LOCUS       NM_001015011            1290 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interleukin 17F (Il17f), mRNA.
ACCESSION   NM_001015011 XM_236987
VERSION     NM_001015011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Singh,M.V., Cicha,M.Z., Kumar,S., Meyerholz,D.K., Irani,K.,
            Chapleau,M.W. and Abboud,F.M.
  TITLE     Abnormal CD161+ immune cells and retinoic acid receptor-related
            orphan receptor gammat-mediate enhanced IL-17F expression in the
            setting of genetic hypertension
  JOURNAL   J Allergy Clin Immunol 140 (3), 809-821 (2017)
   PUBMED   28093217
  REMARK    GeneRIF: Increased RORgammat and IL-17F levels contribute to
            Spontaneously Hypertensive Rat hypertension and might be
            therapeutic targets
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   You,Q.H., Zhang,D., Niu,C.C., Zhu,Z.M., Wang,N., Yue,Y. and
            Sun,G.Y.
  TITLE     Expression of IL-17A and IL-17F in lipopolysaccharide-induced acute
            lung injury and the counteraction of anisodamine or
            methylprednisolone
  JOURNAL   Cytokine 66 (1), 78-86 (2014)
   PUBMED   24548428
  REMARK    GeneRIF: These data suggested that IL-17A and IL-17F maybe play an
            important role in lipopolysaccharide-induced acute lung injury via
            autocrine and paracrine mechanisms.
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Ho,A.W., Shen,F., Conti,H.R., Patel,N., Childs,E.E., Peterson,A.C.,
            Hernandez-Santos,N., Kolls,J.K., Kane,L.P., Ouyang,W. and
            Gaffen,S.L.
  TITLE     IL-17RC is required for immune signaling via an extended SEF/IL-17R
            signaling domain in the cytoplasmic tail
  JOURNAL   J Immunol 185 (2), 1063-1070 (2010)
   PUBMED   20554964
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   You,Q.H., Sun,G.Y., Wang,N., Shen,J.L. and Wang,Y.
  TITLE     Interleukin-17F-induced pulmonary microvascular endothelial
            monolayer hyperpermeability via the protein kinase C pathway
  JOURNAL   J Surg Res 162 (1), 110-121 (2010)
   PUBMED   19577259
  REMARK    GeneRIF: important mediator of increased endothelial permeability
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Yamaguchi,Y., Fujio,K., Shoda,H., Okamoto,A., Tsuno,N.H.,
            Takahashi,K. and Yamamoto,K.
  TITLE     IL-17B and IL-17C are associated with TNF-alpha production and
            contribute to the exacerbation of inflammatory arthritis
  JOURNAL   J Immunol 179 (10), 7128-7136 (2007)
   PUBMED   17982105
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Kuestner,R.E., Taft,D.W., Haran,A., Brandt,C.S., Brender,T.,
            Lum,K., Harder,B., Okada,S., Ostrander,C.D., Kreindler,J.L.,
            Aujla,S.J., Reardon,B., Moore,M., Shea,P., Schreckhise,R.,
            Bukowski,T.R., Presnell,S., Guerra-Lewis,P., Parrish-Novak,J.,
            Ellsworth,J.L., Jaspers,S., Lewis,K.E., Appleby,M., Kolls,J.K.,
            Rixon,M., West,J.W., Gao,Z. and Levin,S.D.
  TITLE     Identification of the IL-17 receptor related molecule IL-17RC as
            the receptor for IL-17F
  JOURNAL   J Immunol 179 (8), 5462-5473 (2007)
   PUBMED   17911633
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Liang,S.C., Tan,X.Y., Luxenberg,D.P., Karim,R.,
            Dunussi-Joannopoulos,K., Collins,M. and Fouser,L.A.
  TITLE     Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and
            cooperatively enhance expression of antimicrobial peptides
  JOURNAL   J Exp Med 203 (10), 2271-2279 (2006)
   PUBMED   16982811
REFERENCE   8  (bases 1 to 1290)
  AUTHORS   Toy,D., Kugler,D., Wolfson,M., Vanden Bos,T., Gurgel,J., Derry,J.,
            Tocker,J. and Peschon,J.
  TITLE     Cutting edge: interleukin 17 signals through a heteromeric receptor
            complex
  JOURNAL   J Immunol 177 (1), 36-39 (2006)
   PUBMED   16785495
REFERENCE   9  (bases 1 to 1290)
  AUTHORS   Starnes,T., Robertson,M.J., Sledge,G., Kelich,S., Nakshatri,H.,
            Broxmeyer,H.E. and Hromas,R.
  TITLE     Cutting edge: IL-17F, a novel cytokine selectively expressed in
            activated T cells and monocytes, regulates angiogenesis and
            endothelial cell cytokine production
  JOURNAL   J Immunol 167 (8), 4137-4140 (2001)
   PUBMED   11591732
REFERENCE   10 (bases 1 to 1290)
  AUTHORS   Hymowitz,S.G., Filvaroff,E.H., Yin,J.P., Lee,J., Cai,L., Risser,P.,
            Maruoka,M., Mao,W., Foster,J., Kelley,R.F., Pan,G., Gurney,A.L., de
            Vos,A.M. and Starovasnik,M.A.
  TITLE     IL-17s adopt a cystine knot fold: structure and activity of a novel
            cytokine, IL-17F, and implications for receptor binding
  JOURNAL   EMBO J 20 (19), 5332-5341 (2001)
   PUBMED   11574464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jun 23, 2015 this sequence version replaced NM_001015011.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091568.1, CV112574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN06680453,
                                           SAMN09345330 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                JAXUCZ010000009.1  30697854-30697918   c
            66-129              JAXUCZ010000009.1  30694023-30694086   c
            130-215             JAXUCZ010000009.1  30693598-30693683   c
            216-436             JAXUCZ010000009.1  30688744-30688964   c
            437-1290            JAXUCZ010000009.1  30686532-30687385   c
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1290
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /note="interleukin 17F"
                     /db_xref="GeneID:301291"
                     /db_xref="RGD:1311398"
     exon            1..65
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     exon            66..129
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     exon            130..215
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..674
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /codon_start=1
                     /product="interleukin-17F precursor"
                     /protein_id="NP_001015011.2"
                     /db_xref="GeneID:301291"
                     /db_xref="RGD:1311398"
                     /translation="MKGSCETTMVKSLLLLMLGFAIISSGAARRNPKVGLSALQKAGN
                     CPPLEDNSVRVDIRIFNQNQGISVPRDFQNRSSSPWDYNITRDPDRFPSEIAEAQCRH
                     SGCINAQGQEDGSMNSVPIQQEILVLRREPQGCSNSFRLEKMLIKVGCTCVTPIVHHA
                     A"
     exon            216..436
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
     exon            437..1290
                     /gene="Il17f"
                     /gene_synonym="IL-17F"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggatggag tagaagcagg aaaacaacag tccatttgga aagaaaaaga tcgggagccc
       61 agcagtgttg aaaaccaagt cttggcaagg gtgacttatc cccattggtt ggattctatt
      121 gcgtgacccg gagacctctc agaagaaagt acttcctgag cgaagaagca gccatcgggg
      181 aatccagcat gaagggctcc tgtgaaacaa ccatggtcaa gtctctgctg ctgttgatgt
      241 tgggatttgc catcatcagc tcgggagcag ctcggaggaa ccccaaagta gggctttctg
      301 ctctgcagaa agccgggaac tgccctcccc tggaggataa cagtgtgaga gttgacattc
      361 gcatcttcaa tcaaaaccag ggcatttctg tcccacgtga cttccagaac cgctccagtt
      421 ccccatggga ttacaatatc acccgagacc ccgaccggtt cccctcagag atcgctgagg
      481 cccagtgcag acactcaggc tgtatcaacg cccaggggca ggaagacggc tccatgaact
      541 ccgtccccat ccagcaagaa atcctggtcc ttcggaggga gccccagggc tgttctaatt
      601 ccttcaggtt ggagaagatg ctcataaaag ttggctgcac ttgcgtcacg cccatcgtcc
      661 accacgcggc ctgacaaagc cacataccga actcagctga agacgctgag gaaaagcctc
      721 ctttgatccc gcgctctgta tgaagcccgc atccccaagt ctttatgctt tctaggtctc
      781 tcagtaaggt gtgcacaaca tccttgaagc tccgtagtag atatagcctt aactttctgg
      841 tatgctttag aattgttaca aatcctggtt agaattgtta gaaatcctgg tgtcaatgct
      901 ttaaactcct gaaaatcaaa gtgaattaag gcacccttgc cccgtctctt tgcgttagat
      961 gatgaccaca tttcttctct gtcaatatag tcactttgat gcagtatcat tcttgtagag
     1021 ctcaatgaag tgctcatatt tctgatggga agaaaacaaa cagaccgtgt gggaggaggc
     1081 ctgtgtagca ggggccgggt tggcaaggac taagcaaaca tctggtatgt gtgtctttag
     1141 aaaaaaattt ggtatctata aatgaggttg gcataaacta ttacatattt atacttgtaa
     1201 gggaactata catatattta tgacctattg attatataaa aatttaatag aaaattaata
     1261 tatgtaataa agtattttta attcaaaaaa
//
