LOCUS       NM_022611               2479 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus interleukin 12B (Il12b), mRNA.
ACCESSION   NM_022611 XM_006246147
VERSION     NM_022611.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Mukherjee,T., Udupa,V.A.V., Prakhar,P., Chandra,K., Chakravortty,D.
            and Balaji,K.N.
  TITLE     Epidermal Growth Factor Receptor-Responsive Indoleamine
            2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri
            Infection
  JOURNAL   J Infect Dis 219 (11), 1841-1851 (2019)
   PUBMED   30615126
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   He,X.P., Chen,P., Yang,K., Liu,B., Zhang,Y., Wang,F., Guo,Z.,
            Liu,X.D., Lou,J.X. and Chen,H.R.
  TITLE     Overexpression of miR-21 is involved in acute monocytic
            leukemia-associated angiogenesis by targeting IL-12
  JOURNAL   Mol Med Rep 18 (4), 4122-4128 (2018)
   PUBMED   30106099
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Xin,A., Masson,F., Liao,Y., Preston,S., Guan,T., Gloury,R.,
            Olshansky,M., Lin,J.X., Li,P., Speed,T.P., Smyth,G.K., Ernst,M.,
            Leonard,W.J., Pellegrini,M., Kaech,S.M., Nutt,S.L., Shi,W.,
            Belz,G.T. and Kallies,A.
  TITLE     A molecular threshold for effector CD8(+) T cell differentiation
            controlled by transcription factors Blimp-1 and T-bet
  JOURNAL   Nat Immunol 17 (4), 422-432 (2016)
   PUBMED   26950239
  REMARK    GeneRIF: There is a common program of effector T cell
            differentiation that is regulated by IL-2 and IL-12 signaling and
            the combined activities of the transcriptional regulators Blimp-1
            and T-bet.
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   He,D., Tao,S., Guo,S., Li,M., Wu,J., Huang,H., Guo,X., Yan,G.,
            Zhu,P. and Wang,Y.
  TITLE     Interaction of TLR-IFN and HLA polymorphisms on susceptibility of
            chronic HBV infection in Southwest Han Chinese
  JOURNAL   Liver Int 35 (8), 1941-1949 (2015)
   PUBMED   25469587
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Lai,C.F., Lin,S.L., Chiang,W.C., Chen,Y.M., Wu,V.C., Young,G.H.,
            Ko,W.J., Kuo,M.L., Tsai,T.J. and Wu,K.D.
  TITLE     Blockade of cysteine-rich protein 61 attenuates renal inflammation
            and fibrosis after ischemic kidney injury
  JOURNAL   Am J Physiol Renal Physiol 307 (5), F581-F592 (2014)
   PUBMED   24920753
REFERENCE   6  (bases 1 to 2479)
  AUTHORS   Ling,P., Gately,M.K., Gubler,U., Stern,A.S., Lin,P., Hollfelder,K.,
            Su,C., Pan,Y.C. and Hakimi,J.
  TITLE     Human IL-12 p40 homodimer binds to the IL-12 receptor but does not
            mediate biologic activity
  JOURNAL   J Immunol 154 (1), 116-127 (1995)
   PUBMED   7527811
REFERENCE   7  (bases 1 to 2479)
  AUTHORS   Rabinowich,H., Herberman,R.B. and Whiteside,T.L.
  TITLE     Differential effects of IL12 and IL2 on expression and function of
            cellular adhesion molecules on purified human natural killer cells
  JOURNAL   Cell Immunol 152 (2), 481-498 (1993)
   PUBMED   7903063
REFERENCE   8  (bases 1 to 2479)
  AUTHORS   Ploemacher,R.E., van Soest,P.L., Boudewijn,A. and Neben,S.
  TITLE     Interleukin-12 enhances interleukin-3 dependent multilineage
            hematopoietic colony formation stimulated by interleukin-11 or
            steel factor
  JOURNAL   Leukemia 7 (9), 1374-1380 (1993)
   PUBMED   7690439
REFERENCE   9  (bases 1 to 2479)
  AUTHORS   Gubler,U., Chua,A.O., Schoenhaut,D.S., Dwyer,C.M., McComas,W.,
            Motyka,R., Nabavi,N., Wolitzky,A.G., Quinn,P.M., Familletti,P.C. et
            al.
  TITLE     Coexpression of two distinct genes is required to generate secreted
            bioactive cytotoxic lymphocyte maturation factor
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4143-4147 (1991)
   PUBMED   1674604
REFERENCE   10 (bases 1 to 2479)
  AUTHORS   Wolf,S.F., Temple,P.A., Kobayashi,M., Young,D., Dicig,M., Lowe,L.,
            Dzialo,R., Fitz,L., Ferenz,C., Hewick,R.M. et al.
  TITLE     Cloning of cDNA for natural killer cell stimulatory factor, a
            heterodimeric cytokine with multiple biologic effects on T and
            natural killer cells
  JOURNAL   J Immunol 146 (9), 3074-3081 (1991)
   PUBMED   1673147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Oct 25, 2022 this sequence version replaced
            XM_006246147.4, NM_022611.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.39850.1,
                                           SRR22582419.600986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000010.1  29390300-29390355
            57-144              JAXUCZ010000010.1  29394403-29394490
            145-411             JAXUCZ010000010.1  29398049-29398315
            412-529             JAXUCZ010000010.1  29398702-29398819
            530-747             JAXUCZ010000010.1  29400580-29400797
            748-926             JAXUCZ010000010.1  29401388-29401566
            927-1051            JAXUCZ010000010.1  29403068-29403192
            1052-2479           JAXUCZ010000010.1  29403767-29405194
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q21"
     gene            1..2479
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /note="interleukin 12B"
                     /db_xref="GeneID:64546"
                     /db_xref="RGD:628704"
     exon            1..56
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1064
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /note="interleukin-12 subunit beta; interleukin-12 p40"
                     /codon_start=1
                     /product="interleukin-12 subunit beta precursor"
                     /protein_id="NP_072133.2"
                     /db_xref="GeneID:64546"
                     /db_xref="RGD:628704"
                     /translation="MCHQKLTFSWFAMVLLVSPLMAMWELEKDVYVVEVDWRPDAPGE
                     TVTLTCDSPEEDDITWTSDQRRGVIGSGKTLTITVREFLDAGQYTCHRGGETLSHSHL
                     LLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVHRNTDLKFNIKSSSSSP
                     ESRAVTCGAASLSAEKVTLNQRDYEKYSVACQEDVTCPTAEETLPIELVVEAQQQNKY
                     ENYSTSFFIRDIIKPDPPKNLQVKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQR
                     KKEKTKETEEECNQKGAFLVEKTSAEVQCKGANICVQAQDRYYNSSCSKWTCVPCRGR
                     S"
     exon            57..144
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            145..411
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            412..529
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            530..747
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            748..926
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1051
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..2479
                     /gene="Il12b"
                     /gene_synonym="Il12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggaaca gtgggtgtcc agacacatca gaccaagcag gcagcagcaa agcaagatgt
       61 gtcatcagaa gttaaccttc tcctggtttg ccatggtttt gctggtgtct ccactcatgg
      121 ccatgtggga gctggagaaa gatgtttatg ttgtagaggt ggactggcgc cccgatgccc
      181 ctggagaaac ggtgaccctc acctgtgaca gtcctgaaga agatgacatc acctggacct
      241 cagaccagag acgtggagtc ataggctctg gaaagaccct gaccatcact gtcagagagt
      301 ttctagatgc tggccaatac acctgccaca gaggaggcga gactctgagc cactcacatc
      361 tgctgctcca caagaaggaa aatggaattt ggtccaccga gattttaaaa aatttcaaaa
      421 ataagacttt cctgaagtgt gaagcaccaa actactccgg acggttcacc tgctcatggc
      481 tggtgcacag aaacacggac ttgaagttta acatcaagag cagcagcagt tcccctgagt
      541 ctcgggcggt gacatgtgga gcagcatctc tgtctgcaga gaaggtcaca ctgaaccaaa
      601 gggactacga gaagtactca gtggcgtgcc aggaggacgt cacctgccca actgccgagg
      661 agaccctgcc cattgaactg gtggtggagg cccagcagca gaataaatat gagaactaca
      721 gcaccagctt cttcatcagg gacatcatca aaccggaccc acccaagaac ctgcaggtga
      781 aacctttgaa gaactctcag gtggaggtca gctgggagta ccctgactcc tggagcactc
      841 cccattccta cttctccctc aagttcttcg tccgcatcca gcgcaagaaa gaaaagacga
      901 aggagacaga ggaggagtgt aaccagaaag gtgcgttcct cgtagagaag acctctgccg
      961 aagtccaatg caaaggggcg aatatctgtg tgcaagcgca ggaccgctac tacaattcat
     1021 catgcagcaa atggacatgt gtaccctgca ggggccgatc ctaagatgta actctggaag
     1081 gaaagaaaag tgcaagtcgt taggaaagaa aaaatttaca ctcatgatgg aagagacccc
     1141 caaaagctat tttctgcttt ttttttggct ttttccagtt tttctgagta cataatgaca
     1201 cctttgctac atttctacac ttaaatgtta aatgcctgca gagacaatga gctaatttat
     1261 gcatagaggt tttagcattc tccacggcct tatgctattg aaatatttaa gtaatttatg
     1321 tatttattaa tttatttctg tatttaacat ttgtgcacca agatgtattg aatatttcat
     1381 gctcgtggcc tgatccacag ggaccacagg ccctattatg caaaatgtaa agttgttatc
     1441 ctctccaaca acccttcaac caaggctccc taggtacctt ggcttttgtg acaaccaata
     1501 agaacacagt attctgacac aagcagtgtt atgtatttgt ggccaataaa gacataggtg
     1561 gtgtttagag agaggaagaa gctgtaaggc agactatgga gagtttagca tagtttcaac
     1621 accaagaagt gatatcgata agaaatcagg gccttctttg gaaaggaagc ctttaaatac
     1681 ctaaatttaa aagaagttta aaggccacat attggtggca tgtgcttttt aatcccggca
     1741 ctcaggaggc caaggcaggt agatctctgt aagtctgagg acagcctggt gtacagagca
     1801 agttccagca cagccaggac cacacagaga aaccttgtct caaaaacaat taaaaaaaaa
     1861 gactagaact tgaaatgcag gtttgggtat atagctcaga gggcagtgtg cttacctaac
     1921 attcgtgaag agctgacatt ggtcctcagc actgcataaa ctaagcttgg tctaatccta
     1981 gcactggggg aagagaggca gaaaactcag aagttcaatg tcatccttag ctacctaaca
     2041 aggccaggct aggcctcata ctagcatgct acaatttctc aaaaagaagg aaaggaaata
     2101 ggggtgggga gattcaatcg cttgcctcct tggcagtccc cacccccaac actctgtaag
     2161 acaggggagc agagacgccc tgggtgtctg gaagaataga agcttttgga agttgagggg
     2221 caagatagtg aagctgtgac gaaaggacct aaaagcctgg gcaccttaat aaccacacaa
     2281 atgggtgcaa agaaaaccat ccgggatcgc catgtcaaca gcccgcgtga acctaaggtg
     2341 cggattggac catgaagacc ctagtgctac gtaagggcac aagggccacg cttctagtag
     2401 tgacttgcat atgcttttca cgtgtttgat tgtctatttg tgctttctga gaccaaataa
     2461 ataaaacctc ttccttgca
//
