LOCUS       NM_001107237            2023 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus IKAROS family zinc finger 1 (Ikzf1), mRNA.
ACCESSION   NM_001107237 XM_001056046 XM_223600
VERSION     NM_001107237.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2023)
  AUTHORS   Young,G.P., Symonds,E.L., Nielsen,H.J., Ferm,L., Christensen,I.J.,
            Dekker,E., van der Vlugt,M., Mallant-Hent,R.C., Boulter,N., Yu,B.,
            Chan,M., Tevz,G., LaPointe,L.C. and Pedersen,S.K.
  TITLE     Evaluation of a panel of tumor-specific differentially-methylated
            DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of
            colorectal cancer
  JOURNAL   Clin Epigenetics 13 (1), 14 (2021)
   PUBMED   33478584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2023)
  AUTHORS   Sharma,B., Shah,R., Jamwal,R.S., Verma,S., Bhat,A., Bhat,G.R.,
            Bakshi,D., Singh,S., Angurana,S., Bhat,A., Vaishnavi,S. and
            Kumar,R.
  TITLE     Evaluation of newly identified Ikaros family zinc finger 1 loci in
            colorectal cancer
  JOURNAL   J Cancer Res Ther 17 (1), 46-50 (2021)
   PUBMED   33723131
REFERENCE   3  (bases 1 to 2023)
  AUTHORS   Musher,B.L., Melson,J.E., Amato,G., Chan,D., Hill,M., Khan,I.,
            Kochuparambil,S.T., Lyons,S.E., Orsini,J. Jr., Pedersen,S.K.,
            Robb,B., Saltzman,J., Silinsky,J., Gaur,S., Tuck,M.K.,
            LaPointe,L.C. and Young,G.P.
  TITLE     Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1
            to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC)
  JOURNAL   Cancer Epidemiol Biomarkers Prev 29 (12), 2702-2709 (2020)
   PUBMED   32958500
REFERENCE   4  (bases 1 to 2023)
  AUTHORS   Zhao,W., Chen,T.B. and Wang,H.
  TITLE     Ikaros is heterogeneously expressed in lung adenocarcinoma and is
            involved in its progression
  JOURNAL   J Int Med Res 48 (8), 300060520945860 (2020)
   PUBMED   32787735
REFERENCE   5  (bases 1 to 2023)
  AUTHORS   Symonds,E.L., Pedersen,S.K., Murray,D., Byrne,S.E., Roy,A.,
            Karapetis,C., Hollington,P., Rabbitt,P., Jones,F.S., LaPointe,L.,
            Segelov,E. and Young,G.P.
  TITLE     Circulating epigenetic biomarkers for detection of recurrent
            colorectal cancer
  JOURNAL   Cancer 126 (7), 1460-1469 (2020)
   PUBMED   31909823
REFERENCE   6  (bases 1 to 2023)
  AUTHORS   Honma,Y., Kiyosawa,H., Mori,T., Oguri,A., Nikaido,T., Kanazawa,K.,
            Tojo,M., Takeda,J., Tanno,Y., Yokoya,S., Kawabata,I., Ikeda,H. and
            Wanaka,A.
  TITLE     Eos: a novel member of the Ikaros gene family expressed
            predominantly in the developing nervous system
  JOURNAL   FEBS Lett 447 (1), 76-80 (1999)
   PUBMED   10218586
REFERENCE   7  (bases 1 to 2023)
  AUTHORS   Kelley,C.M., Ikeda,T., Koipally,J., Avitahl,N., Wu,L.,
            Georgopoulos,K. and Morgan,B.A.
  TITLE     Helios, a novel dimerization partner of Ikaros expressed in the
            earliest hematopoietic progenitors
  JOURNAL   Curr Biol 8 (9), 508-515 (1998)
   PUBMED   9560339
REFERENCE   8  (bases 1 to 2023)
  AUTHORS   Boggs,S.S., Trevisan,M., Patrene,K. and Geogopoulos,K.
  TITLE     Lack of natural killer cell precursors in fetal liver of Ikaros
            knockout mutant mice
  JOURNAL   Nat Immun 16 (4), 137-145 (1998)
   PUBMED   10366784
REFERENCE   9  (bases 1 to 2023)
  AUTHORS   Molnar,A. and Georgopoulos,K.
  TITLE     The Ikaros gene encodes a family of functionally diverse zinc
            finger DNA-binding proteins
  JOURNAL   Mol Cell Biol 14 (12), 8292-8303 (1994)
   PUBMED   7969165
REFERENCE   10 (bases 1 to 2023)
  AUTHORS   Georgopoulos,K., Bigby,M., Wang,J.H., Molnar,A., Wu,P., Winandy,S.
            and Sharpe,A.
  TITLE     The Ikaros gene is required for the development of all lymphoid
            lineages
  JOURNAL   Cell 79 (1), 143-156 (1994)
   PUBMED   7923373
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474055.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056046.1, XM_223600.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680412,
                              SAMN06680417 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2023
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2023
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /note="IKAROS family zinc finger 1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
     exon            1..198
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            199..252
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1499
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /codon_start=1
                     /product="DNA-binding protein Ikaros"
                     /protein_id="NP_001100707.1"
                     /db_xref="GeneID:305501"
                     /db_xref="RGD:1562979"
                     /translation="MDVDEGQDMSQVSGKESPPVSDTPDEGDEPMPVPEDLSTSGAQQ
                     NSKSDRGMGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTG
                     HLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGMYPVIKEETNHSEM
                     AEDLCKIGAERSLVLDRLASNVAKRKSSMPQKFLGDKCLSDMPYDSANYEKDEMMTSH
                     VMDQAINNAINYLGAESLRPLVQTPPGSSEVVPVISSMYQLHKPPSDGPPRSNHSAQD
                     SAVENLLLLSKAKSVSSEREASPSNSCQDSTDTESNAEEQRSGLIYLTNHITPHARNG
                     LALKEEQRAYEVLRAASENSQDAFRVVSTSGEQLKVYKCEHCRVLFLDHVMYTIHMGC
                     HGFRDPFECNMCGYHSQDRYEFSSHITRGEHRYHLS"
     exon            253..369
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            370..537
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            538..660
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            661..795
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
     exon            796..2023
                     /gene="Ikzf1"
                     /gene_synonym="RGD1562979"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcctgac tctacgcagg cactcagtgc ctgacatgcc tgggagaggt ctgcggagcc
       61 gtggagcgtg gtgcaggatt gccttgctcc cacctctgcc cacagacccc ttccacgctg
      121 gcgcgtgcac acaggccggg atgtaaggcg ccatcctaac ttctgccgta agcaggtggg
      181 agggaagaga cgcgagagat aatctgaaga caatggatgt cgatgagggt caagacatgt
      241 cccaagtttc aggaaaggag agccctccag tcagtgacac tccggatgaa ggggatgaac
      301 ccatgcctgt ccccgaggac ctgtccacct ctggagcaca gcagaactcc aagagtgatc
      361 gaggcatggg tgaacggcct ttccagtgca accagtgtgg ggcctccttt acccagaaag
      421 gcaacctact gcggcacatc aagctgcact cgggcgagaa gcccttcaaa tgccatctct
      481 gcaactatgc ctgccgccgg agggacgccc tcaccggcca cctaaggacg cactccgttg
      541 gtaagcctca caaatgtgga tattgtggcc ggagctataa acagcgaagc tctttagaag
      601 aacataaaga gcgatgccac aactacttgg aaagcatggg cctcccgggc atgtacccag
      661 tcattaagga agaaactaac cacagcgaaa tggcagagga cctgtgcaag ataggagcag
      721 agaggtccct tgttctggac aggctggcca gcaacgtcgc caaacgtaag agctctatgc
      781 ctcagaaatt tcttggagac aagtgcctgt cagacatgcc ctatgacagt gccaactatg
      841 agaaggatga gatgatgaca tcccacgtga tggaccaggc catcaacaat gccattaact
      901 acctgggggc tgagtccctg cgcccgttgg tgcagacacc ccctggtagc tccgaggtgg
      961 tgccggtcat cagttccatg taccagctgc acaagccccc ctcagacggc ccaccacggt
     1021 ccaaccactc agcacaggac agcgccgtgg agaacttgct gctgctgtcc aaggccaagt
     1081 ccgtgtcatc agagcgggag gcctccccaa gcaacagctg ccaagactcc acggatacag
     1141 agagcaacgc ggaggaacag cgcagcggtc tcatctacct aaccaaccac atcactccgc
     1201 atgcgcgcaa cgggctggct ctcaaggagg agcagcgcgc ctacgaggtg ctgagggcag
     1261 cctcagagaa ctcgcaggac gccttccgtg tggtcagcac gagtggtgag cagctgaagg
     1321 tgtacaagtg cgaacactgc cgcgtgctct tcctggatca tgtcatgtac accatccaca
     1381 tgggctgcca tggcttccgg gatccctttg agtgtaacat gtgtggttat cacagccagg
     1441 acaggtacga gttctcttcc cacatcacac ggggggagca tcgctaccac ctgagctaaa
     1501 cccagccagg ccccactgaa gcacaaagat agctgggcat gcctctttcc cagcagctgg
     1561 acccacggcg gacaatgttg ggagtggatt tgcaggcagc atttgttctt ttacgttggt
     1621 tgtttgagat ttgatttgcg tttagaagac aagtttttaa tgttagagac aggattccat
     1681 tgcatcagga acgttcagaa cacccatcct tctagacggt tttgttgact gctagctgag
     1741 atttccctgg tatgtggctt cctaacgctc tccctacccg ccccaccccc aaaacagagc
     1801 ccgaatcttc agagaaatta attaaacaat tacccaagta ggagcaaggt ggatttttcc
     1861 ctaagcagag tttataccac aaagattctc caagtcctcc aaaacagcac agggacatca
     1921 gcctgtgcag agaccagggc cgaaggctga acttagaaag ctactattag gccatgtatt
     1981 gcacggcaat gcggtgtcgg aacaagatgt ttgaggtgct gaa
//
