LOCUS       NM_057193               1814 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus interleukin 10 receptor subunit alpha (Il10ra),
            mRNA.
ACCESSION   NM_057193
VERSION     NM_057193.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Lv,Z.C., Cao,X.Y., Guo,Y.X., Zhang,X.D., Ding,J., Geng,J., Feng,K.
            and Niu,H.
  TITLE     MiR-137-5p alleviates inflammation by upregulating IL-10R1
            expression in rats with spinal cord injury
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (11), 4551-4557 (2019)
   PUBMED   31210303
  REMARK    GeneRIF: MiR-137-5p alleviates inflammation by upregulating IL-10R1
            expression in rats with spinal cord injury.
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Shi,J., Wang,H., Guan,H., Shi,S., Li,Y., Wu,X., Li,N., Yang,C.,
            Bai,X., Cai,W., Yang,F., Wang,X., Su,L., Zheng,Z. and Hu,D.
  TITLE     IL10 inhibits starvation-induced autophagy in hypertrophic scar
            fibroblasts via cross talk between the IL10-IL10R-STAT3 and
            IL10-AKT-mTOR pathways
  JOURNAL   Cell Death Dis 7 (3), e2133 (2016)
   PUBMED   26962683
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Lim,S.H., Park,E., You,B., Jung,Y., Park,A.R., Park,S.G. and
            Lee,J.R.
  TITLE     Neuronal synapse formation induced by microglia and interleukin 10
  JOURNAL   PLoS One 8 (11), e81218 (2013)
   PUBMED   24278397
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Perez-Asensio,F.J., Perpina,U., Planas,A.M. and Pozas,E.
  TITLE     Interleukin-10 regulates progenitor differentiation and modulates
            neurogenesis in adult brain
  JOURNAL   J Cell Sci 126 (Pt 18), 4208-4219 (2013)
   PUBMED   23843621
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Rico,M.J., Matar,P. and Scharovsky,O.G.
  TITLE     Modulation of IL-10/IL-10R expression by mafosfamide, a derivative
            of 4-hydroxycyclophosphamide, in a rat B-cell lymphoma
  JOURNAL   Biocell 36 (2), 91-95 (2012)
   PUBMED   23185784
  REMARK    GeneRIF: High IL-10 receptor expression is associated with B-cell
            lymphoma.
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Ledeboer,A., Wierinckx,A., Bol,J.G., Floris,S., Renardel de
            Lavalette,C., De Vries,H.E., van den Berg,T.K., Dijkstra,C.D.,
            Tilders,F.J. and van dam,A.M.
  TITLE     Regional and temporal expression patterns of interleukin-10,
            interleukin-10 receptor and adhesion molecules in the rat spinal
            cord during chronic relapsing EAE
  JOURNAL   J Neuroimmunol 136 (1-2), 94-103 (2003)
   PUBMED   12620647
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Ledeboer,A., Breve,J.J., Wierinckx,A., van der Jagt,S.,
            Bristow,A.F., Leysen,J.E., Tilders,F.J. and Van Dam,A.M.
  TITLE     Expression and regulation of interleukin-10 and interleukin-10
            receptor in rat astroglial and microglial cells
  JOURNAL   Eur J Neurosci 16 (7), 1175-1185 (2002)
   PUBMED   12405978
REFERENCE   8  (bases 1 to 1814)
  AUTHORS   Mathurin,P., Xiong,S., Kharbanda,K.K., Veal,N., Miyahara,T.,
            Motomura,K., Rippe,R.A., Bachem,M.G. and Tsukamoto,H.
  TITLE     IL-10 receptor and coreceptor expression in quiescent and activated
            hepatic stellate cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (6), G981-G990 (2002)
   PUBMED   12016123
REFERENCE   9  (bases 1 to 1814)
  AUTHORS   Ledeboer,A., Binnekade,R., Breve,J.J., Bol,J.G., Tilders,F.J. and
            Van Dam,A.M.
  TITLE     Site-specific modulation of LPS-induced fever and interleukin-1
            beta expression in rats by interleukin-10
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 282 (6), R1762-R1772 (2002)
   PUBMED   12010759
REFERENCE   10 (bases 1 to 1814)
  AUTHORS   Ward,H., Vigues,S., Poole,S. and Bristow,A.F.
  TITLE     The rat interleukin 10 receptor: cloning and sequencing of cDNA
            coding for the alpha-chain protein sequence, and demonstration by
            western blotting of expression in the rat brain
  JOURNAL   Cytokine 15 (5), 237-240 (2001)
   PUBMED   11594787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 19, 2011 this sequence version replaced NM_057193.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ305049.1, FQ223464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000008.1  54474669-54474786   c
            119-239             JAXUCZ010000008.1  54472753-54472873   c
            240-424             JAXUCZ010000008.1  54472086-54472270   c
            425-591             JAXUCZ010000008.1  54471117-54471283   c
            592-745             JAXUCZ010000008.1  54469956-54470109   c
            746-864             JAXUCZ010000008.1  54465793-54465911   c
            865-1814            JAXUCZ010000008.1  54461387-54462336   c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1814
                     /gene="Il10ra"
                     /note="interleukin 10 receptor subunit alpha"
                     /db_xref="GeneID:117539"
                     /db_xref="RGD:620138"
     exon            1..118
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1761
                     /gene="Il10ra"
                     /note="interleukin 10 receptor, alpha"
                     /codon_start=1
                     /product="interleukin-10 receptor subunit alpha"
                     /protein_id="NP_476541.2"
                     /db_xref="GeneID:117539"
                     /db_xref="RGD:620138"
                     /translation="MLPRLLPFLVSISSLSLGFRAHGTELPSPSSVWFEARFFQHILR
                     WMSIPNQSESTYYEVALKKYGTSVWKDIHICSKAQTLSCDLTTSTLDLYHSSGYRARV
                     RAVDNSQYSNWTITETRFTVDEVILTVDSVTLKVSNGFIYGTIHPPRPNLVPVGDEYE
                     QIFTHHRIYRVCIRKFSEQKNITKTVEQENFTLEVPKGMRKFCVKVMPHVESRINKAE
                     WSEEQCLHVTTEHYFTVTNLSIFFLSILILCGALVCLVLLWYIRHPGKLPAVLVFEKP
                     PDFLLANPRCPETLDDIHILDLEAFPKVSPELKDSDLHGSTDSGFGSGKPSLQTEESQ
                     FFLLDSHAQIQETLGKEGSSELQDTCGDNTDSGICLQESSLHSSMGPPWKQQFGYTHQ
                     DQDDSDLVQNSPGHPKHTQDGSALGHGCLLEPEVPEEKDQVMVTFQGYQKQTRWKEEA
                     AEPLDGEIPLAEAFDPELGVRLQGDSAWPPVALATGYLKQESQGMASAPPGTPSRQWN
                     QLAEECSLLGVVSCEDLSIESLGFAHELVPLDCGAASSGLLDSLGTNLVTLPLISSLQ
                     IEE"
     exon            119..239
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     exon            240..424
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     exon            425..591
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     exon            592..745
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     exon            746..864
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1814
                     /gene="Il10ra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggaggcc taaaggccgg ctccagtgga cgatgccgct gtgcgcccag gatgttgccg
       61 cgtttactcc cattcctcgt ctcgatctcc agcctgagcc tgggcttccg cgcacacggg
      121 acagaactgc cgagcccttc ctccgtgtgg tttgaagcca gatttttcca gcacatcctc
      181 cgctggatgt ctatcccaaa ccagtctgag agcacctact acgaagtggc cctcaagaag
      241 tacggaacct cggtctggaa agacatccac atctgtagca aggctcagac attgtcctgc
      301 gatctcacaa cgtccaccct agatctgtac cacagctctg gctaccgggc cagagtccgg
      361 gcagtggaca acagtcagta ttccaactgg accatcactg aaactcgctt cacagtggat
      421 gaagtgattc tgacggtgga tagcgtgacg ctgaaagtaa gcaacggctt catctacggg
      481 acaatccatc cccccaggcc caatttagtc cctgtaggtg acgagtatga acagatcttc
      541 acgcaccacc gcatttacag ggtttgcatt cggaagttct cagaacaaaa gaatataacc
      601 aagacagtgg agcaagaaaa cttcaccctc gaagtcccaa aagggatgag aaagttttgt
      661 gtcaaggtga tgcctcacgt ggaatcccga attaacaagg cagagtggtc ggaggagcag
      721 tgtttacatg tcacgacgga gcattatttc accgtgacca acctcagcat tttcttctta
      781 tccatcctga tactctgtgg agccctggtc tgcctggttc tcctgtggta catccggcac
      841 ccggggaagt tacctgcagt cctggtcttc gagaagcctc ccgactttct gctggccaac
      901 cctcgctgcc cagagactct cgatgacatt cacatcctgg acctggaggc cttcccaaag
      961 gtgtcacccg agctgaaaga ctcagacctg catggcagca ccgacagtgg ctttggcagt
     1021 ggcaaaccat cacttcagac ggaagaatcc caattcttcc tccttgactc ccacgcccag
     1081 atacaggaga ctctgggaaa ggaagggtct tcagagctac aggacacctg tggggacaac
     1141 acggacagtg ggatctgctt gcaggagtcc agcttacact ctagcatggg tcctccctgg
     1201 aagcagcagt tcggatatac ccaccaggac caggatgaca gtgacctagt ccagaactct
     1261 ccagggcatc ctaagcacac acaggatggc tccgccttgg gccatggttg tctcctagag
     1321 cctgaagtcc ctgaggagaa agaccaagtc atggtaacgt tccagggcta ccagaagcag
     1381 accagatgga aggaggaagc agcagaacct ttggacggag agattccctt ggcagaagcc
     1441 tttgatcctg aactcggggt gcgcctgcag ggtgattcag cttggcctcc tgtggctcta
     1501 gccacgggtt atttgaaaca ggagtctcaa gggatggcct ctgctccacc ggggacacca
     1561 agtagacagt ggaatcaact ggctgaggaa tgctcactcc tgggtgtggt tagctgtgaa
     1621 gacctaagca tagagagttt gggttttgcc catgaacttg tccctctgga ctgtggggca
     1681 gcctctagtg gcctcctgga tagccttggc actaatctgg tcaccctgcc attgatctcc
     1741 agcctgcaga tagaagagtg acaggggata aggtttcttt gtattttggc catgcctgct
     1801 cccctcccta tacc
//
