LOCUS       NM_133519               1675 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus interleukin 11 (Il11), mRNA.
ACCESSION   NM_133519
VERSION     NM_133519.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1675)
  AUTHORS   Xiao,R., Gu,L., Li,A.M., Gan,Y.L., He,C.Y., Liao,J.X., Li,Y.S.,
            Xu,L. and Guo,S.L.
  TITLE     IL-11 drives the phenotypic transformation of tracheal epithelial
            cells and fibroblasts to enhance abnormal repair after tracheal
            injury
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (4), 119438 (2023)
   PUBMED   36758859
  REMARK    GeneRIF: IL-11 drives the phenotypic transformation of tracheal
            epithelial cells and fibroblasts to enhance abnormal repair after
            tracheal injury.
REFERENCE   2  (bases 1 to 1675)
  AUTHORS   Menendez-Castro,C., Cordasic,N., Dambietz,T., Veelken,R., Amann,K.,
            Hartner,A. and Hilgers,K.F.
  TITLE     Correlations Between Interleukin-11 Expression and Hypertensive
            Kidney Injury in a Rat Model of Renovascular Hypertension
  JOURNAL   Am J Hypertens 33 (4), 331-340 (2020)
   PUBMED   31840157
  REMARK    GeneRIF: Correlations Between Interleukin-11 Expression and
            Hypertensive Kidney Injury in a Rat Model of Renovascular
            Hypertension.
REFERENCE   3  (bases 1 to 1675)
  AUTHORS   Haider,K.H., Idris,N.M., Kim,H.W., Ahmed,R.P., Shujia,J. and
            Ashraf,M.
  TITLE     MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic
            signalling pathway in preconditioning of skeletal myoblasts
  JOURNAL   Cardiovasc Res 88 (1), 168-178 (2010)
   PUBMED   20498256
  REMARK    GeneRIF: miR-21 is a key regulator of Erk1/2-Stat3 signalling
            downstream of IL-11 during preconditioning of skeletal myoblasts.
REFERENCE   4  (bases 1 to 1675)
  AUTHORS   Chetty,A., Cao,G.J., Manzo,N., Nielsen,H.C. and Waxman,A.
  TITLE     The role of IL-6 and IL-11 in hyperoxic injury in developing lung
  JOURNAL   Pediatr Pulmonol 43 (3), 297-304 (2008)
   PUBMED   18214944
  REMARK    GeneRIF: IL-11 and IL-6 provide protective effects against
            oxidant-mediated injury in fetal type II cells and IL-11 provides
            protection in vivo by down-regulation of caspase-mediated cell
            death
REFERENCE   5  (bases 1 to 1675)
  AUTHORS   Grehan,J.F., Levay-Young,B.K., Fogelson,J.L.,
            Francois-Bongarcon,V., Benson,B.A. and Dalmasso,A.P.
  TITLE     IL-4 and IL-13 induce protection of porcine endothelial cells from
            killing by human complement and from apoptosis through activation
            of a phosphatidylinositide 3-kinase/Akt pathway
  JOURNAL   J Immunol 175 (3), 1903-1910 (2005)
   PUBMED   16034134
REFERENCE   6  (bases 1 to 1675)
  AUTHORS   Li,R., Hartley,L. and Robb,L.
  TITLE     Cloning of rat interleukin 11 and interleukin 11 receptor alpha
            chain and analysis of their expression in rat uterus in the
            peri-implantation period
  JOURNAL   Reproduction 122 (4), 593-600 (2001)
   PUBMED   11570967
REFERENCE   7  (bases 1 to 1675)
  AUTHORS   Yamaguchi,M., Miki,N., Ono,M., Ohtsuka,C., Demura,H., Kurachi,H.,
            Inoue,M., Endo,H., Taga,T., Kishimoto,T. et al.
  TITLE     Inhibition of growth hormone-releasing factor production in mouse
            placenta by cytokines using gp130 as a signal transducer
  JOURNAL   Endocrinology 136 (3), 1072-1078 (1995)
   PUBMED   7867561
REFERENCE   8  (bases 1 to 1675)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
REFERENCE   9  (bases 1 to 1675)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   10 (bases 1 to 1675)
  AUTHORS   Paul,S.R., Bennett,F., Calvetti,J.A., Kelleher,K., Wood,C.R.,
            O'Hara,R.M. Jr., Leary,A.C., Sibley,B., Clark,S.C., Williams,D.A.
            et al.
  TITLE     Molecular cloning of a cDNA encoding interleukin 11, a stromal
            cell-derived lymphopoietic and hematopoietic cytokine
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7512-7516 (1990)
   PUBMED   2145578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000027.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_133519.6.
            
            On Feb 10, 2021 this sequence version replaced NM_133519.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345330,
                              SAMN09345331 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JACYVU010000027.1  1150514-1150634
            122-294             JACYVU010000027.1  1152145-1152317
            295-381             JACYVU010000027.1  1152426-1152512
            382-543             JACYVU010000027.1  1152622-1152783
            544-1675            JACYVU010000027.1  1155683-1156814
FEATURES             Location/Qualifiers
     source          1..1675
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1675
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /note="interleukin 11"
                     /db_xref="GeneID:171040"
                     /db_xref="RGD:621475"
     exon            1..121
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..714
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /codon_start=1
                     /product="interleukin-11 precursor"
                     /protein_id="NP_598203.4"
                     /db_xref="GeneID:171040"
                     /db_xref="RGD:621475"
                     /translation="MNCVCHLVLVVLSLWPDRVVAPGPPAGSPRVSSDPRADLDSAVL
                     LTRSLLADTRQLAAQMRDKFPADGDHNLDSLPTLAMSAGTLGSLQLPGVLTRLRVDLM
                     SYFRHVQWLRRAAGPSLKTLEPELGALQARLERLLRRLQLLMSRLALPQAAPDQPAVP
                     LGPPASAWGSIRAAHAILGGLHLTLDWAVRGLLLLKTRL"
     exon            122..294
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /inference="alignment:Splign:2.1.0"
     exon            295..381
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /inference="alignment:Splign:2.1.0"
     exon            382..543
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1675
                     /gene="Il11"
                     /gene_synonym="Il-11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgaggccc agctgacccc ctgggctccc ccggcagcgg acagggaagg gttaaaggcc
       61 ccctcccccc ggctccctgc cccctgccct ggggaacccc tggcctgtgg ggacatgaac
      121 tgtgtttgtc acctggtcct ggtggtgctg agcctctggc cagatagagt cgttgcccct
      181 gggccaccag ctggctcccc tcgagtgtct tcagaccctc gtgcagatct ggatagcgct
      241 gtcctcttga ccaggtccct cctggcagac acacggcaac tagctgcaca gatgagagac
      301 aaattcccag ctgatggaga ccacaatctg gactccctac ctaccttggc catgagcgct
      361 gggacactgg gatctttgca gcttcctgga gtgctgacaa ggcttcgagt agacttaatg
      421 tcctacttcc gacatgtaca gtggttgcgc cgggcagctg gtccttccct aaagactctg
      481 gagccagagc tgggtgccct gcaagcccga ctggaacggc tacttcgtcg cttacagctc
      541 ttgatgtctc gcctagcctt gccccaggca gccccggacc aacctgcggt ccctctgggc
      601 cctcctgcct cggcctgggg aagcatccgg gcagctcatg ccatcctagg agggctgcac
      661 ctgaccttgg actgggccgt gcggggcctg ctgttgttaa agactcggct gtaactcagg
      721 actgaaagcc accatcgaca tcgtccttta aagccagatc ttatttattt atttattttg
      781 gtacttggag cgggggagca tgatgaacag gggcatgcca caccccaaac agccacaccc
      841 agctagataa agtccttcca ggagacctgg gtgagggggc tcacctgtgg cttatttata
      901 cttatttatt taaagaattg gggtgggtgc atctgagacc ctgaggagca gggaactgag
      961 atcctgggtc ctgggtcttt acgaagtcta ttcacagtgt cttcctcact tttttattat
     1021 ttattaaaca attacttttt atattaggag gatggagggg gggaaaggaa gcctggggtt
     1081 tttataccaa aatgtgattt tttttttgtg acacagagaa gtggggtatt taactattaa
     1141 tgtggggtat ataactattt agaggttatt agcaggaata ttccaaaggg atctgagtgt
     1201 aaaccggtac cctagcactt caaaggtcct caacagatac ttagcaaacg gaccgaaaca
     1261 cctcatgtct aacagcacct gcatggtaca gagatagcaa ggttcaaggt gtttcagcaa
     1321 gagtcacgca ccctggcaaa tgggaaacaa cttaggtttt cggggggggg gggggggcag
     1381 gggacggatg aatctagtta gggaagttcc aggcaaagac ttctttagat gttgaacgtc
     1441 cctgtgcccc gagagcagca gaggatagaa cctctctttc tatacatgga tatagatttt
     1501 ttttgttttt caaaatggaa acaccaaaat gttgacaaca gctgcctcag ggttgaaaac
     1561 aagagatggc actgtgggtg actgttattg tttgtgcttg cattttccag agtttccacc
     1621 atgactgtat tttgcatgac acgtttacaa acaataataa acactatttt tagaa
//
