LOCUS       NM_001170604            2835 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1),
            mRNA.
ACCESSION   NM_001170604
VERSION     NM_001170604.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2835)
  AUTHORS   Qian,C., Jiang,T., Zhang,W., Ren,C., Wang,Q., Qin,Q., Chen,J.,
            Deng,A. and Zhong,R.
  TITLE     Increased IL-23 and IL-17 expression by peripheral blood cells of
            patients with primary biliary cirrhosis
  JOURNAL   Cytokine 64 (1), 172-180 (2013)
   PUBMED   23910013
REFERENCE   2  (bases 1 to 2835)
  AUTHORS   Watanabe,T., Kitani,A., Murray,P.J. and Strober,W.
  TITLE     NOD2 is a negative regulator of Toll-like receptor 2-mediated T
            helper type 1 responses
  JOURNAL   Nat Immunol 5 (8), 800-808 (2004)
   PUBMED   15220916
REFERENCE   3  (bases 1 to 2835)
  AUTHORS   Smits,H.H., van Beelen,A.J., Hessle,C., Westland,R., de Jong,E.,
            Soeteman,E., Wold,A., Wierenga,E.A. and Kapsenberg,M.L.
  TITLE     Commensal Gram-negative bacteria prime human dendritic cells for
            enhanced IL-23 and IL-27 expression and enhanced Th1 development
  JOURNAL   Eur J Immunol 34 (5), 1371-1380 (2004)
   PUBMED   15114670
REFERENCE   4  (bases 1 to 2835)
  AUTHORS   Hoeve,M.A., de Boer,T., Langenberg,D.M., Sanal,O., Verreck,F.A. and
            Ottenhoff,T.H.
  TITLE     IL-12 receptor deficiency revisited: IL-23-mediated signaling is
            also impaired in human genetic IL-12 receptor beta1 deficiency
  JOURNAL   Eur J Immunol 33 (12), 3393-3397 (2003)
   PUBMED   14635048
REFERENCE   5  (bases 1 to 2835)
  AUTHORS   Pirhonen,J., Matikainen,S. and Julkunen,I.
  TITLE     Regulation of virus-induced IL-12 and IL-23 expression in human
            macrophages
  JOURNAL   J Immunol 169 (10), 5673-5678 (2002)
   PUBMED   12421946
REFERENCE   6  (bases 1 to 2835)
  AUTHORS   Parham,C., Chirica,M., Timans,J., Vaisberg,E., Travis,M.,
            Cheung,J., Pflanz,S., Zhang,R., Singh,K.P., Vega,F., To,W.,
            Wagner,J., O'Farrell,A.M., McClanahan,T., Zurawski,S., Hannum,C.,
            Gorman,D., Rennick,D.M., Kastelein,R.A., de Waal Malefyt,R. and
            Moore,K.W.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   7  (bases 1 to 2835)
  AUTHORS   Poltorak,A., Merlin,T., Nielsen,P.J., Sandra,O., Smirnova,I.,
            Schupp,I., Boehm,T., Galanos,C. and Freudenberg,M.A.
  TITLE     A point mutation in the IL-12R beta 2 gene underlies the IL-12
            unresponsiveness of Lps-defective C57BL/10ScCr mice
  JOURNAL   J Immunol 167 (4), 2106-2111 (2001)
   PUBMED   11489994
REFERENCE   8  (bases 1 to 2835)
  AUTHORS   Oppmann,B., Lesley,R., Blom,B., Timans,J.C., Xu,Y., Hunte,B.,
            Vega,F., Yu,N., Wang,J., Singh,K., Zonin,F., Vaisberg,E.,
            Churakova,T., Liu,M., Gorman,D., Wagner,J., Zurawski,S., Liu,Y.,
            Abrams,J.S., Moore,K.W., Rennick,D., de Waal-Malefyt,R., Hannum,C.,
            Bazan,J.F. and Kastelein,R.A.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
REFERENCE   9  (bases 1 to 2835)
  AUTHORS   Gillespie,K.M., Szeto,C.C., Betin,V.M. and Mathieson,P.W.
  TITLE     Role of beta1 and beta2 subunits of the interleukin-12 receptor in
            determining T helper 1/T helper 2 responses in vivo in the rat
  JOURNAL   Immunology 99 (1), 109-112 (2000)
   PUBMED   10651948
REFERENCE   10 (bases 1 to 2835)
  AUTHORS   Presky,D.H., Yang,H., Minetti,L.J., Chua,A.O., Nabavi,N., Wu,C.Y.,
            Gately,M.K. and Gubler,U.
  TITLE     A functional interleukin 12 receptor complex is composed of two
            beta-type cytokine receptor subunits
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14002-14007 (1996)
   PUBMED   8943050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 30, 2022 this sequence version replaced NM_001170604.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.55720.1,
                                           SRR26360181.1369467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000016.1  18666682-18666824   c
            144-203             JAXUCZ010000016.1  18665383-18665442   c
            204-318             JAXUCZ010000016.1  18664457-18664571   c
            319-518             JAXUCZ010000016.1  18664060-18664259   c
            519-655             JAXUCZ010000016.1  18662869-18663005   c
            656-722             JAXUCZ010000016.1  18662172-18662238   c
            723-848             JAXUCZ010000016.1  18661773-18661898   c
            849-931             JAXUCZ010000016.1  18661324-18661406   c
            932-1169            JAXUCZ010000016.1  18660647-18660884   c
            1170-1337           JAXUCZ010000016.1  18659703-18659870   c
            1338-1472           JAXUCZ010000016.1  18658961-18659095   c
            1473-1628           JAXUCZ010000016.1  18658482-18658637   c
            1629-1763           JAXUCZ010000016.1  18658186-18658320   c
            1764-1860           JAXUCZ010000016.1  18656335-18656431   c
            1861-1942           JAXUCZ010000016.1  18655862-18655943   c
            1943-2835           JAXUCZ010000016.1  18654207-18655099   c
FEATURES             Location/Qualifiers
     source          1..2835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2835
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /note="interleukin 12 receptor subunit beta 1"
                     /db_xref="GeneID:171333"
                     /db_xref="RGD:620025"
     exon            1..143
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2293
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /note="interleukin 12 receptor, beta 1"
                     /codon_start=1
                     /product="interleukin-12 receptor subunit beta-1
                     precursor"
                     /protein_id="NP_001164075.1"
                     /db_xref="GeneID:171333"
                     /db_xref="RGD:620025"
                     /translation="MDMTGLPGTSKHIIFLLLCQLSASSRGDSCCVEKISYPDEASGP
                     SLGPRDLSCYRVSGTDYECSWQYDGPEDNVAHFLWCCFAHPNPTHTSFGQECCCYFSS
                     GRSRTVQFWEQDGISTLSKVNFWVESRLGNRTLKSQEISQYLYNWTKLTPPLGHIRVS
                     RSRGELRMDWNVSDGAGAEVQLRRRMPTTNWTLGDCGPQVSSGLGVIGDIHGSSSESC
                     LCPSENMAQEIQIRRRRRLSSGAPGGPWSNWSMSVCVPPEFLPQAEIKFLVEPLNQDG
                     RRRLTMEGQTPQLAVPEGCRDRPGAQVKKHLVLVHMLACRCQARTWKTVPLGKTLDLS
                     GAAYDLDVLAQTRFGRSIIQKWPLPAQELTETRTLNVIVEGNVTSMQWAAQPPGTAYC
                     LEWQPWGQDRNHTDCTLIAPEEEDPAKMVTHTWSSKPTLDQEECYRITVFASKNPKNP
                     MMWATVLSSYYFGGNVSRVGTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRC
                     EAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTAMLPGSWSRPQRFSVEVQI
                     SRLSIVFASLGSFASVLLVGSLGYIGLNRAAWHLCPPLPTPCGSTAVEFPGSQDKQAW
                     QWRNPEDFPEVLYPRDALVVEMPRDRDDETESPQATPERALDTRWPLGTEGQVQGLSE
                     ARLPDLAREDCPRGDLAHVTLPLLLGDVTQGASVLGDLWWIHKTVEPGPPTLGQEA"
     exon            144..203
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            204..318
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            319..518
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            519..655
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            656..722
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            723..848
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            849..931
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1169
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1337
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1472
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1628
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1763
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1860
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1942
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2835
                     /gene="Il12rb1"
                     /gene_synonym="Il12rb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtgtttc cgagtgctga caaggtggca gggccccttc agccgtgctg aagttcctgg
       61 ggcctcaagg ctcctcatgg acatgacggg gctgccaggg accagcaagc acatcatctt
      121 cctcctgctt tgccagctaa gcgcctccag ccgaggtgac agctgctgcg ttgagaagat
      181 atcataccca gatgaagcct caggcccctc cttaggaccc agggacttga gctgctacag
      241 ggtttccggg acagactatg agtgctcctg gcagtatgat ggccctgagg acaatgttgc
      301 tcacttcctg tggtgctgct ttgctcatcc aaaccctacc cacaccagct ttggccaaga
      361 atgctgctgc tacttctctt cgggccggtc tcggactgtg cagttctggg aacaggatgg
      421 tatctctacg ttgtccaagg tcaacttctg ggtcgagtct cggcttggga acaggacctt
      481 gaagtctcag gagatatcgc agtacctgta caactggacc aagctcaccc ctcctctggg
      541 acacatcaga gtgtcacgat cacgcgggga gttgcgaatg gactggaatg tgtcggatgg
      601 ggccggtgct gaggtacaac tgaggcgccg gatgcccaca acgaattgga ccttgggtga
      661 ctgcggacct caggttagct ctggcttagg tgtgattggt gacattcacg gtagcagttc
      721 tgagtcctgc ctctgccctt ctgagaacat ggcccaggaa atccagatac ggagacggcg
      781 gcgcctctcc tcaggagctc ctggaggtcc ctggagtaat tggagcatgt ctgtgtgtgt
      841 cccgcctgaa ttcctccccc aggctgagat taagttcctg gtggagcccc tgaaccaaga
      901 tggaaggagg cgtctgacta tggaagggca gacaccacag ctggcagtcc cggagggctg
      961 cagggaccgg cctggggcgc aggtgaagaa gcacttggtg ctggtgcaca tgctggcctg
     1021 caggtgccag gctcggacct ggaagaccgt gcccctgggc aagacgctgg acctctccgg
     1081 tgccgcctac gacctggatg tactcgccca gactcgcttc ggccgcagca tcatccagaa
     1141 gtggcccctt cctgcccaag agctcacaga gacaagaacc ctgaatgtca tcgtggaagg
     1201 caacgtgaca tccatgcagt gggcagccca gcctccaggc actgcctact gccttgagtg
     1261 gcagccatgg ggccaggaca ggaaccacac ggactgtact ctgattgcac cagaagaaga
     1321 ggacccagcc aagatggtga cgcacacctg gagctccaag cctaccctgg accaggagga
     1381 atgttaccgc atcactgtct tcgcctccaa gaaccccaag aatcccatga tgtgggccac
     1441 ggtcctgtcc agttactact ttgggggtaa cgtctcaagg gtcggaactc cacgccacgt
     1501 gtcggtgagg aaccacaccg aggactcagt gtccgtggag tggacagcgt cacagctgag
     1561 cacctgccca ggggtcctga cgcaatacgt cgtgcgctgc gaggctgaag atggcacgtg
     1621 ggagtcagag ttgctcgtgc cacccacgaa gacccaagtg acactaaaca gtctgcgcag
     1681 ccgcgtggtg tacaaggttc aggtgcgagc tgacactgcg atgctcccag gctcctggag
     1741 ccgtccccag cgcttcagcg ttgaggtgca gatttcccgt ttatccatcg ttttcgcgtc
     1801 tctgggaagc ttcgccagcg tcctcctcgt gggcagtctc ggatacattg gcttaaacag
     1861 ggctgcctgg cacttgtgcc cacctctgcc tacgccctgt ggcagcactg ctgtggagtt
     1921 ccctggcagc caggacaagc aggcttggca atggcgcaac cctgaggact tccccgaggt
     1981 gttgtaccca cgagacgcgc tggtggtgga gatgcccagg gacagagatg atgagacaga
     2041 gtcgccccag gccacccctg agcgcgccct ggacacaagg tggcccttgg gaactgaggg
     2101 gcaggtgcaa ggactctcag aggccaggct cccggacctg gctagagagg actgtccccg
     2161 tggtgacctg gcccacgtga cactcccgct gctcctggga gatgtgaccc agggagcctc
     2221 ggtacttggt gatctttggt ggatccataa gaccgtggag ccaggaccac ccactttggg
     2281 tcaagaggcc tgactgctgc attcccagcc tgttccctcc ttaggagccc ctgacctgca
     2341 acagctggtc acaatgactg tcctatttta tagatgtgac tcttgaggcc cagagaagat
     2401 gaatgtctga cctgaggtca cacagcatta gcaggacaca gacccaggtc ccctcccacc
     2461 cactccctcc ctcccgtgcc tatagccaca cagtctgtga ggagaataca gaaaccacca
     2521 agaaggggaa agtgcttcat gcagccctgc ttggtatcct cagggcaagg ctggtcccta
     2581 tcactggtct gtttggggtt ggggggcatc cttccattct gaagggacat ggtcaaaggc
     2641 tcagtttgcc tccagtgtcc tgggctggag ttcaactcca ggagtaacag acaggatgaa
     2701 tctagattgt aataacttag gtgacctaaa cagcagggcc tagacatgca cagggaggtt
     2761 atacatctgg actcagtctc cctgttgtag cactgggcac tgaataaatg ggtcttccca
     2821 gtgactgaca aacaa
//
