LOCUS       NM_001412558            3622 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interleukin 12 receptor subunit beta 2 (Il12rb2),
            mRNA.
ACCESSION   NM_001412558 XM_006236613
VERSION     NM_001412558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3622)
  AUTHORS   Watanabe,T., Kitani,A., Murray,P.J. and Strober,W.
  TITLE     NOD2 is a negative regulator of Toll-like receptor 2-mediated T
            helper type 1 responses
  JOURNAL   Nat Immunol 5 (8), 800-808 (2004)
   PUBMED   15220916
REFERENCE   2  (bases 1 to 3622)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   3  (bases 1 to 3622)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
REFERENCE   4  (bases 1 to 3622)
  AUTHORS   Gillespie,K.M., Szeto,C.C., Betin,V.M. and Mathieson,P.W.
  TITLE     Role of beta1 and beta2 subunits of the interleukin-12 receptor in
            determining T helper 1/T helper 2 responses in vivo in the rat
  JOURNAL   Immunology 99 (1), 109-112 (2000)
   PUBMED   10651948
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 6, 2022 this sequence version replaced XM_006236613.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.19580.1,
                                           SRR26643287.11250.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000004.1  97844820-97844937   c
            119-305             JAXUCZ010000004.1  97842919-97843105   c
            306-415             JAXUCZ010000004.1  97822264-97822373   c
            416-742             JAXUCZ010000004.1  97820909-97821235   c
            743-857             JAXUCZ010000004.1  97818457-97818571   c
            858-1051            JAXUCZ010000004.1  97817433-97817626   c
            1052-1194           JAXUCZ010000004.1  97815377-97815519   c
            1195-1345           JAXUCZ010000004.1  97811778-97811928   c
            1346-1425           JAXUCZ010000004.1  97795191-97795270   c
            1426-1642           JAXUCZ010000004.1  97782873-97783089   c
            1643-1843           JAXUCZ010000004.1  97775282-97775482   c
            1844-1942           JAXUCZ010000004.1  97769300-97769398   c
            1943-2101           JAXUCZ010000004.1  97769059-97769217   c
            2102-2239           JAXUCZ010000004.1  97764693-97764830   c
            2240-2330           JAXUCZ010000004.1  97764190-97764280   c
            2331-2430           JAXUCZ010000004.1  97761009-97761108   c
            2431-3622           JAXUCZ010000004.1  97756089-97757280   c
FEATURES             Location/Qualifiers
     source          1..3622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..3622
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor subunit beta 2"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
     exon            1..118
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..305
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..415
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2949
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor, beta 2"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2
                     precursor"
                     /protein_id="NP_001399487.1"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
                     /translation="MAHTVRGCSLALIFLFMWLLIKANIDVCKLGTVTVQPAPVIPLG
                     STANISCSLNPKQGCSHYPSYNELILLKFVNDVLVEKLHGKKVHGHPSHSSIFQVTNL
                     SLGMTLFVCKLNCSNSQKTQPVPVCGVEISVGVAPESPQSISCVQKGEHGTVACSWNS
                     GKVTYLKTYYTLQLTGPNNVTYQNQCYSDNRQNCSRLDLGINLTPDLAESRFIVHVTA
                     TNDLGNSSSLLHTFTFLDIVRPLPPWDIRINFLNASGSRCTLQWEDEGQVVLNRLRYQ
                     PLNSTSWNMVNATNAKGRYDLQDLRPFTEYEFQISSKLHLSQGSWSNWSESLRTRTPE
                     EEPVGTLDIWYMKQDIDCDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNT
                     TRHTFWTGVIPRTGAWTASVSAANSKGTSAPTHINIVDLCGTGFLAPHQVSAKSGNMD
                     NIMVTWQPPGKADSVIREYIVEWRALQQGSVMNLTPHWLRIPPYNMSALISEKIKPYI
                     CYEIRVHALSEDQGGCSSIRGDSSHKVPLSGPHITAITEKKESLFISWTHIPFLEQRG
                     CILHYRIYWKERHSTAQPELCEIQYRHSQNSHPISSLQPKVTYVLWMTAVTAAGESPQ
                     GNEREFCPQGKANWKTFVISSICIAIIVVGTFSIRYFRQKAFTLLSTLKPQWYCRTIP
                     DPANSTWVKKYPIMEEKIQPPMDNLLMAWSAPEEPEPLIINEVLYQMIPVGRQPYCFK
                     RGQGFQGYSTSKEDTIYLATNPQTTGTLTAESRQLVNLYKVLGSRDPDSKLGNLTSPL
                     TVTPVNYLPTHEGYLPSNIEDLSSHEVDPSDSLDLDHQHISLSIFASSSLRPLTFCGE
                     RLTLDRLKMGYEK"
     exon            416..742
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..857
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1051
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1194
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1345
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1425
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1642
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1843
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1942
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2101
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2239
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2330
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2430
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..3622
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggaggacc acgctgcagc gcggactcca gcaatggcgc tgcgctaggc tttcgggtgc
       61 caggaccctc tccgtgtcct gagcgcggga agaacttcag tgaacgccga ggaacccggc
      121 agagggtgat gtcacaacat gaagcaaacc tgtcgggatt tcccagtgct caagagacag
      181 aaatgaacca atgtctacgt gttccccctg acgccgcctc gacacattgg ccacacagag
      241 ggatgttagc actgaggtac caagaaaagc cccgaggaat aaattaagga ggaaacatcc
      301 tgcaggagag caagagttgc attctggagt tgactgctca tggcacacac tgttagagga
      361 tgctcattgg cacttatttt tttgttcatg tggctgttga ttaaagcaaa tatagatgtg
      421 tgcaagcttg gcaccgtgac tgtccagcct gcccctgtga ttccacttgg gtcaactgcc
      481 aatatttcct gctctttgaa tcccaaacaa ggctgttcgc attatcctag ttataacgaa
      541 ttaatcctct taaagtttgt caatgatgtc cttgtcgaaa aactccatgg caaaaaagtc
      601 catggccacc ctagtcattc ctccatattt caagtcacca acctgtctct tggtatgact
      661 ctgtttgtct gcaagctaaa ctgtagcaac tctcaaaaga cacaaccagt gccagtgtgt
      721 ggagtggaga tctcagtcgg tgttgctcca gagtcacctc aaagcatatc atgtgtccag
      781 aaaggagagc atggaactgt ggcctgctcc tggaactctg ggaaagttac ttatctgaaa
      841 acctattaca ctttacagtt aactggacca aacaatgtga cctatcagaa ccagtgttat
      901 tctgacaatc gtcagaattg tagtcgtctg gatcttggga tcaatctgac ccctgattta
      961 gccgaatcca ggttcatagt ccatgttact gccaccaatg atcttggaaa ttcttcttca
     1021 cttctgcata cattcacatt cttggacata gtgaggcctc ttcctccgtg ggacatcaga
     1081 atcaactttc taaatgcttc tgggagcaga tgtacactgc agtgggaaga tgaggggcaa
     1141 gtggtactca atcgactcag ataccagcct cttaacagca catcctggaa tatggttaat
     1201 gctacaaatg ccaaaggaag atatgacctg caagatctga gaccattcac agaatatgaa
     1261 tttcagatct cctctaagct acatctctct cagggaagtt ggagtaattg gagtgagtca
     1321 ctgagaactc gaacaccaga ggaagagcct gttgggacat tagacatctg gtacatgaaa
     1381 caagatattg actgtgacag acaacagatc tctcttttct ggaagagtct gaatccatca
     1441 gaggcaaggg ggaagatcct ccactatcag gtgactttac aggaggtgac gaagaaaact
     1501 acactgcaga atactacaag acataccttc tggaccgggg tcattcccag aactggggct
     1561 tggactgcat ctgtgtctgc agccaactca aaaggcactt ctgcacccac tcacattaac
     1621 atagtggacc tgtgtggcac tgggttcctg gctcctcacc aggtctctgc aaagtcaggg
     1681 aacatggaca acatcatggt gacctggcag cctcctggga aagctgactc tgtgattcgg
     1741 gagtacatag tggaatggag ggctctccaa caagggagcg tcatgaacct taccccacac
     1801 tggctgcgaa ttccccccta caacatgtct gctctgattt cagagaagat aaagccctat
     1861 atctgttacg aaatccgggt acatgcactg tcagaggacc aaggagggtg cagctccatc
     1921 cggggtgact ccagtcacaa agtgccactg agtggccctc atatcactgc tatcacagag
     1981 aaaaaggaaa gcctttttat ttcctggacc cacatccctt tcctggagca aaggggctgc
     2041 atcctccatt acagaatata ttggaaggag cgacactcta ctgcgcaacc cgagctctgt
     2101 gaaattcagt acagacactc tcaaaactca catccaataa gcagcctaca gcccaaggtg
     2161 acatatgtcc tatggatgac agctgtgaca gctgctggtg aaagtcccca aggaaatgaa
     2221 agggaatttt gtccacaggg caaagccaac tggaaaacat tcgtgatatc aagcatttgc
     2281 atcgctatca tcgtggtggg cactttctca attcgttact tcaggcaaaa ggcatttact
     2341 ctcctttcta ctctcaaacc ccaatggtat tgcagaacta ttccagatcc agcaaatagc
     2401 acttgggtaa agaagtaccc cattatggag gagaagatcc agccacctat ggacaatctc
     2461 ctgatggcct ggtccgctcc tgaagagcct gagcccctga tcatcaatga agtcctctac
     2521 caaatgatcc cagtaggcag acaaccctat tgcttcaaaa gaggacaagg gttccaaggt
     2581 tactctacct ccaaggaaga cacaatatac cttgccacca atccacaaac tacaggaact
     2641 ctcacagctg agtcgagaca actagtgaat ctatacaagg tgctaggaag cagggaccct
     2701 gactcaaaac tgggcaacct gaccagcccc ttgacagtca ccccagtgaa ctaccttcct
     2761 acccatgaag gctatttacc ctccaacata gaagacctct catcacatga agttgaccca
     2821 agtgattctt tagacctgga ccatcaacat atttctcttt ccatttttgc atcaagttct
     2881 ctccgcccac tcaccttctg tggtgagagg ctgactctag atcggttaaa gatgggctac
     2941 gagaaatgag gcttgatacc tagaaagtca atgtacccca ttagggcagc acagtatatc
     3001 tacccagttc ctactcccat ggtcaccatc tttggtagta tatagctttg ggacaatgca
     3061 aacaagccag ttgtctctgg attaagttag cttcaccaga gagacttcag tcttatgcat
     3121 aaaaagataa gacaccaaca cagataaaca tcaataaagg gcacccaaga tagccatgct
     3181 caacatctgt ggcacacaca cgtgtttaag cgtgcacaca cacacctgtc aatcactatc
     3241 agcttgatgg agaattacct ctgtactctt attccatgaa acttttctgt tatggcccaa
     3301 catcagttat ctctgggtct aaaacctcaa tctacaagaa cccagacttt gctgttctgt
     3361 ttcttcataa ctatggactg actcggcacc ctctatcata ccactggcaa agtccagtgc
     3421 cacttgaaag gttcaagaca gttttttctt aaaacatcaa gcctgactat ctccaccaca
     3481 tcctctccag taacactact tttctgtgtt tggtattttc atttaacaaa gtatctatta
     3541 caagtttgta cttccttttc taacctaaca aattagcaat gtgtccatat agcccagtcc
     3601 tataaatttt ttatcttttg tt
//
