LOCUS       NM_001107047            2333 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus IKAROS family zinc finger 3 (Ikzf3), mRNA.
ACCESSION   NM_001107047 XM_001081400 XM_220921
VERSION     NM_001107047.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Li X, Xu Z, Du W, Zhang Z, Wei Y, Wang H, Zhu Z, Qin L, Wang L, Niu
            Q, Zhao X, Girard L, Gong Y, Ma Z, Sun B, Yao Z, Minna JD, Terada
            LS and Liu Z.
  TITLE     Aiolos promotes anchorage independence by silencing p66Shc
            transcription in cancer cells
  JOURNAL   Cancer Cell 25 (5), 575-589 (2014)
   PUBMED   24823637
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Archambaud C, Nahori MA, Soubigou G, Becavin C, Laval L, Lechat P,
            Smokvina T, Langella P, Lecuit M and Cossart P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Caballero R, Setien F, Lopez-Serra L, Boix-Chornet M, Fraga MF,
            Ropero S, Megias D, Alaminos M, Sanchez-Tapia EM, Montoya MC,
            Esteller M, Gonzalez-Sarmiento R and Ballestar E.
  TITLE     Combinatorial effects of splice variants modulate function of
            Aiolos
  JOURNAL   J Cell Sci 120 (Pt 15), 2619-2630 (2007)
   PUBMED   17646674
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Romero F, Martinez-A C, Camonis J and Rebollo A.
  TITLE     Aiolos transcription factor controls cell death in T cells by
            regulating Bcl-2 expression and its cellular localization
  JOURNAL   EMBO J 18 (12), 3419-3430 (1999)
   PUBMED   10369681
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A,
            Andrikopoulos K, Liang L, Pillai S, Morgan BA and Georgopoulos K.
  TITLE     Aiolos regulates B cell activation and maturation to effector state
  JOURNAL   Immunity 9 (4), 543-553 (1998)
   PUBMED   9806640
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K and
            Morgan BA.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E,
            Wu P, Neben S and Georgopoulos K.
  TITLE     Aiolos, a lymphoid restricted transcription factor that interacts
            with Ikaros to regulate lymphocyte differentiation
  JOURNAL   EMBO J 16 (8), 2004-2013 (1997)
   PUBMED   9155026
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220921.4, XM_001081400.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132287, SAMEA5756307
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2333
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /note="IKAROS family zinc finger 3"
                     /db_xref="GeneID:303511"
                     /db_xref="RGD:1307024"
     exon            1..57
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1580
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /note="zinc finger protein, subfamily 1A, 3 (Aiolos)"
                     /codon_start=1
                     /product="zinc finger protein Aiolos"
                     /protein_id="NP_001100517.1"
                     /db_xref="GeneID:303511"
                     /db_xref="RGD:1307024"
                     /translation="MEDIQPSAELKSTEEQPLPTESPEALNDYSLPKPHEIENVDGTE
                     APANEDEDAGEDLMMKVKDEYSERDENILKPEPMVDAEESEPPYSYAREYSDYENIKL
                     ERHGPYDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGN
                     LLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLE
                     EHKERCRAFLQNPDLGDAASVEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIG
                     EKRHCFDANYNPGYMYEKENEMMQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEM
                     VPVISSVYPIALTRADMPNGAPQELEKKRILLPEKILPSERGLSPNNSAQDSTDTDSN
                     HEDRQNHIYQQGHMVLPQARNGMPLLKEVPRSFELLKPPPICLRDSIKVINKEGEVMD
                     VFRCDHCHVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRAML
                     K"
     exon            58..111
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            112..213
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            214..474
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..642
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            643..759
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..876
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..2333
                     /gene="Ikzf3"
                     /gene_synonym="Zfpn1a3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaccgggg agcctgagcg acagctacag cccgcgcggc ccgcggcgac atggaagata
       61 tacagccaag tgcggagctg aaaagcactg aggagcaacc tctgcccaca gaaagcccgg
      121 aagctctgaa tgactacagt ttacccaaac ctcatgagat tgaaaatgtg gacggtacag
      181 aagccccagc caatgaagac gaagatgcag gagaagactt gatgatgaaa gtgaaagatg
      241 agtacagcga gagagatgag aatattctga agcccgagcc catggtagac gcagaggaga
      301 gcgaaccgcc ttacagctat gcaagagagt acagcgacta tgaaaacatt aagctggaga
      361 gacacgggcc gtacgacagc agcagaccca ccagtgggaa gatgaactgc gatgtgtgcg
      421 gcttatcctg cattagcttc aatgtcttga tggttcacaa gcgaagccat accggtgaac
      481 gcccgttcca gtgtaatcag tgtggggcat cttttactca gaaaggtaat ctccttcgcc
      541 acattaagct gcacacaggg gaaaaacctt ttaagtgtca cctctgcaac tacgcatgcc
      601 aaaggagaga cgcactcacg ggacacctta ggacacattc tgtggagaag ccctacaagt
      661 gtgagttctg cggaagaagc tacaagcaga gaagctccct ggaggaacac aaggaacgct
      721 gccgtgcgtt tcttcagaac cctgacctgg gggatgctgc aagtgtggag gcgagacaca
      781 tcaaagccga gatgggaagt gaaagagctc tcgttctgga cagattggca agcaatgtgg
      841 ctaaacgaaa aagctcgatg cctcagaaat tcattggtga gaagcgccac tgctttgacg
      901 ccaactacaa tccgggctac atgtacgaaa aggagaacga gatgatgcag acccggatga
      961 tggaccaagc catcaacaac gccatcagct atctcggggc tgaagccctt cgccccttag
     1021 tccagactcc gcctgctccc acctctgaga tggtcccagt catcagcagc gtgtacccca
     1081 tagcacttac tcgggccgat atgcccaatg gggccccaca ggagctggag aagaaacgga
     1141 tcctcctgcc agagaagatc ttgccttctg aacgaggtct gtcccccaat aacagtgccc
     1201 aggattccac agacaccgac agcaaccacg aggatcgcca gaatcacatc taccaacagg
     1261 gccacatggt cctcccccag gcccgcaacg ggatgccact tctcaaggag gtacctcgct
     1321 ctttcgaact cctcaagccc cctcccatct gcctgaggga ctccatcaaa gtgatcaaca
     1381 aagaagggga ggtgatggat gtgttccggt gtgaccactg ccacgtcctc ttcctagatt
     1441 atgtgatgtt caccatccac atggggtgcc acggtttccg tgaccccttt gagtgtaaca
     1501 tgtgtggata tcgaagccac gatcgctacg aattctcctc tcacatcgcc aggggagaac
     1561 acagagccat gttgaagtga gcatccgtct ccaagcgcac acctaagggt cagcattgtt
     1621 tttaaaagct gatgacaacc ttacccagta gaccgaactc aaacccacag ccctgcccag
     1681 gtacatcagc tctcagtcat ggctggcagg agcggtcaga gagacactgc cctcatccag
     1741 aaactgtctg cagagctgtc atgtcacttt gggaaacctc cctctcccgt cagttgaatt
     1801 cgatgggatt taaaagccaa agaagaatct ggttcattat cttttgtagc aatccactgg
     1861 agctcctggc caattggctg caggaatcat tcgctggaat tctcagccat atgtggaaaa
     1921 gccttttgat cctatgccca gatccacacg cacagcagaa caactgacca gctacccttg
     1981 cccttgggca ccaacacaag gcagaagggt tagcaaggca gaagggttag tgtgttgtca
     2041 tccctccctt cacgtccaaa cagtaaagaa gaggtgttta taacagtaag gacccgctgt
     2101 cagtaatgga agaccctatt tgtggcgctt caatccactt cctatcacgc aagcaaaaca
     2161 aaactgaagc catctgagga cccttctgct ttacctgatg tcgcaaggga caacctcaga
     2221 caatttggcc tgagccagaa ctctgatcct cctgcctctg tctggaggaa aattctgaac
     2281 cggaagagcc aatgatttta aacatcgggt atcatggaaa ccgcagtcat cca
//
