LOCUS       NM_001107883            3845 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus interleukin 17 receptor A (Il17ra), mRNA.
ACCESSION   NM_001107883 XM_001058514 XM_232247
VERSION     NM_001107883.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3845)
  AUTHORS   Farouk,S., Sabet,S., Abu Zahra,F.A. and El-Ghor,A.A.
  TITLE     Bone marrow derived-mesenchymal stem cells downregulate IL17A
            dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver
            fibrosis
  JOURNAL   PLoS One 13 (10), e0206130 (2018)
   PUBMED   30346985
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3845)
  AUTHORS   Ganesan,R. and Rasool,M.
  TITLE     Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61,
            IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis
            by fibroblast-like synoviocytes in rheumatoid arthritis
  JOURNAL   Mol Immunol 91, 134-144 (2017)
   PUBMED   28898718
  REMARK    GeneRIF: findings demonstrate that IL-17 regulates SHP-2 expression
            and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and
            RANKL in AA-FLS and may reveal a new insight into the pathogenesis
            of RA.
REFERENCE   3  (bases 1 to 3845)
  AUTHORS   Zhang,S.C., Zheng,Y.H., Yu,P.P., Min,T.H., Yu,F.X., Ye,C., Xie,Y.K.
            and Zhang,Q.Y.
  TITLE     Lentiviral vector-mediated down-regulation of IL-17A receptor in
            hepatic stellate cells results in decreased secretion of IL-6
  JOURNAL   World J Gastroenterol 18 (28), 3696-3704 (2012)
   PUBMED   22851861
  REMARK    GeneRIF: Down-regulation of the IL-17RA receptor by shRNA decreased
            IL-6 expression induced by IL-17A via p38 MAPK and ERK1/2
            phosphorylation in HSCs
REFERENCE   4  (bases 1 to 3845)
  AUTHORS   Arif,S., Moore,F., Marks,K., Bouckenooghe,T., Dayan,C.M.,
            Planas,R., Vives-Pi,M., Powrie,J., Tree,T., Marchetti,P.,
            Huang,G.C., Gurzov,E.N., Pujol-Borrell,R., Eizirik,D.L. and
            Peakman,M.
  TITLE     Peripheral and islet interleukin-17 pathway activation
            characterizes human autoimmune diabetes and promotes
            cytokine-mediated beta-cell death
  JOURNAL   Diabetes 60 (8), 2112-2119 (2011)
   PUBMED   21659501
REFERENCE   5  (bases 1 to 3845)
  AUTHORS   Chen,K., Pociask,D.A., McAleer,J.P., Chan,Y.R., Alcorn,J.F.,
            Kreindler,J.L., Keyser,M.R., Shapiro,S.D., Houghton,A.M.,
            Kolls,J.K. and Zheng,M.
  TITLE     IL-17RA is required for CCL2 expression, macrophage recruitment,
            and emphysema in response to cigarette smoke
  JOURNAL   PLoS One 6 (5), e20333 (2011)
   PUBMED   21647421
REFERENCE   6  (bases 1 to 3845)
  AUTHORS   Simonian,P.L., Roark,C.L., Wehrmann,F., Lanham,A.M., Born,W.K.,
            O'Brien,R.L. and Fontenot,A.P.
  TITLE     IL-17A-expressing T cells are essential for bacterial clearance in
            a murine model of hypersensitivity pneumonitis
  JOURNAL   J Immunol 182 (10), 6540-6549 (2009)
   PUBMED   19414809
REFERENCE   7  (bases 1 to 3845)
  AUTHORS   Rickel,E.A., Siegel,L.A., Yoon,B.R., Rottman,J.B., Kugler,D.G.,
            Swart,D.A., Anders,P.M., Tocker,J.E., Comeau,M.R. and Budelsky,A.L.
  TITLE     Identification of functional roles for both IL-17RB and IL-17RA in
            mediating IL-25-induced activities
  JOURNAL   J Immunol 181 (6), 4299-4310 (2008)
   PUBMED   18768888
REFERENCE   8  (bases 1 to 3845)
  AUTHORS   Kokubu,T., Haudenschild,D.R., Moseley,T.A., Rose,L. and Reddi,A.H.
  TITLE     Immunolocalization of IL-17A, IL-17B, and their receptors in
            chondrocytes during fracture healing
  JOURNAL   J Histochem Cytochem 56 (2), 89-95 (2008)
   PUBMED   17827167
  REMARK    GeneRIF: Members of the IL-17 family were localized in chondrocytes
            in the fracture callus. It parallels the localization of these
            cytokines and their receptors in chondrocytes during an
            endochondral differentiation program in the epiphyseal growth
            plate.
REFERENCE   9  (bases 1 to 3845)
  AUTHORS   Kuestner,R.E., Taft,D.W., Haran,A., Brandt,C.S., Brender,T.,
            Lum,K., Harder,B., Okada,S., Ostrander,C.D., Kreindler,J.L.,
            Aujla,S.J., Reardon,B., Moore,M., Shea,P., Schreckhise,R.,
            Bukowski,T.R., Presnell,S., Guerra-Lewis,P., Parrish-Novak,J.,
            Ellsworth,J.L., Jaspers,S., Lewis,K.E., Appleby,M., Kolls,J.K.,
            Rixon,M., West,J.W., Gao,Z. and Levin,S.D.
  TITLE     Identification of the IL-17 receptor related molecule IL-17RC as
            the receptor for IL-17F
  JOURNAL   J Immunol 179 (8), 5462-5473 (2007)
   PUBMED   17911633
REFERENCE   10 (bases 1 to 3845)
  AUTHORS   Toy,D., Kugler,D., Wolfson,M., Vanden Bos,T., Gurgel,J., Derry,J.,
            Tocker,J. and Peschon,J.
  TITLE     Cutting edge: interleukin 17 signals through a heteromeric receptor
            complex
  JOURNAL   J Immunol 177 (1), 36-39 (2006)
   PUBMED   16785495
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Aug 11, 2009 this sequence version replaced NM_001107883.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               JAXUCZ010000004.1  155339742-155339979
            239-263             JAXUCZ010000004.1  155348792-155348816
            264-410             JAXUCZ010000004.1  155349659-155349805
            411-523             JAXUCZ010000004.1  155350464-155350576
            524-650             JAXUCZ010000004.1  155351024-155351150
            651-698             JAXUCZ010000004.1  155353571-155353618
            699-862             JAXUCZ010000004.1  155353804-155353967
            863-946             JAXUCZ010000004.1  155355587-155355670
            947-1031            JAXUCZ010000004.1  155356067-155356151
            1032-1043           JAXUCZ010000004.1  155356858-155356869
            1044-1151           JAXUCZ010000004.1  155357084-155357191
            1152-1193           JAXUCZ010000004.1  155358738-155358779
            1194-3845           JAXUCZ010000004.1  155359731-155362382
FEATURES             Location/Qualifiers
     source          1..3845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3845
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /note="interleukin 17 receptor A"
                     /db_xref="GeneID:312679"
                     /db_xref="RGD:1306559"
     exon            1..238
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..2707
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /codon_start=1
                     /product="interleukin-17 receptor A precursor"
                     /protein_id="NP_001101353.2"
                     /db_xref="GeneID:312679"
                     /db_xref="RGD:1306559"
                     /translation="MATPRRWPRVVPGPALGWLLLLLSALFRGRASLRLLDFPALVCS
                     QEGLNCRVENSTCLDDSWIYPRNLTPSSPKNIYLHLNVSSTQHGDLVPVLHVEWTLQT
                     DASILYLEGAELSILKLNTNEQLCVKFKFLSKLSNHHKRWRFSFSHFVVDPGQEYEVT
                     VHHLPKPIPDGDPNHKSKTILVPGCEDTEMKMTTPCVSSGSLWNPNITVETLDTQHLR
                     VDFTLWNESTPYQILLESFSGSENQSCFEDIKQISAPGQEEFHQRSNVTFTLSKSGWC
                     CHHLVQVQPFFNSCQNDCLRHAVTVPCPVISETPVSITAADYIPLWVYGLITLIAILL
                     VGSVILLIICMTWRLSGADQEKHGDDSKVNGILPTTDLTPPPLQPRKVWIVYSADHPL
                     YVDVVLKFAQFLITACGTEVALDLLEEQTISEMGVMTWVSRQKQEMEESGSKIIVLCS
                     RGTRAKWKAILGWAEPAVQLRCDHWKPAGDLFTAAMNMILPDFKRPACFGTYIVCYFS
                     GICNERDVPDLFNITSRYPLMDKFEEVYFRIQDLEMFEPGRMHHVKELTGENYLQSPS
                     GRQLKEAVVRFQEWQTRYPDWFERENLCLAGDQDLPSLDEEVFEDPLLPPGGRIVKQQ
                     PLVRELPSEGCLVVDVCAREEESGVVKLEPQLWPQRQLMAQTLQTLVLPTEQVPAAHV
                     VEPVRLLDGTGAATQLAIAEDGEACPLLGVRRNSILCLPMDSDDSPLCSTPMMSPDHL
                     QGDAREQLESLMLSVLQHSLSAQAQEGWPRPEVVLKDCMPSEEEQRQSVQSDQGYISR
                     SSPQPPDWLTEEEELELGESGESLSPEELRSLRSVQRRLFFWELEKNPGWDSRGQEQK
                     ISLPPGPPNPAT"
     exon            239..263
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            264..410
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            411..523
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            524..650
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            651..698
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            699..862
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            863..946
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1031
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1043
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1151
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1193
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..3845
                     /gene="Il17ra"
                     /gene_synonym="Il17r"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaagtcgac ctgcgtcagt cctcggctag gaaagcccgt cgtgggccct cgctgtccgg
       61 cggagccagc cgcgagcgct ccgcgaccag gccgggggcc atggcgactc cgcgccgctg
      121 gccacgggtc gtccccgggc ccgcgctggg atggctgctt ctgctgttga gcgcgctgtt
      181 ccggggccgc gcctccctgc gcctcctcga cttcccggct ctagtctgct cgcaggaggg
      241 gctgaactgc agagtcgaga atagtacttg cctggatgac agctggattt accctcgaaa
      301 cctgacgccg tcttccccga aaaacatcta tctccatctg aacgtttcgt ctacccagca
      361 cggagaccta gtccctgtgt tgcacgttga gtggaccttg cagacagatg ccagcatcct
      421 gtatctcgag ggtgcagagc tgtccatcct gaagctgaac accaatgagc agctgtgtgt
      481 caagttcaag tttctgtcca agctgtcgaa tcatcataag cggtggcggt tctccttcag
      541 tcacttcgtg gtagatcctg gccaggagta tgaggtgact gttcaccacc tgcccaagcc
      601 catccctgac ggggacccaa accacaagtc caagaccatc ttagtgcctg gctgcgagga
      661 cacggagatg aagatgacta caccgtgtgt gagctcaggc agcctttgga accccaacat
      721 cacagtggag accttggaca cccagcatct tcgagtggac ttcaccctgt ggaatgaatc
      781 caccccctac cagatcctgc tggaaagttt ttcgggctca gagaaccaga gctgctttga
      841 agacattaaa cagatatctg cgcccggaca ggaggaattc caccagcgat ccaatgtcac
      901 attcactctg agcaagtctg gctggtgctg ccaccacctc gtgcaggtcc agcccttctt
      961 caacagctgc caaaatgact gcttgagaca cgctgtgact gtgccctgcc cagtcatctc
     1021 agagacccca gtttccataa cagccgcaga ctatattccc ctctgggtgt atggcctcat
     1081 caccctcatc gccatcctgc tggtgggctc tgtcatcctg ctgattatct gcatgacctg
     1141 gaggctttct ggtgctgatc aagagaaaca tggagatgac tccaaagtca atggcatctt
     1201 gccaacaaca gacctgactc ccccacccct gcagcccagg aaggtctgga tcgtctactc
     1261 ggctgaccac cccctctatg tggacgtggt cctaaagttc gcccagttcc tgatcactgc
     1321 ctgtggtact gaagtagccc ttgacctgct ggaagagcag accatctctg agatgggggt
     1381 catgacttgg gtgagccggc agaagcagga aatggaggag agcggttcca agatcatcgt
     1441 cctgtgctcc cgagggaccc gagctaagtg gaaagccatc ttgggttggg cggagcctgc
     1501 tgtccagcta cggtgtgacc actggaagcc tgctggggac cttttcacag cagccatgaa
     1561 catgattcta ccagacttca agaggccagc ctgcttcggc acctacattg tttgctactt
     1621 cagtggcatc tgtaacgaga gggatgtccc cgacctcttc aacatcacct ccaggtaccc
     1681 acttatggac aaatttgagg aggtttactt ccggatccag gacctggaga tgtttgaacc
     1741 tggccggatg caccatgtca aagagctcac aggggaaaat tacctgcaga gccctagtgg
     1801 ccggcagctc aaggaggctg tggttaggtt ccaggagtgg caaacccggt accccgactg
     1861 gtttgagcga gagaacctct gcttagcagg tgaccaagac cttccatccc tggatgagga
     1921 agtgtttgaa gacccactgc tgccaccagg gggaagaatc gtcaaacagc agcccctggt
     1981 gcgggagctg ccttcagaag gctgccttgt ggtagatgtc tgtgccaggg aggaagaaag
     2041 tggagtggta aagctggagc ctcagctgtg gccacaaaga cagctaatgg ctcagaccct
     2101 ccaaaccttg gtgctgccaa cagaacaggt ccctgcagct catgtggtgg agcctgtccg
     2161 tcttctagat ggcactggag cagctaccca gctggccatt gccgaggacg gcgaggcttg
     2221 cccgctgctt ggggtccgga ggaacagcat cctttgcctc cccatggact cagatgactc
     2281 gcctctctgt agcactccaa tgatgtcacc tgaccacctc caaggcgatg caagagagca
     2341 gctagaaagc ctgatgctct cggtgctgca gcatagcctg agcgcacagg ctcaggaggg
     2401 ctggccgagg cctgaggtgg tcctcaagga ctgcatgccc tctgaggagg agcagcggca
     2461 gtcagtgcag tcagaccagg gctacatctc cagaagctcc ccgcaacccc ccgactggct
     2521 cacagaggag gaagagctag aactgggtga gtccggtgag tctctctctc cggaggagct
     2581 gcggagcctg aggagtgtcc agcggcggct tttcttctgg gagcttgaga agaaccctgg
     2641 ctgggacagc agaggccagg agcagaagat cagcctcccc cctgggcctc ctaatcctgc
     2701 tacttaagag gatgtctgct gtactgtgcg tgtgggggaa gtgcccagct tggagatacg
     2761 ggcatctgcg tctgacatag tattgtatgc ctgaagtccc agcacttggg ggctgggact
     2821 tgatggtctc ctgaacacag gggttcaggg ccagcatgaa aacatagcaa ggtctcagag
     2881 aaataaatgc agacatcttg gttctggtcc ctaaacgctc ccctgtacct gatatggacg
     2941 gaacgtctgg tcatcattgc acaagagtcc acagcccgct cccagaacca acagccaagt
     3001 gtggcgctca ttccttgaac atttattctg tacctactag tcaggcattt ggaattcaaa
     3061 aacaagttac atgacacagt cttggccaca aagaagctta acattcagta aagatgtgaa
     3121 attagccaga atgaacagag ggcccctccc ctggccgcag aaggggggcg gggatcgggg
     3181 tctgggcagg aggggagctg cattcctggg ggagcagcct gcggcttggg tatcaaggag
     3241 ccagagtaag ctgtgtgcta gggtgggagc agctggggac tgctttcata agtggatctg
     3301 ctgccctgtg ggggagcaaa ctgtatgcca aagttcccca gaagtcttct cagatcggtt
     3361 ttttagaaag agtcagtata gaaacgggtg atgcaaactt aagaagcagg aagaggcgtg
     3421 tgaaatcctg tgctcaagtg ctggctgcca gtccgtggga gagctgaggc atgtgattct
     3481 tcgtgggctg cagccaccag atcccagcag cttgggagtc taagatccct cggctctacc
     3541 tcaggtacag tgatggagta aagaaaggtg gagaacatgg caggctctcc aaggtcagag
     3601 ggaagcatcg ctgtgtagct ccgtatgaga agccgcttta aggtagctcc tgggcgccct
     3661 cttggagcag acagcagcct tgcagcacag gttctggaga acgcacaggt ctgcatgccc
     3721 tggctaccca cttccaatcg tctcgactgc agtgagaaaa ggaccatgaa tgctgtggga
     3781 aacgagaatg cagtgactgt gtgtgctgta atgaagacgt aataaagtta ctgttttggt
     3841 aagaa
//
