LOCUS       NM_001191750            2610 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus interleukin 12 receptor subunit beta 2 (Il12rb2),
            mRNA.
ACCESSION   NM_001191750 XM_231873
VERSION     NM_001191750.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Watanabe,T., Kitani,A., Murray,P.J. and Strober,W.
  TITLE     NOD2 is a negative regulator of Toll-like receptor 2-mediated T
            helper type 1 responses
  JOURNAL   Nat Immunol 5 (8), 800-808 (2004)
   PUBMED   15220916
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Gillespie,K.M., Szeto,C.C., Betin,V.M. and Mathieson,P.W.
  TITLE     Role of beta1 and beta2 subunits of the interleukin-12 receptor in
            determining T helper 1/T helper 2 responses in vivo in the rat
  JOURNAL   Immunology 99 (1), 109-112 (2000)
   PUBMED   10651948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_231873.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.19587.1,
                                           SRR26643299.19580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000004.1  97822264-97822339   c
            77-403              JAXUCZ010000004.1  97820909-97821235   c
            404-518             JAXUCZ010000004.1  97818457-97818571   c
            519-712             JAXUCZ010000004.1  97817433-97817626   c
            713-855             JAXUCZ010000004.1  97815377-97815519   c
            856-1006            JAXUCZ010000004.1  97811778-97811928   c
            1007-1086           JAXUCZ010000004.1  97795191-97795270   c
            1087-1303           JAXUCZ010000004.1  97782873-97783089   c
            1304-1504           JAXUCZ010000004.1  97775282-97775482   c
            1505-1603           JAXUCZ010000004.1  97769300-97769398   c
            1604-1762           JAXUCZ010000004.1  97769059-97769217   c
            1763-1900           JAXUCZ010000004.1  97764693-97764830   c
            1901-1991           JAXUCZ010000004.1  97764190-97764280   c
            1992-2091           JAXUCZ010000004.1  97761009-97761108   c
            2092-2610           JAXUCZ010000004.1  97756762-97757280   c
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..2610
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor subunit beta 2"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
     CDS             1..2610
                     /gene="Il12rb2"
                     /note="interleukin 12 receptor, beta 2"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-2
                     precursor"
                     /protein_id="NP_001178679.1"
                     /db_xref="GeneID:171334"
                     /db_xref="RGD:620026"
                     /translation="MAHTVRGCSLALIFLFMWLLIKANIDVCKLGTVTVQPAPVIPLG
                     STANISCSLNPKQGCSHYPSYNELILLKFVNDVLVEKLHGKKVHGHPSHSSIFQVTNL
                     SLGMTLFVCKLNCSNSQKTQPVPVCGVEISVGVAPESPQSISCVQKGEHGTVACSWNS
                     GKVTYLKTYYTLQLTGPNNVTYQNQCYSDNRQNCSRLDLGINLTPDLAESRFIVHVTA
                     TNDLGNSSSLLHTFTFLDIVRPLPPWDIRINFLNASGSRCTLQWEDEGQVVLNRLRYQ
                     PLNSTSWNMVNATNAKGRYDLQDLRPFTEYEFQISSKLHLSQGSWSNWSESLRTRTPE
                     EEPVGTLDIWYMKQDIDCDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNT
                     TRHTFWTGVIPRTGAWTASVSAANSKGTSAPTHINIVDLCGTGFLAPHQVSAKSGNMD
                     NIMVTWQPPGKADSVIREYIVEWRALQQGSVMNLTPHWLRIPPYNMSALISEKIKPYI
                     CYEIRVHALSEDQGGCSSIRGDSSHKVPLSGPHITAITEKKESLFISWTHIPFLEQRG
                     CILHYRIYWKERHSTAQPELCEIQYRHSQNSHPISSLQPKVTYVLWMTAVTAAGESPQ
                     GNEREFCPQGKANWKTFVISSICIAIIVVGTFSIRYFRQKAFTLLSTLKPQWYCRTIP
                     DPANSTWVKKYPIMEEKIQPPMDNLLMAWSAPEEPEPLIINEVLYQMIPVGRQPYCFK
                     RGQGFQGYSTSKEDTIYLATNPQTTGTLTAESRQLVNLYKVLGSRDPDSKLGNLTSPL
                     TVTPVNYLPTHEGYLPSNIEDLSSHEVDPSDSLDLDHQHISLSIFASSSLRPLTFCGE
                     RLTLDRLKMGYEK"
     exon            1..76
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            77..403
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..518
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..712
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..855
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1006
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1086
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1303
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1504
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1603
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1762
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1900
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1991
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2091
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2610
                     /gene="Il12rb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcacaca ctgttagagg atgctcattg gcacttattt ttttgttcat gtggctgttg
       61 attaaagcaa atatagatgt gtgcaagctt ggcaccgtga ctgtccagcc tgcccctgtg
      121 attccacttg ggtcaactgc caatatttcc tgctctttga atcccaaaca aggctgttcg
      181 cattatccta gttataacga attaatcctc ttaaagtttg tcaatgatgt ccttgtcgaa
      241 aaactccatg gcaaaaaagt ccatggccac cctagtcatt cctccatatt tcaagtcacc
      301 aacctgtctc ttggtatgac tctgtttgtc tgcaagctaa actgtagcaa ctctcaaaag
      361 acacaaccag tgccagtgtg tggagtggag atctcagtcg gtgttgctcc agagtcacct
      421 caaagcatat catgtgtcca gaaaggagag catggaactg tggcctgctc ctggaactct
      481 gggaaagtta cttatctgaa aacctattac actttacagt taactggacc aaacaatgtg
      541 acctatcaga accagtgtta ttctgacaat cgtcagaatt gtagtcgtct ggatcttggg
      601 atcaatctga cccctgattt agccgaatcc aggttcatag tccatgttac tgccaccaat
      661 gatcttggaa attcttcttc acttctgcat acattcacat tcttggacat agtgaggcct
      721 cttcctccgt gggacatcag aatcaacttt ctaaatgctt ctgggagcag atgtacactg
      781 cagtgggaag atgaggggca agtggtactc aatcgactca gataccagcc tcttaacagc
      841 acatcctgga atatggttaa tgctacaaat gccaaaggaa gatatgacct gcaagatctg
      901 agaccattca cagaatatga atttcagatc tcctctaagc tacatctctc tcagggaagt
      961 tggagtaatt ggagtgagtc actgagaact cgaacaccag aggaagagcc tgttgggaca
     1021 ttagacatct ggtacatgaa acaagatatt gactgtgaca gacaacagat ctctcttttc
     1081 tggaagagtc tgaatccatc agaggcaagg gggaagatcc tccactatca ggtgacttta
     1141 caggaggtga cgaagaaaac tacactgcag aatactacaa gacatacctt ctggaccggg
     1201 gtcattccca gaactggggc ttggactgca tctgtgtctg cagccaactc aaaaggcact
     1261 tctgcaccca ctcacattaa catagtggac ctgtgtggca ctgggttcct ggctcctcac
     1321 caggtctctg caaagtcagg gaacatggac aacatcatgg tgacctggca gcctcctggg
     1381 aaagctgact ctgtgattcg ggagtacata gtggaatgga gggctctcca acaagggagc
     1441 gtcatgaacc ttaccccaca ctggctgcga attcccccct acaacatgtc tgctctgatt
     1501 tcagagaaga taaagcccta tatctgttac gaaatccggg tacatgcact gtcagaggac
     1561 caaggagggt gcagctccat ccggggtgac tccagtcaca aagtgccact gagtggccct
     1621 catatcactg ctatcacaga gaaaaaggaa agccttttta tttcctggac ccacatccct
     1681 ttcctggagc aaaggggctg catcctccat tacagaatat attggaagga gcgacactct
     1741 actgcgcaac ccgagctctg tgaaattcag tacagacact ctcaaaactc acatccaata
     1801 agcagcctac agcccaaggt gacatatgtc ctatggatga cagctgtgac agctgctggt
     1861 gaaagtcccc aaggaaatga aagggaattt tgtccacagg gcaaagccaa ctggaaaaca
     1921 ttcgtgatat caagcatttg catcgctatc atcgtggtgg gcactttctc aattcgttac
     1981 ttcaggcaaa aggcatttac tctcctttct actctcaaac cccaatggta ttgcagaact
     2041 attccagatc cagcaaatag cacttgggta aagaagtacc ccattatgga ggagaagatc
     2101 cagccaccta tggacaatct cctgatggcc tggtccgctc ctgaagagcc tgagcccctg
     2161 atcatcaatg aagtcctcta ccaaatgatc ccagtaggca gacaacccta ttgcttcaaa
     2221 agaggacaag ggttccaagg ttactctacc tccaaggaag acacaatata ccttgccacc
     2281 aatccacaaa ctacaggaac tctcacagct gagtcgagac aactagtgaa tctatacaag
     2341 gtgctaggaa gcagggaccc tgactcaaaa ctgggcaacc tgaccagccc cttgacagtc
     2401 accccagtga actaccttcc tacccatgaa ggctatttac cctccaacat agaagacctc
     2461 tcatcacatg aagttgaccc aagtgattct ttagacctgg accatcaaca tatttctctt
     2521 tccatttttg catcaagttc tctccgccca ctcaccttct gtggtgagag gctgactcta
     2581 gatcggttaa agatgggcta cgagaaatga
//
