LOCUS       NM_012854                682 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus interleukin 10 (Il10), mRNA.
ACCESSION   NM_012854
VERSION     NM_012854.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 682)
  AUTHORS   Ren,Z.Y., Wang,J., Xu,F., Gao,Y., He,Q., Pan,B. and Lyu,S.C.
  TITLE     IL-10 dependent modulatory effect of regulatory B10 cells on local
            scar formation following Roux-en-Y choledochojejunostomy in a novel
            rat model
  JOURNAL   Int Immunopharmacol 126, 111309 (2024)
   PUBMED   38048666
  REMARK    GeneRIF: IL-10 dependent modulatory effect of regulatory B10 cells
            on local scar formation following Roux-en-Y choledochojejunostomy
            in a novel rat model.
REFERENCE   2  (bases 1 to 682)
  AUTHORS   Yang,L., Cao,J., Du,Y., Zhang,X., Hong,W., Peng,B., Wu,J., Weng,Q.,
            Wang,J. and Gao,J.
  TITLE     Initial IL-10 production dominates the therapy of mesenchymal stem
            cell scaffold in spinal cord injury
  JOURNAL   Theranostics 14 (2), 879-891 (2024)
   PUBMED   38169599
  REMARK    GeneRIF: Initial IL-10 production dominates the therapy of
            mesenchymal stem cell scaffold in spinal cord injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 682)
  AUTHORS   Kosyreva,A.M., Dzhalilova,D.S., Tsvetkov,I.S., Makarova,M.A. and
            Makarova,O.V.
  TITLE     Ex Vivo Production of IL-1beta and IL-10 by Activated Blood Cells
            of Wistar Rats with Different Resistance to Hypoxia after Systemic
            Inflammatory Response Syndrome
  JOURNAL   Bull Exp Biol Med 176 (2), 290-296 (2023)
   PUBMED   38194074
  REMARK    GeneRIF: Ex Vivo Production of IL-1beta and IL-10 by Activated
            Blood Cells of Wistar Rats with Different Resistance to Hypoxia
            after Systemic Inflammatory Response Syndrome.
REFERENCE   4  (bases 1 to 682)
  AUTHORS   Changaei,M., Javidan,M., Ramezani Tehrani,F., Mosaffa,N.,
            Noroozzadeh,M., Hosseinzadeh,R. and Rajaei,S.
  TITLE     Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in the embryo
            implantation site of rat model with prenatal androgen-induced
            polycystic ovary syndrome
  JOURNAL   Am J Reprod Immunol 90 (1), e13702 (2023)
   PUBMED   37062956
  REMARK    GeneRIF: Reduced expression of Il10, Stat3, Hoxa10, and Itgb3 in
            the embryo implantation site of rat model with prenatal
            androgen-induced polycystic ovary syndrome.
REFERENCE   5  (bases 1 to 682)
  AUTHORS   Huynh,T., Reed,C., Blackwell,Z., Phelps,P., Herrera,L.C.P.,
            Almodovar,J., Zaharoff,D.A. and Wolchok,J.
  TITLE     Local IL-10 delivery modulates the immune response and enhances
            repair of volumetric muscle loss muscle injury
  JOURNAL   Sci Rep 13 (1), 1983 (2023)
   PUBMED   36737628
  REMARK    GeneRIF: Local IL-10 delivery modulates the immune response and
            enhances repair of volumetric muscle loss muscle injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 682)
  AUTHORS   Berg,D.J., Kuhn,R., Rajewsky,K., Muller,W., Menon,S., Davidson,N.,
            Grunig,G. and Rennick,D.
  TITLE     Interleukin-10 is a central regulator of the response to LPS in
            murine models of endotoxic shock and the Shwartzman reaction but
            not endotoxin tolerance
  JOURNAL   J Clin Invest 96 (5), 2339-2347 (1995)
   PUBMED   7593621
REFERENCE   7  (bases 1 to 682)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   8  (bases 1 to 682)
  AUTHORS   Goodman,R.E., Oblak,J. and Bell,R.G.
  TITLE     Synthesis and characterization of rat interleukin-10 (IL-10) cDNA
            clones from the RNA of cultured OX8- OX22- thoracic duct T cells
  JOURNAL   Biochem Biophys Res Commun 189 (1), 1-7 (1992)
   PUBMED   1280414
REFERENCE   9  (bases 1 to 682)
  AUTHORS   de Waal Malefyt,R., Abrams,J., Bennett,B., Figdor,C.G. and de
            Vries,J.E.
  TITLE     Interleukin 10(IL-10) inhibits cytokine synthesis by human
            monocytes: an autoregulatory role of IL-10 produced by monocytes
  JOURNAL   J Exp Med 174 (5), 1209-1220 (1991)
   PUBMED   1940799
REFERENCE   10 (bases 1 to 682)
  AUTHORS   Vieira,P., de Waal-Malefyt,R., Dang,M.N., Johnson,K.E.,
            Kastelein,R., Fiorentino,D.F., deVries,J.E., Roncarolo,M.G.,
            Mosmann,T.R. and Moore,K.W.
  TITLE     Isolation and expression of human cytokine synthesis inhibitory
            factor cDNA clones: homology to Epstein-Barr virus open reading
            frame BCRFI
  JOURNAL   Proc Natl Acad Sci U S A 88 (4), 1172-1176 (1991)
   PUBMED   1847510
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from L02926.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012854.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02926.1, X60675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="AO"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..682
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="interleukin 10"
                     /db_xref="GeneID:25325"
                     /db_xref="RGD:2886"
     exon            1..166
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..538
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /note="CSIF; IL-10; cytokine synthesis inhibitory factor;
                     interferon 2a"
                     /codon_start=1
                     /product="interleukin-10 precursor"
                     /protein_id="NP_036986.2"
                     /db_xref="GeneID:25325"
                     /db_xref="RGD:2886"
                     /translation="MPGSALLCCLLLLAGVKTSKGHSIRGDNNCTHFPVSQTHMLREL
                     RAAFSQVKTFFQKKDQLDNILLTDSLLQDFKGYLGCQALSEMIKFYLVEVMPQAENHG
                     PEIKEHLNSLGEKLKTLWIQLRRCHRFLPCENKSKAVEQVKNDFNKLQDKGVYKAMNE
                     FDIFINCIEAYVTLKMKN"
     exon            167..226
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            227..379
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            380..445
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
     exon            446..682
                     /gene="Il10"
                     /gene_synonym="If2a; IL10X"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catgcctggc tcagcactgc tatgttgcct gctcttactg gctggagtga agaccagcaa
       61 aggccattcc atccggggtg acaataactg cacccacttc ccagtcagcc agacccacat
      121 gctccgagag ctgagggctg ccttcagtca agtgaagact ttctttcaaa agaaggacca
      181 gctggacaac atactgctga cagattcctt actgcaggac tttaagggtt acttgggttg
      241 ccaagccttg tcagaaatga tcaagtttta cctggtagaa gtgatgcccc aggcagagaa
      301 ccatggccca gaaatcaagg agcatttgaa ttccctggga gagaagctga agaccctctg
      361 gatacagctg cgacgctgtc atcgatttct cccctgtgag aataaaagca aggcagtgga
      421 gcaggtgaag aatgatttta ataagctcca agacaaaggt gtctacaagg ccatgaatga
      481 gtttgacatc ttcatcaact gcatagaagc ctacgtgaca ctcaaaatga aaaattgaac
      541 cacccggcat ctactggact gcaggacata aatagagctt ctaaatctga tccagagatc
      601 ttagctaacg ggagcaactc cttggaaaac ctcgtttgta cctctctcca aaatatttat
      661 tacctctgat acctcagttc cc
//
