LOCUS       NM_001106916            9369 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus IKAROS family zinc finger 2 (Ikzf2), mRNA.
ACCESSION   NM_001106916 XM_001054364 XM_237228
VERSION     NM_001106916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9369)
  AUTHORS   Muto,S., Owada,Y., Inoue,T., Watanabe,Y., Yamaura,T., Fukuhara,M.,
            Okabe,N., Matsumura,Y., Hasegawa,T., Osugi,J., Hoshino,M.,
            Higuchi,M., Suzuki,H. and Gotoh,M.
  TITLE     Clinical significance of expanded Foxp3 Helios regulatory T cells
            in patients with non-small cell lung cancer
  JOURNAL   Int J Oncol 47 (6), 2082-2090 (2015)
   PUBMED   26460798
REFERENCE   2  (bases 1 to 9369)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Feb 16, 2022 this sequence version replaced NM_001106916.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2134791.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               JAXUCZ010000009.1  78640152-78640359   c
            209-312             JAXUCZ010000009.1  78638824-78638927   c
            313-361             JAXUCZ010000009.1  78637284-78637332   c
            362-466             JAXUCZ010000009.1  78636342-78636446   c
            467-733             JAXUCZ010000009.1  78543867-78544133   c
            734-901             JAXUCZ010000009.1  78536631-78536798   c
            902-1039            JAXUCZ010000009.1  78516402-78516539   c
            1040-1183           JAXUCZ010000009.1  78509497-78509640   c
            1184-9369           JAXUCZ010000009.1  78495676-78503861   c
FEATURES             Location/Qualifiers
     source          1..9369
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..9369
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /note="IKAROS family zinc finger 2"
                     /db_xref="GeneID:301476"
                     /db_xref="RGD:1308686"
     exon            1..208
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..312
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..361
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1908
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /note="zinc finger protein, subfamily 1A, 2 (Helios)"
                     /codon_start=1
                     /product="zinc finger protein Helios"
                     /protein_id="NP_001100386.2"
                     /db_xref="GeneID:301476"
                     /db_xref="RGD:1308686"
                     /translation="METDGIDGYITCDNELSPEGEQATMAIDLTSSTPNGQHASPGHM
                     TSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEDPLIESGEVADNRKVQDLQGE
                     GGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIK
                     LHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERC
                     HNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKR
                     KSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALH
                     PLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDGPISLIRPKSR
                     PQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPPYMKEDVKALDATKAP
                     KGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRS
                     QDRYEFSSHIVRGEHTFH"
     exon            362..466
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..733
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..901
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1039
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1183
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..9369
                     /gene="Ikzf2"
                     /gene_synonym="Zfpn1a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctaaccctg ctcctcgctg aagatggagg aagtaaaaac aggattaccc ttagctacag
       61 atccactgcc ttagtttcca ccaccaactg cagtgcacaa acacacgtta ggcacaggaa
      121 agaaagaaag agagagaggg agaggacaca ctaacagtaa acacaaacaa aagggtgatg
      181 ggattatttt actgcatgca ctgctgagcc cgacattgtc acctcctctt tgaggggtta
      241 gaagaagctg ggatctcccg acagagctgg aaatggtgat gaatgttttt taatcaaagg
      301 acaatttctt ttcactgcac tttgactatg gaaacggacg gaattgatgg ctacataacg
      361 tgtgacaatg agctttcacc tgaaggggag caggccacca tggccattga cctcacttca
      421 agcacaccca atggacagca cgcctcgcca ggtcacatga caagcacaaa ttctgtaaag
      481 ctggaaatgc agagtgatga agagtgtgac aggcagcccc tgagccgtga ggacgagatc
      541 aggggccacg atgaggggag cagcctagaa gatcccctaa ttgagagcgg cgaggtggcc
      601 gacaacagga aagtccagga ccttcaaggc gagggaggaa tccggcttcc gaatggtaaa
      661 ctgaaatgtg acgtctgtgg catggtttgc attgggccca atgtgcttat ggtacataaa
      721 cggagtcaca ctggtgagcg gcccttccac tgtaaccagt gtggagcttc ttttacccag
      781 aagggcaacc ttctgagaca cataaagtta cactctggag agaagccgtt caaatgtcct
      841 ttctgtagct atgcttgtag aagaagggac gctctcacag gacacctcag gacccactct
      901 gtgggtaaac ctcacaagtg taactactgt ggccgaagct acaagcagcg cagctcactg
      961 gaggaacaca aggaacgctg tcacaactat ctccagaatg tcagcatgga ggctgccggg
     1021 caggtcatga gtcaccatgt cccgcccatg gaagattgta aggaacaaga gcctatcatg
     1081 gacaacaata tttctctggt gccttttgag agacctgctg tcatagagaa gctcacggcc
     1141 aatatgggaa agcgcaaaag ctccaccccg cagaagtttg tgggggaaaa gctcatgcga
     1201 ttcagctacc cagatattca ttttgatatg aacttaacgt acgagaagga ggctgagctg
     1261 atgcagtctc atatgatgga ccaagccatc aacaatgcaa tcacctacct tggagctgag
     1321 gcccttcacc ctctgatgca gcacgcacca agcacaatcg ccgaggtggc cccagttata
     1381 agctcagctt attctcaggt ctatcatcca aacaggatag aaagacccat tagcagggag
     1441 acagctgata gtcacgagaa caacatggat ggccccatct ctctcatcag accaaagagt
     1501 cgaccccagg aaagagaggc ctctcccagc aatagctgcc tcgattctac tgactcagaa
     1561 agcagccatg atgaccgcca gtcctaccaa ggaaaccctg ccttaaatcc caagaggaaa
     1621 caaagcccac cttacatgaa ggaggatgtc aaggctttgg atgctaccaa ggcccccaag
     1681 ggctctctga aggacatcta caaggttttc aacggagaag gagaacagat aagggccttc
     1741 aagtgtgagc actgccgagt ccttttccta gaccatgtca tgtacaccat tcacatgggt
     1801 tgccatggct accgggaccc actggaatgc aacatctgtg gctacagaag ccaggaccgc
     1861 tacgagtttt catcacacat tgttcgaggg gagcacacat tccactaggc cttttcattc
     1921 caaaggggac ccctatgaag aactgcacat gaagaaatac tgcacttaca gtcccacctt
     1981 ccctcagatg gtgacatgct tacttcttca tgctgtcact gtctatattt cttattttgt
     2041 ggacaaaatg tcatttgctc tgcctaatta caataaggaa gaaacaagag aaaagggatg
     2101 ggatgttcac tgataacttg gcttgtttat ttcgtgagca tttaaagcag ttcatttcgg
     2161 ccatgcgtcc ttgctaaggc ctatcatgat ttaggagatc actcagttca tagagattcc
     2221 tctaagatat tctgatttgc cattcatgtt caggattatg atagaaggca ggaaagttga
     2281 gagttctctg ggtaggattt tgggcaattc aaaacagtct aagtcatttt actctcaaag
     2341 aagatgtttc aaaatgtaaa cccattttat tttctgttct tagagatcat ggaacacaaa
     2401 cacgatgtta ttttccataa ctacaaggat gagttgaatt gttatgggtt ctgtgtttac
     2461 ctcccctacg gaatttataa ttgagtatgt tttacactgt atcctatagc aaaactttta
     2521 aactacaggt agtcaagggc cactatgata catctgaggt cctttgatct tatttttcta
     2581 aacttgcgca ctgtttttcc atagttttga tgactggcat tttatagaca ccctggcagc
     2641 cttactttta acacctgtaa caaatagtat ttttatgtag ttttcagaat aacatatgtt
     2701 cgcaagagtg ggtaagaggc agtcagtaat ttccaggaag aattctgctt ttcacaattt
     2761 gagattgttt tttttttttc ttttaagctg taagatgccg gcagcctagt atacatattt
     2821 gcttctaaag gtgtgtttac gattgtcact ttatcagcat tcagtgttaa ccagtcagca
     2881 gaaaagtgta attaggcgaa cagtaggggg aattcccact ctaagaaccc ttttctggta
     2941 tttctcttca agctgtgagc agtcagtgtt ctatcatagt tcattcctct ttgactcttg
     3001 gtatagaagg tcttaaagag ccttgctaac agctgcttcc tctgaaatca tggagcaact
     3061 gttaattgga cctgaaagtg ctcacctgaa ccctggaagg tcttttattt actagggcta
     3121 tgtattccac tatttcttca gtaatgtcat tgcctttgct ggagacaaaa gggaacctct
     3181 ttgttaccag aatagcatag tgcaggtcaa acaaacaaac agaaagtttt ctgtcagcct
     3241 tcctggagct gagaatgtga cactcttcag gagagggtcc cgcactttaa aaataaaaac
     3301 aaaaagttca actctagagg cccttatcag aaatgaatct caacccctta gtcaagaatc
     3361 tactgtcttc tcttaatttg cacatgacat atacttccat atttcatgct caggttttaa
     3421 tccgatcgct gcgagttctc agcttttctt tttctttccg aagttcactt gcatgtgtgg
     3481 gtagggttgg agcacactgt catcaaggca tttgggggaa tccatttggc agatatatac
     3541 atatacatat atatatatat atatatatat atatatatat agatagatag agagagagag
     3601 agcgagctgc ttgtgttaga ggaaaagaag cctgaccata agtggattat ttgacagcca
     3661 tttgtaaatg ctgaaaggtc ttctgggagg taacacatag ctgctccatc agacctttga
     3721 ctgtcatgcc aaaaccatgt ttgctgtggg aagtgttaag actcaagtag tgtccaccga
     3781 tgagcaacgt gtgtgctcct aacgtgcgtg ctcctaacgt gcttcacagg tttccttctg
     3841 ttcatttaag caacttccta gccctaccgt agccagagcc acgtagttct gacttgcttc
     3901 ttttactaac tcttatcttc gttatttctg gagaaatatc caaatggtac ctttacatgt
     3961 aagagaatgc accaaaaaaa aaaagagcta tatcaaatgc caactgttgg gttttccaag
     4021 ttttgttttc gtatcccttg gtacattgtg aaaacacagt ttactcaggg ataaaacatc
     4081 tcgtcacgcc ttccttgtcc ccgtttagcc tgcacactct ggaatcacag tggaaaggat
     4141 atttatttct gaatgaggta aataagttta aggctcatga catttttgtt ttaatgtaac
     4201 ttaaggaagc atccggatgc ctgtctgggt gttcgttttg gctcattgtg gacacatgca
     4261 agcgtctgct gtcaactttc cttctctctg ctcgcaccta ctgtgttaac aatcatgcac
     4321 ctatctgccc taggacgaaa ctgactttag gtgtactgaa agagtcgtgt ccttccccca
     4381 caaaggtggt accgacgtgc tctgcctttc tgatcccatt ttattggaaa acctgattta
     4441 ttcagaggag tgagctataa gggtttattg gttgtacata cacacttagc attttttttc
     4501 agctgcatgg cacaaggtac agataaaagt agatagctct gatgtgacag ggacaaatga
     4561 gggcaaagtg aacccaagac tcgtgagtta ctataaactc tgtggaccct cagtgacggt
     4621 cacacttgct tctgtttcac caaagagaat aggagacacg gtagcaccta aaagtaagca
     4681 tgatggccag ataccaaata aatcaaattt acataaccgt cacaagacca gtttacttag
     4741 gtgaaatgtc acccttgaga gaggatttga gggcatgaaa atgggttacc ctctgtgttt
     4801 tccagtttgt cgggaattta acagatggct ctgccctcat tttgcccaaa ttattattat
     4861 tatttttgat ctccagttcc ttctggagaa acatgctgcc tcccggtaac cgtgatgaat
     4921 tgcttgttat aaaggctttt tagagcagtg agaacagcca gcatgatgag cggtggaggg
     4981 aaacactgtc attcaaacat tccattaaga agtgtctgga taaaatgggg atatgagggc
     5041 cgaccattaa gatttaggac gaagtcgcct ggctggctgg catgcgtaca ggtcagtgtt
     5101 tgaatgcagt atagttcaca tgcacatgtg tattgcacat tcttttaata aaaattcaca
     5161 gaaaagaagc agttagaaat caccagttgt gttgcaaagg catagagtta gaagtacagt
     5221 ccagcaggtg tattaggaaa gcccaaagtt gtccatgtgt ctttaagact aatggccatt
     5281 taaatcgcga atctccattg cctgcatcga gaaaaacaaa gcaaagggaa tgcaatgaaa
     5341 cagtgaaagg gtattaagtt ggctggtgga tatttgaaga agtaccaatt cttttccgag
     5401 tggaagaaaa tgcaggaaat gacttagcaa ctttggcttg tatgcgtgat ttcctgtcca
     5461 gtggtacacc tcacaagttt gtagtttcca agacttcatc ttctctccaa aatgctaagt
     5521 cagggtagaa aggtgtgctg aagaggcccg aaagcaccag gagagcgtct gtcctagatt
     5581 caggacagca cgtacactat ccaagtcacc tgctgtagtg tttcagcctg ggattattct
     5641 ttttactata aaattgtaga ctggtggtca tcggcagttg tatttcatgt tatttcaata
     5701 actactgtct gtataattat tctacagcag acgctccccc aggtccaaaa agggaaaaaa
     5761 gtgaggggtg aattgaaact ttgtatatat aaaagttatt ttataaatat tttagtcttc
     5821 cagtttctgc aaaataatta aaatatacag taactggtct cttaacccct gaatttaatg
     5881 tattaaatac ttataaaatt ttatattggt gccttttaaa aatgcattga gagtgctggg
     5941 tagctgtttg gctccaccac acttggactg tgtatttttt aagaaaaaaa aaatcacata
     6001 aaatctaagt actctctaat tcacctttgt gttcttagaa aaaaagaaag gaaaaaagct
     6061 gctaaaagac tttaccagac ttttagctga gctggcaaat gtgacaagaa actttgaaac
     6121 cagattttaa tctttttggc ttgatggtat ttctggacac tattctgtcg gggcaaaatt
     6181 gtagactcac atgtcagcag tgaattggat tatgctatgt ggtttaattt attcttgagg
     6241 aagaatatgt tttgcatcac acagggggtt ctttgtataa tttggagtca ataattacag
     6301 tattgttttg ctttaaaaaa atgcccgact ggtgttgctc tagtcttggg tcttctgtct
     6361 tctaacctgt agttgtttgg tggaatggtg tgcaaatgtg gaccattgtt tcctcctgaa
     6421 caaaacaaag ctcagctctc aagtcccatg actccaaagt gtcatctcag atgtttaacg
     6481 cggggttgtc tgtcactttg tgaagggtgt cttcgactat gacaactttg taaaaaacga
     6541 gctgctggtt ttacaaagta gacatcatat gaccaagaag ctgtgatgtg ctagtgtttc
     6601 tttccgtcat agtgtactct taggccaaat aatgacacct tgaatatttt tacatttatt
     6661 acagagacct aaaattttgg aattctaaaa ggtttttatg taatgctcta tcttacagca
     6721 gttttctctt ctcttgctgt actgtgagtc tgtgcgtatt tttttcttac gcacccttgg
     6781 aaatgagttt ttagttctgt ttatggtgtt tctctcccat acactcgttt atatacgttc
     6841 tgtacacatt tcttatgaag ccacctttct tgtgcataga caagtgacaa gtacatgaac
     6901 cactagttcc ctaagatgac ttttatatta tgaattaata tgaaatttat agatcatgtg
     6961 ctaagcccca ttaagtgcag aataaaaact tcctataggt ccaaataagc cagtgtgcac
     7021 tgaattgggc cttcagttta cctcgagtga cacgaagtaa ggaaagcttg ggcagatggc
     7081 ggtccctcta gccagcacca tacacttact agcatgtcgc tgagtctcat ttactgggaa
     7141 tggattttta aaggaataca ctggaaggag ggaagggatc gggggacttc tggtgttttt
     7201 gtggttgctt tgtccttttt aaaatgttgt tcaaattgtg gaactgtgat ctaaaaacat
     7261 ttagactgag gagcaccgga gaggatgtcc gtcaatcact tgcccttctg taccgctaag
     7321 ttctggtttc gcctctccct tcctctcacc tcctcatccc cactctgtat gtagccctcc
     7381 tcgccattgc ttctccatgt ctctctcgac cctcctacta gttaggaggg caactctgaa
     7441 cttccgactc atgaagtctt aactttttgt ctcagtggtt tttgttagct gtgtagtctg
     7501 ctggcgtatt tttataccct agtggagttt tgtatttcca aagcgtggtt gggttgacat
     7561 ggtaagctgt atagtcctta ccttgcttca tcctcaagta ggaggcacgg aacatgactc
     7621 cagcaattct ggaatcggag tatccgtctg gctcctttgt gcttggattc tgacttgttt
     7681 ggctttcttc ttaaatacaa atcataagag agtagactcc cccatcccca ccaaacactg
     7741 agaggataaa aacggaaagc aagagtctta actttctccc aacggggtgc ggggaggggc
     7801 gagtgcttta acacttctga gtgatatttc aggttcagaa ggggtcccca gacccctcgc
     7861 gctcaccatc gggtcccttg gaccctgtgc tatttgcagc ttcagaatgg ttacttttgt
     7921 gatggagttt aactgctatt ctttttttcc ccataaaagt gcaatacccc tcttgaagtc
     7981 ttaaaaacta tggtaatttt cttcttttct ctttctgaca tttgtttctt ttaccaatga
     8041 tgaaaagaaa ccattggaaa ttgtaacatg tcataggaca taacaagcaa aaatgaaaaa
     8101 ccactccact atgaaaagct gaaaaaaaaa atgtaacaaa tgacttctct gactttctgg
     8161 aaacttcgtt taggctaaat tgccttggaa atcatgagtg agaagtttat cctgaggctg
     8221 aaatatgatt tttctcccac tcttgtctaa tgctcttaag ttaaataact aatatttaat
     8281 gttttcattt ctctcctttt ggaatataaa tatcaaagca cttaggtcag gtttaaatca
     8341 atattacctg ttgaagaaaa attttttaca tatttaaagc agacctgttt caatgcagat
     8401 ggagaagtat cttttgtatt atccatattt atatgtagtg tgctcttttt ttaatacctg
     8461 tgtttctgta gtaagactgc tgtattgtaa atacacgttt tattaaaaag taacatttct
     8521 ttggcatttc ttttgatggc atatactgta tttgtacagt atatgtcttg gctacttaac
     8581 ttttttttct ttaacaatac caaaggtaat tagactattt taaggactaa ttgcttgaca
     8641 gtttctagaa tactttgatt tttttagaag aaaagagaaa aaaaatttaa aaaaaaagtc
     8701 aaaccagtga acctcatttt ttcaaactaa taatttgggg aaataaaaac tattgtttaa
     8761 aaagaaatat atataaatat atatatataa atatctgtaa aattaaaatc ccaaaccttg
     8821 tatgtcaggt ttgctcagtg taatgtaggg gttttttttt ttgttttgtt tttgtttttt
     8881 taaggctcaa atacctcaga aaatggggtt tactatggaa atgctgcggc agtctctgca
     8941 gctgtgtgag ctgtcatcct gctgcatccg gattgggaga cctccactaa acagttttat
     9001 cactgcagac taaaatgtgg gacttgtatt ttctttgttt tttaatgcac acacgtacat
     9061 gctccgtgcg tgtatgtggg taccgtgtat atgtgtgtga gtgttgtata tgcatgtgtg
     9121 aatgtgtgtg tgtgcgtgcg cacgcgtgtg tgtgtacaac taaagaagct gcagaaactt
     9181 tgtaatactt tgtgaaaggg ttatattata aaggtttgta ctgtctgagt gcacagctac
     9241 tggaataaac ttagccaatc tcaggaacaa gcatataatt tgtccaagat ttatttcttc
     9301 tcagaagtgt aagtgcagtt tttaattctg tatattattt aatattttac caataaaata
     9361 aacttctga
//
