LOCUS       NM_145789               3688 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus interleukin 13 receptor subunit alpha 1
            (Il13ra1), mRNA.
ACCESSION   NM_145789
VERSION     NM_145789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Broen,J.C., Dieude,P., Vonk,M.C., Beretta,L., Carmona,F.D.,
            Herrick,A., Worthington,J., Hunzelmann,N., Riemekasten,G.,
            Kiener,H., Scorza,R., Simeon,C.P., Fonollosa,V., Carreira,P.,
            Ortego-Centeno,N., Gonzalez-Gay,M.A., Airo',P., Coenen,M.J.,
            Tsang,K., Aliprantis,A.O., Martin,J., Allanore,Y. and Radstake,T.R.
  CONSRTM   Spanish Systemic Sclerosis Group
  TITLE     Polymorphisms in the interleukin 4, interleukin 13, and
            corresponding receptor genes are not associated with systemic
            sclerosis and do not influence gene expression
  JOURNAL   J Rheumatol 39 (1), 112-118 (2012)
   PUBMED   22045834
REFERENCE   2  (bases 1 to 3688)
  AUTHORS   Graham,B.B., Mentink-Kane,M.M., El-Haddad,H., Purnell,S., Zhang,L.,
            Zaiman,A., Redente,E.F., Riches,D.W., Hassoun,P.M., Bandeira,A.,
            Champion,H.C., Butrous,G., Wynn,T.A. and Tuder,R.M.
  TITLE     Schistosomiasis-induced experimental pulmonary hypertension: role
            of interleukin-13 signaling
  JOURNAL   Am J Pathol 177 (3), 1549-1561 (2010)
   PUBMED   20671265
REFERENCE   3  (bases 1 to 3688)
  AUTHORS   Pendergrass,S.A., Hayes,E., Farina,G., Lemaire,R., Farber,H.W.,
            Whitfield,M.L. and Lafyatis,R.
  TITLE     Limited systemic sclerosis patients with pulmonary arterial
            hypertension show biomarkers of inflammation and vascular injury
  JOURNAL   PLoS One 5 (8), e12106 (2010)
   PUBMED   20808962
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3688)
  AUTHORS   Beghe,B., Hall,I.P., Parker,S.G., Moffatt,M.F., Wardlaw,A.,
            Connolly,M.J., Fabbri,L.M., Ruse,C. and Sayers,I.
  TITLE     Polymorphisms in IL13 pathway genes in asthma and chronic
            obstructive pulmonary disease
  JOURNAL   Allergy 65 (4), 474-481 (2010)
   PUBMED   19796199
REFERENCE   5  (bases 1 to 3688)
  AUTHORS   Chiba,Y., Onoda,S., Todoroki,M., Nishida,Y. and Misawa,M.
  TITLE     Upregulation of interleukin-13 receptor chains in bronchial smooth
            muscle tissues of mouse experimental asthma
  JOURNAL   J Smooth Muscle Res 46 (1), 49-55 (2010)
   PUBMED   20383033
REFERENCE   6  (bases 1 to 3688)
  AUTHORS   Kim,H.B., Lee,Y.C., Lee,S.Y., Jung,J., Jin,H.S., Kim,J.H.,
            Kim,B.S., Kang,M.J., Jang,S.O., Kim,J., Kimm,K., Shin,E.S.,
            Lee,S.G. and Hong,S.J.
  TITLE     Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated
            with total IgE in Korean children with atopic asthma
  JOURNAL   J Hum Genet 51 (12), 1055-1062 (2006)
   PUBMED   17006604
REFERENCE   7  (bases 1 to 3688)
  AUTHORS   Wongpiyabovorn,J., Suto,H., Ushio,H., Izuhara,K., Mitsuishi,K.,
            Ikeda,S., Nakao,A., Okumura,K. and Ogawa,H.
  TITLE     Up-regulation of interleukin-13 receptor alpha1 on human
            keratinocytes in the skin of psoriasis and atopic dermatitis
  JOURNAL   J Dermatol Sci 33 (1), 31-40 (2003)
   PUBMED   14527737
REFERENCE   8  (bases 1 to 3688)
  AUTHORS   Blease,K., Jakubzick,C., Schuh,J.M., Joshi,B.H., Puri,R.K. and
            Hogaboam,C.M.
  TITLE     IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic
            airway disease in mice
  JOURNAL   J Immunol 167 (11), 6583-6592 (2001)
   PUBMED   11714828
REFERENCE   9  (bases 1 to 3688)
  AUTHORS   Pierrot,C., Beniguel,L., Begue,A. and Khalife,J.
  TITLE     Expression of a functional IL-13Ralpha1 by rat B cells
  JOURNAL   Biochem Biophys Res Commun 287 (4), 969-976 (2001)
   PUBMED   11573960
REFERENCE   10 (bases 1 to 3688)
  AUTHORS   Ahmed,S., Ihara,K., Sasaki,Y., Nakao,F., Nishima,S., Fujino,T. and
            Hara,T.
  TITLE     Novel polymorphism in the coding region of the IL-13 receptor
            alpha' gene: association study with atopic asthma in the Japanese
            population
  JOURNAL   Exp Clin Immunogenet 17 (1), 18-22 (2000)
   PUBMED   10686479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1 and BC093615.1.
            
            On Mar 18, 2021 this sequence version replaced NM_145789.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093615.1, SRR26360186.272667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000021.1  120214605-120214642
            39-3688             BC093615.1         1-3650
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..3688
                     /gene="Il13ra1"
                     /note="interleukin 13 receptor subunit alpha 1"
                     /db_xref="GeneID:252963"
                     /db_xref="RGD:628741"
     exon            1..168
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1367
                     /gene="Il13ra1"
                     /note="interleukin 13 receptor, alpha 1"
                     /codon_start=1
                     /product="interleukin-13 receptor subunit alpha-1
                     precursor"
                     /protein_id="NP_665732.2"
                     /db_xref="GeneID:252963"
                     /db_xref="RGD:628741"
                     /translation="MARPAWLGELLVLLLFAASLDQVALATEVQPPVTNLSVSVENLC
                     TIVWTWSPPEGASPNCSLRYFSHFDDQQDKKIAPETRRKKELPLNEKICLQVGSQCST
                     NESEKPSPLVKKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGKNTSPDTNYTLYY
                     WYSSLGKSLQCENIHREGQHIGCSFKLTKVESNYEHHNIQIMVKDNAGKIRPSYKIVS
                     FTSNVKPGPPHIKHLFLKNGALFVQWKNPQNFSSRCLSYEVEVNSTQTDSYNSNSLEV
                     EEDKCQNSEFDRNMEGASCFISPGVLANTVYTVRVRVKTNKLCFDDNDLWSNWSEALS
                     IGKEPNSTFYTTMLLIIPVFVAVVIIILLFYLKRLKIIIFPPIPDPGKIFKEMFGDQN
                     DDTLHWKKYDIYEKQSKEETDSVVLIENLKKAAP"
     exon            169..308
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..447
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..568
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..753
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..911
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..959
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1092
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1189
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1274
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..3688
                     /gene="Il13ra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcggccg ggaagtggga gctagaacag aggaggcgga gactgccgcg gctccagccg
       61 ggccgggctc ggaggcgagg ggctgcatgg cgcggccagc gtggctgggc gagctgttgg
      121 tgctgctgct ttttgccgcc tccctggacc aagttgccct ggccacagaa gttcagccac
      181 ctgtaacgaa tttgagtgtc tctgtcgaaa atctctgcac aatagtgtgg acatggagtc
      241 ctcctgaggg agccagtcca aattgcagtc tcagatattt tagtcatttt gatgaccaac
      301 aggataagaa aattgctcct gaaactcgtc gtaaaaagga attaccccta aatgagaaaa
      361 tctgtctgca agtggggtcc cagtgtagca ccaatgaaag tgagaagcct agccctttgg
      421 tgaaaaagtg catctcaccc cccgaagggg atcctgagtc tgctgtgacc gaactgcagt
      481 gcatttggca caacctgagc tatatgaagt gttcctggct ccctggaaag aatacaagcc
      541 cggacaccaa ctatactctt tactattggt acagcagcct ggggaaaagt cttcaatgtg
      601 aaaacatcca cagagaaggt caacacattg gttgttcctt taaattgact aaagtggaat
      661 ctaattatga acatcataac attcagataa tggtcaagga taatgctggg aaaattaggc
      721 catcctacaa aatagtgtcc ttcacttcca atgtgaaacc cggtcctcca catattaaac
      781 atcttttcct caaaaatggt gccttattcg tgcagtggaa gaacccacag aatttcagta
      841 gcagatgttt gtcttatgaa gtagaagtca atagcactca aactgacagc tataattcta
      901 actctttaga ggttgaagag gacaaatgcc agaattctga atttgataga aacatggagg
      961 gtgcaagttg tttcatatct cccggtgttc ttgccaacac tgtctacaca gtcagagtaa
     1021 gagtcaaaac aaacaagtta tgctttgatg acaacgacct gtggagtaat tggagcgaag
     1081 cgctgagtat aggtaaggag ccgaattcca ccttctacac caccatgtta ctcatcattc
     1141 cagtctttgt cgcagtggta atcataattc tcctttttta cctgaaaagg cttaagatca
     1201 ttatatttcc tccaattcct gatcctggca agatttttaa agaaatgttt ggagaccaga
     1261 atgatgatac cctgcactgg aaaaagtatg acatctatga gaaacaatcg aaagaagaaa
     1321 ccgactctgt agtgctgata gaaaacctga agaaagcggc tccatgatgg ggactcgaga
     1381 tttctttttt gcctttaatg tgaccctgtg aagatttatt gcattctcca tttgttatct
     1441 ggggactcgt taaatagaaa ctgaaactac tcttgaaaaa caggcagctc ctaagagcct
     1501 caggtcttga tgtgactctt gcaccaaaaa tccaaactaa aggagctctt caagaaaagc
     1561 agagttcttc tcattcttgc tcaatcctaa aagcagatgt cctttgcaaa atctccaaac
     1621 tagaggacaa agaaaaggga gcaatgacca tgaattcatc ttatcaggaa ttgtgacggc
     1681 ttcctaagga atctctgctt gctctgtatt ctttgtgtgg aataagatca agaaatgttt
     1741 cttgagagga atttcatttg gggtgtgtac actaatgttg tacttaccac agaacatcta
     1801 gcaaacaaaa ctgatagaat ctgctgccta ttgttcagga acccactgag taatatttgt
     1861 agcttttaaa ctacaatatc attatctact tcaatagcat tttcctctga ttggaaattc
     1921 ccagaaatca tcttggacca tggtaatgac acgtagagaa aaggcatagg caacttttcc
     1981 accaaggctg atttatgtca ttgcttgtct tttaggacag tggaggcaga atgaggtagt
     2041 ctctaatgat ggatgcttac ctttcatttc tgctactcaa gtcaagtata gactatgtat
     2101 ctagcttgtg ccaaaccttt aagtatgagg agggatggga cctcccaccc atgggtttac
     2161 atatatttgg ggctccttat ttttcatcac cttctttatc ccccagatag gcatttccgg
     2221 acttttgaac ttcccatctt ctgtttatgc ccccattgtg cctactcccc catcctcttt
     2281 cttgtaacct tttcactcag tggaattgag gagacaattt tgcttagact acctagtgga
     2341 gcaggaaata ctctgcatct caggtaaaaa aaatgagtag actgaacaac aatatgtaat
     2401 tcatgcatat tttacaactt ccctgtgagc ctgcaatttg agattttcaa gcaattggtg
     2461 tttctgtgtg ttttctaaat agagatgacg tctttttttt ccacttagaa tttagcccta
     2521 tttgcttgag agggggaaaa aataagattc atatctgttt ctctttgttt gcaaaataag
     2581 ccgtacaatg gctgttttct atgctgtaag tggtcctgtc aattctgtat tttactgaga
     2641 gggaggcaag tggagctcca actatgtgct tgctttttgc atatattagg tttccaattc
     2701 tattcccaca atatatgttc atgtacatcc ccccattctg accatttcct gaaaatttaa
     2761 aacagtgaga gttacacccc cttctctttc tcctacagat cactagccag gactgaagca
     2821 tttgatatca aaattttcca ggcatgtatc agttcctgtt aataaaacga taccagttgc
     2881 atctcttgtt cttaagcagg gcagataaga gacccctgct ctccacaggt tgggaccacg
     2941 gggaaccttg cttgcctggt agtggaggag cattgtgcct ggaatttcag gaaatagggg
     3001 aacatggcac aattgatgcc atttcctcct ggcacttttt ggtatcagat tgtggctggg
     3061 atacaggcat tctgggtgtt gcagtctcct attagtcagt agaaacaaga cttcgctttc
     3121 ttgcataagt gtgaaatact ccttccccgg ggtatcatag ttctgagaag gaaagcatcg
     3181 taaatgcctt gtacagagcc attgtttact actggcctgt gttgatggag ctgaagagca
     3241 tgttttgaaa tgctctggaa accgtcaatg ctgacagtct tacagcatgg aaacaaagac
     3301 atcctatttt gcttcaaatt ctcattcaga agtacagtag caggggggaa ggggacagac
     3361 agcaaatagg agtacctttg ttttaacaga caaaagtaat ctccaggcct taagaactct
     3421 tcatgatatc agtacattgc ttattggtaa cttgtaagtt catatattga cgaaggtata
     3481 tagatttttc cccacttaca tacgtaaatc caacataaag cggacattcc tacattcctt
     3541 tcctttcatt cagatgatgt ttctgaatct gggcactgaa gggatggcat acaataatgt
     3601 taatgttttc agtaatgtct tcaactagga ggctttctgt tgaactactt atacagaagt
     3661 aaaataaata ttgtcttttt gtatgtca
//
