LOCUS       NM_139116               1713 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Rattus norvegicus interleukin 11 receptor subunit alpha 1
            (Il11ra1), transcript variant 1, mRNA.
ACCESSION   NM_139116
VERSION     NM_139116.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Zuo,D., Zheng,Q., Xiao,M., Wang,X., Chen,H., Xu,J., Zhang,Q.,
            Xiong,Y., Ye,L. and Feng,Z.
  TITLE     Anti-apoptosis effect of recombinant human interleukin-11 in
            neonatal hypoxic-ischemic rats through activating the
            IL-11Ralpha/STAT3 signaling pathway
  JOURNAL   J Stroke Cerebrovasc Dis 32 (2), 106923 (2023)
   PUBMED   36521373
  REMARK    GeneRIF: Anti-apoptosis effect of recombinant human interleukin-11
            in neonatal hypoxic-ischemic rats through activating the
            IL-11Ralpha/STAT3 signaling pathway.
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Nieminen,P., Morgan,N.V., Fenwick,A.L., Parmanen,S., Veistinen,L.,
            Mikkola,M.L., van der Spek,P.J., Giraud,A., Judd,L., Arte,S.,
            Brueton,L.A., Wall,S.A., Mathijssen,I.M., Maher,E.R., Wilkie,A.O.,
            Kreiborg,S. and Thesleff,I.
  TITLE     Inactivation of IL11 signaling causes craniosynostosis, delayed
            tooth eruption, and supernumerary teeth
  JOURNAL   Am J Hum Genet 89 (1), 67-81 (2011)
   PUBMED   21741611
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Ain,R., Trinh,M.L. and Soares,M.J.
  TITLE     Interleukin-11 signaling is required for the differentiation of
            natural killer cells at the maternal-fetal interface
  JOURNAL   Dev Dyn 231 (4), 700-708 (2004)
   PUBMED   15499555
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Kiessling,S., Muller-Newen,G., Leeb,S.N., Hausmann,M., Rath,H.C.,
            Strater,J., Spottl,T., Schlottmann,K., Grossmann,J.,
            Montero-Julian,F.A., Scholmerich,J., Andus,T., Buschauer,A.,
            Heinrich,P.C. and Rogler,G.
  TITLE     Functional expression of the interleukin-11 receptor alpha-chain
            and evidence of antiapoptotic effects in human colonic epithelial
            cells
  JOURNAL   J Biol Chem 279 (11), 10304-10315 (2004)
   PUBMED   14701802
  REMARK    GeneRIF: IL11RA has a role in apoptosis
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Li,R., Hartley,L. and Robb,L.
  TITLE     Cloning of rat interleukin 11 and interleukin 11 receptor alpha
            chain and analysis of their expression in rat uterus in the
            peri-implantation period
  JOURNAL   Reproduction 122 (4), 593-600 (2001)
   PUBMED   11570967
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Bilinski,P., Roopenian,D. and Gossler,A.
  TITLE     Maternal IL-11Ralpha function is required for normal decidua and
            fetoplacental development in mice
  JOURNAL   Genes Dev 12 (14), 2234-2243 (1998)
   PUBMED   9679067
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Robb,L., Li,R., Hartley,L., Nandurkar,H.H., Koentgen,F. and
            Begley,C.G.
  TITLE     Infertility in female mice lacking the receptor for interleukin 11
            is due to a defective uterine response to implantation
  JOURNAL   Nat Med 4 (3), 303-308 (1998)
   PUBMED   9500603
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF347936.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF347936.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1713
                     /gene="Il11ra1"
                     /note="interleukin 11 receptor subunit alpha 1"
                     /db_xref="GeneID:245983"
                     /db_xref="RGD:621332"
     exon            1..56
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1352
                     /gene="Il11ra1"
                     /note="interleukin-11 receptor alpha chain; interleukin 11
                     receptor, alpha chain 1; interleukin-11 receptor subunit
                     alpha; IL-11RA; IL-11R-alpha; IL-11R subunit alpha; IL-11
                     receptor subunit alpha"
                     /codon_start=1
                     /product="interleukin-11 receptor subunit alpha precursor"
                     /protein_id="NP_620816.1"
                     /db_xref="GeneID:245983"
                     /db_xref="RGD:621332"
                     /translation="MSSSRSGLTRVLVAVATALVSSSTPCPQAWGPPGVQYGQPGRPV
                     MLCCPGVNAGTPVSWFRDGDSRLLQGPDSGLGHRLVLAQVDSRDEGTYVCRTLDGVFG
                     GMVTLKLGSPPARPEVSCQAVDYENFSCTWSPGRVSGLPTRYLTSYRKKTLPGAESQR
                     ESPSTGPWPCPQDPLEASRCVVHGAEFWSEYRINVTEVNPLGASTCLLDVRLQRILRP
                     DPPQGLRVESVPGYPRRLHASWTYPASWRRQPHFLLKFRLQYRPAQHPAWSTVEPIGL
                     EELITDAVAGLPHAVRVSARDFLDAGTWSAWSPEAWGTPSTGPLRDEVPDGSRGHEQK
                     LEAAAQEDSPAPPSPSLQPDPRPLDHRDPLEQVAVLASLGIFSFLGLAVGALALGLWL
                     RLRRSGKDGPQKPGFLAPMIPGDKLPGIPNLQRTPENFS"
     exon            57..156
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..217
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..387
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..502
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..535
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..702
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..866
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1008
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1131
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1228
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1311
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1711
                     /gene="Il11ra1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctgtagg agggagtctt ggaggccatg agcactcagt cactgtgatt ttcaagatga
       61 gcagcagccg ctcagggctg accagggtcc tggtggccgt ggctacagcc ctggtgtctt
      121 cctccacccc ctgcccccaa gcttggggtc ctccaggggt ccagtatggg cagcctggca
      181 ggcccgtgat gctgtgctgc cccggagtga atgctgggac tccggtgtcc tggtttcggg
      241 atggggactc gaggctgctc cagggacctg actctggact aggacacaga ctggtcttgg
      301 cccaggtgga cagccgtgac gagggcactt acgtctgtcg gacgctggat ggtgtatttg
      361 ggggcatggt gaccctgaag ctgggctccc ccccagctcg gccggaggtc tcctgccaag
      421 cagtagacta tgaaaacttt tcttgtactt ggagtccagg ccgggtcagc ggtttgccca
      481 cccgctacct tacttcctac aggaagaaga ccctgccagg agctgagagt cagagggaga
      541 gtccgtctac cgggccttgg ccatgcccac aagaccccct ggaggcttcc cgatgtgtgg
      601 tccacggggc agagttctgg agtgaatacc ggatcaatgt gactgaggtg aacccactgg
      661 gcgccagcac gtgcctactg gatgtgagat tacagaggat cttacgtcct gatccacccc
      721 aagggctgcg ggtggaatca gtacctggct acccgagacg cctgcatgcc agctggacat
      781 accctgcctc ctggcgtcgc cagccccact tcctgctcaa gttccggttg caataccgtc
      841 cagcacagca tccagcctgg tccacggtgg agcccattgg cttggaggag ttgataacag
      901 atgccgtggc tgggctgccc catgcggtac gagtcagcgc cagggacttt ctggatgctg
      961 gcacctggag tgcttggagc ccagaggcct ggggtactcc tagcaccggt cccctgcggg
     1021 atgaggtacc tgatgggagc cggggacacg aacagaagct agaggcagca gctcaggagg
     1081 acagccccgc tcctccaagc ccttccttgc agccagaccc aaggccactt gatcacaggg
     1141 accccttgga gcaagtggct gtgttagcat ctctgggaat cttctctttc cttggcctgg
     1201 ctgttggagc cctggctctg gggctctggc tgaggctgag gcggagtggg aaggacgggc
     1261 ctcaaaagcc tggcttcttg gcaccaatga tcccagggga caagcttcca ggaatcccaa
     1321 acctgcagag gaccccagag aacttcagct gatctcatct gcaaccctgt cagactgggg
     1381 tggttaaatg gacaggcagg aggaggcagg acagcggatc cctatggatg gaggtctcag
     1441 ttcgaagtct ggagcacttt tctttgacac ctgaactcca aacttgctgc cagctgctca
     1501 ctctctggac ctctgatgcc gtccttgagg tggaagtccg cctgaggagc gtgtatcgaa
     1561 gtctgtgtcc ctgtgactgt gtgtgtgtgt gatggggaga gcacgttctc cgtatgtgtg
     1621 tgtatagatg attggagagt gtgtgtgtgg tcttgggctt ggctctcctg gggagcatgg
     1681 agcgtgaaat aaagaggcgg acgtttttgg aaa
//
