LOCUS       NM_001106897            1144 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus interleukin 17A (Il17a), mRNA.
ACCESSION   NM_001106897 XM_001070601 XM_236985
VERSION     NM_001106897.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Ni,J.S., Fu,S.Y., Wang,Z.Y., Ding,W.B., Huang,J., Guo,X.G. and
            Gu,F.M.
  TITLE     Interleukin-17A educated hepatic stellate cells promote
            hepatocellular carcinoma occurrence through fibroblast activation
            protein expression
  JOURNAL   J Gene Med 26 (6), e3693 (2024)
   PUBMED   38860366
  REMARK    GeneRIF: Interleukin-17A educated hepatic stellate cells promote
            hepatocellular carcinoma occurrence through fibroblast activation
            protein expression.
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Yu,Y., Weiss,R.M. and Wei,S.G.
  TITLE     Interleukin 17A Contributes to Blood-Brain Barrier Disruption of
            Hypothalamic Paraventricular Nucleus in Rats With Myocardial
            Infarction
  JOURNAL   J Am Heart Assoc 13 (3), e032533 (2024)
   PUBMED   38240234
  REMARK    GeneRIF: Interleukin 17A Contributes to Blood-Brain Barrier
            Disruption of Hypothalamic Paraventricular Nucleus in Rats With
            Myocardial Infarction.
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Wang,T., Zhang,S., Luo,M., Lu,M., Wei,L., Zhou,X., Wang,H. and
            Xu,D.
  TITLE     Prenatal caffeine exposure induces autism-like behaviors in
            offspring under a high-fat diet via the gut microbiota-IL-17A-brain
            axis
  JOURNAL   Ecotoxicol Environ Saf 269, 115797 (2024)
   PUBMED   38070418
  REMARK    GeneRIF: Prenatal caffeine exposure induces autism-like behaviors
            in offspring under a high-fat diet via the gut
            microbiota-IL-17A-brain axis.
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Mao,D., Jiang,H., Zhang,F., Yang,H., Fang,X., Zhang,Q. and Zhao,G.
  TITLE     HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway
  JOURNAL   Environ Toxicol 38 (7), 1743-1755 (2023)
   PUBMED   37021908
  REMARK    GeneRIF: HDAC2 exacerbates rheumatoid arthritis progression via the
            IL-17-CCL7 signaling pathway.
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Zhou,Y., Song,Z., Chen,S., Yao,F., Liu,J., Ouyang,Z. and Liao,Z.
  TITLE     Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain
            Induced by Tooth Movement
  JOURNAL   Biomed Res Int 2021, 4229491 (2021)
   PUBMED   34725639
  REMARK    GeneRIF: Mechanism of Catechol-O-methyltransferase Regulating
            Orofacial Pain Induced by Tooth Movement.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Lubberts,E., Koenders,M.I. and van den Berg,W.B.
  TITLE     The role of T-cell interleukin-17 in conducting destructive
            arthritis: lessons from animal models
  JOURNAL   Arthritis Res Ther 7 (1), 29-37 (2005)
   PUBMED   15642151
  REMARK    GeneRIF: Review. IL-17 is significant when T cells are a major
            element of the arthritis process. IL-17 can induce joint
            destruction in an IL-1-independent manner & can bypass
            TNF-dependent arthritis.
            Review article
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Ogawa,A., Andoh,A., Araki,Y., Bamba,T. and Fujiyama,Y.
  TITLE     Neutralization of interleukin-17 aggravates dextran sulfate
            sodium-induced colitis in mice
  JOURNAL   Clin Immunol 110 (1), 55-62 (2004)
   PUBMED   14962796
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Barczyk,A., Pierzchala,W. and Sozanska,E.
  TITLE     Interleukin-17 in sputum correlates with airway hyperresponsiveness
            to methacholine
  JOURNAL   Respir Med 97 (6), 726-733 (2003)
   PUBMED   12814161
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Pelidou,S.H., Zou,L.P., Deretzi,G., Oniding,C., Mix,E. and Zhu,J.
  TITLE     Enhancement of acute phase and inhibition of chronic phase of
            experimental autoimmune neuritis in Lewis rats by intranasal
            administration of recombinant mouse interleukin 17: potential
            immunoregulatory role
  JOURNAL   Exp Neurol 163 (1), 165-172 (2000)
   PUBMED   10785455
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Rouvier,E., Luciani,M.F., Mattei,M.G., Denizot,F. and Golstein,P.
  TITLE     CTLA-8, cloned from an activated T cell, bearing AU-rich messenger
            RNA instability sequences, and homologous to a herpesvirus saimiri
            gene
  JOURNAL   J Immunol 150 (12), 5445-5456 (1993)
   PUBMED   8390535
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236985.2, XM_001070601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663594,
                              SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1144
                     /gene="Il17a"
                     /gene_synonym="CTLA-8; IL-17; IL-17A; Il17"
                     /note="interleukin 17A"
                     /db_xref="GeneID:301289"
                     /db_xref="RGD:2888"
     exon            1..85
                     /gene="Il17a"
                     /gene_synonym="CTLA-8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..535
                     /gene="Il17a"
                     /gene_synonym="CTLA-8; IL-17; IL-17A; Il17"
                     /note="cytotoxic T-lymphocyte-associated antigen 8;
                     Interleukin 17 (cytotoxic T-lymphocyte-associated serine
                     esterase 8)"
                     /codon_start=1
                     /product="interleukin-17A precursor"
                     /protein_id="NP_001100367.1"
                     /db_xref="GeneID:301289"
                     /db_xref="RGD:2888"
                     /translation="MSPRRIPSMCLMLLLLLNLEATVKAAVLIPQSSVCPNAEANNFL
                     QNVKVNLKVLNSLSSKASSRRPSDYLNRSTSPWTLSRNEDPDRYPSVIWEAQCRHQRC
                     VNAEGKLDHHMNSVLIQQEILVLKREPEKCPFTFRVEKMLVGVGCTCVSSIVRHAS"
     exon            86..297
                     /gene="Il17a"
                     /gene_synonym="CTLA-8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
     exon            298..1144
                     /gene="Il17a"
                     /gene_synonym="CTLA-8; IL-17; IL-17A; Il17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catccacctc acacgaggca caagctcatc ccgtaccagc tgatcaggac gagcgaccat
       61 gagtccccgg agaattccat ccatgtgcct gatgctgttg ctgctactga acctggaggc
      121 tacagtgaag gcagcggtac tcatccctca aagttcagtg tgtccaaacg ccgaggccaa
      181 taactttctc cagaacgtga aggtcaacct gaaagtcctc aactccctta gctcaaaagc
      241 gagctccaga aggccctcag actacctcaa ccgttccact tcaccctgga ctctgagccg
      301 caatgaggac cctgatagat atccttctgt gatctgggag gcacagtgcc gccaccagcg
      361 ctgtgtcaac gctgagggga agttggacca ccacatgaat tctgttctca tccagcaaga
      421 gatcctggtc ctgaagaggg agcctgagaa gtgccccttc actttccggg tggagaagat
      481 gctggtgggc gtgggctgca cctgcgtttc ctctattgtc cgccatgcgt cctaaacaga
      541 gacctgaggc tagcccctaa gaaacccctg cgtttctctg caaacttcct tgtcttttta
      601 aaacagttca cagttgaatc tcagcaagtg atatggattt aaaggcgggg ttagaattgt
      661 ctgccttcca ccctgaaaag aaggcgcaga ggggatacaa attgcttctt gtttttctgt
      721 gggctttaaa ttatttatgt atttactcta tcccgagata actttgaggc ataagttatt
      781 ttaatgaatt atctacatta ttattatgtt tcttaatgca gaagacaaaa ttcaagacta
      841 agaaatttta ttatttaaaa ggtaaaacct atatttatat gagctattta tgggtctatt
      901 tatttttctt aagtgctaag atcatgatta tcagatctac ctaaggaagt cctaaataat
      961 attaaatatt aattgaaatt tcagttttac tatttgctta tttaaggttc cctcctctga
     1021 atggtgtgaa agtcaaacct cgttttatgt ttttaaatta ttgaggcttc gaaaaattgg
     1081 gcaatttagc ttcctactgt gtgtttaaaa accttgtaac aatatcacta taataaattt
     1141 ttgg
//
