeric receptor
            complex
  JOURNAL   J Immunol 177 (1), 36-39 (2006)
   PUBMED   16785495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced NM_001170565.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.20626.1,
                                           SRR26643297.17114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               JAXUCZ010000004.1  148174628-148174918
            292-313             JAXUCZ010000004.1  148175201-148175222
            314-466             JAXUCZ010000004.1  148175372-148175524
            467-529             JAXUCZ010000004.1  148175764-148175826
            530-639             JAXUCZ010000004.1  148175914-148176023
            640-751             JAXUCZ010000004.1  148178264-148178375
            752-796             JAXUCZ010000004.1  148178655-148178699
            797-936             JAXUCZ010000004.1  148180293-148180432
            937-996             JAXUCZ010000004.1  148180634-148180693
            997-1051            JAXUCZ010000004.1  148182528-148182582
            1052-1233           JAXUCZ010000004.1  148182652-148182833
            1234-1284           JAXUCZ010000004.1  148182919-148182969
            1285-1330           JAXUCZ010000004.1  148183895-148183940
            1331-1452           JAXUCZ010000004.1  148184092-148184213
            1453-1512           JAXUCZ010000004.1  148184543-148184602
            1513-1564           JAXUCZ010000004.1  148184971-148185022
            1565-1660           JAXUCZ010000004.1  148186212-148186307
            1661-2304           JAXUCZ010000004.1  148186428-148187071
FEATURES             Location/Qualifiers
     source          1..2304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2304
                     /gene="Il17rc"
                     /note="interleukin 17 receptor C"
                     /db_xref="GeneID:297520"
                     /db_xref="RGD:1306392"
     exon            1..291
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2220
                     /gene="Il17rc"
                     /codon_start=1
                     /product="interleukin-17 receptor C precursor"
                     /protein_id="NP_001164036.1"
                     /db_xref="GeneID:297520"
                     /db_xref="RGD:1306392"
                     /translation="MPVPWFLLSLALGRSPVVVSLERLMEPQDTAHCSLGLSCHLWDG
                     DVLCLPGSIESAPGPVLVPTRLQTELVLRCPQETDCALCVRVVVHLAVHGHWEEPEEA
                     GKSDSELQGPRNASLQAQVVLSFQAYPIARCALLEVQVPADLVQPGQSVGSAVFDCFE
                     AGLGAEVRIWSYTKPRYQKELNVTQQLPDCRGLEVQDSIQSCWALPWLNVSTDGDNVL
                     LILDVSKEQKFGFLLYWDQAQGPLKSLLYKNLTGPQNITLNHTDLVPCLCIQLWSQEP
                     DSVRTSFCPFKKDPRAHRNLWHMARLRVQSSGSWLLDTPCSLRTEVALCWQAPDQSPC
                     QPLVPPMPQKNVTMNRPFEFPLVKEHPNLCVQVSSWEKVELQECLWADSLGPFKDDML
                     LVEMKTDLNDTSVCALEPSGCTPLPSVASTRAARLGEQLLLDFRTHQCMQLWNDDDLG
                     SLWACPMDKYIHKRWVLVWLACLLLAAALFFFLLLKKDRRKAAPRARPALLLHSADGA
                     YYERLVGALASALSQMPLRVAVDLWSRRELTAHGALAWFHQQRRRTLQEDGVVILLFS
                     PAAVAQCQQWLQLQTVEPGPHDALAAWLSCVLPDFLQGQATGRYVGVYFDGLLHPDTV
                     PALFRVAPLFSLPSQLPAFLDALQGSSSQSPGRPADRAERVAQALLSALDSCT"
     exon            292..313
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            314..466
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            467..529
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            530..639
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            640..751
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            752..796
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            797..936
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            937..996
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1051
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1233
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1284
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1330
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1452
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1512
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1564
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1660
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..2304
                     /gene="Il17rc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actccagctg aaactgggcc gggagtccag gctcacagga gtgggacagc atggcttgag
       61 aggaattcta gcccttgctc tctccctggg acacgtgatt gattggcagc aggggagagg
      121 ggtctgcccc cccttggggg gggcagaacg gggcctcagg cctgggtgct gtctggcacc
      181 tggaagatgc ctgtgccctg gttcctgctg tccttggcac tgggccgaag ccccgtggtc
      241 gtttccctgg agagactcat ggagcctcag gacactgcac actgctctct aggcctctcc
      301 tgccacctct gggatggtga cgtgctctgc ctgcctggaa gcatcgagtc tgccccaggc
      361 cctgtgctag tgcctacccg cctgcagacg gagctggtac tcaggtgtcc acaagagaca
      421 gattgcgccc tctgtgtccg tgtggttgta cacttggctg tgcatgggca ctgggaagag
      481 cccgaagaag ctggaaagtc tgattcagaa ctccaggggc ctaggaacgc ctctctccag
      541 gcccaggtgg tgctctcctt tcaggcctac cccattgctc gctgtgccct gctggaggtc
      601 caggtgcctg ctgacctggt gcagcctggt cagtccgtgg gttctgcagt atttgactgt
      661 tttgaggctg gtcttggggc tgaggtacga atctggtcct acaccaaacc caggtaccag
      721 aaagaactca acgtcacgca gcagttgcct gactgcaggg gtctcgaagt ccaggacagc
      781 atccagagct gctgggccct accctggctc aatgtgtcta cagatggtga caatgttctt
      841 ctgatactgg acgtctctaa ggagcagaaa tttggcttct tactatactg ggatcaggcc
      901 cagggtcctc tcaaatcctt gttgtacaaa aacctgactg gacctcagaa cattacttta
      961 aaccacactg acctggttcc ctgcctctgc attcagttat ggtctcagga gccagactct
     1021 gttaggacca gcttctgccc cttcaagaaa gatccccgtg cacacaggaa cctttggcac
     1081 atggccaggc tgcgggtgca gtcctcaggg agctggctgc tagacacgcc ttgctctcta
     1141 cggaccgagg tggcactgtg ctggcaggca ccagaccaga gtccctgcca gccccttgtg
     1201 ccaccaatgc cccagaagaa tgtcactatg aataggccat ttgagttccc attggtgaaa
     1261 gaacacccca acctctgtgt ccaggtgagc agctgggaga aggttgagct ccaagagtgc
     1321 ttgtgggctg actccttagg gcccttcaag gatgatatgc tgttagtgga gatgaaaact
     1381 gacctaaacg acacatcagt ctgtgccttg gaacccagtg gctgtacacc actgcctagt
     1441 gttgcctcca cgagagctgc tcgccttgga gagcagttgc ttctagactt caggacacac
     1501 cagtgcatgc agctgtggaa tgatgatgac ctgggatcac tgtgggcctg ccccatggac
     1561 aagtacatcc acaagcgctg ggtcctagtg tggctggcct gcctactctt ggctgcggcg
     1621 cttttcttct tcctcctttt aaaaaaggac cgcaggaaag cggcccctcg tgcccgcccg
     1681 gccctgcttc tccactcggc cgatggagca tactacgagc gtctggtggg cgctctggcg
     1741 tccgcgttga gccagatgcc actgcgcgtt gccgtggacc tgtggagccg ccgcgagctg
     1801 accgcgcacg gagccctggc ctggttccac cagcaacggc gccggaccct gcaggaggat
     1861 ggcgtggtca tacttctctt ctcacccgcg gccgtggcgc agtgtcagca gtggctgcag
     1921 ctccagacgg tggagcccgg gccgcatgac gctctggccg cctggctcag ctgcgtgctg
     1981 cccgatttcc tgcaaggcca ggcgaccggc cgctacgtcg gggtctactt tgacgggctg
     2041 ctgcacccag acactgtacc cgccctgttc cgcgtcgcgc cgctcttctc cctgccctcg
     2101 cagctgccgg ccttcctgga tgcactgcag ggaagcagct cccagtcccc cgggcgacct
     2161 gcggacaggg cggaacgagt ggcccaggcg ctgctgtccg ccctagacag ctgtacttag
     2221 agctcggaag ccccaggctg ccgcgaggaa tgggacctgg gaccctgccc tgcactcgaa
     2281 taaaggccga tgcagtattc ctaa
//
