LOCUS       NM_013129               1389 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus interleukin 15 (Il15), transcript variant 1,
            mRNA.
ACCESSION   NM_013129 XM_039097516
VERSION     NM_013129.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1389)
  AUTHORS   Minuzzi,L.G., da Conceicao,L.R., Munoz,V.R., Vieira,R.F.L.,
            Gaspar,R.C., da Silva,A.S.R., Cintra,D.E., Pereira de Moura,L.,
            Ropelle,E.R., Teixeira,A.M. and Pauli,J.R.
  TITLE     Effects of short-term physical training on the interleukin-15
            signalling pathway and glucose tolerance in aged rats
  JOURNAL   Cytokine 137, 155306 (2021)
   PUBMED   33010727
  REMARK    GeneRIF: Effects of short-term physical training on the
            interleukin-15 signalling pathway and glucose tolerance in aged
            rats.
REFERENCE   2  (bases 1 to 1389)
  AUTHORS   Akieda-Asai,S., Ida,T., Miyazato,M., Kangawa,K. and Date,Y.
  TITLE     Interleukin-15 derived from Guanylin-GC-C-expressing macrophages
            inhibits fatty acid synthase in adipocytes
  JOURNAL   Peptides 99, 14-19 (2018)
   PUBMED   29097254
  REMARK    GeneRIF: These results support the hypothesis that IL-15 secreted
            from Gn-GC-C-expressing macrophages contributes to the inhibition
            of fatty acid synthase and lipid accumulation in adipocytes,
            leading to obesity resistance
REFERENCE   3  (bases 1 to 1389)
  AUTHORS   Renaud,S.J., Scott,R.L., Chakraborty,D., Rumi,M.A. and Soares,M.J.
  TITLE     Natural killer-cell deficiency alters placental development in rats
  JOURNAL   Biol Reprod 96 (1), 145-158 (2017)
   PUBMED   28395334
REFERENCE   4  (bases 1 to 1389)
  AUTHORS   Qaisar,N., Lin,S., Ryan,G., Yang,C., Oikemus,S.R., Brodsky,M.H.,
            Bortell,R., Mordes,J.P. and Wang,J.P.
  TITLE     A Critical Role for the Type I Interferon Receptor in Virus-Induced
            Autoimmune Diabetes in Rats
  JOURNAL   Diabetes 66 (1), 145-157 (2017)
   PUBMED   27999109
REFERENCE   5  (bases 1 to 1389)
  AUTHORS   Lacraz,G., Rakotoarivelo,V., Labbe,S.M., Vernier,M., Noll,C.,
            Mayhue,M., Stankova,J., Schwertani,A., Grenier,G., Carpentier,A.,
            Richard,D., Ferbeyre,G., Fradette,J., Rola-Pleszczynski,M.,
            Menendez,A., Langlois,M.F., Ilangumaran,S. and Ramanathan,S.
  TITLE     Deficiency of Interleukin-15 Confers Resistance to Obesity by
            Diminishing Inflammation and Enhancing the Thermogenic Function of
            Adipose Tissues
  JOURNAL   PLoS One 11 (9), e0162995 (2016)
   PUBMED   27684068
  REMARK    Erratum:[PLoS One. 2016 Nov 8;11(11):e0166537. doi:
            10.1371/journal.pone.0166537.. PMID: 27824945]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1389)
  AUTHORS   Ishimitsu,R., Nishimura,H., Yajima,T., Watase,T., Kawauchi,H. and
            Yoshikai,Y.
  TITLE     Overexpression of IL-15 in vivo enhances Tc1 response, which
            inhibits allergic inflammation in a murine model of asthma
  JOURNAL   J Immunol 166 (3), 1991-2001 (2001)
   PUBMED   11160248
REFERENCE   7  (bases 1 to 1389)
  AUTHORS   Kimura,K., Nishimura,H., Matsuzaki,T., Yokokura,T., Nimura,Y. and
            Yoshikai,Y.
  TITLE     Synergistic effect of interleukin-15 and interleukin-12 on
            antitumor activity in a murine malignant pleurisy model
  JOURNAL   Cancer Immunol Immunother 49 (2), 71-77 (2000)
   PUBMED   10823416
REFERENCE   8  (bases 1 to 1389)
  AUTHORS   Kennedy,M.K., Glaccum,M., Brown,S.N., Butz,E.A., Viney,J.L.,
            Embers,M., Matsuki,N., Charrier,K., Sedger,L., Willis,C.R.,
            Brasel,K., Morrissey,P.J., Stocking,K., Schuh,J.C., Joyce,S. and
            Peschon,J.J.
  TITLE     Reversible defects in natural killer and memory CD8 T cell lineages
            in interleukin 15-deficient mice
  JOURNAL   J Exp Med 191 (5), 771-780 (2000)
   PUBMED   10704459
REFERENCE   9  (bases 1 to 1389)
  AUTHORS   Hirose,K., Suzuki,H., Nishimura,H., Mitani,A., Washizu,J.,
            Matsuguchi,T. and Yoshikai,Y.
  TITLE     Interleukin-15 may be responsible for early activation of
            intestinal intraepithelial lymphocytes after oral infection with
            Listeria monocytogenes in rats
  JOURNAL   Infect Immun 66 (12), 5677-5683 (1998)
   PUBMED   9826341
REFERENCE   10 (bases 1 to 1389)
  AUTHORS   Reinecker,H.C., MacDermott,R.P., Mirau,S., Dignass,A. and
            Podolsky,D.K.
  TITLE     Intestinal epithelial cells both express and respond to interleukin
            15
  JOURNAL   Gastroenterology 111 (6), 1706-1713 (1996)
   PUBMED   8942753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Feb 3, 2022 this sequence version replaced
            XM_039097516.1, NM_013129.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               JAXUCZ010000019.1  42544706-42544951
            247-368             JAXUCZ010000019.1  42568992-42569113
            369-539             JAXUCZ010000019.1  42573502-42573672
            540-638             JAXUCZ010000019.1  42599274-42599372
            639-736             JAXUCZ010000019.1  42600481-42600578
            737-821             JAXUCZ010000019.1  42601069-42601153
            822-866             JAXUCZ010000019.1  42605874-42605918
            867-1004            JAXUCZ010000019.1  42608202-42608339
            1005-1389           JAXUCZ010000019.1  42610956-42611340
FEATURES             Location/Qualifiers
     source          1..1389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..1389
                     /gene="Il15"
                     /note="interleukin 15"
                     /db_xref="GeneID:25670"
                     /db_xref="RGD:2887"
     exon            1..246
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            247..368
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            369..539
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            540..638
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..1115
                     /gene="Il15"
                     /note="IL-15"
                     /codon_start=1
                     /product="interleukin-15 preproprotein"
                     /protein_id="NP_037261.1"
                     /db_xref="GeneID:25670"
                     /db_xref="RGD:2887"
                     /translation="MKILKPYMRNTSILYYLCFLLNSHFLTEAGIHVFILGCVSVGLP
                     KTEANWIDVRYDLEKIESLIQFIHIDTTLYTDSDFHPSCKVTAMNCFLLELQVILHEY
                     SNMTLNETVRNVLYLANSTLSSNKNVIESGCKECEELEERNFTEFLQSFIHIVQMFIN
                     TS"
     exon            639..736
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            737..821
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            822..866
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1004
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1389
                     /gene="Il15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcagatct ctgggcttct cagggaaagt caaactgcct ctctgcaagg ccagttgctg
       61 tagatgcaag caacctgtga actcaggcca actccttgtg agacttcaca gaaggcaaag
      121 gcgttccagg acacacagca gctgcggcca actgcccagg gggtggagac tgctctcggg
      181 ctctcagttg cccttcaggt tctgcaccct ggggacctgg cagtggcaga atcatgtggg
      241 catctgaatc cactttgaca tatggccctc tggctcttca aagcagtgtt tgttcatggt
      301 ccatgctggc gaggtcctta agaacacaga agtccatgtc agcagataac cagcctaccg
      361 gaggccaaaa gggtgtggag gaaacctact gctaacagtg aaccactgtc aactgagtat
      421 tccgagaggc agcatcccct gctgactgag aaattgatcc aagcattaac acctgctgga
      481 agaagcagag aaggttgtgc atggtctggg aatcccagag ttcatctaca aacaaagagg
      541 aggcgttctg gatggatggc agctggaagc ccttcgccat agcccgctct tcttcaacac
      601 ttaagcattt acctgggcat taagtaatga aaattttgaa accatatatg aggaatacat
      661 ccatcttgta ctacctgtgt ttccttctca acagtcactt cttaactgag gctggcatcc
      721 atgtcttcat tttgggctgt gtcagtgtag gtctccctaa aacagaggcc aactggatag
      781 atgtaagata cgatctggag aaaattgaaa gtcttattca atttattcat attgatacta
      841 ctctatacac tgacagtgac tttcatccca gttgcaaagt tactgcaatg aactgctttc
      901 tcctggaatt acaggttatt ttgcacgagt acagtaacat gactcttaat gaaacagtaa
      961 gaaacgtgct ctaccttgca aacagcactc tgtcttctaa caagaatgta atagagtctg
     1021 gctgcaagga atgtgaggag ctggaggaga gaaacttcac ggagtttttg cagagtttta
     1081 tacatattgt ccaaatgttc atcaacacgt cctgactgca ctcgaacctc gtcagtgttt
     1141 ctgttattaa gacacctccg cctgctgccc agaggcagca cagctccatg cattcgtgat
     1201 ctgctgggaa accaagctgc ctaacaggaa acggttgagc catttggatc ccatgaaccc
     1261 tcgggaatga agagagggaa agggcttttc tcggacttat ttttgcttgc ttatttttaa
     1321 tttattactt cagttgtgca tatttgtaat ataacagaag atgtggaata aagttgtatg
     1381 catatttta
//
