LOCUS       NM_001105749            4985 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Rattus norvegicus interleukin 16 (Il16), mRNA.
ACCESSION   NM_001105749 XM_001062801 XM_001062855 XM_001062920 XM_218851
VERSION     NM_001105749.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4985)
  AUTHORS   Luo,Z., Han,Q., Lu,J., Ouyang,X., Fan,Y., Liu,Y., Zhou,X., Kong,J.,
            Liu,H., Liu,A. and Chen,D.
  TITLE     IL16 Regulates Osteoarthritis Progression as a Target Gene of
            Novel-miR-81
  JOURNAL   Cartilage 15 (2), 175-183 (2024)
   PUBMED   37086007
  REMARK    GeneRIF: IL16 Regulates Osteoarthritis Progression as a Target Gene
            of Novel-miR-81.
REFERENCE   2  (bases 1 to 4985)
  AUTHORS   Huang,Y., Du,K.L., Guo,P.Y., Zhao,R.M., Wang,B., Zhao,X.L. and
            Zhang,C.Q.
  TITLE     IL-16 regulates macrophage polarization as a target gene of
            mir-145-3p
  JOURNAL   Mol Immunol 107, 1-9 (2019)
   PUBMED   30634164
REFERENCE   3  (bases 1 to 4985)
  AUTHORS   Kang,B.W., Jeon,H.S., Chae,Y.S., Lee,S.J., Park,J.S., Choi,G.S. and
            Kim,J.G.
  TITLE     Impact of Genetic Variation in MicroRNA-binding Site on
            Susceptibility to Colorectal Cancer
  JOURNAL   Anticancer Res 36 (7), 3353-3361 (2016)
   PUBMED   27354594
REFERENCE   4  (bases 1 to 4985)
  AUTHORS   Landi,A., Broadhurst,D., Vernon,S.D., Tyrrell,D.L. and Houghton,M.
  TITLE     Reductions in circulating levels of IL-16, IL-7 and VEGF-A in
            myalgic encephalomyelitis/chronic fatigue syndrome
  JOURNAL   Cytokine 78, 27-36 (2016)
   PUBMED   26615570
REFERENCE   5  (bases 1 to 4985)
  AUTHORS   Park,S.L., Hwang,B., Lee,S.Y., Kim,W.T., Choi,Y.H., Chang,Y.C.,
            Kim,W.J. and Moon,S.K.
  TITLE     p21WAF1 Is Required for Interleukin-16-Induced Migration and
            Invasion of Vascular Smooth Muscle Cells via the p38MAPK/Sp-1/MMP-9
            Pathway
  JOURNAL   PLoS One 10 (11), e0142153 (2015)
   PUBMED   26544695
  REMARK    GeneRIF: p21WAF1 was required for the induction of p38MAPK-mediated
            MMP-9 expression via activation of the Sp-1 binding motif, which
            led to migration and invasion of vascular smooth muscle cells
            interacting with IL-16/CD4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4985)
  AUTHORS   Zhang,X., Wang,L. and Shi,Q.
  TITLE     [Effect of fluticasone inhalation combined with xiaoqinglong
            decoction on pulmonary function and serum interleukin-16 level in
            asthma patients]
  JOURNAL   Zhongguo Zhong Xi Yi Jie He Za Zhi 23 (6), 426-429 (2003)
   PUBMED   12872394
REFERENCE   7  (bases 1 to 4985)
  AUTHORS   de Bie,J.J., Henricks,P.A., Cruikshank,W.W., Hofman,G.,
            Nijkamp,F.P. and van Oosterhout,A.J.
  TITLE     Effect of interleukin-16-blocking peptide on parameters of allergic
            asthma in a murine model
  JOURNAL   Eur J Pharmacol 383 (2), 189-196 (1999)
   PUBMED   10585533
REFERENCE   8  (bases 1 to 4985)
  AUTHORS   Keane,J., Nicoll,J., Kim,S., Wu,D.M., Cruikshank,W.W., Brazer,W.,
            Natke,B., Zhang,Y., Center,D.M. and Kornfeld,H.
  TITLE     Conservation of structure and function between human and murine
            IL-16
  JOURNAL   J Immunol 160 (12), 5945-5954 (1998)
   PUBMED   9637508
REFERENCE   9  (bases 1 to 4985)
  AUTHORS   Hayes,B.B., Gerber,P.C., Griffey,S.S. and Meade,B.J.
  TITLE     Contact hypersensitivity to dicyclohexylcarbodiimide and
            diisopropylcarbodiimide in female B6C3F1 mice
  JOURNAL   Drug Chem Toxicol 21 (2), 195-206 (1998)
   PUBMED   9598300
REFERENCE   10 (bases 1 to 4985)
  AUTHORS   Pravenec,M., Gauguier,D., Schott,J.J., Buard,J., Kren,V., Bila,V.,
            Szpirer,C., Szpirer,J., Wang,J.M., Huang,H. et al.
  TITLE     Mapping of quantitative trait loci for blood pressure and cardiac
            mass in the rat by genome scanning of recombinant inbred strains
  JOURNAL   J Clin Invest 96 (4), 1973-1978 (1995)
   PUBMED   7560090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473980.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_218851.4, XM_001062920.1, XM_001062855.1, XM_001062801.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132293, SAMEA5756307
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..4985
                     /gene="Il16"
                     /note="interleukin 16"
                     /db_xref="GeneID:116996"
                     /db_xref="RGD:1583872"
     exon            1..93
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            94..506
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..4166
                     /gene="Il16"
                     /codon_start=1
                     /product="pro-interleukin-16"
                     /protein_id="NP_001099219.1"
                     /db_xref="GeneID:116996"
                     /db_xref="RGD:1583872"
                     /translation="MEPHSHSGKSRKSTKFRSISRSLILCNAKTSDDSSSPDEKYPDP
                     FETSLCQDKEGFFHSSMQLADTSEAGLSNIPDLALASEAAQLQAAGSDRGKHCRKMFF
                     LKESSTTSSKEKAGKSEAQSSNFLFPKACHQRTRSNSTSVNPYSAREMDFPMTKKSAA
                     PTDRQPYSLCSNRKSLSQQLDYPVSGTARPTRSLSTAQLGQLSGGLQASVISNIVLMK
                     GQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESIAGLT
                     HQDALQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLE
                     SPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGVFIHTLSPGSVAHL
                     DGRLRCGDEIVEINDSPVHCMTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEA
                     VAQAVEGVKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSS
                     SDSSYMSGSPGGSPCSAGAELQPSEGEGSTHSPSLPPGEEQEPCPGVPSRPHQESPPL
                     SESLERDSHPPLKLKNSFEILVRKPTSTKPKPPPRKYFKNDSEPQKKLEEKEKVTDPS
                     GHTLPTCSQETRELLPLLLQEDTAGRTLCTAACCPGPAASTQTSSSTEGEPRRSASPE
                     TPASPGKHPLLKRQARMDYSFDSTTEDPWVRISDCIKNLFSPIMSENHSHMPLQPNAS
                     LGEEDGTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKGPPVAPKPAWFRQSLKGLRN
                     RVPETRRAPEVASAIQTTPVSRDASGPQSQASSSSIRQRISSFENFGSSQLPDRGVQR
                     LSLQPTSGETTRLPGKQDEGRFSGLPAQGTKVTAKHRQTEVEPPSTTFPNSSEVGDPD
                     MSESPPPGQRPNPKALSPDPLLRLLTTQTEDTQGPGFKMPSQRARSFPLTRTQSYETK
                     LLDEKSSKLYSISSQLSSAVMKSLLCLPSSASCGQITCIPKERVSPKSPCNNSAAAEG
                     FGEAVASDTGFSLNLSELREYSEGLTEPGETEDRNHCSSQAGQSVISLLSAEELKKLI
                     EEVRVLDEATLKQLDSIHVTVLHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQ
                     EGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQAVIVTRKAIVEAAHDLNSST
                     DSAASASVASGISVESVEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKG
                     TEQGDAVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTVVIRRNGLEGKQTTAS
                     ADL"
     exon            507..615
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            616..749
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            750..860
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            861..975
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1049
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1266
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1384
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1517
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1605
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..2093
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2238
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..3325
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3494
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3596
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3855
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            3856..3978
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4985
                     /gene="Il16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcagcgc agactactgt gtgctctggt ctctgcaatt gcagaaagca gcaaaggcag
       61 tgacatctcg aagggctgta ccaggagggt cagggaccca tgcagcagca gctaagccta
      121 gttcatctac cactcaccgg ccaaggcctg gagaacagga gaggaagaag cgtggcctca
      181 cttcctctct gaggatggag ccccacagcc actctggaaa gagccggaaa tccacgaaat
      241 ttcgctccat ttcccgttcc ctgatcctct gtaacgccaa gaccagtgat gacagctcca
      301 gccctgatga gaagtacccc gacccttttg agacttcact gtgccaggac aaggagggct
      361 tctttcactc ctccatgcag ctggcagaca catctgaggc tgggctcagc aacataccag
      421 acctggcact ggcctcagag gctgctcaac tccaagcagc tgggagcgat cggggcaagc
      481 actgcaggaa gatgttcttc ctgaaggaat cttctacaac ttcctctaaa gaaaaggctg
      541 gaaaatcaga agcacaaagt agcaacttcc tgtttcctaa agcctgccac caaaggacac
      601 gcagcaactc caccagtgtt aatccctaca gtgccagaga aatggatttt ccaatgacca
      661 agaaatctgc agctcccacc gacaggcagc cctactctct ctgtagcaac aggaagtccc
      721 tctctcaaca actggactac ccagtttcgg gcactgcaag accaactcgg tcactgagca
      781 cagctcagct cgggcagctg tctgggggtc tgcaggcgtc agtcatttcc aacatagtgc
      841 tgatgaaggg ccaggcaaag ggcctgggct tcagcattgt tgggggaaag gacagtattt
      901 acggccctat tgggatttac gtgaagagca tctttgcagg gggagcagct gcagccgacg
      961 ggcggcttca ggaaggtgat gaaattctgg aactcaatgg tgaatcaata gctggcctaa
     1021 cacaccagga tgctttgcag aagtttaagc aagccaagaa gggactgctg accctgacag
     1081 tgaggacgcg cctgacaaca cccccttcac tatgcagcca cctgtctccc ccgctgtgcc
     1141 gctccctgag ctccagcacg tgcggtgccc aggacagcag ccccttctcc ttggaaagcc
     1201 cagcgtctcc tgccagcact gccaaaccca actacagaat catggtggag gtgtcactga
     1261 agaaagaggc aggtgttggc ctgggcattg gcctgtgcag catcccctac ttccagtgca
     1321 tttcgggcgt cttcattcac acgctgtcac caggatccgt ggcgcatctc gatggacggc
     1381 tgaggtgtgg tgatgagatt gtggaaatca atgattctcc agtgcactgc atgaccctca
     1441 atgaagtcta cacaatcctg agccactgtg accctggccc agttcccatc atcgttagcc
     1501 gacatccgga cccacaggtg tctgaacaac aactcaagga agctgtggct caggcagtgg
     1561 aaggcgtcaa gtttgggaag gaaaggcacc agtggagctt ggaaggtgtc aaaaggctgg
     1621 agagcagttg gcatgggcgg cccaccttgg agaaagaacg tgagaagcac tcagcgcccc
     1681 cgcatcgaag ggcccagaag atcatggtcc gatccagcag tgacagcagc tacatgtctg
     1741 ggtcaccagg gggaagtccc tgcagtgcag gtgcggagct acagccttct gagggggaag
     1801 gcagcacaca cagccccagc ctgcccccag gggaggagca agagccgtgt ccaggggtcc
     1861 catccaggcc acatcaggag agcccacccc tttctgagag cttggaaaga gacagccacc
     1921 caccactgaa actgaagaac tcttttgaga ttttggtgag aaagccgaca tccaccaaac
     1981 ccaagcctcc acccagaaaa tactttaaaa atgacagcga gcctcagaag aaactggagg
     2041 agaaagagaa ggtcacagac ccttctgggc acaccttgcc cacctgcagc caggaaacca
     2101 gagagctgct gccactgctg ctacaggaag acactgcagg gagaaccctc tgcaccgctg
     2161 cttgctgccc aggacctgca gccagcacgc agacttcatc ctccacagaa ggagagccaa
     2221 ggaggagtgc cagcccagag actccagcat ccccaggaaa acacccgctg ctgaagaggc
     2281 aggcgcggat ggactatagc tttgacagca ccactgaaga cccttgggtt agaatttccg
     2341 actgcatcaa aaacctattt agccctatca tgagtgagaa ccatagccat atgccactac
     2401 agcccaatgc cagccttggt gaagaggacg ggacacaggg ccacccagag gggggcctgt
     2461 caaaaatgga cactgccaat ggtgctccca ggattttcaa gtcagcagat ggcagcactg
     2521 tgaagaaggg acccccagta gccccaaagc cagcctggtt tcggcagagc ttgaaaggtc
     2581 tgaggaatcg tgttccagaa accagaagag ccccggaagt agcttcagcc attcagacaa
     2641 caccagtttc tagggatgcc tcagggccac agtctcaggc ctcctcctcc tccatccggc
     2701 agagaatcag ctcctttgaa aactttggct cctcacaatt gccagataga ggagtccaga
     2761 gactgagcct gcagcccacc tctggggaga ctaccagact tccaggaaag caagatgaag
     2821 gacggttttc tggtctcccg gctcaaggga ctaaagtaac tgctaaacac aggcagacag
     2881 aggtagagcc tccatctaca accttcccta actcctcaga ggtcggggac ccagatatgt
     2941 ctgagtctcc tcccccaggt cagcgaccca acccgaaagc tttgtctcca gaccctctct
     3001 tgagactgtt gactacacaa actgaggata ctcaaggacc aggtttcaag atgccaagtc
     3061 agcgggcacg gagcttcccc ctgaccagga cccagtccta cgagacaaag ctgctggatg
     3121 aaaagtccag caagctctac tccattagca gtcagctatc ctctgctgtc atgaaatccc
     3181 tgctgtgcct tccatcttca gcctcttgtg gccagatcac gtgcatcccc aaggagaggg
     3241 tgtctccaaa gtcaccctgc aacaacagcg cagctgcaga gggttttggt gaagctgtgg
     3301 cctccgacac agggttttct ctcaaccttt cagagctgag agaatattca gaaggtctca
     3361 cagaacccgg ggaaaccgag gacaggaacc actgttcttc tcaggccggt cagtcagtta
     3421 tctccttgct gagtgcagaa gaactgaaaa aactcattga ggaagtgaga gttctagacg
     3481 aggcgacact gaagcaatta gacagcattc acgtcaccgt cttacacaag gaagaaggtg
     3541 ctgggcttgg attcagcttg gcaggagggg cagatctaga aaacaaggtg atcacggttc
     3601 acagagtgtt tccaaatgga ctggcttccc aggaaggcac gattcagaaa ggcaatgagg
     3661 ttctttccat caatggcaaa tctctcaagg gcgctaccca caatgatgcc ctagctatcc
     3721 ttcgccaagc tcgggaccca aggcaagctg tgattgtcac caggaaagca attgtggagg
     3781 ccgctcatga cctgaactcc tctactgact ctgcagcatc agcttcagta gccagtggca
     3841 tttctgtaga atctgtggag gccactgtct gcacagtgac tctggagaag acctctgcag
     3901 ggctgggctt cagcctggaa ggaggaaagg gctccctgca tggtgacaag cctcttacca
     3961 taaacaggat tttcaaagga acagaacaag gtgatgcggt ccagccaggg gatgagatct
     4021 tgcagctcgc tggcactgct gtgcaaggtc ttacacggtt tgaagcctgg aatgtcatca
     4081 aggcattacc tgatggacct gtcactgtag tcatcagaag gaacggcctc gagggcaagc
     4141 agacgacagc ttctgcagac ttgtagacag ggtgccaatg ctaagacaaa gcgggagcac
     4201 caagctccag taattgctga ttctcagggt ctctgctgcc cacctcaccc aggctgggga
     4261 aagcccaggt gcgcttctgg tagttgctgc tcaggtttgg accttcgggc acactgccca
     4321 tcaagagtgt tgttccaaat atcaggagtc acacagaagt ggctgataca aacctttgac
     4381 tgtacagaga cagcttagtg ataatattct ggtgccgtaa taaagtggtt gtactgcagc
     4441 tttccatgaa ccaaatggcc tggtttgaaa aatcaccttg ggattatgaa agccaccccg
     4501 tggaaacatc ttttcttctc tcatgaacct catgtctcag aggggagctc ctcagaagtc
     4561 aaggctgggc tgggatccta tgaagggtca cttcttgtgc ctctccccag aggtgctggg
     4621 tgatgaccgg gaaagtctcc tcacgactgg tgcttctgca ccatggtgat actgtaccat
     4681 gctgcccggg cacaccacag ccagatgggg gtgcatcttt tgaatgtcct gcttttgaag
     4741 actcataaca ttgcttctgc tgtacgcctg ccgagagcag gcaaaaacct gcctaggttt
     4801 aaggaaaggg gatatctgtg agatgcagaa catcttcaaa cacttacaag actggctttg
     4861 gttgggttga gatcctagga gtggaaccag aagacagagg agtgcaacgc gagttaaggt
     4921 gtggacagga tacatctaca ggacaaacca gcatgggtac cagcataaaa taaattacta
     4981 atgtc
//
