LOCUS       NM_053390                793 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus interleukin 12A (Il12a), mRNA.
ACCESSION   NM_053390
VERSION     NM_053390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   He,X.P., Chen,P., Yang,K., Liu,B., Zhang,Y., Wang,F., Guo,Z.,
            Liu,X.D., Lou,J.X. and Chen,H.R.
  TITLE     Overexpression of miR-21 is involved in acute monocytic
            leukemia-associated angiogenesis by targeting IL-12
  JOURNAL   Mol Med Rep 18 (4), 4122-4128 (2018)
   PUBMED   30106099
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Khalil,M., El-Badawy,O., Sharaf-Eldin,A., Sadek,A. and Sabry,A.
  TITLE     Serum levels of Interleukins 1-Alpha & 12 as Predictors of Disease
            Progression in Hepatitis C Diabetic Patients
  JOURNAL   Egypt J Immunol 25 (1), 181-190 (2018)
   PUBMED   30243010
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Elsayed,H.M., Nabiel,Y. and Sheta,T.
  TITLE     IL12 Gene Polymorphism in Association with Hepatocellular Carcinoma
            in HCV-infected Egyptian Patients
  JOURNAL   Immunol Invest 46 (2), 123-133 (2017)
   PUBMED   27819525
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Li,P., Lu,G., Cui,Y., Wu,Z., Chen,S., Li,J., Wen,X., Zhang,H.,
            Mu,S., Zhang,F. and Li,Y.
  TITLE     Association of IL12A Expression Quantitative Trait Loci (eQTL) With
            Primary Biliary Cirrhosis in a Chinese Han Population
  JOURNAL   Medicine (Baltimore) 95 (19), e3665 (2016)
   PUBMED   27175695
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Houshmandi,N., Najafipour,H., Joukar,S., Dabiri,S., Abbasloo,E.,
            Abdi,E. and Safi,Z.
  TITLE     The effect of interleukins 27 and 35 and their role on mediating
            the action of insulin Like Growth Factor -1 on the inflammation and
            blood flow of chronically inflamed rat knee joint
  JOURNAL   Cytokine 81, 117-126 (2016)
   PUBMED   26994309
  REMARK    GeneRIF: Data show that endogenous interleukins IL-27 and IL-35
            (Ebi3 and Il-12p35 subunits) had inflammatory roles and insulin
            like growth factor -1 (IGF-1) had no effect.
REFERENCE   6  (bases 1 to 793)
  AUTHORS   Hayes,M.P., Wang,J. and Norcross,M.A.
  TITLE     Regulation of interleukin-12 expression in human monocytes:
            selective priming by interferon-gamma of
            lipopolysaccharide-inducible p35 and p40 genes
  JOURNAL   Blood 86 (2), 646-650 (1995)
   PUBMED   7605994
REFERENCE   7  (bases 1 to 793)
  AUTHORS   Ploemacher,R.E., van Soest,P.L., Boudewijn,A. and Neben,S.
  TITLE     Interleukin-12 enhances interleukin-3 dependent multilineage
            hematopoietic colony formation stimulated by interleukin-11 or
            steel factor
  JOURNAL   Leukemia 7 (9), 1374-1380 (1993)
   PUBMED   7690439
REFERENCE   8  (bases 1 to 793)
  AUTHORS   D'Andrea,A., Rengaraju,M., Valiante,N.M., Chehimi,J., Kubin,M.,
            Aste,M., Chan,S.H., Kobayashi,M., Young,D., Nickbarg,E. et al.
  TITLE     Production of natural killer cell stimulatory factor (interleukin
            12) by peripheral blood mononuclear cells
  JOURNAL   J Exp Med 176 (5), 1387-1398 (1992)
   PUBMED   1357073
REFERENCE   9  (bases 1 to 793)
  AUTHORS   Gubler,U., Chua,A.O., Schoenhaut,D.S., Dwyer,C.M., McComas,W.,
            Motyka,R., Nabavi,N., Wolitzky,A.G., Quinn,P.M., Familletti,P.C. et
            al.
  TITLE     Coexpression of two distinct genes is required to generate secreted
            bioactive cytotoxic lymphocyte maturation factor
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4143-4147 (1991)
   PUBMED   1674604
REFERENCE   10 (bases 1 to 793)
  AUTHORS   Stern,A.S., Podlaski,F.J., Hulmes,J.D., Pan,Y.C., Quinn,P.M.,
            Wolitzky,A.G., Familletti,P.C., Stremlo,D.L., Truitt,T.,
            Chizzonite,R. et al.
  TITLE     Purification to homogeneity and partial characterization of
            cytotoxic lymphocyte maturation factor from human B-lymphoblastoid
            cells
  JOURNAL   Proc Natl Acad Sci U S A 87 (17), 6808-6812 (1990)
   PUBMED   2204066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF177031.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..793
                     /gene="Il12a"
                     /note="interleukin 12A"
                     /db_xref="GeneID:84405"
                     /db_xref="RGD:620562"
     exon            1..50
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..682
                     /gene="Il12a"
                     /note="interleukin-12 subunit alpha; IL-12A; CLMF p35;
                     IL-12 subunit p35; cytotoxic lymphocyte maturation factor
                     35 kDa subunit; interleukin 12 p35 subunit"
                     /codon_start=1
                     /product="interleukin-12 subunit alpha precursor"
                     /protein_id="NP_445842.1"
                     /db_xref="GeneID:84405"
                     /db_xref="RGD:620562"
                     /translation="MCQSRYLLFLATLVLLNHLTSARVIPVSGPAKCLNQSQNLLKTT
                     DDMVRTAREKLKHYSCTAGDIDHEDITRDKTSTLEACLPLELHKNESCLATKETSSII
                     RGSCLPPQKTSLMMTLCLGSIYEDLKMYQSEFQAINAALQSHNHQQITLDRNMLMAID
                     ELMRSLNHSGETLHQKAPMGEADPYRVKMKLCILLHAFSTRVMTINRVMNYLSSS"
     exon            51..184
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     exon            185..298
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     exon            299..340
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     exon            341..382
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     exon            383..526
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
     exon            527..793
                     /gene="Il12a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcatccagc tgctcctctc agtgccggtc cagcatgtgt caatcacgct acctcctctt
       61 cttggccacc cttgtcctcc taaaccacct cacttcggcc agggtcatac cagtctctgg
      121 acctgccaag tgtcttaacc agtcccaaaa cctgctgaag accacggacg acatggtgag
      181 gacggccaga gaaaaattga aacattactc ttgcactgct ggagacatcg atcatgaaga
      241 catcacacgg gacaaaacca gcacactgga ggcctgctta ccactggaac tccacaagaa
      301 tgagagttgc ctggctacta aagagacttc ttccataata agagggagct gcctgcctcc
      361 acaaaagact tctttgatga tgaccctgtg ccttggtagc atctatgagg acttgaagat
      421 gtaccagtca gagttccagg ccataaatgc agcacttcag agccacaatc atcagcagat
      481 cactctggac agaaacatgc tgatggctat tgatgagcta atgcggtctc tgaatcacag
      541 cggcgagact ctgcaccaga aagctcccat gggagaagca gatccttaca gagtgaagat
      601 gaagctctgt atcctgctcc atgccttcag cacccgagtc atgactatca acagggtgat
      661 gaactatctg agctcctcct aaggaggagg gctaggagtc aggtagtcct ggcctggttg
      721 accttcagct cctgtaggaa tctgtaaccc caaaggtggc acggctgcct cagcgtgggc
      781 ccctccattg tgt
//
